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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Insights into Lectins
edited by Yuichiro Sato
submission deadline 30 Dec 2025 | 1 articles | Viewed by 163 | Submission Open
Keywords: lectin; carbohydrate-binding specificity; virus; antiviral activity; cancer; anticancer activity; glycan-targeted therapy
(This special issue belongs to the Section Molecular Biology)
Molecular Basis for Sustainable Management of Migratory Insects
edited by
submission deadline 30 Dec 2025 | Viewed by 152 | Submission Open
Keywords: migrant insects; molecular basis of population growth; migration and reproduction; migration and immunity; migration and diapause; migration and orientation; molecular regulation of migration
(This special issue belongs to the Section Molecular Biology)
Recent Research in RNA-Protein Networks
edited by Hidenori Tani
submission deadline 30 Dec 2025 | Viewed by 47 | Submission Open
Keywords: machine learning; bioinformatics; ribonucleoprotein; RNA-protein complex; alternative splicing; RNA stability; RNA localization
(This special issue belongs to the Section Molecular Biology)
Stem Cell Innovations and Reproductive Biotechnologies
edited by
submission deadline 30 Dec 2025 | Viewed by 14 | Submission Open
Keywords: mammals; birds; stem cell research; pluri-/multipotency; differentiation/dedifferentiation; assisted reproductive technologies (ARTs); transgenic research; biomedicine
(This special issue belongs to the Section Molecular Biology)
Telocytes: Unraveling Their Roles in Health and Disease
edited by
submission deadline 30 Dec 2025 | Viewed by 10 | Submission Open
Keywords: telocytes; telopodes; intercellular communication; stem cell niche; extracellular vesicles; regenerative medicine; tissue remodelling; stromal cells
(This special issue belongs to the Section Molecular Biology)
Research Progress of Metabolomics in Health and Disease submission deadline 31 Dec 2025 | 7 articles | Viewed by 7244 | Submission Open
Keywords: metabolomics; health; diseases; target metabolites; mass spectrometry; hyphenated techniques
(This special issue belongs to the Section Molecular Biology)
Targeted Delivery of Nucleic Acids
edited by Yong-Serk Park
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4047 | Submission Open
Keywords: nucleic acid delivery; gene delivery; pDNA delivery; siRNA delivery; miRNA delivery; mRNA delivery; CRISPR-Cas delivery; nanoparticle; lipid nanoparticle; targeted therapy
(This special issue belongs to the Section Molecular Biology)
Advances in Forensic Molecular Biology and Genetics
edited by
submission deadline 31 Dec 2025 | Viewed by 993 | Submission Open
Keywords: nuclear and mt-DNA; rapid DNA analysis; next-generation sequencing; mRNA analysis; microbiome analysis; barcode DNA; time since deposition; fluid identification; DNA phenotyping; DNA ancestry
(This special issue belongs to the Section Molecular Biology)
Molecular Entomology of Insects of Economic Importance: Advanced Molecular Approaches for Insect Pest Management
edited by
submission deadline 31 Dec 2025 | Viewed by 387 | Submission Open
Keywords: molecular entomology; insect pests; agricultural pests; disease vectors; beneficial insects; CRISPR; RNA interference; genome-wide approaches; computational biology; nanotechnology
(This special issue belongs to the Section Molecular Biology)
Molecular Breeding for Important Economic Traits in Livestock submission deadline 31 Dec 2025 | Viewed by 335 | Submission Open
Keywords: molecular breeding; livestock genetics; economic traits; genomic selection; adipogenesis; feed efficiency; disease resistance; non-coding RNAs; multi-omics; genetic improvement
(This special issue belongs to the Section Molecular Biology)
The Role of Iron in Human Physiology: Molecular Mechanisms and Therapeutic Applications
edited by
submission deadline 31 Dec 2025 | Viewed by 100 | Submission Open
Keywords: iron; hepcidin; ferroportin; ferritin; transferrin; metabolic regulation; cell signaling; cellular processes; mitochondrial function; stress response; inflammation; ferroptosis; gene regulation; disorders
(This special issue belongs to the Section Molecular Biology)
Organoid Models in Host–Pathogen Interactions and Disease Pathogenesis
edited by
submission deadline 31 Dec 2025 | Viewed by 90 | Submission Open
Keywords: organoids; host– pathogen interaction; infectious disease models; mucosal immunity; tissue engineering; microbial pathogenesis; immune organoids; 3D culture systems
(This special issue belongs to the Section Molecular Biology)
Molecular and Cellular Research on Adipose Tissue Development and Functions, 2nd Edition
edited by
submission deadline 31 Dec 2025 | Viewed by 79 | Submission Open
