Next Article in Journal
Deconstructing Wine Grape Cell Walls with Enzymes During Winemaking: New Insights from Glycan Microarray Technology
Next Article in Special Issue
Well-Defined Pre-Catalysts in Amide and Ester Bond Activation
Previous Article in Journal
Contributions and Challenges of High Throughput qPCR for Determining Antimicrobial Resistance in the Environment: A Critical Review
Previous Article in Special Issue
[2+2+2] Annulation of N-(1-Naphthyl)acetamide with Two Alkynoates via Cleavage of Adjacent C–H and C–N Bonds Catalyzed by an Electron-Deficient Rhodium(III) Complex
Article Menu
Issue 1 (January-1) cover image

Export Article

Open AccessReview

Recent Advances in the Addition of Amide/Sulfonamide Bonds to Alkynes

1
Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, 168 Hua Guan Road, Chengdu 610052, China
2
State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China
3
University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, China
*
Author to whom correspondence should be addressed.
Academic Editor: Michal Szostak
Molecules 2019, 24(1), 164; https://doi.org/10.3390/molecules24010164
Received: 11 December 2018 / Revised: 27 December 2018 / Accepted: 27 December 2018 / Published: 4 January 2019
(This article belongs to the Special Issue Amide Bond Activation)

Abstract

The addition of amide/sulfonamide bonds to alkynes is not only one of the most important strategies for the direct functionalization of carbon–carbon triple bonds, but also a powerful tool for the downstream transformations of amides/sulfonamides. The present review provides a comprehensive summary of amide/sulfonamide bond addition to alkynes, including direct and metal-free aminoacylation, based-promoted aminoacylation, transition-metal-catalyzed aminoacylation, organocatalytic aminoacylation and transition-metal-catalyzed aminosulfonylation of alkynes up to December 2018. The reaction conditions, regio- and stereoselectivities, and mechanisms are discussed and summarized in detail. View Full-Text
Keywords: amide bond; sulfonamide bond; alkynes; addition reaction; aminoacylation; aminosulfonylation amide bond; sulfonamide bond; alkynes; addition reaction; aminoacylation; aminosulfonylation
Figures

Scheme 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed
Printed Edition Available!
A printed edition of this Special Issue is available here.

Share & Cite This Article

MDPI and ACS Style

Zhao, F.; Li, P.; Liu, X.; Jia, X.; Wang, J.; Liu, H. Recent Advances in the Addition of Amide/Sulfonamide Bonds to Alkynes. Molecules 2019, 24, 164.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top