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Clinical Management for Metabolic Syndrome and Obesity: 2nd Edition

A Special Issue of Journal of Clinical Medicine (ISSN 2077-0383) belonging to the section "Endocrinology & Metabolism".

Deadline for manuscript submissions: 20 May 2027 | Viewed by 98

Editors


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Guest Editor
Unidad de Endocrinología Pediátrica, Hospital Universitario Araba, 01004 Vitoria-Gasteiz, Spain
Interests: pediatric endocrinology; small for gestational age; vitamin D deficiency
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
1. Instituto Investigación Sanitaria Aragón, Avenida San Juan Bosco, 50009 Zaragoza, Spain
2. Miguel Servet University Hospital, 50009 Zaragoza, Spain
Interests: pediatric endocrinology; growth hormone; endocrinology and metabolism
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is my pleasure to invite you to contribute to the Special Issue entitled “Clinical Management for Metabolic Syndrome and Obesity: 2nd Edition.” Building upon the success of our first edition, which featured 12 published papers, we are excited to launch this new volume.

For more details, please visit: https://www.mdpi.com/journal/jcm/special_issues/91XOFU6012

It is an honor to present this Special Issue of the Journal of Clinical Medicine. Obesity, and childhood obesity in particular, is now recognized as one of the major pandemics of the early 21st century.

The concurrent COVID-19 pandemic not only underscored the critical need for global action against health crises, but it also contributed to a surge in obesity and metabolic syndrome cases following mandatory quarantine periods. Notably, the prevalence of childhood obesity has reached 30–50% in certain populations across Southern Europe, the Americas, and developing nations.

As a result, children with obesity face a high risk of chronic illness in adulthood, and we are increasingly observing the early onset of traditionally adult conditions—such as type 2 diabetes mellitus (T2DM)—within pediatric populations.

The emergence of novel diagnostic challenges, the adoption of advanced screening protocols, and the growing clinical significance of metabolic dysfunction-associated steatotic liver disease (MASLD) are reshaping the field.

Coupled with the rising tide of new GLP-1 receptor agonists, these advancements will not only transform the paradigm for diagnosing and monitoring these patients but also offer profound hope for the future.

We look forward to receiving your valuable submissions to this Special Issue.

Dr. Ignacio Díez López
Dr. Antonio De Arriba-Muñoz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obesity
  • metabolic syndrome
  • hepatic steatosis
  • diabetes mellitus
  • children
  • GLP-1

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Published Papers (1 paper)

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Review

27 pages, 374 KB  
Review
Resistance Training with Aerobic Active Recovery in Obesity and Metabolic Syndrome: Translational Rationale, Proposed Training Protocol, and Multi-Omics Research Framework—A Narrative Review
by Karol Makiel and Agnieszka Suder
J. Clin. Med. 2026, 15(17), 6671; https://doi.org/10.3390/jcm15176671 (registering DOI) - 28 Aug 2026
Abstract
Background/Objectives: Resistance training with aerobic active recovery (RT-AR) is a proposed session architecture in which controlled low-impact aerobic activity replaces part of passive inter-set recovery. This hypothesis-driven narrative review evaluates its rationale in adults with obesity and metabolic syndrome (MetS) and proposes a [...] Read more.
Background/Objectives: Resistance training with aerobic active recovery (RT-AR) is a proposed session architecture in which controlled low-impact aerobic activity replaces part of passive inter-set recovery. This hypothesis-driven narrative review evaluates its rationale in adults with obesity and metabolic syndrome (MetS) and proposes a multi-omics research framework. Methods: Structured searches of PubMed/MEDLINE and Scopus were combined with a narrative synthesis of systematic reviews, meta-analyses, controlled intervention studies, and mechanistic studies. Dedicated high-sensitivity searches were performed for studies directly evaluating aerobic active recovery during resistance-training inter-set recovery. Results: No randomized chronic intervention studies directly evaluating RT-AR in adults with obesity or MetS were identified; therefore, the rationale presented here is based on indirect evidence from conventional exercise and mechanistic studies. Evidence from overweight, abdominal-obesity, insulin-resistance, or type 2 diabetes cohorts was treated as partially applicable or indirect when the target phenotype differed. Aerobic, resistance, and combined training support improvements in body composition, cardiometabolic outcomes, physical function, and selected adipokines, whereas microbiota and DNA-methylation findings remain heterogeneous and are not RT-AR-specific. Conclusions: RT-AR should be regarded as a testable training architecture rather than an established therapeutic modality. Future trials should determine whether its effects exceed those attributable to total exercise dose, whether the resistance-training stimulus is preserved, and how diet, medication use, sex, and other major modifiers influence clinical and multi-omics responses. Full article
(This article belongs to the Special Issue Clinical Management for Metabolic Syndrome and Obesity: 2nd Edition)
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