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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Pharmacotherapy in Critical Care: Clinical Insight and Emerging Strategy

edited by

Caterina Aurilio

submission deadline 31 Oct 2026 | Viewed by 567 | Submission Open

Keywords: sepsis; multidrug resistance; extracorporeal treatments; intracranial hypertension; immunomodulation; organ support; precision medicine; intensive care pharmacology

(This special issue belongs to the Section Medical Research)

Artificial Intelligence and Deep Learning Models for Human Diseases Diagnosis and Prediction

edited by

Mobarak I. Hoque

Long Bai

and Shilong Yao

submission deadline 31 Oct 2026 | Viewed by 335 | Submission Open

Keywords: artificial intelligence in medicine; clinical decision support; medical imaging; precision medicine; healthcare innovation; trustworthy AI; healthcare analytics; predictive modeling; digital health

(This special issue belongs to the Section Medical Research)

Precision Approaches in Solid Tumor Oncology: From Molecular Pathways to Therapy Response

edited by

Cristina Díaz del Arco

and Luís Ortega-Medina

submission deadline 31 Oct 2026 | Viewed by 297 | Submission Open

Keywords: biomarkers; histology; immunohistochemistry; solid tumors; precision oncology; therapy response

(This special issue belongs to the Section Medical Research)

Pathological Mechanisms of Heart Failure with Preserved Ejection Fraction

edited by

Mei Methawasin

and Erik Blackwood

submission deadline 31 Oct 2026 | Viewed by 252 | Submission Open

Keywords: diastolic dysfunction; microvascular inflammation; sarcomere dysfunction; cytoskeletal alteration; mitochondrial dysfunction; oxidative stress; immunometabolic remodeling; calcium handling dysregulation; protein quality control; post translational modification; epigenetic regulation; systemic inflammation; inter-organ crosstalk; cardiometabolic–kidney disease; cellular senescence

(This special issue belongs to the Section Physiology and Pathology)

Poultry Nutrition and Gut Microbiota Health

edited by

Ala Abudabos

submission deadline 31 Oct 2026 | Viewed by 250 | Submission Open

Keywords: gut health; microbiota; necrotic enteritis; coccidiosis; immunity; poultry; natural additives

(This special issue belongs to the Section Animal Science)

Pathogenesis, Diagnosis and Therapy of Complex Pediatric Sinonasal and Skull Base Lesions

edited by Vijay Patel, Jillian Plonsker and Michael Levy

submission deadline 31 Oct 2026 | Viewed by 224 | Submission Open

Keywords: pediatric; skull base; endoscopy; interventional visualization

(This special issue belongs to the Section Medical Research)

Environmental and Microbial Stressors in Neuronal Dysfunction: Mechanistic Insights

edited by

Ovidiu Dumitru Ilie

and Adriana Petrovici

submission deadline 31 Oct 2026 | Viewed by 217 | Submission Open

Keywords: experimental neurotoxicology; neuropsychiatric disorders; neurotrophin signaling; BDNF–Trk pathway; oxidative stress; gut–brain axis; microbiota–brain interactions; toxicant-induced neuronal dysfunction; zebrafish (Danio rerio) model; rodent models; behavioral phenotyping; brain histopathology

(This special issue belongs to the Section Physiology and Pathology)

Molecular Epidemiology and Evolution of Pathogenic Viruses

edited by

Yoshiyuki Suzuki

submission deadline 31 Oct 2026 | Viewed by 176 | Submission Open

Keywords: molecular epidemiology; molecular evolution; pathogenic virus; antigenicity; phylogeny; mutation; recombination; reassortment; natural selection; interspecies transmission

(This special issue belongs to the Section Epidemiology)

Advances in Research on Phytohormones

edited by

Kincső Decsi

submission deadline 1 Nov 2026 | Viewed by 733 | Submission Open

Keywords: stress tolerance; plant hormones; secondary metabolites; biostimulants; nanoparticles; transcriptomics; genome-wide analysis; biochemical pathways; stress defense responses

(This special issue belongs to the Section Plant Science)

