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Molecules 2019, 24(2), 274; https://doi.org/10.3390/molecules24020274

Chemistry of Bridged Lactams: Recent Developments

1
Department of Chemistry, Wroclaw University, F. Joliot-Curie 14, 50-383 Wroclaw, Poland
2
Department of Chemistry, Rutgers University, 73 Warren Street, Newark, NJ 07102, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Michal Szostak
Received: 28 December 2018 / Revised: 9 January 2019 / Accepted: 10 January 2019 / Published: 12 January 2019
(This article belongs to the Special Issue Amide Bond Activation)
Full-Text   |   PDF [11269 KB, uploaded 14 January 2019]   |  

Abstract

Bridged lactams represent the most effective and wide-ranging method of constraining the amide bond in a non-planar conformation. A previous comprehensive review on this topic was published in 2013 (Chem. Rev. 2013, 113, 5701–5765). In the present review, which is published as a part of the Special Issue on Amide Bond Activation, we present an overview of the recent developments in the field of bridged lactams that have taken place in the last five years and present a critical assessment of the current status of bridged lactams in synthetic and physical organic chemistry. This review covers the period from 2014 until the end of 2018 and is intended as an update to Chem. Rev. 2013, 113, 5701–5765. In addition to bridged lactams, the review covers recent advances in the chemistry of bridged sultams, bridged enamines and related non-planar structures. View Full-Text
Keywords: amide bond; bridged lactams; twisted amides; amides; Winkler-Dunitz parameters; N–C activation; hypersensitivity; nitrogen heterocycles; distortion; bridged sultams amide bond; bridged lactams; twisted amides; amides; Winkler-Dunitz parameters; N–C activation; hypersensitivity; nitrogen heterocycles; distortion; bridged sultams
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Szostak, R.; Szostak, M. Chemistry of Bridged Lactams: Recent Developments. Molecules 2019, 24, 274.

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