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Molecules 2019, 24(5), 830; https://doi.org/10.3390/molecules24050830

Weinreb Amides as Directing Groups for Transition Metal-Catalyzed C-H Functionalizations

Department of Chemistry-BMC, Uppsala University, BOX 576, 75-123 Uppsala, Sweden
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Academic Editor: Michal Szostak
Received: 28 January 2019 / Revised: 15 February 2019 / Accepted: 15 February 2019 / Published: 26 February 2019
(This article belongs to the Special Issue Amide Bond Activation)
Full-Text   |   PDF [4432 KB, uploaded 26 February 2019]   |  

Abstract

Weinreb amides are a privileged, multi-functional group with well-established utility in classical synthesis. Recently, several studies have demonstrated the use of Weinreb amides as interesting substrates in transition metal-catalyzed C-H functionalization reactions. Herein, we review this part of the literature, including the metal catalysts, transformations explored so far and specific insights from mechanistic studies. View Full-Text
Keywords: C-H functionalization; directing groups; amides; transition metals; catalysis C-H functionalization; directing groups; amides; transition metals; catalysis
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Kalepu, J.; Pilarski, L.T. Weinreb Amides as Directing Groups for Transition Metal-Catalyzed C-H Functionalizations. Molecules 2019, 24, 830.

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