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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Sarcopenia, Musculoskeletal, and Neuromuscular Disorders: Physical Therapy and Rehabilitation Perspectives

edited by

Do-youn Lee

and

Myoung-Kwon Kim

submission deadline 20 Jul 2026 | 1 articles | Viewed by 511 | Submission Open

Keywords: sarcopenia; musculoskeletal diseases; neuromuscular disorders; muscle mass; low back pain; neck pain; gait and balance; physical therapy; rehabilitation medicine

(This special issue belongs to the Section Clinical Rehabilitation)

Integrating Artificial Intelligence into Plastic, Reconstructive, and Aesthetic Surgery: Innovations, Challenges, and Clinical Application

edited by

Roberto Cuomo

and

Gianluca Marcaccini

submission deadline 20 Jul 2026 | 1 articles | Viewed by 306 | Submission Open

Keywords: plastic; reconstructive; aesthetic surgery; artificial intelligence; AI in plastic surgery

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

State of the Art in Spinal Cord Injuries: Clinical Rehabilitation and Management

edited by

Valerio Pisani

submission deadline 20 Jul 2026 | 1 articles | Viewed by 267 | Submission Open

Keywords: neurorehabilitation; assistive technologies; neuroplasticity; neuromodulation; spinal cord injury

(This special issue belongs to the Section Clinical Rehabilitation)

Minimally Invasive Spine Surgery: Evidence, Advances and Controversies

edited by

Miltiadis Georgiopoulos

, Constantine Constantoyannis,

Mark A. MacLean

and Oliver Lasry

submission deadline 20 Jul 2026 | Viewed by 239 | Submission Open

Keywords: spine surgery; minimally invasive; MIS; MISS; endoscopic; tubular; fusion; laminectomy; discectomy; decompression; percutaneous; robotic; robotic-assisted; navigation; augmented-reality

(This special issue belongs to the Section Clinical Neurology)

Advances in Clinical Management of Temporomandibular Joint Diseases

edited by

João Luiz Monteiro

submission deadline 20 Jul 2026 | Viewed by 174 | Submission Open

Keywords: minimally invasive surgical procedure; artificial intelligence; temporomandibular joint disorders; temporomandibular disorders; temporomandibular joint

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Current Challenges in Adult Congenital Heart Diseases

edited by

Agata Bielecka-Dabrowa

submission deadline 20 Jul 2026 | Viewed by 150 | Submission Open

Keywords: adult congenital heart disease; quality of life; pregnancy in congenital heart disease; heart failure; arrhythmia; septal defect; congenital valve stenosis; coarctation of the Aorta; Fontan circulation; Tetralogy of Fallot

(This special issue belongs to the Section Cardiology)

Pre-Hospital and In-Hospital Emergency Care Research

edited by

Marcus Eng Hock Ong

Fahad Javaid Siddiqui

and Yohei Okada

submission deadline 20 Jul 2026 | Viewed by 130 | Submission Open

Keywords: pre-hospital; in-hospital; emergency care; emergency medical services; acute care

(This special issue belongs to the Section Emergency Medicine)

Current Concepts in Melanoma: Innovations in Early Detection, Prognosis and Management

edited by Babar Khan Rao

submission deadline 20 Jul 2026 | Viewed by 123 | Submission Open

Keywords: melanoma; early detection; non-invasive diagnostic innovations; artificial intelligence-assisted diagnosis; melanoma management

(This special issue belongs to the Section Dermatology)

Exercise for Healthy Aging: Clinical Physiology, Functional Outcomes, and Implications for Clinical Practice

edited by

Jerónimo Aragón-Vela

and

Rafael A. Casuso

submission deadline 20 Jul 2026 | Viewed by 113 | Submission Open

Keywords: exercise; healthy aging; functional independence; mitochondrial adaptations; physical activity interventions; neuromuscular function; cardiorespiratory fitness; metabolic health; biomarkers of aging

(This special issue belongs to the Section Sports Medicine)

Cataract and Refractive Surgery, and Intraocular Lens (IOL) Implantation: Advancing Diagnosis and Management

edited by Olga Reitblat

submission deadline 20 Jul 2026 | Viewed by 84 | Submission Open

Keywords: cataract surgery; premium intraocular lenses (IOLs); IOL power calculation; visual outcomes; refractive cataract surgery; multifocal IOL; extended depth of focus (EDOF) IOL; toric IOL; full range; vision IOL; biometry

