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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Novel Insights into the Use of Artificial Intelligence in Clinical Medicine
edited by Sharon C. Kiang and Roger T. Tomihama
submission deadline 20 Jun 2026 | Viewed by 78 | Submission Open
Keywords: artificial intelligence; disease predictive models; wearable technology; surgical innovation; molecular targeting; big data science; machine learning; deep learning
Sepsis: Clinical Advances and Practical Updates
edited by
submission deadline 20 Jun 2026 | Viewed by 54 | Submission Open
Keywords: sepsis pathophysiology; host immune response; biomarkers for sepsis; early sepsis diagnosis; immunotherapy in sepsis; antimicrobial stewardship
(This special issue belongs to the Section Intensive Care)
Clinical Advances in the Pharmacotherapy of Diabetes
edited by Jonathan Watanabe, and
submission deadline 20 Jun 2026 | Viewed by 54 | Submission Open
Keywords: diabetes; microvascular complications; macrovascular complications; diabetes technology; pharmacoepidemiology; care delivery; novel therapies
(This special issue belongs to the Section Pharmacology)
Clinical Insights in Pediatric Dentistry
edited by
submission deadline 20 Jun 2026 | Viewed by 53 | Submission Open
Keywords: pediatric dentistry; caries management; dental trauma; preventive dentistry; behavior management; interdisciplinary care; clinical innovations
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Advanced Endoscopy and Imaging in Gastrointestinal Diseases submission deadline 20 Jun 2026 | Viewed by 51 | Submission Open
Keywords: advanced endoscopy; gastrointestinal imaging; minimally invasive therapy; early diagnosis; image-guided intervention; surgical planning; patient outcomes; gastrointestinal diseases
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advances in Rhinosinusitis and Nasal Polyposis: From Emerging Trends and Therapeutic Opportunities to Surgery
edited by Gian Luca Fadda, Giovanni Cavallo and
submission deadline 20 Jun 2026 | Viewed by 46 | Submission Open
Keywords: nasal polyps; chronic rhinosinusitis; asthma; endoscopic sinus surgery; anatomical variation; biologic treatment; type-2 inflammation; paranasal sinuses; CRSwNP; late response; long term; remission; dupilumab; control
(This special issue belongs to the Section Otolaryngology)
Clinical Advances and Challenges in Liver Transplantation: 3rd Edition
edited by
submission deadline 20 Jun 2026 | Viewed by 45 | Submission Open
Keywords: liver transplantation (LT); elderly donors; steatotic livers; donors after circulatory death (DCD); hepatocellular carcinoma (HCC); perioperative management
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Advances in Scoliosis and Spinal Disorders: Diagnosis and Management
edited by Tejas Subramanian
submission deadline 20 Jun 2026 | Viewed by 44 | Submission Open
Keywords: spine surgery; adult spinal deformity; frailty; sarcopenia; muscle health; postoperative recovery; patient-reported outcomes
(This special issue belongs to the Section Orthopedics)
Clinical Research on Minimally Invasive Spine Surgery
edited by Daniel K. Fahim
submission deadline 20 Jun 2026 | Viewed by 41 | Submission Open
Keywords: minimally invasive spine surgery; spine tumors; spine trauma; spine fractures; lumbar stenosis; lumbar spondylolisthesis; lumbar disc herniation; lumbar radiculopathy; thoracic disc herniations; cervical radiculopathy
(This special issue belongs to the Section Orthopedics)
Endoscopic Management of Pancreaticobiliary Disease: Updates and Future Directions
edited by
submission deadline 20 Jun 2026 | Viewed by 40 | Submission Open
Keywords: pancreaticobiliary disease; ERCP; interventional EUS; tissue acquisition; early detection of pancreaticobiliary malignancy; management of AEs
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Obsessive–Compulsive Disorder: Clinical Advances and Future Perspectives—Second Edition
