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Marine Drugs
Special Issues
Advances in Secondary Metabolites from Mangrove Holobiont
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Advances in Secondary Metabolites from Mangrove Holobiont

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Chemoecology for Drug Discovery".

Deadline for manuscript submissions: 1 November 2025 | Viewed by 576

Special Issue Editors

Prof. Dr. Xuefeng Zhou

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Guest Editor
Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China
Interests: marine natural product chemistry; drug leads; pharmacological mechanism; marine microorganisms; biotransformation
Special Issues, Collections and Topics in MDPI journals
Dr. Huaming Tao

E-Mail Website
Guest Editor
Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China
Interests: marine natural products; natural product synthesis; active skeleton synthesis methodology; pharmacological mechanism

Special Issue Information

Dear Colleagues,                

Mangroves are complex and unique ecosystems, and their holobiont includes the close connections among various organisms, such as mangrove plants, microorganisms (such as fungi, bacteria, etc.), and animals. Through the study of secondary metabolites from mangrove holobionts, it is possible to gain an in-depth understanding of the ways in which these symbionts communicate and interact through chemical signal molecules. The natural products in mangrove holobionts often have unique chemical structures and diverse biological activities. Many compounds isolated from mangrove-related microorganisms have been found to have pharmacological activities, such as antibacterial, antiviral, anti-tumor, and anti-inflammatory, providing rich lead compound resources for the research and development of new drugs. These natural products have special biosynthetic mechanisms that are different from those of terrestrial organisms. Studying their synthetic pathways can discover new chemical reactions, enzymatic catalytic mechanisms, etc., providing new ideas for the development of disciplines, such as bio-organic chemistry and synthetic biology and inspiring researchers to synthesize complex compounds with application value through bionic synthesis and other means.

Prof. Dr. Xuefeng Zhou
Dr. Huaming Tao
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mangrove holobiont
  • natural products
  • pharmacological activities
  • biosynthetic mechanisms
  • symbionts communicate
  • lead compound

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Published Papers (2 papers)

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Research

12 pages, 1750 KiB  
Article
Catechol Siderophores from a Mangrove-Derived Bacteria Serratia marcescens F2-2 and Their Cytotoxic Activity
by Gang Zhang, Xunming Wang, Xingwang Zhang, Lin Ye, Longyang Ke, Shimin Fan, Xuan Hong, Guoqiang Li, Bingye Yang and Lianzhong Luo
Mar. Drugs 2025, 23(6), 241; https://doi.org/10.3390/md23060241 - 30 May 2025
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Abstract
Serratia marcescens is a common Gram-negative and facultative anaerobic bacillus that produces serratiochelins with several bioactivities. In this study, four catechol siderphores (1–4), including two new ones named serratiochelins E (1) and F (2), were [...] Read more.
Serratia marcescens is a common Gram-negative and facultative anaerobic bacillus that produces serratiochelins with several bioactivities. In this study, four catechol siderphores (1–4), including two new ones named serratiochelins E (1) and F (2), were obtained from the fermentation of a mangrove-derived bacterium, S. marcescens F2-2. The structures were elucidated with various spectroscopic methods such as NMR and HR-ESI-MS. Absolute and geometric configurations of the new compounds were established by employing quantum NMR calculations in conjunction with DP4+ probability analysis, ECD calculations, and the advanced Marfey’s method. The bioactivity test showed that serratiochelin B (3) displayed weak but selective cytotoxicity against HepG2 cancer cells with an IC50 of 50.6 μmol/L and could trigger apoptosis through both Bcl-2/Bax/caspase-3 and Fas/FasL/caspase-8 signaling pathways. These findings deepen the understanding of siderophores of S. marcescens and provide a lead for research on anti-liver cancer drugs. Full article
(This article belongs to the Special Issue Advances in Secondary Metabolites from Mangrove Holobiont)
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Graphical abstract

15 pages, 3835 KiB  
Article
New Bioactive Polyketides from the Mangrove-Derived Fungus Daldinia eschscholzii HJX1P2
by Miao Yu, Yikang Qiu, Shiji Chen, Jueying Shi, Xiu Gong, Jiayi Feng, Fangru Lin, Weinv Zeng, Wenyuan Kang, Caijuan Zheng and Guolei Huang
Mar. Drugs 2025, 23(6), 238; https://doi.org/10.3390/md23060238 - 30 May 2025
Viewed by 176
Abstract
Three new naphthalene–chroman dimer derivatives, daldinaphchromes A–C (1–3), two new chroman derivatives, daldichromes A (5) and B (6), along with five known compounds (4, 7–10) were isolated from the mangrove-derived [...] Read more.
Three new naphthalene–chroman dimer derivatives, daldinaphchromes A–C (1–3), two new chroman derivatives, daldichromes A (5) and B (6), along with five known compounds (4, 7–10) were isolated from the mangrove-derived fungus Daldinia eschscholzii HJX1P2. Their structures and stereochemistries were elucidated through detailed NMR and MS analyses, calculated electronic circular dichroism, and comparison with previously reported data. Compound 1 demonstrated inhibitory effects on nitric oxide (NO) production in LPS-induced RAW 264.7 cells, with an IC50 value of 62.9 µM, and more effectively suppressed the expression of interleukin (IL)-6 than dexamethasone. A further mechanistic study suggested that 1 could prohibit the expression of iNOS in RAW 264.7 cells, and the molecular docking study suggested a possible interaction between 1 and the iNOS protein. Compounds 7 and 8 exhibited moderate to potent DPPH radical scavenging activity, with IC50 values of 117.4 and 46.2 µM, respectively, compared with the positive control ascorbic acid (IC50 = 45.6 µM). Compounds 4 and 10 showed ABTS+ radical scavenging activity, with IC50 values of 66.6 and 33.2 µM, respectively, which were equal to or lower than that of the positive control vitamin C (IC50 = 59.7 µM). Compounds 1–3, 7, and 9 showed antibacterial activity against three Staphylococcus aureus strains, with MIC values of 74.4–390.6 μM. Full article
(This article belongs to the Special Issue Advances in Secondary Metabolites from Mangrove Holobiont)
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