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Marine Drugs
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Bioactive Secondary Metabolites of Marine Fungi, 3rd Edition
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Bioactive Secondary Metabolites of Marine Fungi, 3rd Edition

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Structural Studies on Marine Natural Products".

Deadline for manuscript submissions: 15 August 2025 | Viewed by 2624

Special Issue Editor

Prof. Dr. Hee Jae Shin

E-Mail Website
Guest Editor
Korea Institute of Ocean Science and Technology (KIOST), Busan, Republic of Korea
Interests: marine natural products; biomedical applications; drug discovery; anticancer compounds; anti-inflammatory compounds; antimicrobial compounds
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Fungi represent a significant proportion of the microbial diversity on Earth. The discovery of new secondary metabolites from marine fungi has increased dramatically over the last few decades, cumulating in over 1000 new metabolites. The biosynthesis of these metabolites is dependent on ecological, physical, and biological factors, and, therefore, small changes in these conditions can generate an entirely new set of metabolites. Thus, understanding the chemical language of marine fungi and the development of new culture techniques are needed to discover novel fungal metabolites with potent biological activities.

Based on the success of the Special Issue “Bioactive Secondary Metabolites of Marine Fungi 2.0” (https://www.mdpi.com/journal/marinedrugs/special_issues/U82S20H572), as well as the critical relevance of this topic, we are pleased to announce the third edition of this Special Issue.

This Special Issue will highlight marine fungal natural products as potential molecules for the discovery of new drugs, empathizing the structural diversity and bioactivities of marine fungal secondary metabolites.

As a Guest Editor for this Special Issue, I invite you to submit your research results on marine fungi, ranging from the isolation and structure elucidation of new natural products to biosynthetic pathways of marine fungal metabolites.

Prof. Dr. Hee Jae Shin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine fungi
  • secondary metabolites
  • structure determination
  • bioactive compounds
  • fungal diversity
  • natural products
  • therapeutic agents
  • novel compounds

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Published Papers (3 papers)