edited by Andrea Fagiolini
submission deadline 20 Jun 2026 | Viewed by 40 | Submission Open
Keywords: obsessions– compulsions; anxiety; OCD symptoms; treatment options; functional impairment
(This special issue belongs to the Section Mental Health)
Aortic Valve Replacement: Current Trends, Future Perspectives, and Emerging Technologies
edited by
submission deadline 20 Jun 2026 | Viewed by 39 | Submission Open
Keywords: aortic valve; heart valve prosthesis; transcatheter aortic valve replacement; surgical aortic valve replacement; aortic valve insufficiency; minimally invasive surgical procedures; treatment outcome; vulnerable populations
(This special issue belongs to the Section Cardiology)
Contemporary Issues and Emerging Trends in Colorectal Surgery submission deadline 20 Jun 2026 | Viewed by 39 | Submission Open
Keywords: abdominal surgery; minimally invasive surgery; colorectal surgery; colorectal cancer; inflammatory bowel disease; image-guided surgery; transational research; artificial intelligence; operative endoscopy; screening; early diagnosis; ERAS
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Stroke Care: From Acute Interventions to Long-Term Recovery submission deadline 20 Jun 2026 | Viewed by 38 | Submission Open
Keywords: cerebrovascular diseases; acute ischemic stroke; intravenous thrombolysis; endovascular thrombectomy; intracerebral hemorrhage; etiology; cerebral amyloid angiopathy; stroke rehabilitation
(This special issue belongs to the Section Clinical Neurology)
The Changing Landscape of Biliary Cancers
edited by Arvind Arora
submission deadline 20 Jun 2026 | Viewed by 38 | Submission Open
Keywords: biliary tract cancer; cholangiocarcinoma; gallbladder cancer; precision oncology; molecular profiling; immunotherapy; targeted therapy; clinical trials; multidisciplinary care; early detection; global oncology
(This special issue belongs to the Section Oncology)
Oral and Maxillofacial Surgery: Clinical Progress, Challenges and Opportunities
edited by Janet Hayes Southerland and Leslie Robin Halpern
submission deadline 20 Jun 2026 | Viewed by 38 | Submission Open
Keywords: OMFS; surgery; research; innovation; interdisciplinary; cosmetic; pharmacology; cancer; repair; nerve; TMJ; rehabilitation; orthognathic; disorder; bleeding
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Innovations in Neurorehabilitation—2nd Edition
edited by
submission deadline 20 Jun 2026 | Viewed by 34 | Submission Open
Keywords: clinical neurophysiology; neuroengineering; robotics; non-invasive transcranial brain stimulation; spinal stimula-tion; regenerative rehabilitation; neuroimaging; brain– computer interface; brain-spinal interface; virtual reality; higher-level cognitive functions; vision rehabilitation
(This special issue belongs to the Section Clinical Rehabilitation)
Clinical Advances in Endocarditis: From Diagnosis to Treatment
edited by Ram Sharony and Katia Orvin
submission deadline 20 Jun 2026 | Viewed by 33 | Submission Open
Keywords: endocarditis; infective endocarditis; prosthetic valve endocarditis; TAVR endocarditis; advanced cardiac imaging
(This special issue belongs to the Section Cardiology)
Recent Progress in Anterior Cruciate Ligament Injury and Reconstruction
edited by Patrick Weninger
submission deadline 20 Jun 2026 | Viewed by 33 | Submission Open
Keywords: anterior cruciate ligament; ACL reconstruction; ACL repair; ACL preservation; orthobiologics; stem cells; rehabilitation
(This special issue belongs to the Section Sports Medicine)
Pediatric Ophthalmology: Current Progress and Future Options submission deadline 20 Jun 2026 | Viewed by 33 | Submission Open
Keywords: pediatric ophthalmology; genetic eye diseases; gene therapy; genetic counseling; telemedicine; diagnostic tools; blindness in childhood; congenital cataract; visual rehabilitation; myopia control
(This special issue belongs to the Section Ophthalmology)
Chronic Kidney Disease: From Diagnosis to Treatment
