Special Issues

Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Migraine and Headache: From Pathophysiological Aspects
edited by
submission deadline 31 Aug 2025 | 2 articles | Viewed by 1424 | Submission Open
Keywords: migraine; headache; pathophysiology; treatment; medication
(This special issue belongs to the Section Physiology and Pathology)
Encephalitis: From Molecular Pathophysiology to Therapy
edited by Anna Tröscher and Judith Wagner
submission deadline 31 Aug 2025 | 1 articles | Viewed by 1045 | Submission Open
Keywords: infectious encephalitis; autoimmune encephalitis; neuroinflammation; pathophysiology; diagnostics; therapy
(This special issue belongs to the Section Physiology and Pathology)
Clinical Manifestations and Treatment of Autoimmune Diseases: 2nd Edition submission deadline 31 Aug 2025 | 1 articles | Viewed by 655 | Submission Open
Keywords: autoimmunity; immunobiology; vaccine; leucocytes; immune system
(This special issue belongs to the Section Medical Research)
Recent Advances in Plant Genomics and Genetics
edited by , , Long Chen and
submission deadline 31 Aug 2025 | Viewed by 593 | Submission Open
Keywords: high-throughput genotyping; plant genetics; plant genomics; genetic markers; genetic improvements; genome editong; CRISPR/Cas9; genomic selection
(This special issue belongs to the Section Genetics and Genomics)
Recent Advances in Bone Biology
edited by Barbara Peruzzi, and Giulia Battafarano
submission deadline 31 Aug 2025 | Viewed by 190 | Submission Open
Keywords: bone tissue engineering; bone-targeted therapies; genetic bone diseases; bone mechanotransduction; bone cell pathophysiology; bone metabolism
(This special issue belongs to the Section Physiology and Pathology)
Integrating Health Informatics and Artificial Intelligence for Advanced Medicine
edited by
submission deadline 31 Aug 2025 | Viewed by 181 | Submission Open
Keywords: artificial intelligence; machine learning; artificial neural networks; prognosis; treatment; medicine; health care; pathology
(This special issue belongs to the Section Medical Research)
From Physiology and Pathology Research to Clinical Insights in Gastrointestinal Disorders
edited by , and Ana Lascu
submission deadline 31 Aug 2025 | Viewed by 167 | Submission Open
Keywords: cellular signaling; inflammation; oxidative stress; cellular death and proliferation; motility; digestion and absorption; vascular patterns; gut microbiota
(This special issue belongs to the Section Physiology and Pathology)
Cutting-Edge Techniques and Innovations in the Management of Aortic Aneurysm
edited by Dimitrios Iliopoulos
submission deadline 31 Aug 2025 | Viewed by 152 | Submission Open
Keywords: aneurysm; aorta; aortic root; biomechanics; aortic dissection; thoracoabdominal aneurysm; valve-sparing aortic root replacement; perfusion
(This special issue belongs to the Section Medical Research)
New Insights into Pediatric Rheumatic and Autoimmune Diseases
edited by Lampros Fotis
submission deadline 31 Aug 2025 | Viewed by 144 | Submission Open
Keywords: arthritis; juvenile; autoimmune diseases; biomarkers; diagnostic imaging; juvenile dermatomyositis; lupus erythematosus; systemic; pediatric rheumatology; vasculitis
(This special issue belongs to the Section Medical Research)
Migraine and Headache: From Clinical and Therapeutic Aspects
edited by
submission deadline 31 Aug 2025 | Viewed by 144 | Submission Open
Keywords: migraine; headache; treatment; medication
(This special issue belongs to the Section Medical Research)
Body Fluid-Based Biomarkers for Cognitive Impairment
edited by Wei Li
submission deadline 31 Aug 2025 | Viewed by 136 | Submission Open
Keywords: Alzheimer’ s disease and related dementia (ADRD); body fluid-based biomarkers; cognitive impairments; early diagnosis; treatment; prognosis
(This special issue belongs to the Section Medical Research)
