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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Management in Dry Eye Disease: Current Strategies and Emerging Protocols
edited by Sunil Shah and Raquel Gil-Cazorla
submission deadline 20 May 2027 | 3 articles | Viewed by 1448 | Submission Open
Keywords: dry eye disease; ocular surface; diagnostics; inflammation; biomarkers; emerging therapies
(This special issue belongs to the Section Ophthalmology)
Clinical Advances in General and Regional Anesthesia
edited by Luciano Frassanito
submission deadline 20 May 2027 | 2 articles | Viewed by 1442 | Submission Open
Keywords: oncoanesthesia; perinatal anesthesia; ventilatory support; hemodynamic monitoring; regional anesthesia
(This special issue belongs to the Section Anesthesiology)
Beyond Efficacy and Trials: Real-World Value and Effectiveness in Autoimmune Rheumatic Joint Diseases
edited by
submission deadline 20 May 2027 | 2 articles | Viewed by 1356 | Submission Open
Keywords: effectiveness; efficacy; autoimmune rheumatic joint diseases; patient-reported outcomes; quality of life
(This special issue belongs to the Section Immunology & Rheumatology)
Emerging Trends in Atrial Fibrillation Management
edited by Guy Rozen
submission deadline 20 May 2027 | 1 articles | Viewed by 1316 | Submission Open
Keywords: cardiology; atrial fibrillation; left atrial appendage occlusion; echocardiography; pulse field ablation
(This special issue belongs to the Section Cardiology)
Current Advances in Dysphagia Assessment and Management
edited by
submission deadline 20 May 2027 | 3 articles | Viewed by 1224 | Submission Open
Keywords: dysphagia; pathophysiology; swallowing; assessment; swallowing surgery; clinical outcomes
(This special issue belongs to the Section Otolaryngology)
Innovations and Clinical Advances in CMR and Echocardiography
edited by Raluca Tomoaia and
submission deadline 20 May 2027 | 1 articles | Viewed by 1201 | Submission Open
Keywords: cardiac magnetic resonance; echocardiography; cardiomyopathy; ischaemic heart disease; valvular heart disease; risk stratification; clinical outcomes
(This special issue belongs to the Section Cardiology)
Diagnosis, Treatment and Comorbidities in Chronic Obstructive Pulmonary Disease (COPD): 3rd Edition
edited by Juan Luis Rodriguez Hermosa, José Luis Álvarez-Sala Walther and Myriam Calle Rubio
submission deadline 20 May 2027 | 2 articles | Viewed by 1183 | Submission Open
Keywords: COPD; diagnosis; comorbidities; respiratory rehabilitation; inhaled therapy; biological therapies
(This special issue belongs to the Section Respiratory Medicine)
Knee Surgery: Clinical Treatment and Management
edited by Nikolai Ramadanov
submission deadline 20 May 2027 | 2 articles | Viewed by 1156 | Submission Open
Keywords: knee surgery; sports knee injuries; ligament reconstruction; meniscal surgery; cartilage repair; knee osteotomy; knee arthroplasty; clinical outcomes; surgical techniques
(This special issue belongs to the Section Orthopedics)
Contemporary Advances in Abdominal Surgery: Precision Care, Digital Innovation, and Future Perspectives
edited by Calin Molnar
submission deadline 20 May 2027 | 3 articles | Viewed by 877 | Submission Open
Keywords: abdominal surgery; precision surgery; digital surgery; artificial intelligence; minimally invasive surgery; surgical oncology; perioperative care
(This special issue belongs to the Section General Surgery)
Cardiac Intensive Care: Clinical Insights and Advances
edited by , and Valentina Bellini
submission deadline 20 May 2027 | 1 articles | Viewed by 831 | Submission Open
Keywords: acute heart failure; artificial intelligence; cardiac intensive care; cardiogenic shock; cardiac surgery; extracorporeal life support; hemodynamic monitoring; machine learning; mechanical circulatory support; outcomes and prognostication; palliative care; postcardiotomy care; precision medicine; resuscitation science; shock management; ventricular assist devices
(This special issue belongs to the Section Intensive Care)
The Role of Cardiovascular Imaging in Pericardial, Myocardial and Vascular Inflammation submission deadline 20 May 2027 | 1 articles | Viewed by 802 | Submission Open