Gut Microbiome and Neurodegenerative Disease

edited by Scott A. Jackson and

Leigh A. Frame

submission deadline 15 Nov 2026 | Viewed by 358 | Submission Open

Keywords: gut microbiome; gut–brain axis; neurodegenerative disease; Alzheimer’s disease; Parkinson’s disease; microbiota–host interactions; microbial metabolites; blood–brain barrier; enteric nervous system; vagus nerve signaling; dysbiosis; metagenomics; multi-omics; microbiome biomarkers; translational microbiome research

(This special issue belongs to the Section Physiology and Pathology)

Immunopathology of Oral Mucosal Disease

edited by Dinko Martinovic

submission deadline 15 Nov 2026 | Viewed by 210 | Submission Open

Keywords: immunopathology; immune dysfunction; oral mucosal diseases; oral squamous cell carcinoma; oral potentially malignant disorders; oral lichen planus; recurrent aphthous stomatitis

(This special issue belongs to the Section Physiology and Pathology)

Preload, Afterload and Diastolic Heart Disease

edited by Ryou Tanaka

submission deadline 15 Nov 2026 | Viewed by 138 | Submission Open

Keywords: preload; afterload; diastolic dysfunction; heart failure with preserved ejection fraction (HFpEF); ventricular–arterial coupling; cardiac remodeling; hemodynamic assessment

(This special issue belongs to the Section Physiology and Pathology)

Mucopolysaccharidosis-Plus: From Molecular Defects to Therapeutic Strategies

edited by Zuzanna Cyske

submission deadline 20 Nov 2026 | Viewed by 363 | Submission Open

Keywords: mucopolysaccharidosis; mucopolysaccharidosis-plus syndrome; MPSPS; VPS33A; therapy; patomechanism; diagnostic; patients’ care

(This special issue belongs to the Section Medical Research)

Molecular Imaging in Neurodegenerative Diseases

edited by

Chrissa Sioka

and

Alexandros Giannakis

submission deadline 24 Nov 2026 | 1 articles | Viewed by 1636 | Submission Open

Keywords: molecular imaging; neurodegenerative diseases; PET; MRI; radiotracers; amyloid; tau; neuroinflammation; biomarkers; precision medicine

(This special issue belongs to the Section Radiobiology and Nuclear Medicine)

Molecular Mechanisms and Pharmacological Innovations of Osteoarthritis

edited by Alessandro Conforti and Martina Gentile

submission deadline 27 Nov 2026 | 3 articles | Viewed by 2902 | Submission Open

Keywords: osteoarthritis; pathogenesis; disease-modifying therapies; inflammation; cartilage degeneration

(This special issue belongs to the Section Medical Research)

Musculoskeletal Medicine in Rheumatic Diseases: 2nd Edition

edited by

Florentin Ananu Vreju

and Emilio Filippucci

submission deadline 27 Nov 2026 | 1 articles | Viewed by 710 | Submission Open

Keywords: rheumatic disease; rheumatoid arthritis; spondylarthritis; microcrystal arthritis; musculoskeletal ultrasonography; biologic treatment; disease-modifying antirheumatic drugs; imagining techniques

(This special issue belongs to the Section Medical Research)

Otolaryngology and Sleep Medicine: From Precision Diagnosis to Advanced Therapeutics

edited by

Antonino Maniaci

submission deadline 28 Nov 2026 | 1 articles | Viewed by 1735 | Submission Open

Keywords: sleep-disordered breathing; otolaryngology; sleep medicine; pulmonology; neurology

(This special issue belongs to the Section Medical Research)

Advances on Physiotherapy and Functional Rehabilitation in Chronic Conditions

edited by

Anna Arnal-Gómez

submission deadline 30 Nov 2026 | 4 articles | Viewed by 6630 | Submission Open

Keywords: physiotherapy; chronic condition; functionality; pain

(This special issue belongs to the Section Medical Research)

Microvascular and Macrovascular Response in Healthy and Critically Ill

edited by Andrius Pranskunas and

Marius Brazaitis

submission deadline 30 Nov 2026 | 4 articles | Viewed by 5734 | Submission Open

Keywords: microcirculation; glycocalyx; peripheral perfusion; systemic hemodynamic; body temperature; dynamic maneuvers; remote ischemic conditioning; exercise; adaptation

