Role of the Fungal Cell Wall in Pathogenesis and Resistance to Antifungal Drugs

Dear Colleagues,

Although the fungal cell wall has been studied for decades, this continues as a very active research area. The wall is essential for cell survival and in pathogenic organisms works as a molecular scaffold to display molecules involved in host damage and disguising the immune system. The conceptualization of the cell-wall-like protective armor, and a tough and impenetrable shield is no longer accepted, and instead, our current visualization of this organelle is like a dynamic, flexible, porous, and plastic wall. This malleability is in response to adaptation to different environments and the presence of stressors and harmful compounds, such as drugs. Because of the nature of its components, the wall is also a source of pathogen-associated molecular patterns recognized by immune receptors, a fundamental step in the establishment of an innate immune response that leads to protective antifungal immunity. In this issue, we seek to gather outstanding contributions on these subjects to generate a specialized repository of up-to-date information about the relevance of the fungal cell wall in pathogenesis and resistance to antifungal drugs.

Prof. Dr. Hector M. Mora-Montes
Dr. José A. Martínez-Álvarez
Guest Editors

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