Keywords: inflammatory cardiovascular disease; pericarditis; myocarditis; inflammatory cardiomyopathy; echocardiography; nuclear techniques; cardiac computed tomography; cardiovascular magnetic resonance; arrhythmia; heart failure
(This special issue belongs to the Section Cardiology)
Clinical Management for Metabolic Syndrome and Obesity: 2nd Edition
edited by and Antonio De Arriba-Muñoz
submission deadline 20 May 2027 | 1 articles | Viewed by 648 | Submission Open
Keywords: obesity; metabolic syndrome; hepatic steatosis; diabetes mellitus; children; GLP-1
(This special issue belongs to the Section Endocrinology & Metabolism)
Advances in Systemic Therapy for Cholangiocarcinoma: Current Evidence and Emerging Approaches
edited by and
submission deadline 20 May 2027 | 1 articles | Viewed by 633 | Submission Open
Keywords: cholangiocarcinoma; systemic therapy; targeted therapy; biomarkers; precision medicine; translational oncology
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advanced Technologies in Orthopedic Surgery: Progress, Challenges and Opportunities
edited by and Daniel Pérez-Prieto
submission deadline 20 May 2027 | 2 articles | Viewed by 506 | Submission Open
Keywords: orthopedic surgery; traumatology; orthopedic infections; osteomyelitis; prosthetic joint infections; robotic-assisted surgery; biomaterials; 3D printing surgical planning; AI in orthopedics
(This special issue belongs to the Section Orthopedics)
Clinical Applications and Advances in Anesthesia and Pain Management
edited by
submission deadline 20 May 2027 | 1 articles | Viewed by 498 | Submission Open
Keywords: anesthesia; pain management; perioperative care; multimodal analgesia; ERAS; opioid-sparing; regional anesthesia; outcome-driven monitoring
(This special issue belongs to the Section Anesthesiology)
Current Concepts in Prostate Cancer: From Early Detection to Therapeutic Innovations
edited by , and Igor Duquesne
submission deadline 20 May 2027 | 1 articles | Viewed by 475 | Submission Open
Keywords: prostate cancer; miRNA; PSMA PET/CT; radiomics; multiparametric MRI (mpMRI); active surveillance; robot-assisted radical prostatectomy (RARP); focal therapy; functional outcomes; Quality of Life (QoL)
(This special issue belongs to the Section Oncology)
Oral and Maxillofacial Surgery: From Disease Diagnosis and Treatment to Functional and Esthetic Reconstruction
edited by Sho Mitsugi, Manabu Habu and Masahiro Watanabe
submission deadline 20 May 2027 | Viewed by 413 | Submission Open
Keywords: jaw deformity; orthognathic surgery; oral cancer; reconstructive surgery; temporomandibular joint; jaw fracture; AI; simulation
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Radiology and Nuclear Medicine for Precision Medical Care: Bridging Innovation from Bench to Patient
edited by
submission deadline 20 May 2027 | 1 articles | Viewed by 408 | Submission Open
Keywords: radiology; precision medicine; diagnostic imaging; emergency radiology; computed tomography (CT); magnetic resonance imaging (MRI); multimodality imaging; quantitative imaging; imaging biomarkers; oncologic imaging; cancer imaging; prostate cancer imaging; renal tumors; pulmonary embolism; thoracic imaging; chest imaging; cardiac CT; abdominal imaging; trauma
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Extracorporeal Membrane Oxygenation (ECMO): Clinical Application and Advances
edited by
submission deadline 20 May 2027 | Viewed by 405 | Submission Open
Keywords: extracorporeal membrane oxygenation (ECMO); venoarterial ECMO; venovenous ECMO; extracorporeal cardiopulmonary resuscitation (ECPR); cardiogenic shock; acute respiratory distress syndrome (ARDS); mechanical circulatory support; ECMELLA; ECCO2R; cannulation techniques; anticoagulation; mobile ECMO; donation after circulatory death (DCD); normothermic regional perfusion (NRP); organ donation; organ preservation; transplantation
(This special issue belongs to the Section Intensive Care)
Thoracolumbar Spine Injuries: Current Concepts and Future Directions submission deadline 20 May 2027 | 1 articles | Viewed by 391 | Submission Open
