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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Mass Spectrometry-Based Proteomics: From Biomarker Discovery to Translational Applications

edited by

Yanlong Ji

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1609 | Submission Open

Keywords: mass spectrometry; LC-MS method development; phosphoproteomics; glycoproteomics; biomarker discovery; multi-omics data integration

(This special issue belongs to the Section Biochemistry)

Studying Multi-Target Drug Approaches and Posttranslational Modification (PTM) Therapies

edited by

Guo-Ping Zhou

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1597 | Submission Open

Keywords: multi-target therapy; network analysis tools; multi-label proteins; web-server predictor; posttranslational modifications (PTMs); 3D structures; rational drug design

(This special issue belongs to the Section Molecular Informatics)

Research Progress and Therapeutic Targets of Chronic Kidney Disease

edited by

Stefanos Roumeliotis

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1583 | Submission Open

Keywords: blood pressure; cardiovascular disease; chronic kidney disease; diabetes; hypertension; inflammation; oxidative stress; sodium glucose transporter-2; vascular calcification

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Radiolabeled Compounds for Theranostic Applications in Oncology

edited by

Cyril Fersing

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1574 | Submission Open

Keywords: radiopharmaceuticals; theranostic; cancer therapy; targeted radionuclide therapy; molecular imaging; positron emission tomography; single-photon emission tomography; radiolabeling

(This special issue belongs to the Section Molecular Oncology)

Research Progress on Oocyte Development

edited by

Ken-ichi Sato

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1559 | Submission Open

Keywords: oocyte maturation; germ cell development; folliculogenesis; oocyte quality; egg cell development; oocyte activation; meiotic progression; fertility

(This special issue belongs to the Section Molecular Biology)

Tuberculosis: Host Immunity, Diagnosis and Treatment

edited by

Veronica Edith Garcia

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1540 | Submission Open

Keywords: tuberculosis; immune response; diagnosis; treatment; antibiotics; resistance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nanoscience in Plants: Omics Approaches to Elucidate the Role of Nanoparticles

edited by

Setsuko Komatsu

and Zahed Hossain

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1506 | Submission Open

Keywords: nanoparticles; plant; omics-based techniques; bioinformatics; systems biology; nanotoxicology

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular and Immune Mechanisms in Pathogenic Mycobacteria Infections

edited by Fabiana Bigi and Federico Carlos Blanco

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1484 | Submission Open

Keywords: Mycobacterium tuberculosis; virulence; pathogens

(This special issue belongs to the Section Molecular Microbiology)

Advances in Biomarker Discovery for Rare Diseases

edited by

Bridget E. Bax

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1475 | Submission Open

Keywords: biomarker; rare diseases; pathological processes; cystic fibrosis; Duchenne muscular dystrophy; Ehlers-Danlos syndrome; haemophilia; sickle cell disease; primary biliary cholangitis; fabry disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into Chronic Inflammatory Demyelinating Polyneuropathy and Neuroimmunological Diseases

edited by

Fumitaka Shimizu

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1442 | Submission Open

Keywords: chronic inflammatory demyelinating polyneuropathy (CIDP); multiple sclerosis (MS); neuromyelitis optica spectrum disorder (NMOSD); myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD); autoimmune encephalitis; paraneoplastic neurological syndrome; Guillain-Barre syndrome (GBS); myositis; blood-brain barrier; blood-nerve barrier

(This special issue belongs to the Section Molecular Neurobiology)

Computational Genomics and Bioinformatics in Microbiology

edited by

Andreas Martin Lisewski

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1421 | Submission Open

Keywords: computational microbial genomics; comparative genomics; structural genomics; functional genomics; genomic data bioinformatics

(This special issue belongs to the Section Molecular Informatics)

Unraveling the Enigma of Colorectal Cancer: From Mechanisms to Therapeutic Advances

edited by Valentina Belli and

Vincenza Ciaramella

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1392 | Submission Open

Keywords: Colorectal cancer; tumour microenvironment; epigenetics; diagnostic molecules; immune evasion; biomarkers; drug resistance; precision medicine; targeted

(This special issue belongs to the Section Molecular Oncology)

