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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Hypertension in Adults: Current Updates on Diagnosis, Treatment and Management—Second Edition

edited by Emelina Stambolliu and Antonios A. Argyris

submission deadline 25 Aug 2026 | Viewed by 34 | Submission Open

Keywords: essential hypertension; nighttime blood pressure; blood pressure measurement; blood pressure management; blood pressure medical treatment; hypertension thresholds

(This special issue belongs to the Section Vascular Medicine)

Complications of Laparoscopic Cholecystectomy: Surgical Outcomes and Clinical Challenges

edited by

Roberto Cirocchi

submission deadline 25 Aug 2026 | Viewed by 30 | Submission Open

Keywords: laparoscopic cholecystectomy; bile duct injury; management of intraoperative injuries; surgical outcomes; postoperative infections

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Updates of Pediatric Craniofacial Surgery

edited by Federica Tosi

submission deadline 25 Aug 2026 | Viewed by 27 | Submission Open

Keywords: pediatric craniofacial surgery; craniosynostosis; near-infrared spectroscopy; blood transfusion; perioperative monitoring; pediatric anesthesia; hemodynamic management; tissue oxygenation

(This special issue belongs to the Section Clinical Pediatrics)

Bariatric Surgery: Clinical Advances and Future Directions

edited by

Natalia Dowgiałło-Gornowicz

and

Mateusz Wityk

submission deadline 25 Aug 2026 | Viewed by 24 | Submission Open

Keywords: metabolic surgery; bariatric surgery; reflux; laparoscopy; conversion surgery; obesity

(This special issue belongs to the Section General Surgery)

Emerging Trends and Therapeutic Innovations in Corneal and Ocular Surface Disorders

edited by

Zala Lužnik Marzidovšek

and Špela Štunf Pukl

submission deadline 25 Aug 2026 | Viewed by 18 | Submission Open

Keywords: corneal diseases; ocular surface disorders; regenerative medicine; stem cell therapy; gene therapy; nanomedicine and targeted drug delivery

(This special issue belongs to the Section Ophthalmology)

Recent Advances and Future Perspective of Subarachnoid Hemorrhage

edited by

Tihamer Molnar

submission deadline 26 Aug 2026 | Viewed by 25 | Submission Open

Keywords: subarachnoid bleeding; neuromonitoring; neuroimaging; delayed cerebral infarction; biomarkers; personalized medicine; AI-guided decision support; outcome

(This special issue belongs to the Section Clinical Neurology)

Clinical Updates in Heart Failure: Innovations in Diagnosis, Therapy and Management

edited by Paolo Severino

submission deadline 28 Aug 2026 | Viewed by 43 | Submission Open

Keywords: heart failure; HFrEF therapy; HFpEF phenotyping; right ventricular dysfunction; renal congestion assessment; diuretic resistance; NT-proBNP dynamics; cardiac imaging; post-discharge management

(This special issue belongs to the Section Cardiology)

The New Perspective in Transcatheter Aortic Valve Implantation (TAVI)

edited by Salvatore Giordano, Arturo Giordano and Nicola Corcione

submission deadline 31 Aug 2026 | Viewed by 48 | Submission Open

Keywords: transcatheter aortic valve implantation (TAVI); structural heart intervention; aortic stenosis; valve technology and durability; imaging and procedural optimization

(This special issue belongs to the Section Cardiovascular Medicine)

Chronic Obstructive Pulmonary Disease (COPD): Treatment and Management—Second Edition

edited by

Maurizio Marvisi

and Alfredo Antonio Chetta

submission deadline 31 Aug 2026 | Viewed by 42 | Submission Open

Keywords: chronic obstructive pulmonary disease (COPD); treatable traits; precision medicine; COPD comorbidities; COPD mortality

(This special issue belongs to the Section Respiratory Medicine)

Clinical Management of Type 1 Diabetes: 2nd Edition

edited by Carmen Quirós

submission deadline 31 Aug 2026 | Viewed by 35 | Submission Open

Keywords: type 1 diabetes; continuous glucose monitoring; hybrid closed loop; hypoglycemia; physical activity; new onset type 1 diabetes; pre-stage 3 type 1 diabetes; smart insulin pens

(This special issue belongs to the Section Endocrinology & Metabolism)

Advances in Anticoagulant and Antiplatelet Therapy for Coronary Artery Disease: 2nd Edition

edited by

Giuseppe De Luca

submission deadline 31 Aug 2026 | Viewed by 34 | Submission Open

Keywords: platelet; anticoagulant therapy; antiplatelet therapy; coronary artery disease (CAD); atrial fibrillation (AF); thromboembolic events; myocardial ischemic; bleeding events; aspirin; clopidogrel; cardiovascular and cerebrovascular diseases; diagnosis and treatment; percutaneous coronary intervention; acute coronary syndrome

(This special issue belongs to the Section Cardiology)

Optimizing the Surgical Journey: From Abdominal Operation to Recovery

edited by

Alessio Giordano

and Carlo Bergamini

submission deadline 1 Sep 2026 | Viewed by 46 | Submission Open

Keywords: surgical complications; comanagement; comorbidities; elective surgical procedure; emergency surgery procedure; multidisciplinary approach; hospitalist

(This special issue belongs to the Section General Surgery)

Cardiac Intensive Care Units: Clinical Advances and Future Challenges

edited by Luca Baldetti

submission deadline 10 Sep 2026 | Viewed by 24 | Submission Open

Keywords: cardiac intensive care; heart failure; cardiogenic shock; mechanical circulatory support; invasive hemodynamic monitoring; acute cardiac care; shock; myocardial infarction

