Pulmonary Embolism Research

A pulmonary embolism (PE) is the occlusion of a pulmonary blood vessel by a clot in one or more of the pulmonary arteries or its branches. Untreated pulmonary embolism carries a high mortality rate (100,000–300,000/year in the USA), especially when a right ventricular strain pattern is present. The incidence of pulmonary embolism is estimated to be 60–70 per 100,000 of the population, and for deep venous thrombosis, it is estimated to be 124 per 100,000. This is likely to be an underestimation, as in the autopsy setting, PE is clinically diagnosed in a higher number of cases (<50%). In addition, with acute pulmonary embolism, we have been challenged by chronic thromboembolic pulmonary hypertension (CTEPH). Diagnosis remains a challenge, and the patient can be asymptomatic to cardiogenic shock due to right-heart failure. Significant research has been done in the pathophysiology, diagnostic, and therapeutic modalities. Newer diagnostic and therapeutic modalities have emerged, but the complications of CTEPH remain. This Special Issue will try to address the research gaps in pulmonary embolisms, CTEPH, risk factors of PE in trauma, obesity, people with coagulation disorder, pregnant patients, COPD, and CHF patients. We will also focus on the pathology of protease activated receptors (PARs), the newer therapeutic technologies, and any advancement in the understanding of pathophysiology. Lastly, the microthrombus formation in the pulmonary artery among COVID-19 patients will also be addressed.

Dr. Salim Surani
Guest Editor

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