Hormonal and Metabolic Markers in Health and Disease

edited by

Rafał Podgórski

and

Kornelia Łach

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1386 | Submission Open

Keywords: hormonal biomarkers; molecular mechanism of endocrine disorders; steroidogenesis; hormonal dysregulation; endocrine disruptors; metabolomics; metabolic regulation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in the Molecular Diagnosis and Treatment of Neurodegenerative Diseases

edited by

Bruno Manadas

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1351 | Submission Open

Keywords: neurodegenerative disorders; biomarkers; treatment; omics; systems biology

(This special issue belongs to the Section Molecular Neurobiology)

Hearing Loss: Molecular Biological Insights, 2nd Edition

edited by María Beatriz Durán-Alonso

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1342 | Submission Open

Keywords: genetics; microRNA; epigenetics; CRISPR; multi-omics; presbycusis; ototoxicity; development

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in the Physiopathology of Neurodevelopmental Disorders

edited by Antonio Falace

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1301 | Submission Open

Keywords: neuronal development; synaptogenesis; developmental and epileptic encephalopathy; epilepsy; biomarkers; neuroimmunology; translational research; cortical malformation; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Paradigm Iconoclasm

edited by

Vance G. Nielsen

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1293 | Submission Open

Keywords: paradigm shift; biochemistry; cell signaling; coagulation; toxinology

(This special issue belongs to the Section Biochemistry)

Drug Delivery Systems and Treatment of Human Diseases: Prospects and Challenges

edited by

Aruna Sharma

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1226 | Submission Open

Keywords: nanodrug delivery; blood– brain barrier; antibodies therapy; molecular mechanism; neuroprotection

(This special issue belongs to the Section Molecular Pharmacology)

Biotic and Abiotic Stress Responses of Vegetable Crops

edited by Yongqiang Tian

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1208 | Submission Open

Keywords: vegetable crops; biotic stress; abiotic stress; physiological responses; molecular mechanisms; genetic mechanisms; resistance breeding; resistance biotechnology; management strategies

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms and Therapies of Gastrointestinal Cancer

edited by

Donatella Delle Cave

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1162 | Submission Open

Keywords: tumor microenvironment; therapy resistance; genetic mutations; oncogenes; molecular diagnostics

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms of Sarcoma Initiation and Metastasis

edited by

Shinji Miwa

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1153 | Submission Open

Keywords: sarcoma; molecular target; metastasis; apoptosis; angiogenesis; microenvironment

(This special issue belongs to the Section Molecular Oncology)

Protein Structure and Its Interactions

edited by

Dong Hae Shin

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1142 | Submission Open

Keywords: protein– protein interactions (PPIs); protein– ligand binding; molecular recognition; binding affinity and specificity; molecular interface analysis

(This special issue belongs to the Section Molecular Biology)

Chitosan: Structural and Chemical Modification, Properties and Application, 2nd Edition

edited by

Joanna Kluczka

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1139 | Submission Open

Keywords: chitosan modification; adsorption removal; membrane separation; food preservation; environmental remediation; wastewater treatment; disease treatment; agricultural production; tissue engineering

(This special issue belongs to the Section Macromolecules)

Microbial Omics: Decoding Microbial Life

edited by

Nicole Hansmeier

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1125 | Submission Open

Keywords: omics technologies; omics methodologies; microorganisms; proteomics; genomics; transcriptomics; bioinformatics; artificial intelligence for omics; microbial physiology; microbial adaptation to environmental challenges; interspecies and host-microbe interactions; environmental monitoring

(This special issue belongs to the Section Molecular Microbiology)

The Brain’s Regeneration Potential: The Role of Neural Progenitor Cells in Neuropsychiatric Therapy

edited by

Beatriz Caballero

and

Yaiza Potes

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1059 | Submission Open

Keywords: neural stem cells; neural progenitor cells; neuropsychiatric disorders; neurodegeneration; neurogenesis; neuroplasticity; melatonin; psychoactive drugs

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research on Skeletal Muscle Metabolism and Diseases

edited by Shen-Liang Chen

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1048 | Submission Open

Keywords: muscle; metabolism; mitochondria; peroxisome; stem cell; cahcexia

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Chemical Tools for Microbial Functionalization: Bridging Organic Chemistry and Biotechnology

edited by Stefania Cicco and

Danilo Vona

submission deadline 20 Jan 2026 | Viewed by 977 | Submission Open

Keywords: organometallic biochemistry; green chemistry; bioorthogonal; living polymers; living functionalization; hybrid materials

(This special issue belongs to the Section Molecular Microbiology)