New Insights into Cellular Inflammation and Regeneration
edited by
submission deadline 31 Aug 2025 | Viewed by 125 | Submission Open
Keywords: cellular inflammation; tissue regeneration; immune modulation; regenerative medicine; inflammatory pathways; immune cells and tissue repair; chronic inflammation; biomarkers of regeneration; immune-tissue crosstalk; wound healing; fibrosis and regeneration; inflammation resolution; tissue remodeling; regenerative microenvironment; inflammation-driven pathogenesis; translational immunology
(This special issue belongs to the Section Physiology and Pathology)
Gene Regulation and Expression in Tumors
edited by and Dawid Sobański
submission deadline 31 Aug 2025 | Viewed by 113 | Submission Open
Keywords: gene regulation; tumor biology; transcriptional dysregulation and epigenetics; cancer biomarkers; therapeutic targets; multi-omics approaches
(This special issue belongs to the Section Physiology and Pathology)
The Drug Development for Neurodegenerative Diseases
edited by David R. Elmaleh
submission deadline 31 Aug 2025 | Viewed by 101 | Submission Open
Keywords: neurodegenerative disease; drug treatment approaches; quality of life improvement
(This special issue belongs to the Section Pharmaceutical Science)
Innovative Drug Development: Balancing Efficacy and Toxicity in Novel Pharmaceuticals
edited by
submission deadline 31 Aug 2025 | Viewed by 93 | Submission Open
Keywords: drug development; pharmaceuticals; bioactive compounds; new drug candidates; drug delivery systems; pharmaceutical formulations; efficacy and toxicity screening
(This special issue belongs to the Section Pharmaceutical Science)
Emerging Trends in Tumor Pathology and Precision Oncology
edited by and Gabriele Gaggero
submission deadline 15 Sep 2025 | 2 articles | Viewed by 3641 | Submission Open
Keywords: gynecologic pathology; pediatric pathology; neuropathology; molecular diagnostics; precision oncology
(This special issue belongs to the Section Physiology and Pathology)
New Insights Into Leishmaniasis and Chagas Disease: Focus on Diagnosis and Genetic Characterization of Parasites: 2nd Edition
edited by and Cristina Ballart
submission deadline 15 Sep 2025 | 1 articles | Viewed by 2015 | Submission Open
Keywords: leishmania; leishmaniasis; chagas disease; American trypanosomiasis; Trypanosoma cruzi; diagnostics; genetic diversity; characterization; neglected tropical disease
(This special issue belongs to the Section Epidemiology)
Postbiotics—Bioactive Microbial Compounds as Health-Promoting Agents submission deadline 15 Sep 2025 | Viewed by 112 | Submission Open
Keywords: gut microbiota; postbiotics; prebiotics; microbiota-derived metabolites; postbiotic supplementation; postbiotics and health benefits; dysbiosis
(This special issue belongs to the Section Microbiology)
Advances in Endoscopy for Hepatic, Pancreatic, and Biliary Diseases
edited by John Ong
submission deadline 16 Sep 2025 | 1 articles | Viewed by 1241 | Submission Open
Keywords: endoscopic intervention; endoscopic ultrasound; lumen apposing metal stent; radiofrequency ablation; endoscopic sleeve gastroplasty; cholangioscopy; endoscopic retrograde cholangiopancreatography; liver disease; biliary disease; pancreatobiliary disease
(This special issue belongs to the Section Medical Research)
Targeting Mitochondrial Dysfunction in Neurodegenerative Diseases
edited by and Oualid Sbai
submission deadline 25 Sep 2025 | Viewed by 251 | Submission Open
Keywords: mitochondria; neurodegeneration; oxidative stress; calcium homeostasis; mitochondrial fission/fusion; inflammation; gut– brain axis; mitophagy; NLRP3 inflammasome
(This special issue belongs to the Section Physiology and Pathology)
Carbon and Nitrogen Cycles in Terrestrial Ecosystems
edited by
submission deadline 26 Sep 2025 | 3 articles | Viewed by 3294 | Submission Open