edited by Debra Hain
submission deadline 20 Jun 2026 | Viewed by 31 | Submission Open
Keywords: chronic kidney disease; type 2 diabetes; diabetic complications; hemodialysis; nephrology nursing; older adults; palliative care; therapy; hypertension
(This special issue belongs to the Section Nephrology & Urology)
Current and Emerging Treatment Options in Pancreatic Cancer
edited by Venkata C.K. Sunkesula
submission deadline 20 Jun 2026 | Viewed by 31 | Submission Open
Keywords: pancreas surgery; pancreatic cystic lesions; chronic pancreatitis; pancreatic cancer; EUS-guided; fine-needle ablation; endoscopic radiofrequency ablation; minimal invasive surgery; pancreatic intraepithelial neoplasia
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Neuroimmunological Disorders: Mechanisms and Therapies submission deadline 20 Jun 2026 | Viewed by 31 | Submission Open
Keywords: neuroinflammatory; multiple sclerosis; neuromyelitis optica spectrum disorders; mog associated disease; autoimmune/paraneoplastic encephalitis  
(This special issue belongs to the Section Clinical Neurology)
Cardiovascular Disease in the Elderly: Cardiogeriatric Assessment, Prevention, Treatment Outcomes and Perspectives
edited by Georgia Vamvakou
submission deadline 20 Jun 2026 | Viewed by 31 | Submission Open
Keywords: cardiovascular diseases; elderly patients; cardiogeriatric assessment; diagnosis and therapeutic planning; healthy aging; digital medicine
(This special issue belongs to the Section Cardiovascular Medicine)
Assisted Knee Arthroplasty: From Preoperative Planning to Postoperative Outcomes
edited by and Matteo Innocenti
submission deadline 20 Jun 2026 | Viewed by 30 | Submission Open
Keywords: assisted knee arthroplasty; robotic-assisted surgery; computer navigation; preoperative planning; patient-specific alignment; minimally invasive surgery; digital health technologies
(This special issue belongs to the Section Orthopedics)
Current Perspectives and Emerging Trends in Cardiothoracic Surgery
edited by Zsolt Szabo and
submission deadline 20 Jun 2026 | Viewed by 30 | Submission Open
Keywords: minimally invasive cardiac surgery; minimally invasive thoracic surgery; minimally invasive valve surgery; non-intubated and spontaneous ventilation techniques; thymus surgery; prehabilitation; chronic comorbidities (DM; COPD); cardiopulmonary bypass outcomes; extracorporeal life support (ECLS); emerging trends in cardiothoracic surgery
(This special issue belongs to the Section General Surgery)
Endoscopic Innovations in Gastrointestinal Diseases: From Diagnosis to Therapy
edited by Mattia Brigida and Gianluca Andrisani
submission deadline 20 Jun 2026 | Viewed by 30 | Submission Open
Keywords: endoscopic innovation; gastrointestinal diseases; advanced endoscopic imaging; therapeutic endoscopy; artificial intelligence; minimally invasive therapy; personalized medicine
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Cardiotoxicity Within Cardio-Oncology: Clinical Advances from Prediction to Management submission deadline 20 Jun 2026 | Viewed by 29 | Submission Open
Keywords: cardio-oncology; cardiotoxicity; cancer therapy– related cardiac dysfunction; heart failure in cancer patients; biomarkers; multimodality imaging; risk stratification; cardioprotection; cancer survivors' care; multidisciplinary approach
(This special issue belongs to the Section Cardiology)
Hematoinflammatory Diseases: Bridging Autoimmunity and Autoinflammation
edited by Andrés González García and
submission deadline 20 Jun 2026 | Viewed by 28 | Submission Open
Keywords: hematoinflammatory diseases; clonal hematopoiesis; vexas syndrome; castleman disease; Igg4-related disease; cytokine storm; autoinflammatory syndromes; immunopathogenesis; targeted therapies; biomarkers
(This special issue belongs to the Section Immunology & Rheumatology)
New Advances in Oral and Facial Surgery: 2nd Edition
edited by
submission deadline 20 Jun 2026 | Viewed by 27 | Submission Open