Molecular Issues in Optic Neuropathy

edited by

Nitza Goldenberg-Cohen

submission deadline 20 Jan 2026 | 1 articles | Viewed by 924 | Submission Open

Keywords: optic neuropathy; neuroprotection; glaucoma induced neuropathy; molecular pathways; novel therapeutics strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Compounds in Neurological Diseases

edited by

Ivan Cruz-Chamorro

submission deadline 20 Jan 2026 | 1 articles | Viewed by 861 | Submission Open

Keywords: natural compounds; neuroprotection; neuroinflammation; oxidative stress; mitochondrial dysfunction; autophagy; bioactive molecules (polyphenols; flavonoids; melatonin; etc.); nutraceuticals (bioactive peptides; hydrolysates; etc.); neurodegenerative diseases

(This special issue belongs to the Section Molecular Neurobiology)

Lipid Droplet–Mitochondria Interactions in Health and Disease

edited by Anton Petcherski

submission deadline 20 Jan 2026 | Viewed by 832 | Submission Open

Keywords: mitochondria; lipid droplets; metabolism; lipotoxicity; metabolically active tissue; triacylglycerides; fatty acid oxidation

(This special issue belongs to the Section Biochemistry)

Pathogenesis and Therapy of Oral Carcinogenesis, 3rd Edition

edited by

Marko Tarle

and

Ivica Lukšić

submission deadline 20 Jan 2026 | Viewed by 781 | Submission Open

Keywords: oral cancer; oral premalignant disorders; tumor microenvironment; molecular biomarkers; targeted therapy; oral tumorigenesis

(This special issue belongs to the Section Molecular Oncology)

Ion Transporter-Based Biomarkers for Sperm Quality

edited by

Elisabeth Pinart

submission deadline 20 Jan 2026 | Viewed by 751 | Submission Open

Keywords: ion transporters; sperm quality; cryotolerance

(This special issue belongs to the Section Molecular Biology)

Rational Design and Synthesis of Bioactive Molecules, 2nd Edition

edited by

Irena Kostova

submission deadline 20 Jan 2026 | Viewed by 742 | Submission Open

Keywords: synthesis; structure; bonding; reactivity; chemical properties; physical properties; pharmacological activity; structure– activity relationship; applications

(This special issue belongs to the Section Molecular Biology)

DNA Damage and Repair: Current Research

edited by

Mahara A. Valverde Ramírez

and Emilio Rojas

submission deadline 20 Jan 2026 | 1 articles | Viewed by 715 | Submission Open

Keywords: DNA damage; DNA repair; endogenous compounds; exogenous compounds; therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Green Chemistry Biocatalysis—Advances in the Use of Sustainable Solvents for Biocatalytic Processes

edited by

Rita Craveiro

and

Alexandre Paiva

submission deadline 20 Jan 2026 | Viewed by 711 | Submission Open

Keywords: biocatalysts; enzymes; sustainability; green solvents; biotechnology; biochemical process engineering

(This special issue belongs to the Section Biochemistry)

Advancements and Trends in Plant Genomics

edited by Rongbin Hu

submission deadline 20 Jan 2026 | 2 articles | Viewed by 710 | Submission Open

Keywords: plant; genomics; next-generation sequencing; third-generation sequencing; CRISPR-Cas

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Insights into Microglia in Neurological Diseases

edited by

Pyung-Hwan Kim

submission deadline 20 Jan 2026 | 1 articles | Viewed by 703 | Submission Open

Keywords: microglia; neuroinflammation; neurodegenerative diseases; molecular signaling; central nervous system (CNS)

(This special issue belongs to the Section Molecular Neurobiology)

Targeting Epilepsy: Molecular Mechanisms, Neuroinflammation and Emerging Therapies

edited by

Karoly Orban-Kis

submission deadline 20 Jan 2026 | 1 articles | Viewed by 696 | Submission Open

Keywords: epilepsy; molecular targets; antiepileptic drug discovery; neuroinflammation; epileptogenesis; ion channels; pharmacoresistance; translational neuroscience

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cell Membrane Electroporation and Electroosmosis Mechanisms

edited by

Paulius Ruzgys

submission deadline 20 Jan 2026 | Viewed by 649 | Submission Open

Keywords: nanosecond electroporation; calcium electroporation; small-molecule electrotransfer; abscopal effect; bacterial electroporation; irreversible electroporation; electrochemotherapy; immune response; apoptosis

(This special issue belongs to the Section Biochemistry)

