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Marine Drugs
Special Issues
Marine Microalgal Biorefinery for Bioactive Compound Production 2024
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Marine Microalgal Biorefinery for Bioactive Compound Production 2024

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Biotechnology Related to Drug Discovery or Production".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 2795

Special Issue Editor

Dr. Xiaojin Song

E-Mail Website
Guest Editor
Key Laboratory of Biofuels, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China
Interests: microalgae; lipids; polyunsaturated fatty acids; metabolic engineering; fermentation engineering

Special Issue Information

Dear Colleagues,

Given the sustainable status of marine microalgae as raw materials, their conversion into bioproducts is currently celebrated as a green solution with the potential to alleviate various challenges. In recent years, extensive research has been conducted on biotechnology and bioprocessing, aiming to enhance the technical and economic feasibility of producing bioproducts from various sources. Specifically, the development of synthetic biology and artificial intelligence has opened up opportunities for maximizing the potential productivity of marine microalgae. This special issue invites original research papers and reviews that focus on the latest innovative developments in marine microalgal bioprocess engineering, including upstream biotechnological advancements, downstream separation and purification processes, as well as discussions on the efficiency of the entire product and process lifecycle.

Dr. Xiaojin Song
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioengineering technologies
  • bioproducts
  • cultivation
  • fermentation
  • high throughput screening
  • marine microalgae
  • metabolic engineering
  • separation and purification processes
  • synthetic biology

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Published Papers (2 papers)

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Research

33 pages, 5186 KiB  
Article
Mixotrophic Cultivation of Dunaliella tertiolecta in Cheese Whey Effluents to Enhance Biomass and Exopolysaccharides (EPS) Production: Biochemical and Functional Insights
by Konstantina Tsotsouli, Spyros Didos, Konstantinos Koukaras and Anagnostis Argiriou
Mar. Drugs 2025, 23(3), 120; https://doi.org/10.3390/md23030120 - 11 Mar 2025
Viewed by 656
Abstract
The rapid growth of the dairy industry has resulted in a significant increase in the generation of effluents, which are characterized by a high organic content that poses environmental challenges. In alignment with sustainable practices and the principles of the circular economy, this [...] Read more.
The rapid growth of the dairy industry has resulted in a significant increase in the generation of effluents, which are characterized by a high organic content that poses environmental challenges. In alignment with sustainable practices and the principles of the circular economy, this study investigates the valorization of cheese whey (CW) effluents through the cultivation of the microalga Dunaliella tertiolecta under mixotrophic conditions. The research aims to utilize cheese whey effluents as a supplemental growth medium to enhance the production of algal biomass and extracellular polymeric substances (EPSs). The results reveal that CW facilitated a 37% improvement in D. tertiolecta growth and led to an approximately eight times greater biomass productivity compared to under photoautotrophic conditions, while the EPS production increased by 30%. Chemical and techno-functional analyses of the microalgal biomass and EPSs suggest promising applications as natural product additives for the food industry. Biomass derived from photoautotrophic culture demonstrated greater antioxidant activity and total polyphenols content. Additionally, the lipid profile revealed 16 distinct fatty acids. On the other hand, biomass from the mixotrophic culture exhibited higher protein levels and eight fatty acids, indicating the influence of the cultivation mode on the biochemical composition. Regarding the EPSs, mixotrophic cultivation resulted in elevated antioxidant activity and total polyphenols content, as well as higher protein and sugar levels. Furthermore, the EPSs produced under mixotrophic conditions exhibited superior techno-functional properties compared to those of the photoautotrophic culture, making them ideal candidates for use as alternative natural food additives. Full article
(This article belongs to the Special Issue Marine Microalgal Biorefinery for Bioactive Compound Production 2024)
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18 pages, 8210 KiB  
Article
Comprehensive Assessment of Herbicide Toxicity on Navicula sp. Algae: Effects on Growth, Chlorophyll Content, Antioxidant System, and Lipid Metabolism
by Chunyan Zheng, Jie Yang, Yunting Wang, Waqas Ahmed, Amir Khan, Jiannan Li, Jiechang Weng, Sajid Mehmood and Weidong Li
Mar. Drugs 2024, 22(9), 387; https://doi.org/10.3390/md22090387 - 28 Aug 2024
Cited by 1 | Viewed by 1672
Abstract
This study investigated the effects of herbicide exposure on Navicula sp. (MASCC-0035) algae, focusing on growth density, chlorophyll content, antioxidant system, and lipid metabolism. Navicula cultures were exposed to different concentrations of atrazine (ATZ), glyphosate (Gly), and acetochlor (ACT) for 96 h. Results [...] Read more.
This study investigated the effects of herbicide exposure on Navicula sp. (MASCC-0035) algae, focusing on growth density, chlorophyll content, antioxidant system, and lipid metabolism. Navicula cultures were exposed to different concentrations of atrazine (ATZ), glyphosate (Gly), and acetochlor (ACT) for 96 h. Results showed a significant decrease in cell numbers, with higher herbicide concentrations having the most noticeable impacts. For instance, Gly-G2 had reduced cell populations by 21.00% at 96 h. Chlorophyll content varied, with Gly having a greater impact on chlorophyll a compared to ATZ and ACT. Herbicide exposure also affected the antioxidant system, altering levels of soluble sugar, soluble protein, and reactive oxygen species (ROS). Higher herbicide rates increased soluble sugar content (e.g., ATZ, Gly, and ACT-G2 had increased by 14.03%, 19.88%, and 19.83%, respectively, at 72 h) but decreased soluble protein content, notably in Gly-G2 by 11.40%, indicating cellular stress. Lipid metabolism analysis revealed complex responses, with changes in free proline, fatty acids, and lipase content, each herbicide exerting distinct effects. These findings highlight the multifaceted impacts of herbicide exposure on Navicula algae, emphasizing the need for further research to understand ecological implications and develop mitigation strategies for aquatic ecosystems. Full article
(This article belongs to the Special Issue Marine Microalgal Biorefinery for Bioactive Compound Production 2024)
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