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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Mitochondria in Aging and Aging-Related Diseases

edited by

Yongting Luo

submission deadline 20 May 2025 | Viewed by 462 | Submission Open

Keywords: mitochondria; aging; reactive oxygen species; antioxidants; mitochondrial metabolism; mitochondrial biogenesis; mitochondrial dynamics; mtDNA mutations; mitophagy; mitochondrial signalling; inflammation; cancer; metabolic disease; cardiovascular disease; neurodegenerative disease; life span

(This special issue belongs to the Section Molecular Biology)

Calcification in Human Diseases: Pathological Aspects and Therapeutic Strategies

edited by Antonella Bonetti

submission deadline 20 May 2025 | Viewed by 462 | Submission Open

Keywords: ectopic calcification; tissue calcinosis; cardiovascular calcification; anti-calcific effect; calcification reduction; anti-calcific model

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Design, Synthesis and Characterization of Multiscale Nanostructured Porous Materials and Functional Interfaces for Separation

edited by

Gang Han

submission deadline 20 May 2025 | Viewed by 438 | Submission Open

(This special issue belongs to the Section Materials Science)

Molecular Research on Neurotoxins

edited by Abdeslem El Idrissi

submission deadline 20 May 2025 | Viewed by 435 | Submission Open

Keywords: neurotoxins; natural toxins; neuroprotection; detoxification; neuroscience

(This special issue belongs to the Section Molecular Neurobiology)

Challenges of Immune Checkpoint Inhibitor Therapy

edited by

Tibor Bakacs

submission deadline 20 May 2025 | Viewed by 428 | Submission Open

Keywords: immune checkpoint inhibitor; ICI; safety of ICI drugs; irAE of ICI drugs; ultra-low-dose ICI; cost saving with ICI drugs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Lipids and Vitamins in Health and Disease

edited by

Elisabetta Albi

and Paola Signorelli

submission deadline 20 May 2025 | Viewed by 421 | Submission Open

Keywords: lipid; vitamin; metabolism; diet; nutrition

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Role of Cortex in Health and Disease

edited by Valentina Licheri

submission deadline 20 May 2025 | Viewed by 418 | Submission Open

Keywords: neurodevelopmental disorder; corticogenesis; molecular mechanisms; cognitive deficits; behavioral deficits

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights into Vasculitis

edited by I-Chun Lin

submission deadline 20 May 2025 | Viewed by 415 | Submission Open

Keywords: Kawasaki disease; multiomics; artificial intelligence; precision medicine; diagnosis; pathogenesis; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Dietary Antioxidants in Human Health

edited by

Marika Cordaro

Roberta Fusco

and

Rosanna Di Paola

submission deadline 20 May 2025 | Viewed by 402 | Submission Open

Keywords: diet; functional food; oxidative stress; mitochondrial disfunction; human health; animal models; nutrition; molecular pathways; human pathology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Insights into Male Infertility and Sperm Biology

edited by

Monica Muratori

submission deadline 20 May 2025 | Viewed by 379 | Submission Open

Keywords: male infertility; sperm DNA fragmentation; sperm oxidative stress; sperm nuclear condensation; assisted reproductive technologies; genomics; epigenomics; transcriptomics; proteomics; metabolomics

(This special issue belongs to the Section Molecular Biology)

New Insights into the Roles of Cellular Plasticity in Disease

edited by

Jun-ichi Hanai

submission deadline 20 May 2025 | Viewed by 375 | Submission Open

Keywords: cellular plasticity; phenotypic heterogeneity; neoplasms; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

State-of-the-Art Molecular Genetics and Genomics in Poland: 3rd Edition

edited by

Ewa Fiedorowicz

and

Anna Cieslinska

submission deadline 20 May 2025 | Viewed by 361 | Submission Open

Keywords: RNA; DNA; DNA structure; damage; and repair; post-translational modifications; autophagy; cell cycle; gene expression; functions and therapy; mutation; nuclear organization; polymerase; nucleic acid– protein interactions; molecular clone; sequencing analysis; epigenetics; transcriptomics; genetics of aging; genetic disorders; SNP; etc

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Mechanisms of Sarcoma Initiation and Metastasis

edited by

Shinji Miwa

submission deadline 20 May 2025 | Viewed by 355 | Submission Open

Keywords: sarcoma; molecular target; metastasis; apoptosis; angiogenesis; microenvironment

(This special issue belongs to the Section Molecular Oncology)