Keywords: squamous cell carcinoma; oro-pharyngeal tumors; skin tumors; plastic and reconstructive surgery; facial plastic surgery; facial reanimation; facial nerve palsy; head and neck surgery; maxillofacial surgery; aesthetic surgery; orthognatic surgery; dental implant surgery
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Frontiers in Myocardial Infarction: From Acute Revascularization to Long-Term Secondary Prevention
edited by
submission deadline 20 Jun 2026 | Viewed by 27 | Submission Open
Keywords: complete revascularization; myocardial infarction; vulnerable plaque; imaging guided PCI; biomarkers; secondary prevention; microvascular disease; endothelial dysfunction
(This special issue belongs to the Section Cardiology)
Stroke in Patients with Atrial Fibrillation: Risk, Manifestation and Prevention submission deadline 20 Jun 2026 | Viewed by 26 | Submission Open
Keywords: anticoagulant treatment; atrial fibrillation; arrhythmia; personalized medicine; stroke
(This special issue belongs to the Section Cardiology)
Clinical Research Advances in Gynecologic Oncology
edited by
submission deadline 20 Jun 2026 | Viewed by 25 | Submission Open
Keywords: ovarian cancer; endometrial cancer; breast cancer; molecular biology; gynecological cancers
(This special issue belongs to the Section Oncology)
Advances in Cardiovascular Rehabilitation: The Central Role of Exercise in Prevention and Care
edited by Massimo Pistono
submission deadline 20 Jun 2026 | Viewed by 25 | Submission Open
Keywords: cardiac rehabilitation; secondary prevention; physical exercise; cardiovascular health; aerobic exercise; cardio-oncology rehabilitation
(This special issue belongs to the Section Cardiovascular Medicine)
Current and Emerging Management Strategies in Gynecologic Oncology
edited by Grzegorz Szewczyk
submission deadline 20 Jun 2026 | Viewed by 25 | Submission Open
Keywords: gynecologic oncology; surgical approach; molecular diagnostics; novel therapies; rare gynecological cancers; risk factors
(This special issue belongs to the Section Obstetrics & Gynecology)
Arterial Stiffness and Cardiovascular Risk: New Advances and Challenges
edited by
submission deadline 20 Jun 2026 | Viewed by 24 | Submission Open
Keywords: arterial stiffness; vascular aging; anti-inflammation; cardiovascular risk; personalized medicine
(This special issue belongs to the Section Cardiovascular Medicine)
Advances in the Field of Cariology submission deadline 20 Jun 2026 | Viewed by 20 | Submission Open
Keywords: dental caries; caries diagnosis; caries risk assessment; minimally invasive dentistry; preventive strategies
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Advancements in Anesthesia and Pain Management
edited by Brittany L. Willer and Vidya T. Raman
submission deadline 20 Jun 2026 | Viewed by 20 | Submission Open
Keywords: perioperative innovation; regional and multimodal analgesia; translational anesthesiology; artificial intelligence in anesthesia; patient-centered pain management
(This special issue belongs to the Section Anesthesiology)
Therapies for Heart Failure: Clinical Updates and Perspectives
edited by Cristina Tudoran, Stela Iurciuc and Dragos Cozma
submission deadline 20 Jun 2026 | Viewed by 19 | Submission Open
Keywords: mechanisms of heart failure; new therapies for heart failure; chronic and acute heart failure; new approaches to managing heart failure patients; special populations; clinical outcome
(This special issue belongs to the Section Cardiology)
Atrial Fibrillation and Its Complications: Preventive Strategies and Relative Evidence—2nd Edition
edited by Roberto Galea
submission deadline 20 Jun 2026 | Viewed by 19 | Submission Open
Keywords: atrial fibrillation; catheter ablation; oral anticoagulation; left atrial appendage closure; stroke prevent
(This special issue belongs to the Section Cardiology)
Cancer Stem Cells and Cellular Therapies in Cancer: Advances and Clinical Prospects