Keywords: thoracolumbar spine trauma; burst fracture; AO Spine classification; clinical trials; epidemiology; sex and gender; Hounsfield units; artificial intelligence; minimally invasive surgery; individualized care
(This special issue belongs to the Section Orthopedics)
Recent Advances on Imaging-Guided Cancer Treatment
edited by , Dragoș-Ovidiu Alexandru and Daniela Dumitrescu
submission deadline 20 May 2027 | Viewed by 371 | Submission Open
Keywords: imaging-guided cancer treatment; oncologic imaging; quantitative medical imaging; imaging-based algorithms; innovative medical software; computational oncology; multimodality imaging; image-guided clinical decision-making; precision oncology
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Current Perspectives on Coronary Artery Disease
edited by
submission deadline 20 May 2027 | 1 articles | Viewed by 349 | Submission Open
Keywords: ischemic heart disease; coronary artery disease; prevention strategies; treatment options; multidisciplinary approach; interven-tional cardiology; research lines; bifurcation lesions; chronic total occlusion
(This special issue belongs to the Section Cardiology)
Improving Short- and Long-Term Neurological Outcomes in Perioperative Anesthesia and Critical Care submission deadline 20 May 2027 | Viewed by 338 | Submission Open
Keywords: perioperative brain injury; neuroprotection; multimodal neuromonitoring; delirium; neurocritical care; cerebral perfusion and oxygenation; precision anesthesia; artificial intelligence in critical care
(This special issue belongs to the Section Intensive Care)
Human Microbiota Analysis: Focus on Pediatric Clinical Applications submission deadline 20 May 2027 | Viewed by 319 | Submission Open
Keywords: microbiota; diet; lifestyle; eubiosis; dysbiosis; omics approach; pediatric
(This special issue belongs to the Section Clinical Pediatrics)
Management and Treatment Strategies for Diabetic Kidney Disease
edited by Luca Visconti
submission deadline 20 May 2027 | Viewed by 288 | Submission Open
Keywords: diabetic kidney disease; hemodialysis; cardiovascular; dialysis; diabetic nephropathy; diabetes
(This special issue belongs to the Section Nephrology & Urology)
Stroke Recovery and Neuroplasticity: Bridging Research to Rehabilitation submission deadline 20 May 2027 | Viewed by 284 | Submission Open
Keywords: stroke; neuroplasticity; artificial intelligence; EEG; neuromodulation; TMS; tDCS; tACS; functional recovery prediction
(This special issue belongs to the Section Clinical Neurology)
Clinical Management of Thyroid Diseases
edited by Diana Loreta Pãun, Mihaela Stanciu and Mihaela Popescu
submission deadline 20 May 2027 | Viewed by 272 | Submission Open
Keywords: thyroid genetics; autoimmune thyroiditis; thyroid cancer; thyroid puncture techniques; radiofrequency ablation treatment
(This special issue belongs to the Section Endocrinology & Metabolism)
Pancreato-Biliary Interventional Endoscopy: 3rd Edition
edited by
submission deadline 20 May 2027 | Viewed by 259 | Submission Open
Keywords: endotherapy; pancreatobiliary disease; pancreatobiliary endoscopy; interventional EUS; ERCP; biliary access; biliary cannulation; endoscopic stenting; biliary drainage; pancreatic drainage; EUS-guided biliary drainage (EUS-BD); EUS-guided pancreatic drainage (EUS-PD); cholangioscopy
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Novel Diagnostic and Therapeutic Methods in Jaundice and Related Diseases
edited by and Angela C Cheung
submission deadline 20 May 2027 | Viewed by 251 | Submission Open
Keywords: primary biliary cholangitis; Alagille syndrome; cholestasis; familial intrahepatic cholestasis; ileal bile acid transporters inhibitors; pruritus
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Advances in Multidisciplinary Emergency and Acute Disease Management: Risk, Triage and Clinical Strategies to Improve Patient Outcomes
edited by Aikaterini Apostolopoulou
submission deadline 20 May 2027 | Viewed by 141 | Submission Open
Keywords: emergency medicine; acute care; risk stratification; triage; patient outcomes
(This special issue belongs to the Section Emergency Medicine)
