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Molecules 2018, 23(9), 2225; https://doi.org/10.3390/molecules23092225

K2S2O8-Promoted Aryl Thioamides Synthesis from Aryl Aldehydes Using Thiourea as the Sulfur Source

College of Chemistry and Chemical Engineering, Jinzhong University, Yuci 030619, China
These authors contributed equally to this work
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Received: 30 July 2018 / Revised: 24 August 2018 / Accepted: 29 August 2018 / Published: 1 September 2018
(This article belongs to the Special Issue Amide Bond Activation)
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Abstract

Thiourea as a sulfur atom transfer reagent was applied for the synthesis of aryl thioamides through a three-component coupling reaction with aryl aldehydes and N,N-dimethylformamide (DMF) or N,N-dimethylacetamide (DMAC). The reaction could tolerate various functional groups and gave moderate to good yields of desired products under the transition-metal-free condition. View Full-Text
Keywords: aryl thioamides; thiourea; C-H/C-N activation; C-S formation; transition-metal-free aryl thioamides; thiourea; C-H/C-N activation; C-S formation; transition-metal-free
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Bian, Y.; Qu, X.; Chen, Y.; Li, J.; Liu, L. K2S2O8-Promoted Aryl Thioamides Synthesis from Aryl Aldehydes Using Thiourea as the Sulfur Source. Molecules 2018, 23, 2225.

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