(This special issue belongs to the Section Physiology and Pathology)

Artificial Intelligence and Machine Learning for Biomedical Diagnostics and Prognostics

edited by

César Byron Guevara Maldonado

Victoria López

and

Diego Fernando Riofrío Luzcando

submission deadline 30 Nov 2026 | 6 articles | Viewed by 5182 | Submission Open

Keywords: artificial intelligence; machine learning; diagnostic and prognostic modeling; multimodal data integration; explainable AI

(This special issue belongs to the Section Medical Research)

Advances in Veterinary Infectious Diseases: Pathogenesis, Diagnostics, and Control Strategies

edited by

Hye-Mi Lee

submission deadline 30 Nov 2026 | 1 articles | Viewed by 4737 | Submission Open

Keywords: veterinary infectious diseases; zoonoses; animal health; pathogen transmission; vaccine development; immunology; antiviral strategies; emerging pathogens; diagnostic tools; public health

(This special issue belongs to the Section Animal Science)

Advances in Emergency and Critical Care Medicine

edited by

Yu-Jang Su

submission deadline 30 Nov 2026 | 3 articles | Viewed by 4033 | Submission Open

Keywords: emergency medicine; critical care; trauma; infectious diseases; elderly

(This special issue belongs to the Section Medical Research)

Neurological and/or Muscle–Skeletal Disorders—Across of the Life Cycle

edited by

Gelu Onose

and Andrada Mirea

submission deadline 30 Nov 2026 | 4 articles | Viewed by 3913 | Submission Open

Keywords: adult neuro-/muscle–skeletal comprehensive prevention, treatment, and rehabilitation; child/adolescent neuro-/muscle-skeletal-comprehensive prevention, treatment, and rehabilitation; elderly neuro-/muscle-skeletal-comprehensive prevention, treatment, and rehabilitation; healthy lifestyle/primary prevention; secondary prevention; functioning; telehealth/medicine

(This special issue belongs to the Section Medical Research)

Thyroid and Parathyroid Diseases: Advances in Molecular Imaging

edited by

Petra Petranović Ovčariček

and

Luca Giovanella

submission deadline 30 Nov 2026 | 2 articles | Viewed by 3527 | Submission Open

Keywords: thyroid cancer; parathyroid imaging; hyperparathyroidism; benign thyroid diseases; molecular imaging; radioactive iodine; radioiodine-refractory thyroid cancer; theranostics

(This special issue belongs to the Section Medical Research)

Nutrition, Exercise and Stress

edited by Maleah Holland-Winkler

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2161 | Submission Open

Keywords: nutrition; exercise; stress

(This special issue belongs to the Section Physiology and Pathology)

Stem Cell Biology, Tissue Formation, Cell Plasticity and Regenerative Medicine

edited by

Eustace Johnson

submission deadline 30 Nov 2026 | 3 articles | Viewed by 1856 | Submission Open

Keywords: stem cell biology; development and tissue formation; growth; tissue repair and regeneration; cell plasticity; model organisms and systems; clinical translation; regenerative medicine

(This special issue belongs to the Section Cell Biology and Tissue Engineering)

Advances in Diagnostic Management of Cardiovascular Diseases

edited by Carlo Gaudio,

Luigi Spadafora

and

Marco Bernardi

submission deadline 30 Nov 2026 | 2 articles | Viewed by 1852 | Submission Open

Keywords: cardiovascular diagnostics; advanced imaging; biomarkers; artificial intelligence; risk stratification

(This special issue belongs to the Section Medical Research)

The Brain-Boosting Power of Exercise: Improving Cerebrovascular and Cognitive Health

edited by

Dean E. Mills

and

Edward Bliss

submission deadline 30 Nov 2026 | 2 articles | Viewed by 1644 | Submission Open

Keywords: exercise; training; cerebrovascular; cognition; aerobic; resistance; multimodal

(This special issue belongs to the Section Physiology and Pathology)