Keywords: process-based modeling and machine learning; field experiments and meta-analysis; terrestrial carbon and nitrogen cycles; role of living organisms in biogeochemical cycles
(This special issue belongs to the Section Diversity and Ecology)
Sports Medicine: Nutritional Sciences and Nutritional Biochemistry: 2nd Edition
edited by
submission deadline 26 Sep 2025 | 1 articles | Viewed by 1875 | Submission Open
Keywords: sport nutrition; sport supplementation; sport biochemistry; metabolomics; miRNA
(This special issue belongs to the Section Physiology and Pathology)
Metabolic Health: The Interplay Between NAFLD, MAFLD, MASLD and Cardiovascular Disease
edited by and Monika Różycka-Kosmalska
submission deadline 29 Sep 2025 | 5 articles | Viewed by 6857 | Submission Open
Keywords: non-alcoholic fatty liver disease (NAFLD); metabolic-dysfunction-associated fatty liver disease (MAFLD); metabolic-dysfunction-associated steatotic liver disease (MASLD); cardiovascular disease (CVD); cardiac arrhythmias; structural heart disease; coronary artery disease; hypertension
(This special issue belongs to the Section Medical Research)
Current Advances in Diagnosis and Treatment of Sepsis
edited by Chih-Huang Li
submission deadline 29 Sep 2025 | 5 articles | Viewed by 6171 | Submission Open
Keywords: sepsis; biomarkers; prediction; immunotherapy; AI model
(This special issue belongs to the Section Medical Research)
Advancements in Cardiovascular Epidemiology: Integrating Predictive Modeling into Public Health
edited by and Matina Kouvari
submission deadline 29 Sep 2025 | 1 articles | Viewed by 3123 | Submission Open
Keywords: CVD epidemiology; public health interventions; predictive modeling; risk stratification; cardiometabolic risk factors
(This special issue belongs to the Section Epidemiology)
Advances in Knee Biomechanics
edited by Jason Shearn
submission deadline 30 Sep 2025 | 9 articles | Viewed by 22424 | Submission Open
Keywords: knee; tendon; ligament; injury; repair; healing; biomechanics; advanced techniques
(This special issue belongs to the Section Physiology and Pathology)
Advanced Strategies in Fracture Treatments
edited by and Chun-Yu Chen
submission deadline 30 Sep 2025 | 9 articles | Viewed by 13397 | Submission Open
Keywords: state of the art; peri-articular fracture; osteoporotic fracture; fragility fracture; treatment protocols
(This special issue belongs to the Section Medical Research)
Plants as a Promising Biofactory for Bioactive Compounds: 2nd Edition
edited by
submission deadline 30 Sep 2025 | 6 articles | Viewed by 10761 | Submission Open
Keywords: plant cell culture; plant tissue culture; medicinal plants; secondary metabolites; bioactive compounds; nutraceuticals; recombinant proteins; biologics
(This special issue belongs to the Section Plant Science)
Etiology, Prediction and Prognosis of Ischemic Stroke
edited by , and Jiang Li
submission deadline 30 Sep 2025 | 3 articles | Viewed by 5167 | Submission Open
Keywords: ischemic stroke; recurrent stroke; etiology; machine learning; artificial intelligence; subtyping; prediction; prognosis; genetic risk factors; lifestyle factors; environmental factors; biomarkers; cerebrovascular diseases; prevention; treatment strategies
(This special issue belongs to the Section Physiology and Pathology)
A Paradigm Shift in Airway and Pain Management—2nd Edition
edited by
submission deadline 30 Sep 2025 | 3 articles | Viewed by 4405 | Submission Open
Keywords: airway management; pain management; ultrasonography; motor activity; nerve block; anesthesia; conduction; regenerative medicine; multidisciplinary/comprehensive care program; transarterial embolization for pain management; joint denervation for pain management
(This special issue belongs to the Section Medical Research)