Keywords: adipose tissue; development; expansion; white adipose tissue; brown adipose tissue; beige adipose tissue; adipocytes; adipogenesis; lipogenesis; peroxisome proliferator-activated receptor gamma (PPAR-γ ); CCAAT enhancer binding proteins (CEBP-α ; CEBP-β ; and CEBP-δ ); carbohydrate response element binding protein (ChREBP)
(This special issue belongs to the Section Molecular Biology)
Molecular Adaptations of Arthropod Vectors to Oxidative Stress submission deadline 31 Dec 2025 | Viewed by 41 | Submission Open
Keywords: oxidative stress; arthropod vectors; molecular adaptation; redox biology; proteomics; stress response mechanisms
(This special issue belongs to the Section Molecular Biology)
New Discoveries in Virus–Cytoskeleton Regulation submission deadline 31 Dec 2025 | Viewed by 40 | Submission Open
Keywords: viruses; cytoskeleton dynamics; actin; tubulin and intermediate filaments; infection; pathogenesis; therapies
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms Associated with Exercise for Health and Performance
edited by Ciro José Brito
submission deadline 31 Dec 2025 | Viewed by 34 | Submission Open
Keywords: exercise science; sports medicine; aging; genetic and exercise; endocrinology; immunology
(This special issue belongs to the Section Molecular Biology)
RNA-Mediated Post-Transcriptional Regulation in Bacteria Roles of Small RNAs, Small Proteins, and RNA Modifications
edited by Karl M Thompson
submission deadline 31 Dec 2025 | Viewed by 24 | Submission Open
Keywords: bacterial post-transcriptional regulation; small RNAs (sRNAs); small open reading frames (smORFs); RNA modifications; epitranscriptomics
(This special issue belongs to the Section Molecular Biology)
Advances in Stem Cell Biology and Translational Medicine
edited by Yangluowa Qu
submission deadline 31 Dec 2025 | Viewed by 23 | Submission Open
Keywords: stem cell regulation; differentiation; proliferation; self-renewal; stem cell-based therapy; tissue engineering; translational research
(This special issue belongs to the Section Molecular Biology)
Novel Biochemical, Genetic, and Molecular Biology Approaches in Human Reproduction
edited by Athanasios Zikopoulos
submission deadline 31 Dec 2025 | Viewed by 23 | Submission Open
Keywords: reproductive biology; infertilit; epigenetics in reproduction; maternal-fetal health; precision medicine
(This special issue belongs to the Section Molecular Biology)
Molecular Biology of Human Reproduction
edited by
submission deadline 31 Dec 2025 | Viewed by 22 | Submission Open
Keywords: human reproduction; genomics; transcriptomics; proteomics; imaging technologies
(This special issue belongs to the Section Molecular Biology)
Innovative Approaches to RNA-Based Therapeutics
edited by
submission deadline 31 Dec 2025 | Viewed by 12 | Submission Open
Keywords: RNA therapeutic; RNA drug; antisense therapy; siRNA; delivery; oligonucleotides; mRNA vaccine
(This special issue belongs to the Section Molecular Biology)
Red Blood Cells: Dynamic Regulators, Disease Indicators and Therapeutic Targets
edited by Leonid Livshits
submission deadline 31 Dec 2025 | Viewed by 9 | Submission Open
Keywords: red blood cell (RBC); RBC biochemical; hemodynamic; biophysical properties
(This special issue belongs to the Section Molecular Biology)
Cellular, Immune and Molecular Pathways of Injury and Disease in Forensic and Legal Medicine
edited by
submission deadline 31 Dec 2025 | Viewed by 8 | Submission Open
Keywords: molecular autopsy; cellular injury pathways; ischemia and hypoxia markers; molecular profiling of fatal injuries; forensic genetics and toxicogenomic
(This special issue belongs to the Section Molecular Biology)
Poly- and Oligo-Saccharides as Pharmaceutical Agents in Biology and Medicine
edited by
submission deadline 1 Jan 2026 | Viewed by 114 | Submission Open
Keywords: polysaccharides; oligosaccharides; isolation and purification; structural and functional analyses; biological mechanisms of action; cellular & molecular targets and interactions; pharmaceutical drug development; cancer; cardiovascular disease; diabetes
(This special issue belongs to the Section Molecular Biology)
Advances in Molecular Forensic Pathology and Toxicology: An Update
edited by
submission deadline 20 Jan 2026 | 5 articles | Viewed by 5876 | Submission Open
Keywords: biomarkers; immunohistochemistry; histopathology; forensic pathology; forensic toxicology; forensic biomarkers; toxicological biomarkers; neuropathology; mRNA; post-mortem interval; cerebral damage; in vitro; in vivo; and in silico models; hypoxic– ischemic brain injury; pregnancy biomarkers; vitality
(This special issue belongs to the Section Molecular Biology)
Protein and Protein Interactions
edited by Wu Xu
submission deadline 20 Jan 2026 | 3 articles | Viewed by 5734 | Submission Open
