ijms-logo

Journal Browser

Journal Browser

Applications of Stem Cells and Extracellular Vesicles in Regenerative Medicine

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 July 2025 | Viewed by 2879

Special Issue Editors


E-Mail Website
Guest Editor
Department Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea
Interests: MSCs; extracellular vesicles; wound healing; regenerative medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue on “Applications of Stem Cells and Extracellular Vesicles in Regenerative Medicine” explores the innovative use of stem cells and extracellular vesicles (EVs) to advance regenerative medicine. Key topics include the use of pluripotent stem cells, which have the ability to differentiate into various cell types, making them crucial for tissue engineering and the development of new therapies. Gene editing technologies are discussed as tools to enhance the therapeutic potential of these stem cells, allowing for precise modifications that improve their efficacy and safety. The therapeutic potential of stem cells and EVs extends to numerous clinical applications, particularly in treating neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease, wound ahealing, ischemic diseases, etc. These applications also include disease modeling, which helps with understanding the pathologies of various conditions and testing new treatments. The integration of stem cells and EVs into regenerative medicine is intended to repair and regenerate damaged tissues, offering promising solutions for a wide range of diseases and injuries. This Special Issue underscores the importance of conducting ongoing research to optimize these technologies and translate them into effective clinical treatments.

Overall, this Special Issue will provide a comprehensive overview of how research on stem cells and their EVs can revolutionize healthcare by offering new treatments for previously untreatable diseases, underscoring both its immense promise and ongoing challenges in clinical translation.

Dr. Ramya Lakshmi Rajendran
Dr. Prakash Gangadaran
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • regenerative medicine
  • pluripotent stem cells
  • cell differentiation
  • tissue engineering
  • gene editing
  • therapeutic potential
  • clinical applications
  • neurodegenerative disorders
  • disease modeling

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

37 pages, 5693 KiB  
Review
Alzheimer’s Disease Pathology and Assistive Nanotheranostic Approaches for Its Therapeutic Interventions
by Anuvab Dey, Subhrojyoti Ghosh, Ramya Lakshmi Rajendran, Tiyasa Bhuniya, Purbasha Das, Bidyabati Bhattacharjee, Sagnik Das, Atharva Anand Mahajan, Anushka Samant, Anand Krishnan, Byeong-Cheol Ahn and Prakash Gangadaran
Int. J. Mol. Sci. 2024, 25(17), 9690; https://doi.org/10.3390/ijms25179690 - 7 Sep 2024
Cited by 3 | Viewed by 1872
Abstract
Alzheimer’s disease (AD) still prevails and continues to increase indiscriminately throughout the 21st century, and is thus responsible for the depreciating quality of health and associated sectors. AD is a progressive neurodegenerative disorder marked by a significant amassment of beta-amyloid plaques and neurofibrillary [...] Read more.
Alzheimer’s disease (AD) still prevails and continues to increase indiscriminately throughout the 21st century, and is thus responsible for the depreciating quality of health and associated sectors. AD is a progressive neurodegenerative disorder marked by a significant amassment of beta-amyloid plaques and neurofibrillary tangles near the hippocampus, leading to the consequent loss of cognitive abilities. Conventionally, amyloid and tau hypotheses have been established as the most prominent in providing detailed insight into the disease pathogenesis and revealing the associative biomarkers intricately involved in AD progression. Nanotheranostic deliberates rational thought toward designing efficacious nanosystems and strategic endeavors for AD diagnosis and therapeutic implications. The exceeding advancements in this field enable the scientific community to envisage and conceptualize pharmacokinetic monitoring of the drug, sustained and targeted drug delivery responses, fabrication of anti-amyloid therapeutics, and enhanced accumulation of the targeted drug across the blood–brain barrier (BBB), thus giving an optimistic approach towards personalized and precision medicine. Current methods idealized on the design and bioengineering of an array of nanoparticulate systems offer higher affinity towards neurocapillary endothelial cells and the BBB. They have recently attracted intriguing attention to the early diagnostic and therapeutic measures taken to manage the progression of the disease. In this article, we tend to furnish a comprehensive outlook, the detailed mechanism of conventional AD pathogenesis, and new findings. We also summarize the shortcomings in diagnostic, prognostic, and therapeutic approaches undertaken to alleviate AD, thus providing a unique window towards nanotheranostic advancements without disregarding potential drawbacks, side effects, and safety concerns. Full article
Show Figures

Figure 1

Back to TopTop