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Amide Bond Activation of Biological Molecules

Department of Chemistry and Biochemistry, Auburn University, Auburn, AL 36849, USA
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Author to whom correspondence should be addressed.
Academic Editor: Michal Szostak
Molecules 2018, 23(10), 2615; https://doi.org/10.3390/molecules23102615
Received: 7 September 2018 / Revised: 9 October 2018 / Accepted: 9 October 2018 / Published: 12 October 2018
(This article belongs to the Special Issue Amide Bond Activation)
Amide bonds are the most prevalent structures found in organic molecules and various biomolecules such as peptides, proteins, DNA, and RNA. The unique feature of amide bonds is their ability to form resonating structures, thus, they are highly stable and adopt particular three-dimensional structures, which, in turn, are responsible for their functions. The main focus of this review article is to report the methodologies for the activation of the unactivated amide bonds present in biomolecules, which includes the enzymatic approach, metal complexes, and non-metal based methods. This article also discusses some of the applications of amide bond activation approaches in the sequencing of proteins and the synthesis of peptide acids, esters, amides, and thioesters. View Full-Text
Keywords: peptide bond cleavage; amide bond resonance; twisted amides; enzymes; metal complexes; catalysts peptide bond cleavage; amide bond resonance; twisted amides; enzymes; metal complexes; catalysts
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MDPI and ACS Style

Mahesh, S.; Tang, K.-C.; Raj, M. Amide Bond Activation of Biological Molecules. Molecules 2018, 23, 2615. https://doi.org/10.3390/molecules23102615

AMA Style

Mahesh S, Tang K-C, Raj M. Amide Bond Activation of Biological Molecules. Molecules. 2018; 23(10):2615. https://doi.org/10.3390/molecules23102615

Chicago/Turabian Style

Mahesh, Sriram, Kuei-Chien Tang, and Monika Raj. 2018. "Amide Bond Activation of Biological Molecules" Molecules 23, no. 10: 2615. https://doi.org/10.3390/molecules23102615

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