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Review

23 pages, 4813 KiB  
Review
Marine Fungal Metabolites as Potential Antidiabetic Agents: A Comprehensive Review of Their Structures and Enzyme Inhibitory Activities
by Zimin Wang, Meirong Zhao, Yunxia Yu, Fandong Kong, Nanxin Lin and Qi Wang
Mar. Drugs 2025, 23(4), 142; https://doi.org/10.3390/md23040142 - 26 Mar 2025
Viewed by 399
Abstract
Diabetes mellitus has emerged as a global public health crisis, with Type 2 diabetes (T2D) constituting over 90% of cases. Current treatments are palliative, primarily focusing on blood glucose modulation. This review systematically evaluates 181 bioactive compounds isolated from 66 marine fungal strains [...] Read more.
Diabetes mellitus has emerged as a global public health crisis, with Type 2 diabetes (T2D) constituting over 90% of cases. Current treatments are palliative, primarily focusing on blood glucose modulation. This review systematically evaluates 181 bioactive compounds isolated from 66 marine fungal strains for their inhibitory activities against key diabetes-related enzymes, including α-glucosidase, protein tyrosine phosphatase 1B (PTP1B), dipeptidyl peptidase-4 (DPP-4), glycogen synthase kinase-3β (GSK-3β), and fatty acid-binding protein 4 (FABP4). These compounds, categorized into polyketides, alkaloids, terpenoids, and lignans, exhibit multitarget engagement and nanomolar-to-micromolar potency. The review highlights the potential of marine fungal metabolites as novel antidiabetic agents, emphasizing their structural novelty and diverse mechanisms of action. Future research should focus on overcoming challenges related to yield and extraction, leveraging advanced technologies such as genetic engineering and synthetic biology to enhance drug development. Full article
(This article belongs to the Special Issue Bioactive Secondary Metabolites of Marine Fungi, 3rd Edition)
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65 pages, 25172 KiB  
Review
Diterpenoids of Marine Organisms: Isolation, Structures, and Bioactivities
by Qi Shi, Shujie Yu, Manjia Zhou, Peilu Wang, Wenlong Li, Xin Jin, Yiting Pan, Yunjie Sheng, Huaqiang Li, Luping Qin and Xiongyu Meng
Mar. Drugs 2025, 23(3), 131; https://doi.org/10.3390/md23030131 - 18 Mar 2025
Viewed by 584
Abstract
Diterpenoids from marine-derived organisms represent a prolific source of secondary metabolites, characterized by their exceptionally promising chemical structures and pronounced pharmacological properties. In recent years, marine diterpenoids have garnered considerable attention and are regarded as a prominent area of scientific research. As a [...] Read more.
Diterpenoids from marine-derived organisms represent a prolific source of secondary metabolites, characterized by their exceptionally promising chemical structures and pronounced pharmacological properties. In recent years, marine diterpenoids have garnered considerable attention and are regarded as a prominent area of scientific research. As a vital class of metabolites, diterpenoids show diverse biological activities, encompassing antibacterial, antifungal, antiviral, anti-inflammatory, inhibitory, and cytotoxic activities, among others. With the rapid advancement of equipment and identified technology, there has been a tremendous surge in the discovery rate of novel diterpenoid skeletons and bioactivities derived from marine fungi over the past decade. The present review compiles the reported diterpenoids from marine fungal sources mainly generated from January 2000 to December 2024. In this paper, 515 diterpenoids from marine organisms are summarized. Among them, a total of 281 structures from various fungal species are included, comprising 55 from sediment, 39 from marine animals (predominantly invertebrates, including 17 from coral and 22 from sponges), and 53 from marine plants (including 34 from algae and 19 from mangrove). Diverse biological activities are exhibited in 244 compounds, and among these, 112 compounds showed great anti-tumor activity (45.90%) and 110 metabolites showed remarkable cytotoxicity (45.08%). Furthermore, these compounds displayed a range of diverse bioactivities, including potent anti-oxidant activity (2.87%), promising anti-inflammatory activity (1.64%), great anti-bacterial activity (1.64%), notable anti-thrombotic activity (1.23%), etc. Moreover, the diterpenoids’ structural characterization and biological activities are additionally elaborated upon. The present critical summary provides a comprehensive overview of the reported knowledge regarding diterpenoids derived from marine fungi, invertebrates, and aquatic plants. The systematic review presented herein offers medical researchers an extensive range of promising lead compounds for the development of marine drugs, thereby furnishing novel and valuable pharmaceutical agents. Full article
(This article belongs to the Special Issue Bioactive Secondary Metabolites of Marine Fungi, 3rd Edition)
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52 pages, 6163 KiB  
Review
Secondary Metabolites from the Mangrove Ecosystem-Derived Fungi Penicillium spp.: Chemical Diversity and Biological Activity
by Guojun Zhou, Jin Cai, Bin Wang, Wenjiao Diao, Yu Zhong, Shaodan Pan, Weijia Xiong, Guolei Huang and Caijuan Zheng
Mar. Drugs 2025, 23(1), 7; https://doi.org/10.3390/md23010007 - 26 Dec 2024
Viewed by 1293
Abstract
Mangrove ecosystems have attracted widespread attention because of their high salinity, muddy or sandy soil, and low pH, as well as being partly anoxic and periodically soaked by tides. Mangrove plants, soil, or sediment-derived fungi, especially the Penicillium species, possess unique metabolic pathways [...] Read more.
Mangrove ecosystems have attracted widespread attention because of their high salinity, muddy or sandy soil, and low pH, as well as being partly anoxic and periodically soaked by tides. Mangrove plants, soil, or sediment-derived fungi, especially the Penicillium species, possess unique metabolic pathways to produce secondary metabolites with novel structures and potent biological activities. This paper reviews the structural diversity and biological activity of secondary metabolites isolated from mangrove ecosystem-derived Penicillium species over the past 5 years (January 2020–October 2024), and 417 natural products (including 170 new compounds, among which 32 new compounds were separated under the guidance of molecular networking and the OSMAC approach) are described. The structures were divided into six major categories, including alkaloids, polyketides, terpenoids, benzene derivatives, steroids, and other classes. Among these natural products, the plausible biosynthetic pathways of 37 compounds were also proposed; 11 compounds have novel skeleton structures, and 26 compounds contain halogen atoms. A total of 126 compounds showed biological activities, such as cytotoxic, antifungal, antibacterial, anti-inflammatory, and α-glucosidase-inhibitory activities, and 11 compounds exhibited diverse biological activities. These new secondary metabolites with novel structures and potent bioactivities will continue to guide the separation or synthesis of structurally novel and biologically active compounds and will offer leading compounds for the development and innovation of pharmaceuticals and pesticides. Full article
(This article belongs to the Special Issue Bioactive Secondary Metabolites of Marine Fungi, 3rd Edition)
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