New Advances in Radiation Therapy

Dear Colleagues,

Radiation oncology continues to evolve as a discipline where technological advancement, biological insight, and therapeutic innovation converge. This Special Issue brings together a series of contributions that reflect some of the most dynamic and promising directions in contemporary clinical and translational research.

Central to this evolution is the increasing adoption of adaptive radiotherapy, which enables treatment adaptation in response to anatomical and functional changes, improving precision without compromising workflow feasibility. The spread of new hadrontherapy centers has made particle therapy available in an ever-increasing number of countries. In parallel, modern fractionation approaches—including hypofractionation and ultra-hypofractionation—are redefining therapeutic paradigms across multiple tumor sites, supported by growing clinical evidence and an improved understanding of radiobiological responses.

The integration of systemic agents, particularly immunotherapy and novel targeted drugs, in combination with radiotherapy or concurrent radiochemotherapy, is expanding treatment opportunities in both curative and metastatic settings. At the same time, radiomics and artificial intelligence are emerging as essential tools in decision support, risk stratification, and treatment personalization, offering a data-driven layer of refinement to existing protocols.

The articles in this collection reflect these trends, offering both technical depth and clinical relevance. By capturing the interplay between innovation and practical application, this Special Issue aims to contribute to the ongoing advancement in patient-centered, precision-based radiation oncology.

Dr. Angela Sardaro
Dr. Lilia Bardoscia
Guest Editors

Dr. Elisa Ciurlia
Guest Editor Assistant

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