Omega-3 Fatty Acids in Health and Disease

Dear Colleagues,

The role of the major dietary omega-3 fatty acids (alpha-linolenic acid, eicosapentaenoic acid and docosahexaenoic acid) in human health has generated controversy. The effects of omega-3 fatty acids on cardiometabolic risk factors, such as obesity, insulin resistance, and dyslipidaemia (especially hypertriglyceridaemia) are widely reported in scientific journals, as well as in the mass media. In addition, omega-3 fatty acids are precursors of bioactive metabolites, such as eicosanoids, lipoxins, resolvins, protectins, maresins, and nitrolipids; these metabolites play an important role in physiological processes, such as the regulation of cardiovascular function, the resolution of inflammation, and neuroprotection. Finally, omega-3 fatty acids interfere with cardiac electrophysiology via a variety of mechanisms, thereby potentially mediating cardiac arrhythmias.

This Special Issue of the Journal of Clinical Medicine will emphasize the mechanisms underlying the responses of omega-3 fatty acids with regard to the following important aspects of human health and disease:

• Memory and healthy aging
• Metabolic syndrome risk factors
• Cardiovascular disease
• Neurodegenerative disease
• Bone health
• Cancer
• Inflammation
• Nutrigenomics and nutrigenetics

Prof. Dr. Lindsay Brown
Prof. Dr. Bernhard Rauch
Dr. Hemant Poudyal
Guest Editors

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