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Open AccessReview

Direct Transamidation Reactions: Mechanism and Recent Advances

Laboratory of Organic Synthesis Bio- and Organocatalysis, Chemistry Department, Universidad de los Andes, Cra. 1 No 18A-12 Q:305, Bogotá 111711, Colombia
Author to whom correspondence should be addressed.
Academic Editor: Michal Szostak
Molecules 2018, 23(9), 2382;
Received: 24 August 2018 / Revised: 12 September 2018 / Accepted: 13 September 2018 / Published: 18 September 2018
(This article belongs to the Special Issue Amide Bond Activation)
Amides are undeniably some of the most important compounds in Nature and the chemical industry, being present in biomolecules, materials, pharmaceuticals and many other substances. Unfortunately, the traditional synthesis of amides suffers from some important drawbacks, principally the use of stoichiometric activators or the need to use highly reactive carboxylic acid derivatives. In recent years, the transamidation reaction has emerged as a valuable alternative to prepare amides. The reactivity of amides makes their direct reaction with nitrogen nucleophiles difficult; thus, the direct transamidation reaction needs a catalyst in order to activate the amide moiety and to promote the completion of the reaction because equilibrium is established. In this review, we present research on direct transamidation reactions ranging from studies of the mechanism to the recent developments of more applicable and versatile methodologies, emphasizing those reactions involving activation with metal catalysts. View Full-Text
Keywords: transamidation; amide; amine; catalyst; catalysis transamidation; amide; amine; catalyst; catalysis
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MDPI and ACS Style

Acosta-Guzmán, P.; Mateus-Gómez, A.; Gamba-Sánchez, D. Direct Transamidation Reactions: Mechanism and Recent Advances. Molecules 2018, 23, 2382.

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