Interdisciplinarity in Cardiovascular Diseases: From Pathophysiology to Diagnosis and Treatment: 3rd Edition submission deadline 30 Sep 2025 | 6 articles | Viewed by 4113 | Submission Open
Keywords: interdisciplinarity team; cardiovascular diseases; cardiovascular complications; gastro-esophago-enterology and hepatology; metabolic-associated steato-hepatitis; gut microbiota; nephrocardiology; pulmonary diseases; rheumatology diseases; endocrinology diseases
(This special issue belongs to the Section Physiology and Pathology)
Advancements in Postoperative Management of Patients After Surgery
edited by , , and Alessandro Cappellani
submission deadline 30 Sep 2025 | 3 articles | Viewed by 3353 | Submission Open
Keywords: surgery; ERAS; postoperative management; recovery; pain
(This special issue belongs to the Section Medical Research)
Multi-Omics for Diagnosing Diseases: Bioinformatics Approaches and Integrative Data Analyses submission deadline 30 Sep 2025 | 1 articles | Viewed by 1458 | Submission Open
Keywords: bioinformatics; computer hardware; software; and methods; first-/second-/third-generation sequencing; clinical genomics; mendelian diseases; whole-exome sequencing; evolutionary and comparative genomics; whole-genome sequencing; multi-omics; microbiome diseases
(This special issue belongs to the Section Genetics and Genomics)
Skin Diseases and Dermatologic Comorbidities
edited by Alessia Paganelli, and
submission deadline 30 Sep 2025 | 1 articles | Viewed by 706 | Submission Open
Keywords: skin diseases; dermatologic comorbidities; metabolic impairment; autoimmunity; cytokines; serum markers
(This special issue belongs to the Section Physiology and Pathology)
Enhancements in Screening Pathways for Early Detection of Lung Cancer submission deadline 30 Sep 2025 | 1 articles | Viewed by 612 | Submission Open
Keywords: lung cancer screening; early diagnosis; multidisciplinary pathways; liquid biopsy; exhaled breath condensate; molecular imaging; sub-lobar resection; artificial intelligence
(This special issue belongs to the Section Medical Research)
Natural Substances in Nutrition and Health of Animals: 2nd Edition submission deadline 30 Sep 2025 | 2 articles | Viewed by 578 | Submission Open
Keywords: natural products; organic acids; probiotics; prebiotics; and synbiotics; plant extracts; animal nutrition; animal physiology; animal embryology; animal reproduction; animal models
(This special issue belongs to the Section Animal Science)
Advances in Livestock Breeding, Nutrition and Metabolism
edited by
submission deadline 30 Sep 2025 | Viewed by 538 | Submission Open
Keywords: genetic selection; livestock breeding; genome editing; animal nutrition; precision feeding; nutritional additives; feed conversion; metabolism; animal health; sustainability
(This special issue belongs to the Section Animal Science)
Acari: Biodiversity, Biogeography and Taxonomy Studies
edited by Pavel B. Klimov
submission deadline 30 Sep 2025 | Viewed by 493 | Submission Open
Keywords: phylogenetics; systematics; evolution and co-evolution; biodiversity; ecology; host associations; role of mites in agriculture and medicine
(This special issue belongs to the Section Animal Science)
New Insights into Athlete Physiology submission deadline 30 Sep 2025 | Viewed by 328 | Submission Open
Keywords: sport physiology; physical performance; injury prevention; cognition; artificial intelligence; dose– response relationship
(This special issue belongs to the Section Physiology and Pathology)
Precision Therapies in Cancer: Advancements and Future Directions
edited by and Krushna Chandra Hembram
submission deadline 30 Sep 2025 | Viewed by 318 | Submission Open
Keywords: precision oncology; cancer theragnostic; molecular targeting; immunotherapy
(This special issue belongs to the Section Medical Research)
From Pathophysiology to Pathology—an Update on Diabetic Kidney Disease
edited by Sharma Prabhakar
