Artificial Intelligence in Medicine: Shaping the Future of Healthcare

A special issue of Medicina (ISSN 1648-9144).

Deadline for manuscript submissions: 20 June 2026 | Viewed by 1545

Special Issue Editors


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Guest Editor
1. Prevention and Cardiovascular Recovery, Department VI-Cardiology, University Clinic of Internal Medicine and Ambulatory Care, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania
2. Research Centre of Timisoara Institute of Cardiovascular Diseases, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Interests: preventive medicine; cardiology; AI; evidence based medicine
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Guest Editor
1.Department V, Internal Medicine I—Discipline of Medical Semiology I, "Victor Babesș” University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisșoara, Romania
2. Center of Advanced Research in Cardiology and Hemostasology, "Victor Babesș” University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisșoara, Romania
Interests: cardiovascular diseases; artificial intelligence; preventive medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Artificial intelligence (AI) has rapidly become a cornerstone of innovation in contemporary medicine, enabling advances that extend from diagnostic imaging to drug discovery and personalized therapeutics. By leveraging large-scale biomedical data and sophisticated algorithms, AI holds the promise of enhancing clinical decision-making, improving efficiency, and fostering more precise and preventive healthcare. This Special Issue is dedicated to advancing scholarly discourse on AI in medicine, showcasing both frontier research and critical perspectives on its integration into healthcare systems.

The origins of AI in medicine can be traced to early expert systems such as MYCIN in the 1970s, which attempted to support physicians in diagnosing bacterial infections. While pioneering, these systems were limited in scope and adaptability. Subsequent progress in machine learning and deep neural networks has catalyzed more impactful applications. Notable milestones include IBM’s Watson for Oncology, which demonstrated the potential of AI-assisted clinical decision support, and DeepMind’s AlphaFold, which revolutionized protein structure prediction with direct implications for drug development. Similarly, AI-driven diagnostic models in ophthalmology and radiology have achieved performance on par with human experts.

This Special Issue aims to provide a platform for interdisciplinary engagement on the methodological, clinical, and societal dimensions of AI in medicine. Its scope extends to algorithmic innovation, translational studies, and evaluations of medical-related ethical, regulatory, and policy challenges. A central objective is to bridge the gap between technical development and clinical application, thereby fostering responsible adoption of AI technologies.

Contributions will spotlight AI-enabled diagnostics in radiology and pathology, predictive models for disease onset and progression, natural language processing applied to electronic health records, machine-based learning, and digital twin technologies. Advances in generative AI for drug discovery, as exemplified by recent computational approaches to molecular design, represent another frontier of considerable promise.

We welcome original research articles and systematic reviews addressing applications of AI across diverse clinical domains. Submissions exploring implementation frameworks, clinical validation, scalability, and interdisciplinary collaboration are encouraged. Equally vital are contributions examining medical ethics and regulatory issues, including machine-based learning, data governance, and transparency in AI-assisted care.

Dr. Nilima Rajpal Kundnani
Prof. Dr. Daniel Florin Lighezan
Guest Editors

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Keywords

  • artificial intelligence
  • machine learning
  • diagnostic imaging
  • clinical decision support systems
  • precision medicine

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Published Papers (1 paper)

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Research

23 pages, 2066 KB  
Article
Intelligent Attention-Driven Deep Learning for Hip Disease Diagnosis: Fusing Multimodal Imaging and Clinical Text for Enhanced Precision and Early Detection
by Jinming Zhang, He Gong, Pengling Ren, Shuyu Liu, Zhengbin Jia, Lizhen Wang and Yubo Fan
Medicina 2026, 62(2), 250; https://doi.org/10.3390/medicina62020250 - 24 Jan 2026
Cited by 1 | Viewed by 1062
Abstract
Background and Objectives: Hip joint disorders exhibit diverse and overlapping radiological features, complicating early diagnosis and limiting the diagnostic value of single-modality imaging. Isolated imaging or clinical data may therefore inadequately represent disease-specific pathological characteristics. Materials and Methods: This retrospective study [...] Read more.
Background and Objectives: Hip joint disorders exhibit diverse and overlapping radiological features, complicating early diagnosis and limiting the diagnostic value of single-modality imaging. Isolated imaging or clinical data may therefore inadequately represent disease-specific pathological characteristics. Materials and Methods: This retrospective study included 605 hip joints from Center A (2018–2024), comprising normal hips, osteoarthritis, osteonecrosis of the femoral head (ONFH), and femoroacetabular impingement (FAI). An independent cohort of 24 hips from Center B (2024–2025) was used for external validation. A multimodal deep learning framework was developed to jointly analyze radiographs, CT volumes, and clinical texts. Features were extracted using ResNet50, 3D-ResNet50, and a pretrained BERT model, followed by attention-based fusion for four-class classification. Results: The combined Clinical+X-ray+CT model achieved an AUC of 0.949 on the internal test set, outperforming all single-modality models. Improvements were consistently observed in accuracy, sensitivity, specificity, and decision curve analysis. Grad-CAM visualizations confirmed that the model attended to clinically relevant anatomical regions. Conclusions: Attention-based multimodal feature fusion substantially improves diagnostic performance for hip joint diseases, providing an interpretable and clinically applicable framework for early detection and precise classification in orthopedic imaging. Full article
(This article belongs to the Special Issue Artificial Intelligence in Medicine: Shaping the Future of Healthcare)
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