Keywords: protein and protein interactions; ligand and protein interactions; computational method; geometry-based; energy-based; conformational changes; binding site prediction; structural biology; computational biology and bioinformatics
(This special issue belongs to the Section Molecular Biology)
Molecular Insights into Zoology
edited by
submission deadline 20 Jan 2026 | 5 articles | Viewed by 5602 | Submission Open
Keywords: zoology; genomics; transcriptomics; phylogeny; molecular evolution; mtDNA; eDNA; RNA; molecular zoolog
(This special issue belongs to the Section Molecular Biology)
Transporters in Health and Disease submission deadline 20 Jan 2026 | 4 articles | Viewed by 5413 | Submission Open
Keywords: transporters; disease; regulation; drugs; toxicity; signaling
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms Involved in Sperm Development, Maturation, and Fertilization (3rd Edition)
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 5286 | Submission Open
Keywords: sperm physiology; seminal plasma; extracellular vesicles; reproduction; spermatogenesis; capacitation; fertility
(This special issue belongs to the Section Molecular Biology)
Molecular Research Landscape of Pulmonary Arterial Hypertension
edited by Cármen Brás-Silva
submission deadline 20 Jan 2026 | 2 articles | Viewed by 4397 | Submission Open
Keywords: pulmonary arterial hypertension; right ventricle; right heart failure; molecular mechanisms; vascular disease; translational research; therapy
(This special issue belongs to the Section Molecular Biology)
New Insights into Satellite DNAs submission deadline 20 Jan 2026 | 2 articles | Viewed by 3932 | Submission Open
Keywords: satellite DNA; satellitome; satellite DNA organization; satellite DNA evolution; satellite DNA origin; satellite DNA transcription; satellite DNA function; satellite DNA regulation; satellite RNA; heterochromatin; centromere; telomere; gene regulation; cancer; biomarkers; epigenetics; next-generation sequencing (NGS); nanopore sequencing; PacBio sequencing
(This special issue belongs to the Section Molecular Biology)
Protein Networks and Their Signaling submission deadline 20 Jan 2026 | 1 articles | Viewed by 1785 | Submission Open
Keywords: protein-protein interaction; chromatin/nucleosome; signaling; protein structure; drug design
(This special issue belongs to the Section Molecular Biology)
Oxidative Stress in Dermatology, Aesthetics and Regenerative Medicine submission deadline 20 Jan 2026 | Viewed by 1772 | Submission Open
Keywords: oxidative stress; redox system; antioxidant chemical species; dermatology; aesthetics; regenerative medicine; inflammatory; degenerative skin diseases
(This special issue belongs to the Section Molecular Biology)
Molecular and Cellular Mechanisms of Skin Diseases (Second Edition)
edited by
submission deadline 20 Jan 2026 | 3 articles | Viewed by 1688 | Submission Open
Keywords: hyperproliferative skin diseases; psoriasis; keratinocyte carcinoma; actinic keratosis; atopic dermatitis; skin inflammation; inflammation-associated skin diseases; epidermal differentiation; epidermal cell metabolism; 3D models; in vivo models
(This special issue belongs to the Section Molecular Biology)
Protein Signal Transduction in the Nucleus
edited by Jaekyung Shim
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1583 | Submission Open
Keywords: inner nuclear membrane protein; protein network; LEM-domain proteins; nuclear lamina; signal transcription; transcriptional regulation
(This special issue belongs to the Section Molecular Biology)
New Insights into Male Infertility and Sperm Biology
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 1356 | Submission Open
Keywords: male infertility; sperm DNA fragmentation; sperm oxidative stress; sperm nuclear condensation; assisted reproductive technologies; genomics; epigenomics; transcriptomics; proteomics; metabolomics
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Adult Stem Cell Research
edited by Dongsu Park
submission deadline 20 Jan 2026 | 2 articles | Viewed by 1214 | Submission Open
Keywords: tissue-resident stem cells; skeletal stem/progenitor cells; hematopoietic stem cells; tendon/ligament stem cells; musculoskeletal tissue regeneration; stem cell microenvironment; stem cell aging
(This special issue belongs to the Section Molecular Biology)
Chronic Kidney Disease: From Molecular Mechanisms to Therapeutic Approaches
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 976 | Submission Open
Keywords: genetics; epigenetics; inflammation; metabolomics; oxiative stress
(This special issue belongs to the Section Molecular Biology)
Research Progress on Oocyte Development
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 745 | Submission Open
Keywords: oocyte maturation; germ cell development; folliculogenesis; oocyte quality; egg cell development; oocyte activation; meiotic progression; fertility
(This special issue belongs to the Section Molecular Biology)
Wound Repair: From Basic Biology to Tissue Engineering submission deadline 20 Jan 2026 | 1 articles | Viewed by 741 | Submission Open
Keywords: wound healing; tissue engineering; biomaterials; regenerative medicine; chronic wounds
(This special issue belongs to the Section Molecular Biology)
Bone Development and Regeneration—4th Edition
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 586 | Submission Open
Keywords: osteoblast; osteocyte; osteoclast; mesenchymal stem cell; cell differentiation; epigenetics; omics; integrative analysis; biomaterials
(This special issue belongs to the Section Molecular Biology)
Ion Transporter-Based Biomarkers for Sperm Quality
edited by
submission deadline 20 Jan 2026 | Viewed by 553 | Submission Open
Keywords: ion transporters; sperm quality; cryotolerance
(This special issue belongs to the Section Molecular Biology)
Protein Design and Engineering in Biochemistry
edited by Om Prakash Narayan
submission deadline 20 Jan 2026 | 1 articles | Viewed by 530 | Submission Open
Keywords: protein engineering; molecular biology; biochemical tools; computational protein design; directed evolution; CRISPR/Cas9; synthetic biology; biomaterials; protein therapeutics; regenerative medicine
(This special issue belongs to the Section Molecular Biology)
Advanced Research on the Physiology and Toxicology of Aquatic Animals
edited by Xin Zhang
submission deadline 20 Jan 2026 | Viewed by 508 | Submission Open
Keywords: aquatic ecosystem; physiology of aquatic animals; toxicology of aquatic animals; environmental adaptability; environmental pollutants; ecotoxicology; biomarkers; risk assessment
(This special issue belongs to the Section Molecular Biology)
Structure, Function and Dynamics in Proteins: 3rd Edition
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 450 | Submission Open
Keywords: protein structure and dynamics; protein– protein and protein– DNA interactions; protein folding and misfolding; protein aggregation processes; intermediate/misfolded states; conformational equilibria; DNA and ligand recognition mechanisms; membrane receptors; enzyme dynamics; metal-binding proteins; intrinsically disordered proteins; cell signaling; phase separation mechanims; solution- and solid-state NMR; molecular dynamics simulations; time-resolved X-ray; NMR relaxation; in-/on-cell NMR; cryo-EM; fluorescence polarization; surface plasmon resonance; static and dynamic light scattering; isothermal titration calorimetry; microscale thermophoresis; protein– fragment complementation assay; cross-linking; protein microarray
(This special issue belongs to the Section Molecular Biology)
Insights into How Electromagnetic Fields Affect Human Immunity and Metabolic Activity
edited by Jolanta Kaszuba-Zwoińska
submission deadline 20 Jan 2026 | Viewed by 322 | Submission Open
Keywords: electromagnetic fields; metabolism; innate and acquired immunity; cell viability; cell secretory activity; cell death types; pathogenesis of diseases
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms of Animal Reproduction and Development
edited by
submission deadline 20 Jan 2026 | Viewed by 275 | Submission Open
Keywords: spermatogenesis; oogenesis; fertilization; embryogenesis; cell division; cell differentiation; stem cell; abnormal development; obesity; cancer
(This special issue belongs to the Section Molecular Biology)
Progress in Adipokines Research in Cardiovascular Health and Diseases
edited by
submission deadline 20 Jan 2026 | Viewed by 231 | Submission Open
Keywords: adipokine receptors and cell signalling; adipokines and heart failure and hypertrophy; adipokines and myocardial ischemia; adipokines and hypertension; adipokines and thrombosis/atherosclerosis; adipokines and vascular/endothelial function; structure; and integrity; adipokines and cardiovascular inflammation; adipokines; adiposity; and cardiovascular disease in obesity
(This special issue belongs to the Section Molecular Biology)
The Role of Extracellular Vesicles in Drug Delivery submission deadline 20 Jan 2026 | Viewed by 173 | Submission Open
Keywords: red blood cells; red blood cell-extracellular vesicles; drug delivery systems; RNA therapies; EV engineering
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Coagulation Proteins
edited by
submission deadline 20 Jan 2026 | Viewed by 159 | Submission Open
Keywords: coagulation proteins; hemostasis; thrombosis; structural biology; Cryo-EM; inherited coagulation disorders
(This special issue belongs to the Section Molecular Biology)
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