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J. Clin. Med. 2015, 4(9), 1753-1760;

Lipidomics to Assess Omega 3 Bioactivity

Department of Molecular Medicine, University of Padova, Via 8 Febbraio, 2-35122 Padova, Italy
Academic Editors: Lindsay Brown, Bernhard Rauch and Hemant Poudyal
Received: 15 June 2015 / Revised: 19 August 2015 / Accepted: 31 August 2015 / Published: 7 September 2015
(This article belongs to the Special Issue Omega-3 Fatty Acids in Health and Disease)
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How can we resolve the conflict between the strong epidemiological evidence pointing to the usefulness of fish—and, thus, omega 3—consumption with the debacle of supplementation trials? One potential explanation is that the null results obtained thus far are the consequences of ill-contrived investigations that do not allow us to conclude on the effects (or lack thereof) of omega 3 fatty acid supplementation. One potential solution is through the use of lipidomics, which should prove very useful to screen suitable patients and to correlate plasma (or red blood cells, or whole blood, or phospholipid) fatty acid profile with outcomes. This has never been done in omega 3 trials. The wise use of lipidomics should be essential part of future omega 3 trials and would help in untangling this current riddle. View Full-Text
Keywords: lipidomics; omega 3 fatty acids; lipid analysis; lipidome; cardiovascular disease; clinical trials lipidomics; omega 3 fatty acids; lipid analysis; lipidome; cardiovascular disease; clinical trials

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Visioli, F. Lipidomics to Assess Omega 3 Bioactivity. J. Clin. Med. 2015, 4, 1753-1760.

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