Bioinspired and Biobased Materials

edited by

Malgorzata Holynska

submission deadline 20 May 2025 | Viewed by 353 | Submission Open

Keywords: bioinspired materials; biobased materials; bionic materials; materials design and synthesis

(This special issue belongs to the Section Materials Science)

Application of Nanomaterials and Molecular Detection in Human Diseases

edited by

Liangcan He

submission deadline 20 May 2025 | Viewed by 352 | Submission Open

Keywords: cancer; infectious diseases; neurological diseases; hematological disorders; cardiovascular diseases; nanoparticles; nanodrug delivery; nanoimaging

(This special issue belongs to the Section Materials Science)

Application of Electrochemical Materials in Molecular Biology

edited by

Robert Ziółkowski

submission deadline 20 May 2025 | Viewed by 349 | Submission Open

Keywords: electrochemistry; (bio)analytical chemistry; molecular biology; point-of-care; nanomaterials; (bio)molecules

(This special issue belongs to the Section Materials Science)

The Role of Non-Coding RNAs in Female Reproduction

edited by

Angela Caponnetto

submission deadline 20 May 2025 | Viewed by 340 | Submission Open

Keywords: microRNAs; long non-coding RNAs; circular RNAs; female reproduction; reproductive aging; molecular biomarkers; ceRNA network

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advanced Research on Ceramide

edited by Navneet Goyal

submission deadline 20 May 2025 | Viewed by 337 | Submission Open

Keywords: ceramide; sphingolipids; cancer; apoptosis; anticancer drugs

(This special issue belongs to the Section Biochemistry)

The Medicinal Mechanism of Natural Products in Cancer Therapies

edited by

Clement G. Yedjou

submission deadline 20 May 2025 | Viewed by 335 | Submission Open

Keywords: natural product; phytochemicals; protein– ligand interaction; mechanism of action; drug discovery; prevention; treatment

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Insect–Plant Interactions: From Genes to Biochemical Elements

edited by

Beata Gabrys

submission deadline 20 May 2025 | 1 articles | Viewed by 319 | Submission Open

Keywords: genomics; proteomics; metabolomics; infochemicals; phytochemicals

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Applications of Deep Learning in Kidney Diseases

edited by

Michele Provenzano

Vincenzo Pezzi

and

Gianluigi Zaza

submission deadline 20 May 2025 | Viewed by 315 | Submission Open

Keywords: kidney biomarkers; kidney diseases; predictive biomarkers; deep learning; personalized therapy; digital health

(This special issue belongs to the Section Molecular Informatics)

Quantum Chemistry, Vibrational Spectroscopy and Biophysics on Biomolecules

edited by

Mauricio Alcolea Palafox

submission deadline 20 May 2025 | Viewed by 291 | Submission Open

Keywords: molecular simulations; computer calculations; structure predictions; molecular structure; DNA structure; nucleobases pairs; inter-molecular interactions; spectroscopic predictions; scaling; Raman simulations; macromolecular crystallography; molecular modeling; electronic properties

(This special issue belongs to the Section Molecular Biophysics)

Radiosensitizers in the Service of Radiotherapy: Drug Design, Development and Therapy

edited by

Lidia Chomicz-Mańka

submission deadline 20 May 2025 | Viewed by 290 | Submission Open

Keywords: radiosensitizers; radiotherapy; mechanistic studies; drug design; computational chemistry; radiation studies; cytotoxicity; hypoxia; radioresistance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research in Immunotoxicity and Oxidative Stress

edited by

Soo-Jin Choi

submission deadline 20 May 2025 | Viewed by 280 | Submission Open

Keywords: toxicity; macrophage activation; pro-inflammation; anti-inflammation; oxidative stress; foods; food additives; nanomaterials; toxicants; natural compounds

(This special issue belongs to the Section Molecular Toxicology)

Molecular Advances in the Relationship Between Diabetes and Cancers

edited by

Zsuzsanna Németh

submission deadline 20 May 2025 | Viewed by 279 | Submission Open

Keywords: diabetes; insulin resistance; glucose intolerance; glucolipotoxicity; ER stress; oxidative stress; cancer development

(This special issue belongs to the Section Molecular Oncology)

Autoimmune and Inflammatory Diseases: Latest Advances and Prospects

edited by

Paola Galozzi

submission deadline 20 May 2025 | Viewed by 277 | Submission Open

Keywords: autoimmunity; autoimmune disease; inflammation; inflammatory disease; cellular pathways; molecular mechanisms; pathogenesis; therapy