The Impact of High-Value Compounds from Agri-Food and Waste Sources on Cellular Metabolism

edited by

Anna Spagnoletta

Salvatore Nesci

and

Francesca Oppedisano

submission deadline 20 Jan 2026 | Viewed by 620 | Submission Open

Keywords: phytochemicals; agri-food waste; nutraceutical; cell metabolism; mitochondria; antioxidants; ROS; anti-cancer

(This special issue belongs to the Section Biochemistry)

Reaction Kinetics in Bioinorganic Systems

edited by Łukasz Orzeł and Maria Oszajca

submission deadline 20 Jan 2026 | Viewed by 615 | Submission Open

Keywords: reaction mechanisms; kinetics; biologically active metal complexes; metalloproteins; reactive oxygen; nitrogen and sulfur species; biocatalysis; inorganic chemotherapy and phototherapy

(This special issue belongs to the Section Biochemistry)

Phytochemicals: Mechanisms and Applications in Cancer Prevention and Therapy

edited by

Mateusz Kciuk

and

Damian Kołat

submission deadline 20 Jan 2026 | Viewed by 594 | Submission Open

Keywords: phytochemicals; cancer prevention; cancer therapy; molecular mechanisms; signal transduction pathways; anti-oxidant activity; cell death; gene regulation; therapeutic targets

(This special issue belongs to the Section Biochemistry)

Latest Molecular Research on Muscle Atrophy

edited by

Elena Bresciani

submission deadline 20 Jan 2026 | Viewed by 552 | Submission Open

Keywords: muscle atrophy; molecular mechanisms; protein degradation; inflammation; oxidative stress; sarcopenia; cachexia; autophagy; therapeutics; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Endocannabinoids, Cannabinoids and Psychiatry: Biological Mechanisms—3rd Edition

edited by

Aron Weller

and Nicholas V. DiPatrizio

submission deadline 20 Jan 2026 | Viewed by 540 | Submission Open

Keywords: endocannabinoids; cannabinoids; psychiatry; neural mechanisms; molecular mechanisms; epigenetics; imaging; psychopathology; stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neurological Disorders: From Molecular Mechanisms to Nanomedicine

edited by

Aruna Sharma

submission deadline 20 Jan 2026 | Viewed by 517 | Submission Open

Keywords: stroke; brain and spinal cord trauma; Alzheimer’ s disease; Parkinson’ s disease; nanodrug formulation; stem cells; neuroprotection

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Sepsis: Molecular and Biochemical Perspectives

edited by

Akrivi Chrysanthopoulou

submission deadline 20 Jan 2026 | 1 articles | Viewed by 482 | Submission Open

Keywords: sepsis; outcome; molecular diagnosis; machine learning; biochemical biomarkers; targeted immunotherapy; personalized medicine; sepsis inflammatory endotypes

(This special issue belongs to the Section Biochemistry)

Hormone Receptors in Cancer

edited by Rajeshwar R. Tekmal

submission deadline 20 Jan 2026 | Viewed by 463 | Submission Open

Keywords: hormone recptors; hormone-mediated therapies; agonists and antgonists of hormone ligands; coactivators; corepressors

(This special issue belongs to the Section Molecular Oncology)

Insights into How Electromagnetic Fields Affect Human Immunity and Metabolic Activity

edited by Jolanta Kaszuba-Zwoińska

submission deadline 20 Jan 2026 | Viewed by 458 | Submission Open

Keywords: electromagnetic fields; metabolism; innate and acquired immunity; cell viability; cell secretory activity; cell death types; pathogenesis of diseases

(This special issue belongs to the Section Molecular Biology)

Drug Discovery and Development for Renal Disease Treatment

edited by

Keiko Hosohata

submission deadline 20 Jan 2026 | Viewed by 446 | Submission Open

Keywords: kidney disease; medicinal chemistry; drug discovery; computer-assisted drug design; drug targets; in vitro assays; epigenetic targets; multi-targeting compounds; biophysical methods; target engagement studies

(This special issue belongs to the Section Molecular Pharmacology)

The Plant Phenotyping and Phenomics for Breeding

edited by

Jaeil Lyu

submission deadline 20 Jan 2026 | Viewed by 444 | Submission Open

Keywords: plant phenomics; high-throughput phenotyping (HTP); genotype– phenotype association; non-invasive imag-ing; functional genomics; environmental interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Displaying special issue 301-350 on page 7 of 65.

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