(This special issue belongs to the Section Cardiology)

Current Challenges in Clinical Dentistry: 3rd Edition

edited by

Eiji Tanaka

and

Susumu Abe

submission deadline 15 Sep 2026 | Viewed by 83 | Submission Open

Keywords: artificial intelligence; clinical dentistry; cutting-edge device and technology; dental material; challenging hypothesis; preventive dentistry; sleep medicine; digital dentistry; smart dentistry; stomatognathic function

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

State-of-the-Art of Lung Surgery: Modern Horizons in Lung Cancer Treatment

edited by

Alessio Mariolo

and Edouard Sage

submission deadline 15 Sep 2026 | Viewed by 23 | Submission Open

Keywords: lung-cancer-surgery; thoracic oncology; RATS; VATS; induction therapy; neoadjuvant-immunotherapy; non-intubated thoracic surgery; NITS; segmentectomy; lung-sparing surgery; 3D-reconstruction

(This special issue belongs to the Section General Surgery)

Treatment and Clinical Management of Necrotizing Pancreatitis

edited by

Apostolos Gaitanidis

submission deadline 20 Sep 2026 | Viewed by 70 | Submission Open

Keywords: necrotizing pancreatitis; infected necrosis; step-up approach; necrosectomy; minimally invasive surgery; artificial intelligence; lumen-apposing metal stent; pancreatic necrosis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Management in Dry Eye Disease: Current Strategies and Emerging Protocols

edited by Sunil Shah and Raquel Gil-Cazorla

submission deadline 20 Sep 2026 | Viewed by 59 | Submission Open

Keywords: dry eye disease; ocular surface; diagnostics; inflammation; biomarkers; emerging therapies

(This special issue belongs to the Section Ophthalmology)

Perinatal and Postnatal Mental Health: State of the Art

edited by Adriana Mihai

submission deadline 20 Sep 2026 | Viewed by 53 | Submission Open

Keywords: peripartum depression; post-partum depression; parental– infant well-being; early detection; perinatal mental health; postnatal mental health; psychotherapy interventions

(This special issue belongs to the Section Mental Health)

Current Challenges and Approaches to Post-Traumatic Stress Disorder (PTSD)

edited by

Aron Tendler

submission deadline 20 Sep 2026 | Viewed by 42 | Submission Open

Keywords: PTSD treatment; implementation; prevention; prevalence; risk factors

(This special issue belongs to the Section Mental Health)

Advances in the Diagnosis and Management of Sarcoidosis

edited by

Carlos Feijoo-Massó

, Pilar Brito-Zerón and Miriam Akasbi Montalvo

submission deadline 25 Sep 2026 | Viewed by 67 | Submission Open

Keywords: sarcoidosis; diagnosis; biomarkers; imaging; immunopathogenesis; biologic therapy; prognosis; interstitial lung disease

(This special issue belongs to the Section Immunology & Rheumatology)

Clinical Advances in Hepatology

edited by

Dimitrios S. Karagiannakis

and

Theodoros Androutsakos

submission deadline 30 Sep 2026 | Viewed by 58 | Submission Open

Keywords: cirrhosis; portal hypertension; non-invasive tests; viral hepatitis; MASLD; HCC

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Interplay of Motility, Microbiota, and Function: New Insights into GI Disorders, IBS, and SIBO

edited by Tsachi Tsadok Perets

submission deadline 30 Sep 2026 | Viewed by 58 | Submission Open

Keywords: gastrointestinal motility; irritable bowel syndrome (IBS); small intestinal bacterial overgrowth (SIBO); gut microbiota; functional gastrointestinal disorders

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Fibromyalgia: Diagnostic Progress and Therapeutic Advances

edited by

Casandra Isabel Montoro Aguilar

submission deadline 17 Nov 2026 | Viewed by 104 | Submission Open

Keywords: fibromyalgia; chronic pain; central sensitization; diagnostic biomarkers; advanced imaging; molecular markers; autonomic nervous system; cardiovascular regulation; emotional processing; cognitive dysfunction; fatigue; pain modulation; neuromodulation; tDCS

(This special issue belongs to the Section Clinical Neurology)

Clinical Outcomes and Emerging Strategies in Neovascualr Age-Related Macular Degeneration

edited by

Raziyeh Mahmoudzadeh

submission deadline 15 Dec 2026 | Viewed by 27 | Submission Open

Keywords: neovascular age-related macular degeneration; exudative retinal disease; anti-VEGF therapy; tyrosine kinase inhibitors; angiopoietin/Tie-2 modulation; gene therapy; sustained-release platforms; complement pathway inhibition; real-world clinical outcomes

(This special issue belongs to the Section Ophthalmology)

Dental Care: Oral and Systemic Disease Prevention: 2nd Edition

edited by

Kacper Nijakowski

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1713 | Submission Open

Keywords: oral health; oral diseases; oral manifestations; systemic diseases; oral care; dental prevention; dental caries; periodontal disease; oral medicine; dentistry; oral microbiome; salivary diagnostics; AI-assisted tools

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Aortic Diseases: Modern Strategies in Diagnosis, Management, and Prevention of Complications

edited by

Petroula N. Nana

, Tilo Kölbel and José Ignacio F. Torrealba

submission deadline 20 Jul 2027 | Viewed by 163 | Submission Open

Keywords: aortic aneurysm; aortic dissection; genetic aortic disease; acute aortic syndromes; endovascular repair; complica-tions; outcomes

(This special issue belongs to the Section Vascular Medicine)

Insights into Urological Surgery: Evolving Practices, Trends, and Emerging Challenges

edited by