(This special issue belongs to the Section Molecular Immunology)

Hydrogenases: Enzymes and Catalytic Mechanisms Involved in Hydrogen Production

edited by Jean Chaudière

submission deadline 20 May 2025 | Viewed by 269 | Submission Open

Keywords: hydrogenases; metalloenzymes; enzymes; catalytic mechanisms; instability

(This special issue belongs to the Section Molecular Biophysics)

Nutrients and Active Substances in Natural Products: 2nd Edition

edited by Yan Zhang

submission deadline 20 May 2025 | Viewed by 253 | Submission Open

Keywords: nutrients; active substances; natural products; bioactive compounds; functional food development

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Research of Structural Materials in Molecular Science

edited by Fafeng Xia

submission deadline 20 May 2025 | Viewed by 252 | Submission Open

Keywords: nanomaterials; functional materials; gradient materials; biomaterials; structural properties; molecular properties

(This special issue belongs to the Section Materials Science)

Anticancer Antibiotics: Progresses, Opportunities and Challenges

edited by Jose Kaneti

submission deadline 20 May 2025 | Viewed by 250 | Submission Open

Keywords: tetracycline antibiotics; antitumor activity; molecular mechanism; G-quadruplex complexes; computational modeling; pharmacological evaluation

(This special issue belongs to the Section Molecular Pharmacology)

Nanoformulations for the Treatment of Human Diseases

edited by Sergio Acin Martinez

submission deadline 20 May 2025 | Viewed by 243 | Submission Open

Keywords: nanomedicine; nanomaterials nanomedicine; liposomes; nanocrystal; polymeric nanoparticles

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Research for Cancer Immunotherapy

edited by Mariana Malvicini

submission deadline 20 May 2025 | Viewed by 242 | Submission Open

Keywords: cancer immunotherapy; tumor immune microenvironment; tumor immune evasion; adoptive cell therapies; immune checkpoint inhibitors; neoantigen-based vaccines; chemoimmunoresistance; primary immunoresistance; adaptive immunoresistance; tumor associated-macrophages; tumor-immune crosstalk

(This special issue belongs to the Section Molecular Oncology)

Histological and Molecular Perspectives on Immune Mechanisms of the Nasal and Bronchial Mucosa Diseases

edited by

Emanuela Chiarella

submission deadline 20 May 2025 | Viewed by 231 | Submission Open

Keywords: nasal and bronchial mucosa; nasal polyposis; bronchial inflammation; immunotherapy; mucosal immunity; inflammatory biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Studies on Oral Disease and Treatment

edited by

Daniela Adamo

submission deadline 20 May 2025 | Viewed by 230 | Submission Open

Keywords: oral cancer; oral mucosal lesions; chronic pain; temporomandibular joint disorders; periodontal diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Drug Development for Respiratory and Inflammatory Diseases

edited by

Longshuang Huang

and Feng Qian

submission deadline 20 May 2025 | Viewed by 217 | Submission Open

Keywords: sepsis; acute lung injury; pulmonary fibrosis; asthma; infection diseases; inflammation; drug development; respiratory diseases; inflammatory bowel disease; atherosclerosis; rheumatoid arthritis

(This special issue belongs to the Section Molecular Pharmacology)

Single-Atom Catalysts for Small Molecule Transformation

edited by Aijuan Han

submission deadline 20 May 2025 | Viewed by 217 | Submission Open

Keywords: single-atom catalyst; small molecule transformation; rational design; applications

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Allosteric Modulation of Kinases in Cancer Therapeutic Strategies and Challenges

edited by

Nidhi Joshi

submission deadline 20 May 2025 | Viewed by 192 | Submission Open

Keywords: kinase signaling; allosteric modulators; cancer therapy; drug resistance; molecular mechanisms; protein– protein interactions; targeted therapy; conformational changes; ATP-competitive inhibitors; drug design

(This special issue belongs to the Section Molecular Biology)

Nanobiomaterials and Beyond: Innovations in Drug Delivery, Diagnostics, and Therapeutics

edited by

Alexandru Mihai Grumezescu

and

Adelina-Gabriela Niculescu

submission deadline 20 May 2025 | Viewed by 188 | Submission Open

Keywords: nanobiomaterials; drug delivery systems; targeted drug delivery; controlled drug release; stimulus-responsive nanomaterials; biocompatibility; biodegradability; functionalized nanocarriers; theranostics; nanocarriers for cancer therapy; tumor-targeted drug delivery; organ-specific delivery systems; pH-responsive materials; temperature-sensitive nanobiomaterials; light-activated drug delivery; enzyme-responsive systems; multimodal nanomaterials; translational nanomedicine; computational modeling in nanobiomaterials; preclinical studies of nanomaterials