(This special issue belongs to the Section Ophthalmology)

Thoracic Surgery Today: Innovations, Challenges, and Future Perspectives

edited by Jeffrey B. Velotta and

Ory Wiesel

submission deadline 20 Jul 2026 | Viewed by 81 | Submission Open

Keywords: thoracic surgery; minimally invasive thoracic surgery; innovation; esophageal surgery; robotic-assisted thoracic surgery; lung cancer; advanced techniques; thoracic surgical oncology; mediastinal surgery; mesothelioma surgery

(This special issue belongs to the Section General Surgery)

Clinical Application of Digital Transformation in Ophthalmology

edited by

Eisuke Shimizu

submission deadline 20 Jul 2026 | Viewed by 79 | Submission Open

Keywords: clinical application; ocular diseases; artificial intelligence (AI); machine learning/ deep learning; smart ophthalmology

(This special issue belongs to the Section Ophthalmology)

Spine Surgery: Clinical Advances and Practice Updates

edited by

Junho Song

submission deadline 20 Jul 2026 | Viewed by 78 | Submission Open

Keywords: spine surgery; minimally invasive spine surgery; endoscopic spine surgery; robotics; artificial intelligence; spinal deformity; scoliosis; spinal trauma

(This special issue belongs to the Section Orthopedics)

Novel Research in Cardiovascular Imaging

edited by Stanciu Silviu and

Lucia Agoston-Coldea

submission deadline 20 Jul 2026 | Viewed by 78 | Submission Open

Keywords: echocardiography; cardiac CT; CMR; nuclear medicine; artificial intelligence

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Implications of Artificial Intelligence in Patient Care

edited by

Safa Elkefi

and

Luigi Lavorgna

submission deadline 20 Jul 2026 | Viewed by 73 | Submission Open

Keywords: artificial intelligence; clinical decision support; human factors; digital health; patient care; implementation science; medical informatics; trust in AI

(This special issue belongs to the Section Clinical Research Methods)

Current Updates on Pediatric Neurological Disorders and Neurorehabilitation

edited by

Lidia Perenc

and

Justyna Podgórska-Bednarz

submission deadline 20 Jul 2026 | Viewed by 72 | Submission Open

Keywords: child neurological disorders; neurorehabilitation; neurogenetics; treatment; quality of life; rehabilitation teams; congenital brain disorders; trauma; movement disorders; cerebral palsy

(This special issue belongs to the Section Clinical Pediatrics)

Management of Diabetes-Related Cardiovascular Disease: Current Treatment and Future Options

edited by Antonio J. Amor and Tonet Serés-Noriega

submission deadline 20 Jul 2026 | Viewed by 72 | Submission Open

Keywords: type 1 diabetes; type 2 diabetes; cardiovascular disease; biomarkers; atherosclerosis; cardioprotective drugs; vascular ultrasound

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Recent Advances in the Surgical Treatment of Heart Valve Disease

edited by

Beatrice Bacchi

and Aleksander Dokollari

submission deadline 20 Jul 2026 | Viewed by 66 | Submission Open

Keywords: heart valve surgery; prosthetic valves; intervention surgery; minimally invasive and robotic surgery; valve repair and replacement

(This special issue belongs to the Section Cardiology)

Orthodontic Treatment in Clinical Practice: Strategies for Achieving Optimal Outcomes

edited by Adith Venugopal

submission deadline 20 Jul 2026 | Viewed by 66 | Submission Open

Keywords: orthodontics; biomechanics; tooth movement; bone remodeling; malocclusions; smile

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Pneumonia: From Diagnosis to Treatment

edited by

Marie Carmen Valenza

Laura López-López

and

María Granados Santiago

submission deadline 20 Jul 2026 | Viewed by 66 | Submission Open

Keywords: pneumonia; diagnosis; treatment; multidisciplinary care; pulmonary rehabilitation

(This special issue belongs to the Section Respiratory Medicine)