Modern Clinical Approaches to Cholestic Liver Diseases and Its Complications: Diagnosis, Prognosis, and Treatment
edited by
submission deadline 20 May 2027 | Viewed by 136 | Submission Open
Keywords: cholestatic liver disease; primary biliary cholangitis (PBC); primary sclerosing cholangitis (PSC); portal hypertension; cirrhosis; decompensation; cholangiocarcinoma; hepatocellular carcinoma
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advanced Technologies in Prenatal Screening and Maternal Fetal Medicine
edited by Jeffrey Denney, Joshua Nitsche and Matthew Zuber
submission deadline 20 May 2027 | Viewed by 129 | Submission Open
Keywords: prenatal diagnosis; prenatal genetic testing; carrier screening; advances in fetal care; advances in prenatal ultrasound
(This special issue belongs to the Section Obstetrics & Gynecology)
Rhinitis and Rhinosinusitis: Advances in Biomarker Discovery and Therapeutic Innovation
edited by Lara Derycke
submission deadline 20 May 2027 | Viewed by 118 | Submission Open
Keywords: rhinitis; rhinosinusitis; chronic rhinosinusitis; nasal polyps; nasal surgery; precise medicine; biomarker
(This special issue belongs to the Section Otolaryngology)
Innovations in Endovascular Treatment of Thoracic, Thoracoabdominal and Abdominal Aortic Aneurysms
edited by , Enrico Gallitto and
submission deadline 20 May 2027 | Viewed by 112 | Submission Open
Keywords: endovascular aortic repair; TEVAR; EVAR; fenestrated endovascular repair; branched endovascular repair; aortic arch repair; physician-modified endograft; hostile neck anatomy; clinical application of 3D printing; artificial intelligence; aortic remodelling; robotic aortic surgery
(This special issue belongs to the Section Vascular Medicine)
Surgical Management of Brain–Spinal Cord–Nerve Axis Disorders
edited by Ismail Zaed
submission deadline 20 May 2027 | Viewed by 112 | Submission Open
Keywords: neurosurgery; brain disorders; spinal cord pathology; peripheral nerve disorders; surgical management
(This special issue belongs to the Section Clinical Neurology)
Strategies and Outcomes in Complex Cardiac Surgery
edited by Mohammed Morjan, Mateo Marin-Cuartas and Carlos Alberto Mestres
submission deadline 20 May 2027 | Viewed by 109 | Submission Open
Keywords: complex cardiac surgery; infective endocarditis; aortic dissection; aortic arch surgery; surgical innovation; hybrid pro-cedures; cerebral protection; surgical outcomes
(This special issue belongs to the Section Cardiology)
Outcome Measurement and Prediction in Spine Surgery
edited by and Il Choi
submission deadline 20 May 2027 | Viewed by 103 | Submission Open
Keywords: patient-reported outcome measures; spine surgery; endoscopic spine surgery; minimally invasive spine surgery; outcome prediction; machine learning; electronic PROM; measurement timing; patient expectations; clinical outcomes; AI; predictive modeling
(This special issue belongs to the Section Clinical Neurology)
Advances in Acute and Intermediate Critical Care: Management and Monitoring of High-Risk Medical Patients
edited by
submission deadline 20 May 2027 | Viewed by 101 | Submission Open
Keywords: intermediate care unit; critical care; emergency medicine; acute care; high-risk patients; sepsis; acute respiratory failure; non-invasive ventilation; hemodynamic monitoring; artificial intelligence; clinical decision support; point-of-care ultrasound; risk stratification; patient monitoring; critical illness
(This special issue belongs to the Section Emergency Medicine)
Recent Clinical Advances in Endodontics
edited by Carlo Gaeta and
submission deadline 20 May 2027 | Viewed by 99 | Submission Open
Keywords: root canal treatment; endodontics; systemic diseases and apical periodontitis; irrigation; risk factors; new antimicrobial peptides; regenerative endodontics
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Treatment and Management of Rheumatic Diseases, Autoinflammatory Diseases and Autoimmune Disorders: 2nd Edition
edited by Merav Lidar and
submission deadline 20 May 2027 | Viewed by 98 | Submission Open
Keywords: rheumatic diseases; autoinflammatory diseases; autoimmune disorders; rheumatoid arthritis; diagnosis