(This special issue belongs to the Section Materials Science)

Biomarkers in Precision Medicine

edited by

Zhidong Zhou

submission deadline 20 May 2025 | Viewed by 176 | Submission Open

Keywords: biomarkers; precision medicine; novel techniques; artificial intelligence

(This special issue belongs to the Section Molecular Biology)

New Insights of Autophagy and Apoptosis in Cells

edited by

Mirko Pesce

and

Antonia Patruno

submission deadline 20 May 2025 | Viewed by 175 | Submission Open

Keywords: autophagy; apoptosis; signal transduction; cell survival

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Novel Therapies for Skin Diseases

edited by Karin Vicente Greco

submission deadline 20 May 2025 | Viewed by 173 | Submission Open

Keywords: tissue engineering; biocompatible materials; inflammatory and repair tissue responses; wound healing; scaffold-based models; 3D in vitro models; inflammatory models

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Structural and Functional Insights into Chemokines and Chemokine Receptors in Immune Pathologies

edited by

Nidhi Joshi

submission deadline 20 May 2025 | Viewed by 172 | Submission Open

Keywords: chemokines; chemokine receptors; immune pathologies; signaling mechanisms; therapeutic targeting

(This special issue belongs to the Section Molecular Immunology)

The Role of Interleukins in Chronic Inflammatory Diseases and Cancer Progression: Pathways and Therapeutic Implications

edited by

Fabricio Souto

submission deadline 20 May 2025 | Viewed by 135 | Submission Open

Keywords: interleukins; chronic inflammatory diseases; cancer; inflammation; carcinogenesis

(This special issue belongs to the Section Molecular Immunology)

Antioxidant, Anti-Inflammatory, and Antiproliferative Activities of Natural Products—3rd Edition

edited by

Bruno Eto

submission deadline 20 May 2025 | Viewed by 115 | Submission Open

Keywords: bioactive products; anti-infectives; antioxidants; anti-inflammatory; antiproliferative; clinical phytopharmacology; phytopharmacology; polyphytotherapy

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms of Cognitive Dysfunction from COVID-19 Infection and Other Respiratory Viruses

edited by

Abdullah Mosabbir

submission deadline 20 May 2025 | Viewed by 112 | Submission Open

Keywords: long COVID; post-COVID; cognitive dysfunction; virus; cognition; brain; viral infection; virol-ogy; RNA

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Esophageal Inflammation, Injury, and Repair

edited by Anisa Shaker

submission deadline 20 May 2025 | Viewed by 98 | Submission Open

Keywords: GERD; eosinophilic esophagitis; achalasia; esophageal cancer; barrett’ s esophagus; microbiome

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Carbon-Based Nanomedicines

edited by

Marta Kutwin

and Andreas Rosenkranz

submission deadline 20 May 2025 | Viewed by 94 | Submission Open

Keywords: graphene oxide; carbon allotropes; cancer; regenerative medicine; antibacterial

(This special issue belongs to the Section Molecular Nanoscience)

Advances in Dendritic Cell-Based Immunotherapy of Cancer

edited by Helena Haque Chowdhury and Matjaz Jeras

submission deadline 20 May 2025 | Viewed by 83 | Submission Open

Keywords: DC-based immunotherapy of cancer; immunostimulatory dendritic cell (DC) generation; dosage and routes of DC administration; body distribution of DCs post-application; frequency and duration of DC applications; tumour immunosuppressive mechanisms’ modulation; combinatorial DC-based anticancer immunotherapy

(This special issue belongs to the Section Molecular Immunology)

Toxicology of Psychoactive Drugs

edited by Sabrine Bilel and

Matteo Marti

submission deadline 21 May 2025 | 3 articles | Viewed by 1911 | Submission Open

Keywords: psychoactive substances; cannabis; synthetic cannabinoids; cathinones; synthetic opioids; toxicology; receptors; behavioral effects; antagonists; central nervous system

(This special issue belongs to the Section Molecular Toxicology)

Rational Design and Application of Functional Hydrogels

edited by