Advances in Pacemaker Implantation: Past, Present, and Future Challenges

edited by Rahul N. Doshi and

Ankur A. Karnik

submission deadline 20 Jul 2026 | Viewed by 66 | Submission Open

Keywords: pacing; physiologic pacing; left bundle area pacing; leadless pacing; lead management

(This special issue belongs to the Section Cardiology)

Optimizing Outcomes in Pancreato-Biliary Care: Integrating Technology, Technique, and Personalized Approaches

edited by

Andrea Tufo

submission deadline 20 Jul 2026 | Viewed by 65 | Submission Open

Keywords: pancreato-biliary care; pancreatic diseases; biliary diseases; hepato-pancreato-biliary (HPB) surgery; interventional endoscopy; interventional radiology; minimally invasive surgery; EUS-guided procedures; ERCP; personalized care/personalized medicine; multidisciplinary care; clinical outcomes; robotics and AI in PB care

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Cardiac Imaging: Emerging Techniques and Clinical Applications

edited by

Athanasios Frydas

and

Daniel A. Morris

submission deadline 20 Jul 2026 | Viewed by 62 | Submission Open

Keywords: 3D echocardiography; myocardial strain; artificial intelligence; automated quantification; cardiac MRI; cardiac CT; multimodality imaging; machine learning; image-based risk stratification; precision cardiology

(This special issue belongs to the Section Cardiology)

New Perspective of Oral and Maxillo-Facial Surgery：2nd Edition

edited by

Valentino Vellone

Umberto Committeri

and Alessandra Lucchese

submission deadline 20 Jul 2026 | Viewed by 60 | Submission Open

Keywords: maxillofacial surgery; esthetic surgery; orthognatic surgery; TMJ disorders; TMJ surgery; dental implant surgery; 3D imaging; printing applications; tissue engineering; personalized treatment planning; artificial intelligence; squamous cell carcinoma; skin tumors; plastic and reconstructive surgery; head and neck surgery; ENT surgery

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Outcomes in Pediatric Neurosurgery

edited by

Petra Klinge

and Konstantina Svokos

submission deadline 20 Jul 2026 | Viewed by 60 | Submission Open

Keywords: functional outcomes; pediatric neurosurgery; quality of life; innovative technologies; global neurosurgery

(This special issue belongs to the Section Clinical Pediatrics)

New Clinical Insight: From Open Surgery to Minimally Invasive Foot and Ankle Surgery

edited by Enrique A. Testa and Daniel Poggio

submission deadline 20 Jul 2026 | Viewed by 59 | Submission Open

Keywords: minimally invasive surgery; foot surgery; ankle surgery; trauma surgery; orthopedic surgery; ankle arthroscopy

(This special issue belongs to the Section Orthopedics)

Advances in Perioperative Anesthesia: Emerging Techniques and Clinical Practices

edited by Mitchell H. Tsai, Matthew Bergeron Allen and Roya Saffary

submission deadline 20 Jul 2026 | Viewed by 57 | Submission Open

Keywords: perioperative medicine; goal-concordant care; anesthesia co-management; postoperative outcomes; perioperative anesthesia

(This special issue belongs to the Section Anesthesiology)

Colorectal Surgery: Current Concept and Emerging Trends

edited by

Valentin Calu

submission deadline 20 Jul 2026 | Viewed by 56 | Submission Open

Keywords: colorectal surgery; robotic surgery; neoadjuvant treatment; minimally invasive techniques; enhanced recovery

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Advances in Chronic Lymphocytic Leukemia: Focus on Elderly Frail Patients

edited by Driss Chaoui

submission deadline 20 Jul 2026 | Viewed by 55 | Submission Open

Keywords: CLL; elderly; frailty; guidelines; quality of life; IBTK; BCL2; antiCD20

(This special issue belongs to the Section Hematology)

Colorectal Surgery: Advances in Modern Clinical Management

edited by Algimantas A. Tamelis

submission deadline 20 Jul 2026 | Viewed by 55 | Submission Open

Keywords: colorectal cancer management; surgery; complications; organ preservation; screening; colonic diverticular disease; colonic diverticulitis; hemorrhoids

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Current Advances and Future Perspectives in Cardiothoracic Surgery

edited by Tomislav Kopjar

submission deadline 20 Jul 2026 | Viewed by 53 | Submission Open

Keywords: cardiothoracic surgery; minimally invasive techniques; robotic-assisted surgery; personalized therapy; surgical innovation; prosthetic devices; perioperative management; transplantation; technological advances; postoperative care; surgical outcomes; future perspectives; healthcare disparities

(This special issue belongs to the Section General Surgery)

Clinical Outcomes in Lumbar Spinal Stenosis Treatment

edited by Rafał Staszkiewicz and

Beniamin Oskar Grabarek

submission deadline 20 Jul 2026 | Viewed by 52 | Submission Open

Keywords: lumbar spinal stenosis; clinical outcomes; decompression surgery; conservative management; molecular biomarkers; inflammation and fibrosis; neurotrophic factors; personalized medicine; siganling pathways; quality of life

(This special issue belongs to the Section Orthopedics)

Advances in the Management of Cough and Asthma

edited by Ebymar Arismendi

submission deadline 20 Jul 2026 | Viewed by 49 | Submission Open

Keywords: asthma; chronic cough; biomarkers; exacerbations; biologics; precision medicine; airway inflammation; pediatric asthma

(This special issue belongs to the Section Respiratory Medicine)

Clinical Advances in Lower Limb Trauma and Orthopedic Surgery: From Bench to Bedside

edited by

Se Won Lee

and

Jihyo Hwang

submission deadline 20 Jul 2026 | Viewed by 49 | Submission Open

Keywords: lower limb trauma; fracture fixation; arthroplasty; biomechanics; orthopaedic surgery; clin-ical outcomes; minimally invasive techniques; rehabilitation

(This special issue belongs to the Section Orthopedics)

Sarcopenia: Prevention and Treatment Options

edited by Steven Phu

submission deadline 20 Jul 2026 | Viewed by 48 | Submission Open

Keywords: sarcopenia; skeletal muscle; ageing; falls; frailty; exercise; rehabilitation; nutrition

(This special issue belongs to the Section Geriatric Medicine)

Clinical Updates on Anesthesia and Perioperative Medicine

edited by Béla Fülesdi and

Sorin J. Brull

submission deadline 20 Jul 2026 | Viewed by 47 | Submission Open

Keywords: anesthesia; perioperative complications; residual neuromuscular block; postoperative pulmonary complications; intensive care unit acquired weakness; intensive care medicine; airway management; patient safety

(This special issue belongs to the Section Anesthesiology)

Current Challenges and Innovation in Trauma and Acute Care Surgery

edited by Michel Teuben

submission deadline 20 Jul 2026 | Viewed by 47 | Submission Open

Keywords: traumatology; trauma surgery; acute care surgery; femur; injury

(This special issue belongs to the Section Emergency Medicine)

Applications of Artificial Intelligence and Digital Therapeutics in Clinical Medicine: 2nd Edition

edited by

Carlos Escobar

submission deadline 20 Jul 2026 | Viewed by 46 | Submission Open

Keywords: artificial intelligence; biometric sensors; deep learning; digital therapies; Internet of Things; machine learning; virtual reality; augmented reality

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Clinical Medicine)

Targeting the Complement for the Treatment of Autoimmune and Neurodegenerative Diseases of the Central Nervous System

edited by Charalampos Skarlis,

Maria Anagnostouli

and

Evangelia Liouta

submission deadline 20 Jul 2026 | Viewed by 46 | Submission Open

Keywords: complement; biologics; monoclonal antibodies; neurodegenerative diseases; CNS autoimmune diseases

(This special issue belongs to the Section Clinical Neurology)

Advances in Interventional Cardiology: From Access to Outcomes

edited by James Cotton and Benjamin Wrigley

submission deadline 20 Jul 2026 | Viewed by 45 | Submission Open

Keywords: interventional cardiology; acute coronary syndrome; chronic coronary syndrome; TAVI; TAVR; TEER; TMVR; T-TEER; TTVR; service redesign

(This special issue belongs to the Section Cardiology)

Perspectives in Bionic Reconstruction and Post-Amputation Management

edited by

Alexander Gardetto

and Jennifer Ernst

submission deadline 20 Jul 2026 | Viewed by 45 | Submission Open

Keywords: bionic reconstruction; advanced prosthetics; neurorehabilitation; sensory feedback; motor control

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Clinical Diagnosis and Treatment in Oncology: Radiotherapy and Imaging Analysis

edited by

Giuseppe Ferrera

Pierpaolo Alongi

and

Francesco Cuccia

submission deadline 20 Jul 2026 | Viewed by 45 | Submission Open

Keywords: radiomics; metabolic imaging; radiotherapy; predictive factors; response models; PET-CT; artificial intelligence; biomarkers; machine-learning

(This special issue belongs to the Section Oncology)

Clinical Updates on Application of Echocardiography

edited by Aydan Ewers

submission deadline 20 Jul 2026 | Viewed by 44 | Submission Open

Keywords: echocardiography; heart failure; cardiomyopathies; cardiac echocardiography; interventional cardiology; cardiac imaging; pulmonary hypertension

(This special issue belongs to the Section Cardiology)

Stereotactic and Functional Neurosurgery: Clinical Treatment and Future Direction

edited by Michael G. Hart

submission deadline 20 Jul 2026 | Viewed by 43 | Submission Open

Keywords: functional neurosurgery; stereotaxy; deep brain structures; brain computer interfaces; therapeutic delivery; symptom relief

(This special issue belongs to the Section Clinical Neurology)

Dental Care and Oral Health in Adolescents and Children

edited by

Karolina Gerreth

submission deadline 20 Jul 2026 | Viewed by 42 | Submission Open

Keywords: oral health; oral diseases; diagnosis; dental treatment; treatment methods; general health; pediatric dentistry; special care dentistry; immunodeficiency; pediatric dental surgery

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Contactless Magnetocardiography and Related Novel Methods for Non-Invasive Experimental and Clinical Functional Imaging of Normal and Abnormal Cardiac Electrophysiology

edited by

Riccardo Fenici

Donatella Brisinda

and

Peter Fenici

submission deadline 20 Jul 2026 | Viewed by 40 | Submission Open

Keywords: magnetocardiography; non-invasive functional imaging of cardiac electrophysiology; arrhythmogenic mechanisms; atrial fibrillation; magnetoionography; antiarrhythmic drugs; artificial intelligence

(This special issue belongs to the Section Cardiology)

Diagnosis, Treatment and Prognosis of Head and Neck Cancer

edited by

Armando De Virgilio

and Elena Russo

submission deadline 20 Jul 2026 | Viewed by 40 | Submission Open

Keywords: head and neck neoplasms; surgical procedures; minimally invasive surgical procedures; radiotherapy; immunotherapy; biomarkers; treatment outcome; early diagnosis; prognosis; quality of life

(This special issue belongs to the Section Oncology)

Exploring Diagnostic and Therapeutic Advances in Neurodegenerative Disorders

edited by

Stefania Kalampokini

and Effrosyni Koutsouraki

submission deadline 20 Jul 2026 | Viewed by 40 | Submission Open

Keywords: neurodegenerative disease; Parkinson’ s disease; Alzheimer’ s disease; Friedreich’ s ataxia; Huntington’ s disease; Lewy body dementia; dementia; immunosenescence; inflammaging

(This special issue belongs to the Section Clinical Neurology)

Orthodontics: Current Management and Future Options

edited by Arūnas Vasiliauskas and Aistė Kavaliauskienė

submission deadline 20 Jul 2026 | Viewed by 39 | Submission Open

Keywords: digital orthodontics; clear aligner therapy; accelerated tooth movement; micro-implants; artificial intelligence; patient-centred outcomes; treatment efficiency

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Early Diagnosis and Treatment of Hepatitis B and C: Bridging Innovation and Implementation

edited by

Rawi Hazzan

and

Fadi Abu Baker

submission deadline 20 Jul 2026 | Viewed by 39 | Submission Open

Keywords: hepatitis B virus (HBV); hepatitis C virus (HCV); hepatitis delta virus (HDV); early diagnosis; viral hepatitis elimination; functional cure; direct-acting antivirals (DAAs); antiviral therapy; treatment adherence; care cascade; screening programs; health policy

(This special issue belongs to the Section Infectious Diseases)

Displaying special issue 1401-1450 on page 29 of 32.

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