(This special issue belongs to the Section Immunology & Rheumatology)
Lower Urinary Tract Symptoms and Benign Prostatic Hyperplasia (BPH): From Prevention to Diagnosis to Cure
edited by Ilias Giannakodimos
submission deadline 20 May 2027 | Viewed by 94 | Submission Open
Keywords: BPH; LUTS; minimally invasive surgery; diagnosis; treatment; prostate
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Recent Advances in Imaging and Interventional Techniques for Prostate Cancer
edited by Francesco Ziglioli and Umberto Vittorio Maestroni
submission deadline 20 May 2027 | Viewed by 94 | Submission Open
Keywords: prostate cancer; pobotic-assisted and focal therapies; artificial intelligence; radiomics image-guided interventions; multiparametric MRI; PSMA-PET/CT
(This special issue belongs to the Section Nephrology & Urology)
Advances in Ultrasound Imaging for Pulmonary Diseases
edited by Natalia Buda and
submission deadline 20 May 2027 | Viewed by 94 | Submission Open
Keywords: lung ultrasound; thoracic ultrasound; POCUS; respiratory medicine; interstitial lung diseases; pneumonia; acute respiratory failure; pleural diseases; pulmonary edema; pulmonary embolism; interventional pulmonology; critical care; heart failure; artificial intelligence
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Next-Generation Approaches to Out-of-Hospital Cardiac Arrest: From Triage to Post-Resuscitation Care
edited by Young Sun Ro, and Seok-Jin Ryu
submission deadline 20 May 2027 | Viewed by 93 | Submission Open
Keywords: out-of-hospital cardiac arrest; resuscitation; field triage; predictive modeling; artificial intelligence; digital healthcare; post-resuscitation care; neuroprognostication
(This special issue belongs to the Section Emergency Medicine)
Aortic Dissection: Clinical Diagnosis and Treatment for Better Outcomes
edited by Ilaria Franzese and Daniele Linardi
submission deadline 20 May 2027 | Viewed by 91 | Submission Open
Keywords: aortic imaging; aortic surgery; endovascular treatment; aortic dissection; cerebral perfusion; aortic valve
(This special issue belongs to the Section Cardiology)
Application of Imaging in Liver Diseases
edited by Hideaki Ishida
submission deadline 20 May 2027 | Viewed by 87 | Submission Open
Keywords: liver; ultrasound; imaging; fibrosis; gastroenterology; digestive system diseases; hepatology; cholecystitis; hepatocellular carcinoma; chronic liver disease
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Innovations and Clinical Advances in Endovascular Neurosurgery
edited by
submission deadline 20 May 2027 | Viewed by 85 | Submission Open
Keywords: endovascular neurosurgery; mechanical thrombectomy; intracranial aneurysm; flow diversion; arteriovenous malformation; acute ischemic stroke; neurointervention; cerebrovascular disease; minimally invasive techniques; neuroimaging
(This special issue belongs to the Section Clinical Neurology)
Obstructive Sleep Apnoea: Risk Factors, Associated Disorders, and Variability in Disease Severity
edited by Amro Daboul
submission deadline 20 May 2027 | Viewed by 85 | Submission Open
Keywords: obstructive sleep apnoea; interdisciplinary sleep medicine; risk factors; associated disorders; disease severity
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Advances in Autoimmune Disorders—2nd Edition submission deadline 20 May 2027 | Viewed by 84 | Submission Open
Keywords: autoimmune disorders; systemic sclerosis; connective tissue diseases; biomarkers; precision medicine; fibrosis; autoimmunity; immunology; targeted therapies; real-world evidence; artificial intelligence; cardiovascular complications
(This special issue belongs to the Section Immunology & Rheumatology)
Current Advances in Clinical Rehabilitation and Physiotherapy for Musculoskeletal Disorders
edited by
submission deadline 20 May 2027 | Viewed by 84 | Submission Open
Keywords: differential diagnosis; screening for referral; spinal manipulation; low back pain; thoracic pain; neck pain; musculoskeletal disorders; physiotherapy
(This special issue belongs to the Section Clinical Rehabilitation)
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