edited by Agnieszka Rybarczyk and Piotr Wierzbicki
submission deadline 20 Jun 2026 | Viewed by 16 | Submission Open
Keywords: cancer stem cells; cell based therapies; innovative therapies in cancer; tumor microenvironment; cell based therapies; preclinical models; immune-based therapies; treatment resistance
(This special issue belongs to the Section Oncology)
Focus on Multiple Myeloma: Diagnosis, Therapy and Clinical Outcome
edited by
submission deadline 20 Jun 2026 | Viewed by 15 | Submission Open
Keywords: multiple myeloma; novel therapies; treatment approach; prognosis; clinical outcome
(This special issue belongs to the Section Hematology)
New Concepts in the Diagnosis and Treatment of Orthopedic Diseases in Children—2nd Edition submission deadline 20 Jun 2026 | Viewed by 15 | Submission Open
Keywords: pediatric orthopedics; flatfoot; genu valgum; genu varum; hip dysplasia; clubfoot; early onset scoliosis; Scheuermann disease; perthes; epiphysiolysis; scoliosis; pediatric trauma
(This special issue belongs to the Section Clinical Pediatrics)
Innovative Interventional Approaches in the Treatment of Cardiac Arrhythmias
edited by Karolina Weinmann-Emhardt and Jonas Wormann
submission deadline 20 Jun 2026 | Viewed by 15 | Submission Open
Keywords: cardiac electrophysiology; catheter ablation; atrial fibrillation; ventricular tachycardia; pulmonary vein isolation; three-dimensional mapping; pulsed field ablation; radiofrequency ablation; clinical perspectives
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Advances and Future Challenges for Occupational Health
edited by and Vincenza Pellicani
submission deadline 20 Jun 2026 | Viewed by 4 | Submission Open
Keywords: work-related disease; precision medicine; gender differences; aging workforce; preventive strategies
(This special issue belongs to the Section Epidemiology & Public Health)
Advances in Peripheral Vascular Disease: Diagnosis, Management and Surgical Interventions
edited by Nikolaos Zacharias
submission deadline 20 Jun 2026 | Viewed by 2 | Submission Open
Keywords: atherosclerosis; peripheral artery disease; claudication; critical limb threatening ischemia; infrainguinal bypass; femoral stenting
(This special issue belongs to the Section Vascular Medicine)
Clinical Advances and New Perspectives in the Diagnosis and Treatment of Schizophrenia
edited by Pierre S. Chue and Oloruntoba J. Oluboka
submission deadline 22 Jun 2026 | Viewed by 16 | Submission Open
Keywords: psychopharmacology; schizophrenia; long-acting injectable therapy; recovery; team approach to care; integrated care; clozapine; habilitation; rehabilitation; early intervention
(This special issue belongs to the Section Mental Health)
Clinical Insights and Challenges into Cognitive and Mental Health in Older Adults
edited by Dariusz Krok
submission deadline 23 Jun 2026 | Viewed by 30 | Submission Open
Keywords: clinical insights; cognitive and mental health; older adults; psychosomatic interventions; person-centered care
(This special issue belongs to the Section Mental Health)
Clinical Advances of Aesthetic Plastic Surgery and Aesthetic Medicine
edited by Valentina Pinto and Rosalba Russo
submission deadline 25 Jun 2026 | Viewed by 103 | Submission Open
Keywords: aesthetic plastic surgery; aesthetic medicine; emerging technologies and devices in aesthetics; regenerative medicine and surgery; vulvovaginal surgery; complications in aesthetic medicine
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Cardiometabolic Disease and Atherosclerosis: Epidemiology, Prevention, Diagnosis, and Clinical Treatment—2nd Edition
edited by and Konstantinos Mourouzis
submission deadline 25 Jun 2026 | Viewed by 56 | Submission Open
Keywords: atherosclerosis; obesity; cardiometabolic disease; prevention; diabetes mellitus; endothelium; arteriosclerosis; coronary artery disease
(This special issue belongs to the Section Cardiology)
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