Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.0
3.4
Journals
Life
Special Issues
Mechanisms and Novel Biomarkers in Chronic Inflammatory Diseases
share announcement

Mechanisms and Novel Biomarkers in Chronic Inflammatory Diseases

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 751

Special Issue Editors

Dr. Josko Bozic

E-Mail Website
Guest Editor
Department of Pathophysiology, University of Split School of Medicine, 21000 Split, Croatia
Interests: biomarkers, IBD; cardiovascular disorders; diabetes; inflammation
Special Issues, Collections and Topics in MDPI journals
Dr. Nikola Pavlović

E-Mail Website
Guest Editor
Department of Pathophysiology, University of Split School of Medicine, 21000 Split, Croatia
Interests: IBS; SIBO; CAKUT; histology; cardiovascular disorders

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to our Special Issue dedicated to chronic inflammatory diseases, one of the most complex and rapidly evolving areas of modern biomedical research. Chronic inflammation represents a critical link between immune dysregulation, metabolic imbalance, and vascular dysfunction, playing a central role in the development of tissue damage and systemic complications.

Despite significant advances in therapeutic strategies, the molecular and cellular mechanisms underlying chronic inflammatory conditions remain incompletely understood. This Special Issue aims to bring together original research articles and comprehensive reviews that explore the interplay between persistent inflammation, immune regulation, and tissue remodeling across different organs and disease contexts.

A particular focus of this issue is the identification and validation of novel biomarkers with diagnostic, prognostic, or therapeutic relevance. Contributions addressing cytokine profiles, genetic and epigenetic factors, circulating microRNAs, metabolites, and microbiome-derived molecules, as well as translational and clinical studies supporting precision medicine approaches, are especially welcome.

By integrating basic, translational, and clinical perspectives, this Special Issue seeks to provide new insights into disease mechanisms, foster interdisciplinary collaboration, and ultimately contribute to improved patient care.

We warmly invite you to submit your latest work and look forward to your valuable contribution to this collection.

Dr. Josko Bozic
Dr. Nikola Pavlović
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chronic inflammation
  • biomarkers
  • immune regulation
  • molecular mechanisms
  • precision medicine

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

28 pages, 2639 KB  
Article
A Triple-Hit Multi-Omics Framework for Psoriasis: Microbial Metabolic Remodeling and Immune Cell Methylome Signature Associated with an AMP-Dominant Lesional Program
by Yoon Kyeong Lee, Hak Yong Kim and Donghwan Shim
Life 2026, 16(3), 516; https://doi.org/10.3390/life16030516 - 20 Mar 2026
Viewed by 469
Abstract
The gut–skin axis is increasingly implicated in psoriasis pathogenesis, yet the cross-compartment convergence of molecular programs remains incompletely defined. We constructed a conceptual “Triple-Hit” multi-omics framework by integrating five independent public datasets spanning gut microbial functional remodeling (shotgun metagenomics), systemic immune cell methylomes [...] Read more.
The gut–skin axis is increasingly implicated in psoriasis pathogenesis, yet the cross-compartment convergence of molecular programs remains incompletely defined. We constructed a conceptual “Triple-Hit” multi-omics framework by integrating five independent public datasets spanning gut microbial functional remodeling (shotgun metagenomics), systemic immune cell methylomes (PBMC and CD8+ T-cell EPIC 850K), and lesional skin regulatory layers (miRNA and bulk RNA-seq). In the gut compartment, functional profiles exhibited a selective reduction in microbial lipid catabolic potential, including decreased fatty acid degradation and a lowered composite lipid degradation score, alongside heterogeneous shifts across SCFA-associated metabolic pathways. Systemically, PBMC methylomes revealed widespread regional remodeling (45,396 DMRs) enriched for membrane-proximal signaling and cytoskeletal programs, while CD8+ T cells showed specific epigenetic alterations in lipid- and glycosphingolipid-associated loci, suggesting a systemic metabolic–epigenetic alignment. In the skin, we identified a compact miRNA signature (168 DE-miRNAs) and a mechanistically interpretable, directionality-constrained miRNA–mRNA bridge that aligns with an AMP-dominant inflammatory transcriptome, consistent with reduced post-transcriptional restraint. Collectively, these findings support a convergent multi-omics framework linking putative microbial metabolic remodeling, systemic immune priming, and cutaneous effector programs. This study provides a systems-level perspective on psoriasis pathogenesis, highlighting the metabolic–epigenetic–transcriptional convergence as a potential avenue for therapeutic intervention. Full article
(This article belongs to the Special Issue Mechanisms and Novel Biomarkers in Chronic Inflammatory Diseases)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop