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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Understanding and Combating Antimicrobial Resistance: Molecular Insights and Innovative Approaches submission deadline 30 Nov 2025 | Viewed by 40 | Submission Open
Keywords: genetic mutations; horizontal gene transfer; efflux pump mechanisms; biofilm formation; novel antibiotic development; antimicrobial peptides; phage therapy; CRISPR-based tools; antimicrobial stewardship programs
(This special issue belongs to the Section Molecular Biology)
Oral Stem Cells: Molecular Characteristics and the Applications in Regenerative Medicine
edited by and
submission deadline 30 Nov 2025 | Viewed by 37 | Submission Open
Keywords: oral stem cells; regenerative medicine; molecular mechanisms; stem cell therapy; tissue engineering
(This special issue belongs to the Section Molecular Biology)
Signaling in Cells Proliferating in Two- and Three-Dimensional Cultures
edited by Hedwig Sutterluety-Fall
submission deadline 30 Nov 2025 | Viewed by 35 | Submission Open
Keywords: proliferation; signaling; two-dimensional; three-dimensional; cell culturing; in vitro; growth factors
(This special issue belongs to the Section Molecular Biology)
Advancements in Regenerative Medicine Research
edited by
submission deadline 30 Nov 2025 | Viewed by 31 | Submission Open
Keywords: regenerative medicine; tissue repair; wound healing; stem cells; cell differentiation; cell signalling; gene regulation; mechanotransduction; precision medicine
(This special issue belongs to the Section Molecular Biology)
Signal Transduction Pathways: From Molecular Mechanisms to Therapeutic Targets
edited by
submission deadline 30 Nov 2025 | Viewed by 31 | Submission Open
Keywords: signal transduction; molecular mechanism; cell signaling; disease pathways; therapeutic targets
(This special issue belongs to the Section Molecular Biology)
Ion Regulation in Human Pathophysiology
edited by
submission deadline 30 Nov 2025 | Viewed by 30 | Submission Open
Keywords: ion channels; ion gradients; membrane potential; action potential; ion pumps; uniporter; co-transporter; patch-clamp; ion flux; concentration gradient; ion stores; physiological processes; pathophysiological processes
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms Linked to Exercise
edited by Igor Zubrzycki
submission deadline 30 Nov 2025 | Viewed by 29 | Submission Open
Keywords: molecular mechanisms; exercise adaptations; translational health
(This special issue belongs to the Section Molecular Biology)
Molecular Insights in Renal and Epithelial Physiology
edited by Pedro A. Jose
submission deadline 30 Nov 2025 | Viewed by 28 | Submission Open
Keywords: renal and epithelial physiology; ion transport; glomerulo-tubular balance
(This special issue belongs to the Section Molecular Biology)
Toxicity of Animal Venoms and the Components: Molecular Mechanisms of Action
edited by
submission deadline 30 Nov 2025 | Viewed by 26 | Submission Open
Keywords: venom toxicity; biochemical activity; toxin biology; cellular targets; peptide; protein; structure– function relationships
(This special issue belongs to the Section Molecular Biology)
High-Density Lipoproteins in Health and Disease
edited by
submission deadline 20 Dec 2025 | 6 articles | Viewed by 20339 | Submission Open
Keywords: omics; protein; lipid; cardiovascular; neurodegenerative disease; inflammation; preclinical studies; therapy
(This special issue belongs to the Section Molecular Biology)
(Meta)Genomic, Functional, Structural and Evolutionary Analysis of Transport Systems
edited by , Milton Saier and Gabriel Moreno-Hagelsieb
submission deadline 20 Dec 2025 | 3 articles | Viewed by 11210 | Submission Open
Keywords: molecular transport; transport mechanisms; evolution; families and superfamilies; genomics; metagenomics; 3D structural insights; bioinformatics
(This special issue belongs to the Section Molecular Biology)
Current Research on Bioactives from Natural Products submission deadline 20 Dec 2025 | 4 articles | Viewed by 8686 | Submission Open
Keywords: antioxidants; molecular models; natural products; bioactive compounds; food; materials; antimicrobials; mechanisms of action; extraction techniques; health benefits
(This special issue belongs to the Section Molecular Biology)
The Importance of Molecular Circadian Rhythms in Health and Disease submission deadline 20 Dec 2025 | 4 articles | Viewed by 4788 | Submission Open
Keywords: molecular clock; circadian dysfunction; health; chronotherapy; circadian rhythms
(This special issue belongs to the Section Molecular Biology)
New Insight into Radiation Biology and Radiation Exposure
edited by Lynnette Cary
submission deadline 20 Dec 2025 | 2 articles | Viewed by 1413 | Submission Open
Keywords: ionizing radiation; radiation biomarkers; radionuclide; medical countermeasure
(This special issue belongs to the Section Molecular Biology)
Molecular Biology of Fish Stress
edited by , and
submission deadline 20 Dec 2025 | 2 articles | Viewed by 1409 | Submission Open
Keywords: fish stress; molecular biology; omics; apoptosis; inflammation
(This special issue belongs to the Section Molecular Biology)
Effects of Stressors During Pregnancy and Breastfeeding on the Child: Molecular Perspectives submission deadline 20 Dec 2025 | 1 articles | Viewed by 1374 | Submission Open
Keywords: xenobiotics; drugs; gestation; breastfeeding; fetus; placenta; child’ s development; teratogenicity; central nervous system
(This special issue belongs to the Section Molecular Biology)
Design of Bioactive Agents and Interaction with Biological Systems
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 1351 | Submission Open
Keywords: natural and synthetic compounds; bioactive agents and materials; design and discovery; targeting; intermolecular interactions; omics; structure and dynamics of biomolecules; theoretical analysis of biomolecular structures; analytical and biophysical methods; molecular biology/biochemistry; chemical biology/biological chemistry
(This special issue belongs to the Section Molecular Biology)
New Advances in Cancer Genomics
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 815 | Submission Open
Keywords: cancer genomics; biomarker discovery; precision oncology; KRAS and undruggable targets; artificial intelligence in oncology; multi-omics data integration; drug discovery
(This special issue belongs to the Section Molecular Biology)
Physiological and Pathophysiological Aspects of Intracellular and Extracellular Modulator Proteases
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 802 | Submission Open
Keywords: a disintegrin and metalloproteinase domain-containing protein; calpain; ectoproteinase; inflammasome; secretase
(This special issue belongs to the Section Molecular Biology)
Role of Ion Channels in Human Health and Diseases
edited by
submission deadline 20 Dec 2025 | Viewed by 702 | Submission Open
Keywords: sodium current; potassium current; ion channel kinetics; excitable cells; treatments; pathophysiology
(This special issue belongs to the Section Molecular Biology)
New Insights of Autophagy and Apoptosis in Cells submission deadline 20 Dec 2025 | 1 articles | Viewed by 565 | Submission Open
Keywords: autophagy; apoptosis; signal transduction; cell survival
(This special issue belongs to the Section Molecular Biology)
Rethinking Fat: A Deeper Dive into the Diversity and Dynamic Roles of Adipose Tissue
edited by
submission deadline 20 Dec 2025 | Viewed by 548 | Submission Open
Keywords: adipose tissue biology; stem cell commitment and differentiation; thermogenic adipocytes; genetic regulation; metabolic homeostasis; selective targeting
(This special issue belongs to the Section Molecular Biology)
New Insights into the Molecular Mechanisms of the UPR and Cell Stress
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 492 | Submission Open
Keywords: unfolded protein response; ER stress; oxidative stress; mitochondrial dysfunction; cell stress; stress response; UPR signaling pathway; immunity; inflammation; infection
(This special issue belongs to the Section Molecular Biology)
The Role of Fibrinolytic Factors in Disease
edited by
submission deadline 20 Dec 2025 | Viewed by 443 | Submission Open
Keywords: fibrinolysis; plasminogen; plasmin; α 2-antiplasmin; uPA; uPAR; tPA; PAI-1
(This special issue belongs to the Section Molecular Biology)
Adipose Tissue and Adipose Tissue-Derived Stem Cells in Multidisciplinary Research
edited by Oliver Felthaus
submission deadline 20 Dec 2025 | Viewed by 345 | Submission Open
Keywords: adipose tissue; adipose-derived stem cells; regenerative medicine; tissue engineering
(This special issue belongs to the Section Molecular Biology)
Sleep and Breathing: From Molecular Perspectives
edited by Alberto Alonso-Fernández
submission deadline 20 Dec 2025 | Viewed by 326 | Submission Open
Keywords: obstructive sleep apnea; cardiovascular risk; cardiovascular diseases/physiopathology; continuous positive airway pressure; hypertension; biomarkers; diabetes; pregnancy; gene expression profiling; genetic markers; inflammation mediators; oxidative stress; proteomics
(This special issue belongs to the Section Molecular Biology)
Circumventing Resistance to Channel-Targeting Insecticides: A Challenge for Global Health and Food Security
edited by and David Barry Sattelle
submission deadline 20 Dec 2025 | Viewed by 308 | Submission Open
Keywords: pest insects and resistance; resistance in insect vectors of human and livestock diseases; mechanisms of resistance; circumventing resistance; ion channels and resistance; integrated approaches to resistance management; alternating insecticide classes; minimizing risk to beneficial insects; novel control strategies
(This special issue belongs to the Section Molecular Biology)
Mechanotransduction and Tissue Regeneration in Skeletal Muscle
edited by
submission deadline 20 Dec 2025 | Viewed by 276 | Submission Open
Keywords: skeletal muscle tissue regeneration; mechanotransduction; skeletal muscle spindles; tissue-resident macrophages
(This special issue belongs to the Section Molecular Biology)
Growth Factor Signaling in Cancer Progression
edited by and Abdo J. Najy
submission deadline 20 Dec 2025 | Viewed by 266 | Submission Open
Keywords: growth factor signaling; proteolysis; cancer progression; tumor dormancy; metastasis; tumor microenvironment; therapeutic strategies
(This special issue belongs to the Section Molecular Biology)
Molecular Research on Aging: How Can We Live Beyond 100 Years?
edited by
submission deadline 20 Dec 2025 | Viewed by 228 | Submission Open
Keywords: aging; biomarkers; centenarians; longevity interventions; stress resistance and metabolism; age-related diseases
(This special issue belongs to the Section Molecular Biology)
Cell–Cell Communication Through Extracellular Vesicles
edited by Federica Fratini
submission deadline 20 Dec 2025 | Viewed by 193 | Submission Open
Keywords: EV biomarkers; EV biogenesis; EV drug delivery; EV trafficking; EV immuno escape
(This special issue belongs to the Section Molecular Biology)
Neural Stem Cells: Latest Applications and Future Perspectives submission deadline 20 Dec 2025 | Viewed by 187 | Submission Open
Keywords: neural differentiation; embryonic stem cells; neural stem cells; neural progenitor cells; neuropathology; neurological disease
(This special issue belongs to the Section Molecular Biology)
Stem Cell or Exosome-Based Therapy for Kidney Diseases: Mechanisms, Applications, and Future Perspectives
edited by
submission deadline 20 Dec 2025 | Viewed by 175 | Submission Open
Keywords: stem cell therapy; exosome therapy; kidney disease; regenerative medicine; cell differentiation; tissue engineering; drug discovery; in vitro 3D models; anti-inflammation; antioxidant stress; antifibrosis; extracellular vesicles; precision medicine; bioengineering; artificial intelligence; bioinformatics
(This special issue belongs to the Section Molecular Biology)
Coenzyme Q Redox State and Cellular Homeostasis: Implications for Clinical Practice
edited by
submission deadline 20 Dec 2025 | Viewed by 164 | Submission Open
Keywords: coenzyme Q; cellular homeostasis; cellular energy production; antioxidant defense
(This special issue belongs to the Section Molecular Biology)
Biomolecular Condensates and Their Role in Cellular Organization and Disease
edited by Anna Bratek-Skicki
submission deadline 20 Dec 2025 | Viewed by 144 | Submission Open
Keywords: biocondensates; membrane-less organelles; liquid-liquid phase separation; protein aggregation; neurogenerative diseases
(This special issue belongs to the Section Molecular Biology)
Proteases and Their Inhibitors: From Biochemistry to Applications
edited by
submission deadline 20 Dec 2025 | Viewed by 130 | Submission Open
Keywords: proteases; peptidases; proteinases; proteolysis; hydrolysis; enzymes; inhibitors; biotechnology; drug discovery; therapeutics
(This special issue belongs to the Section Molecular Biology)
Molecular Basis of Inorganic Phosphate Transport Regulation in Protozoan Parasites submission deadline 20 Dec 2025 | Viewed by 124 | Submission Open
Keywords: inorganic phosphate transport; protozoan parasites; cell proliferation
(This special issue belongs to the Section Molecular Biology)
MicroRNAs and mRNA in Human Health and Disease
edited by
submission deadline 20 Dec 2025 | Viewed by 71 | Submission Open
Keywords: stem cells; mesenchymal stem cells; gene expression; microRNA; mRNA
(This special issue belongs to the Section Molecular Biology)
The Molecular Life of Sperm: New Horizons in Male Infertility submission deadline 20 Dec 2025 | Viewed by 61 | Submission Open
Keywords: human sperm; fertilization; infertility; biomarkers; genetics
(This special issue belongs to the Section Molecular Biology)
The Role of Ion Channels in Health and Disease
edited by
submission deadline 20 Dec 2025 | Viewed by 56 | Submission Open
Keywords: ion channel; molecular mechanisms; channelopathies; drug discovery; electrophysiology
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms of Stem Cell-Mediated Tendon Regeneration: From Signaling Pathways to Therapeutic Applications
edited by
submission deadline 20 Dec 2025 | Viewed by 32 | Submission Open
Keywords: regenerative medicine; tissue engineering; stem cells; scaffolds; 3D in vitro models; tenogenic differentiation; tendon regeneration; molecular mechanisms; intercellular crosstalk; paracrine signaling; extracellular matrix remodeling
(This special issue belongs to the Section Molecular Biology)
Redox Physiology
edited by Mateusz Mołoń
submission deadline 21 Dec 2025 | Viewed by 286 | Submission Open
Keywords: redox physiology; reactive oxygen species (ROS); reactive nitrogen species (RNS); oxidative stress; oxidation; redox signaling
(This special issue belongs to the Section Molecular Biology)
Spectroscopic Techniques in Molecular Sciences
edited by
submission deadline 25 Dec 2025 | Viewed by 87 | Submission Open
Keywords: spectroscopy; the structure; dynamics; interactions; and functions of molecules; chemical; biological; pharmaceutical; and materials systems
(This special issue belongs to the Section Molecular Biology)
Chromatin Remodelers as Players and Drivers in Pathological States
edited by Matteo De March
submission deadline 30 Dec 2025 | 3 articles | Viewed by 5838 | Submission Open
Keywords: protein structure/function; chromatin remodelers; DNA repair; oncogene/oncosuppressor; cancer
(This special issue belongs to the Section Molecular Biology)
Applications of Stem Cells and Extracellular Vesicles in Regenerative Medicine submission deadline 30 Dec 2025 | 3 articles | Viewed by 5344 | Submission Open
Keywords: regenerative medicine; pluripotent stem cells; cell differentiation; tissue engineering; gene editing; therapeutic potential; clinical applications; neurodegenerative disorders; disease modeling
(This special issue belongs to the Section Molecular Biology)
Mitochondrial Biology and Human Diseases submission deadline 30 Dec 2025 | 4 articles | Viewed by 4610 | Submission Open
Keywords: mitochondria; mitochondrial gene expression; bioenergetics; mitochondriopathies; human diseases
(This special issue belongs to the Section Molecular Biology)
Omics Technologies in Molecular Biology
edited by
submission deadline 30 Dec 2025 | 1 articles | Viewed by 2725 | Submission Open
Keywords: omics technologies; genomics; transcriptomics; proteomics; metabolomics; lipidomics; phenomics; enviromics; big data; machine learning; molecular biology
(This special issue belongs to the Section Molecular Biology)
Cellular Mechanisms and Signaling Pathways in Normal Tissue Repair and Fibrosis
edited by and Jeffrey R. Koenitzer
submission deadline 30 Dec 2025 | 2 articles | Viewed by 743 | Submission Open
Keywords: fibrosis; inflammation; senescence; myofibroblasts; Wnt/hedgehog; extracellular matrix; hedgehog; angiotensin II/transforming growth factor-beta; ephrins
(This special issue belongs to the Section Molecular Biology)
Advances in Leptin Biology submission deadline 30 Dec 2025 | 1 articles | Viewed by 698 | Submission Open
Keywords: leptin; leptin expression; leptin receptor; leptin action
(This special issue belongs to the Section Molecular Biology)
New Insights into Lectins
edited by Yuichiro Sato
submission deadline 30 Dec 2025 | 1 articles | Viewed by 235 | Submission Open
Keywords: lectin; carbohydrate-binding specificity; virus; antiviral activity; cancer; anticancer activity; glycan-targeted therapy
(This special issue belongs to the Section Molecular Biology)
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