submission deadline 30 Sep 2025 | Viewed by 318 | Submission Open
Keywords: diabetic kidney disease; epithelial– mesenchymal transition; renin– angiotensin– aldosterone system; sodium glucose transporter 2; albuminuria
(This special issue belongs to the Section Physiology and Pathology)
New Developments in Mycology submission deadline 30 Sep 2025 | Viewed by 232 | Submission Open
Keywords: fungal diversity; population genetics; phylogeography; mycorrhizae; biotechnology
(This special issue belongs to the Section Microbiology)
Cardiorenal Disease: Pathogenesis, Diagnosis, and Treatments
edited by Pedro Caravaca-Pérez and Jose Jesus Broseta
submission deadline 30 Sep 2025 | Viewed by 179 | Submission Open
Keywords: heart failure; kidney disease; cardiorenal syndrome; diagnosis; treatment
(This special issue belongs to the Section Medical Research)
An Update on Diabetic Kidney Disease: Epidemiology, Diagnosis, Treatment
edited by Sharma Prabhakar
submission deadline 30 Sep 2025 | Viewed by 176 | Submission Open
Keywords: diabetic kidney disease; epithelial– mesenchymal transition; renin– angiotensin– aldosterone system sodium glucose transporter 2; albuminuria
(This special issue belongs to the Section Medical Research)
Testicular and Penile Disorders: Reproductive, Pathophysiological, Diagnostic and Therapeutic Insights
edited by and Yu-Ching Wen
submission deadline 30 Sep 2025 | Viewed by 167 | Submission Open
Keywords: testicular and Penile Disorders; testicle; physiology; infertility
(This special issue belongs to the Section Physiology and Pathology)
2nd Edition—Food Microbiological Contamination submission deadline 30 Sep 2025 | Viewed by 152 | Submission Open
Keywords: food safety; food microbiology; foodborne pathogens; food spoilage; food quality; food contamination; microbiological hazards; natural antimicrobials
(This special issue belongs to the Section Microbiology)
Space Medicine Advancements: From Human Health to Biomedical System Design
edited by Jiwoon Park and
submission deadline 30 Sep 2025 | Viewed by 144 | Submission Open
Keywords: biomedical research in extreme environments including space; effects of gravity and radiation on biological systems; multi-omics studies on astronauts and experimental models; spaceflight analogs for disease modeling and mechanistic studies (in vitro and in vivo models); computational models for astronaut health and risk assessment (simulations and AI models); mitigation of spaceflight-induced pathophysiology and health risks; development of tools; biomarkers; and interventions for remote monitoring and the implementation of countermeasures to safeguard human health; lfe support systems and biotechnology solutions for space explorations
(This special issue belongs to the Section Medical Research)
Advances in Intensive Care Medicine
edited by
submission deadline 30 Sep 2025 | Viewed by 133 | Submission Open
Keywords: machine learning; critical care; intensive care; ARDS; mechanical ventilation; personalized medicine; advances
(This special issue belongs to the Section Medical Research)
Synthetic Genetic Elements, Devices, and Systems: 2nd Edition
edited by and
submission deadline 30 Sep 2025 | Viewed by 130 | Submission Open
Keywords: synthetic biology; synthetic genetic elements/parts; biobricks; artificial gene synthesis; biocomputing; directed evolution; metabolic engineering/cell factory; optogenetics; genetic code expansion; xenobiology
(This special issue belongs to the Section Synthetic Biology and Systems Biology)
Advances in Microvascular Research: 2nd Edition submission deadline 30 Sep 2025 | Viewed by 120 | Submission Open
Keywords: microvascular injury; microvascular dysfunction; microcirculation; vascular inflammation; hypertension; cardiovascular diseases
(This special issue belongs to the Section Physiology and Pathology)
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