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Medicina
Special Issues
Clinical and Translational Approaches to Understanding Aging in Lung Disease
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Clinical and Translational Approaches to Understanding Aging in Lung Disease

A Special Issue of Medicina (ISSN 1648-9144) belonging to the section "Pulmonology".

Deadline for manuscript submissions: 31 October 2026 | Viewed by 897

Editors

Dr. Stefanie Krick

E-Mail Website
Guest Editor
Division of Pulmonary, Allergy and Critical Care Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
Interests: precision medicine; risk prediction; copy number variation; polygenic risk score; omics
Special Issues, Collections and Topics in MDPI journals
Dr. Jarrod Barnes

E-Mail Website
Guest Editor
Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
Interests: glycobiology; pulmonary vascular disease; fibroblast growth factor signalling; vascular remodelling; vascular smooth muscle cells; and pulmonary hypertension
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Life expectancy has significantly increased over the past decade with the prevalence of lung disease increasing markedly with age. Physiological aging leads to molecular changes of the airways, pulmonary vasculature, and parenchyma, thereby causing diminished regenerative capacity and an increased susceptibility to lung infections and diseases. Therefore, studies exploring age-related changes in lung physiology and function are not only crucial for preventing or attenuating disease, but they are also key to better understanding the concept of healthy aging.

This Special Issue will showcase clinical, basic, and translational research that explores aging, hallmarks and pathways of aging, and their connection to vascular and respiratory diseases (e.g., pulmonary fibrosis, bronchiectasis, and pneumonia). The goals of this Special Issue are to highlight the current knowledge regarding how aging influences diagnosis and treatment, to identify gaps in the existing literature, and to discuss research advances that may shape future clinical practice.

We encourage the submission of reviews, research articles, and short communications on a broad spectrum of research topics mentioned above.

We look forward to receiving your contributions.

Dr. Stefanie Krick
Dr. Jarrod Barnes
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lung disease
  • aging
  • chronic inflammation
  • pulmonary fibrosis
  • COPD
  • pulmonary vascular disease
  • senescence
  • airways
  • bronchiectasis
  • lung infections
  • remodeling

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Published Papers (1 paper)

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Research

17 pages, 3793 KB  
Article
Exacerbation Burden and Peripheral Airway Dysfunction as Determinants of Quality of Life in Bronchiectasis: Insights from Impulse Oscillometry
by Vitaliano Nicola Quaranta, Giulia Amoroso, Alessio Marinelli, Maria Rosaria Vulpi, Andrea Portacci, Silvano Dragonieri, Marianna Cicchetti, Leonardo Boccassini, Rossella Novielli, Emanuela Resta and Giovanna Elisiana Carpagnano
Medicina 2026, 62(7), 1381; https://doi.org/10.3390/medicina62071381 - 17 Jul 2026
Viewed by 364
Abstract
Background and Objectives: Health-related quality of life (HRQoL) is a key outcome in bronchiectasis, reflecting the multidimensional burden of the disease. While exacerbation frequency is known to influence patient-reported outcomes, the contribution of peripheral airway dysfunction remains less clearly defined. Impulse oscillometry [...] Read more.
Background and Objectives: Health-related quality of life (HRQoL) is a key outcome in bronchiectasis, reflecting the multidimensional burden of the disease. While exacerbation frequency is known to influence patient-reported outcomes, the contribution of peripheral airway dysfunction remains less clearly defined. Impulse oscillometry (IOS) provides a sensitive assessment of small airway resistance, but its relationship with HRQoL in bronchiectasis has not been fully explored. Materials and Methods: We conducted a cross-sectional observational study including 85 consecutive adults with non-cystic fibrosis bronchiectasis attending a second-level outpatient clinic. Clinical data, exacerbation history, radiological severity, lung function, inflammatory markers, and oscillometric parameters were collected. Peripheral airway resistance was assessed using the R5–R20 parameter derived from IOS. HRQoL was evaluated using the Quality of Life–Bronchiectasis (QoL-B) questionnaire. Associations between QoL-B score and clinical, functional, and inflammatory variables were explored using Spearman correlation and univariate linear regression. Variables with significant associations were entered into a multivariable linear regression model. Results: Patients had a median QoL-B score of 61.5 (IQR 55.5–80.0). Peripheral airway resistance (R5–20) was significantly associated with worse HRQoL in univariate analysis (β = −42.71; 95% CI −83.09 to −2.33; p = 0.038). Exacerbation frequency showed a strong inverse association with QoL-B (β = −5.74; 95% CI −8.60 to −2.89; p < 0.001). In multivariable analysis, exacerbations remained independently associated with poorer QoL (β = −5.365; p = 0.001), whereas the association with R5–20 was attenuated and no longer statistically significant. Conclusions: Peripheral airway dysfunction is associated with impaired HRQoL in bronchiectasis, but exacerbation burden appears to be the dominant independent determinant. These findings support the complementary role of oscillometry and clinical assessment in understanding patient-reported outcomes in bronchiectasis. Full article
(This article belongs to the Special Issue Clinical and Translational Approaches to Understanding Aging in Lung Disease)
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