Drug Safety and Outcomes in Respiratory and Critical Care Medicine

edited by

Josef Yayan

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1478 | Submission Open

Keywords: drug safety; adverse drug reactions; pharmacovigilance; critical care medicine; respiratory diseases; clinical outcomes; intensive care pharmacotherapy; drug–drug interactions

(This special issue belongs to the Section Pharmaceutical Science)

Structural Biology: Mechanisms, Technologies, and Insights

edited by

Mingliang Jin

Xiaoxuan Lin

and Hoa Nguyen

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1433 | Submission Open

Keywords: protein structure; allosteric regulation; protein dynamics; structure-guided therapeutics; structural methodology

(This special issue belongs to the Section Biochemistry, Biophysics and Computational Biology)

Antibiotic Resistance in Biofilm: Mechanisms and Novel Interventions

edited by

Adriana Morar

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1399 | Submission Open

Keywords: biofilm; food industry; antimicrobial resistance; antibiotic resistance gene transfer; antibiofilm activity; control strategies

(This special issue belongs to the Section Microbiology)

Physical Medicine and Rehabilitation: Trends and Applications—5th Edition

edited by

Li-Wei Chou

Jiunn-Horng Kang

Krisna Piravej

and Karen Sui Geok Chua

submission deadline 30 Nov 2026 | 2 articles | Viewed by 1145 | Submission Open

Keywords: clinical physical medicine and rehabilitation; neurorehabilitation; cardiopulmonary rehabilitation; orthopedic rehabilitation; pediatric rehabilitation; geriatric rehabilitation; cancer rehabilitation; musculoskeletal pain management; physical therapy; occupational therapy; speech and swallowing therapy

(This special issue belongs to the Section Epidemiology)

Pathophysiology and Treatments of Obesity

edited by

Francesco Saverio Latteri

, Andrea Peri and

Marcello Agosta

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1100 | Submission Open

Keywords: obesity; bariatric surgery; anti-obesity pharmacotherapy; gLP-1 receptor agonists; gut–brain axis; type 2 diabetes

(This special issue belongs to the Section Medical Research)

Bronchiectasis: Advancing into the Future

edited by

Janice Wang

and Patricia A. Walker

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1079 | Submission Open

Keywords: non-CF bronchiectasis; NCFB; airway microbiome; non-tuberculous mycobacteria (NTM); biologics; endotypes; phenotypes; novel therapeutics; exacerbations

(This special issue belongs to the Section Medical Research)

Bioactive Phytotherapeutics in Metabolic and Inflammatory Disorders

edited by

Oana Cristina Şeremet

and

Octavian Tudorel Olaru

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1052 | Submission Open

Keywords: phytotherapeutics; bioactive compounds; medicinal plants; metabolic disorders; inflammatory disorders; oxidative stress; chronic inflammation

(This special issue belongs to the Section Medical Research)

New Insights and Advances in Heart Failure Research

edited by Tzu-Hurng Cheng

submission deadline 30 Nov 2026 | 2 articles | Viewed by 944 | Submission Open

Keywords: cardiac remodeling; biomarkers; precision medicine; therapeutic innovations

(This special issue belongs to the Section Medical Research)

Cortical Development and Neurotransmission

edited by Christine Hohmann and Joanne Berger-Sweeney

submission deadline 30 Nov 2026 | 1 articles | Viewed by 813 | Submission Open

Keywords: cerebral cortex; neurotransmission; neuromodulatory neurotransmitters; developmental brain disorders; molecular mechanism

(This special issue belongs to the Section Medical Research)

Diagnosis and Therapeutics Approaches in Retinal Diseases

edited by

Jiro Kogo

and Yoshitsugu Matsui

submission deadline 30 Nov 2026 | 1 articles | Viewed by 660 | Submission Open

Keywords: retinal diseases; age-related macular degeneration (AMD); diabetic retinopathy; vitreoretinal; ophthalmology

(This special issue belongs to the Section Medical Research)

Recent Advances in Diagnostics, Monitoring and Management of Neonatal Diseases

edited by Minesh Khashu

submission deadline 30 Nov 2026 | 1 articles | Viewed by 569 | Submission Open

Keywords: newborn; neonate; neonatology; recent advances; diagnostics; monitoring; management; therapeutics

