Special Issue "Chlamydia-like Bacteria: Evolution, Pathogenicity, Diagnostics and Treatment"
Deadline for manuscript submissions: closed (30 June 2016)
Prof. Dr. Eberhard Straube
Institute of Medical Microbiology, University Hospital Jena, Erlanger Allee 101, D-07747 Jena, Germany
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Interests: mechanisms of persistent infection caused by chlamydiae or other bacteria; zoonotic infections by chlamydiae or coxiella; diagnostic and typing procedures of chlamydiae; molecular epidemiology; quality assessment of diagnostic procedures of chlamydial infection; fast identification of medical important microorganisms
Chlamydiae are phylogenetic old bacteria that are very well adapted to their hosts. They are found within the cells of vertebrates and amoebae, while similar particles have been reported in invertebrate species including coelenterates, arthropods, and molluscs. Chlamydiae are small nonmotile
Gram-negative bacteria with a biphasic development cycle. They are not cultivable in media free of living eukaryotic cells. Many chlamydiae coexist in an apparently asymptomatic state within hosts that probably act as a natural reservoir for them. Chlamydiaceae of the order Chlamydiales contain some well-known human pathogens like Chlamydia trachomatis, Chlamydia pneumoniae, as well as Chlamydia psittaci. Other mainly animal pathogens are accidentally found as cause of a severe infection in Man, e.g., Chlamydia abortus. Even other members of Chlamydiales may contain human pathogens, e.g., Simkania negevensis or Waddlia chondrophila that may be found in human respiratory infections. The pathogenic capacity of further members of Chlamydiales, like Parachlamydiae, Protochlamydiae, and Neochlamydiae that are found in several animals or environment is uncertain. Some chlamydiae have a zoonotic importance. Since chlamydiae have the competence to control their host cell, they frequently produce persistent infections.
Thus, it is important to elucidate the mechanisms of host cell control by these bacteria. Insights into these mechanisms will enable us to find adequate diagnostics as well as effective therapy of diseases caused by chlamydiae.
Prof. Dr. Eberhard Straube
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- Persistent infection
- Chlamydia related diseases
- Diagnostic procedures
- Quality assessment
- Molecular typing
- Molecular epidemiology