Metabolic Engineering for the Bioconversion and Biorefinery of C1 Compounds

Dear Colleagues,

The bioconversion and biorefining of one-carbon (C1) compounds (e.g., CO₂, CO/syngas, methane, methanol, and formic acid) using microorganisms is envisioned as an attractive approach for the sustainable biomanufacturing of a wide range of chemicals, fuels, and materials. This offers the potential to develop biorefinery routes decoupled from the use of sugars and, ultimately, of biomass. In this context, further progress in engineering native C1-utilizing microorganisms and providing conventional chassis cell factories with synthetic C1-utilizing capacities is essential for translating laboratory-scale developments into industrial applications.

This Special Issue is aimed at promoting fundamental knowledge on microbial cells able to naturally assimilate C1 compounds, as well as translational research in synthetic and systems biology and the metabolic engineering of microbial cell factories (either native C1-utilizing or with synthetic C1-utilizing capabilities) for the efficient bioconversion of C1 compounds. This includes the development and optimization of enzymes, pathways, chassis cells, and systems for the improved conversion of C1 compounds into biofuels, biochemicals, biomaterials, and biomass.

This Special Issue accepts both original research articles and reviews relevant to this topic.

Dr. Pau Ferrer
Guest Editor

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