(This special issue belongs to the Section Medical Research)

Novel Insights into Musculoskeletal Disorders

edited by Giovanni Noia,

Michele Coviello

Giuseppe Rovere

and Andrea Fidanza

submission deadline 30 Nov 2026 | 1 articles | Viewed by 452 | Submission Open

Keywords: musculoskeletal disorders; diagnosis; therapeutics; regenerative medicine; intervention outcomes; orthopedic treatment

(This special issue belongs to the Section Medical Research)

Fluid Management in Emergency and Intensive Care

edited by

Manu Malbrain

and

Prashant Nasa

submission deadline 30 Nov 2026 | Viewed by 419 | Submission Open

Keywords: fluids; fluid stewardship; resuscitation; shock

(This special issue belongs to the Section Medical Research)

Global Health in a Changing Climate: Interdisciplinary Perspectives on Human Well-Being

edited by Giuseppe Marano,

Marianna Mazza

, Gianandrea Traversi,

Eleonora Gaetani

and Esmeralda Capristo

submission deadline 30 Nov 2026 | Viewed by 401 | Submission Open

Keywords: climate change; global health; mental health; physical health; lifestyle interventions; cross-disciplinary research

(This special issue belongs to the Section Medical Research)

Musculoskeletal Diseases in Older Adults: Diagnosis, Treatment, and Management

edited by

Chun-Feng Huang

submission deadline 30 Nov 2026 | Viewed by 299 | Submission Open

Keywords: osteoporosis; sarcopenia; metabolic syndrome; precision medicine; older adults; frailty; metabolomics; fracture prevention

(This special issue belongs to the Section Medical Research)

Advances in Assessment and Treatment of Human Motor and Sensory Dysfunctions

edited by

Toshiaki Tanaka

and

Yusuke Maeda

submission deadline 30 Nov 2026 | Viewed by 289 | Submission Open

Keywords: motor control; sensorimotor integration; brain function; rehabilitation; balance and gait; robotic therapy; virtual reality; rehabilitation engineering

(This special issue belongs to the Section Physiology and Pathology)

From Environmental Exposure to Health Effects: Advances in Toxicology and Biomonitoring

edited by

Csilla Mišľanová

and

Martina Valachovičová

submission deadline 30 Nov 2026 | Viewed by 287 | Submission Open

Keywords: environmental contaminants; biomonitoring; toxicology; exposure assessment; biomarkers; flow cytometry; mechanisms of toxicity

(This special issue belongs to the Section Physiology and Pathology)

Environmental Determinants of Cardiovascular Disease: Epigenetic Mechanisms and Genetic Interactions

edited by

Andrea Borghini

and

Francesca Gorini

submission deadline 30 Nov 2026 | Viewed by 282 | Submission Open

Keywords: cardiovascular disease; environmental exposure; genetics; epigenetics

(This special issue belongs to the Section Medical Research)

New Insights into Breast Cancer: Current Controversies and Future Perspectives, 2nd Edition

edited by

Alejandro Martin Sanchez

, Flavia de Lauretis and Chiara Valeria Pirrottina

submission deadline 30 Nov 2026 | Viewed by 254 | Submission Open

Keywords: breast cancer diagnosis; breast cancer treatment; breast cancer pathology; conservative mastectomy; breast reconstruction; sentinel node biopsy; chemotherapy; radiotherapy; integrated therapies; targeted therapies; precision medicine

(This special issue belongs to the Section Medical Research)

Mitochondrial Transplantation: Therapeutic Strategies and Applications

edited by

Kei Hayashida

submission deadline 30 Nov 2026 | Viewed by 232 | Submission Open

Keywords: mitochondrial transplantation; mitochondrial therapy; bioenergetics; ischemia–reperfusion injury; immunometabolism; mitochondrial transfer; organ protection; translational medicine

(This special issue belongs to the Section Physiology and Pathology)

Advances in the Diagnosis and Treatment of Liver Diseases

edited by