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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Metabolic Dependencies of the Influence of Intestinal Microbiota During Pregnancy, Childbirth and Infancy
edited by Małgorzata Szczuko and Maciej Ziętek
submission deadline 25 Sep 2025 | Viewed by 19 | Submission Open
Keywords: microbiota; dysbiosis; intestinal microbiome; LPS; zonulin; calprotectin; occludin; SCFA; citrulline; glucagon-like peptide (GLP)-2; LPS binding protein (LBP); amyloid A; intestinal leakage
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Amino Acid Nutrition and Human Health
edited by
submission deadline 28 Sep 2025 | Viewed by 43 | Submission Open
Keywords: amino acids; dietary intake; metabolic disease; starvation; obesity; supplementation; parental nutrition; gene expression; tumour metabolism
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Latest Advances in Oxidative Stress and Brain Injury
edited by
submission deadline 28 Sep 2025 | Viewed by 24 | Submission Open
Keywords: measurement of ROS; pathology of brain injuries; traumatic brain injuries; hypoxic– ischemic brain damage; experimental models of brain injury; targeted therapy of brain injuries; drug abuse and ROS; histological diagnosis of brain injuries; epigenetics of brain injuries; miRNA and prognosis of neural damage; novel approaches and proofs of principle in therapy; quality of life after brain injury
(This special issue belongs to the Section Molecular Neurobiology)
Health Impacts of Environmental Pollution on the Urogenital and Reproductive Systems submission deadline 28 Sep 2025 | Viewed by 4 | Submission Open
Keywords: pollution; endocrine toxicity; endocrine disruptors; human biomonitoring; infertility; cancer; inflammation; oxidative stress
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant Breeding: High-Yield and Quality, Stress-Resistant Trait Genetic Improvement and Application
edited by Juwu Gong
submission deadline 29 Sep 2025 | 1 articles | Viewed by 351 | Submission Open
Keywords: plant breeding; crop genetic improvement; gene editing; stress resistance; crop quality; crop yield; gene resource utilization
(This special issue belongs to the Section Molecular Plant Sciences)
Current Research for Heart Disease Biology and Therapeutics (Third Edition)
edited by Claudia Kusmic
submission deadline 29 Sep 2025 | Viewed by 90 | Submission Open
Keywords: myocardial hypertrophy; cardiac remodeling; heart failure; drug therapy; molecular therapeutic targets; myocardial gene therapy; heart disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Pharmacology of Cardiovascular Disease, 2nd Edition
edited by
submission deadline 30 Sep 2025 | 3 articles | Viewed by 13670 | Submission Open
Keywords: heart failure; internal medicine; cardiovascular disease; metabolic syndrome; pharmacology; cardiology; pharmacodynamics  
(This special issue belongs to the Section Molecular Pharmacology)
The Serum Amyloid A (SAA) Family: (Patho)Physiological Functions in (Non)Mammalian Systems submission deadline 30 Sep 2025 | 5 articles | Viewed by 10197 | Submission Open
Keywords: Serum Amyloid A in (Non)Mammalian systems; phylogenetic overview of different SAA isoforms; expression of SAA1-4 on mRNA and protein level; comparison of SAA with other acute-phase reactants; role of SAA during normal development and inflammation; role of SAA in cancer and other malignancies; potential role of SAA as a suitable biomarker during disease progression
(This special issue belongs to the Section Biochemistry)
Novel Concepts, New Perspectives, and Current Therapies for Parkinson’s Disease: 2nd Edition
edited by
submission deadline 30 Sep 2025 | 6 articles | Viewed by 9897 | Submission Open
Keywords: Parkinson’ s disease; therapy; drug; repurposing; novel compound; neurodegeneration; neuroinflammation
(This special issue belongs to the Section Molecular Neurobiology)
Progress of Molecular Biology and Physiology in Lepidopteran Insects submission deadline 30 Sep 2025 | 6 articles | Viewed by 7813 | Submission Open
Keywords: silkworm; Bombyx mori; Lepidopteran insects; molecular biology; physiology; genome analysis; mode of action; genome editing
(This special issue belongs to the Section Molecular Biology)
Molecular Research on Skeletal Muscle Diseases submission deadline 30 Sep 2025 | 4 articles | Viewed by 7632 | Submission Open
Keywords: muscle contraction; calcium regulation; desease-causing mutations; cross-bridge cycling and kinetics; thin filament; ATPase activity; actin– myosin interaction; therapeutic approaches
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Gynecologic Diseases: From Molecular Basis to Therapy
edited by Domenico Baldini
submission deadline 30 Sep 2025 | 2 articles | Viewed by 5626 | Submission Open
Keywords: infertility; sterility; gynecologic desease; genetic; IVF; gynecologic therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Natural Products with Anti-Inflammatory and Anticancer Activity
edited by
submission deadline 30 Sep 2025 | 4 articles | Viewed by 5094 | Submission Open
Keywords: natural products; medicinal plants; inflammation; cancer; malignant tumour; anti-inflammatory; anti-cancer
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Rice Molecular Breeding and Genetics: 3rd Edition
edited by
submission deadline 30 Sep 2025 | 3 articles | Viewed by 5007 | Submission Open
Keywords: molecular genetics and breeding; cell biology; genetic resource innovation; gene cloning; genome editing; abiotic stress tolerance
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Ecology, Physiology and Biochemistry of Insects, 5th Edition
edited by
submission deadline 30 Sep 2025 | 3 articles | Viewed by 3777 | Submission Open
Keywords: insect development and reproduction; molecular endocrinology/neuropeptides; insect immunity; photoperiodism; cold hardiness; global climate change; insect aging; insect– plant interactions; molecular interactions of insects with microorganisms; chemical communication; biochemistry of insect venoms; insect genomics and proteomics; genetic engineering; molecular; volution/population genetics; insect biotechnology
(This special issue belongs to the Section Molecular Immunology)
Novel Combination Therapies for the Solid Cancers Treatment
edited by
submission deadline 30 Sep 2025 | 3 articles | Viewed by 2705 | Submission Open
Keywords: solid cancer; breast cancer; lung cancer; prostate cancer; colorectal cancer; therapeutic efficacy; drug resistance; genetic mutation; tumor microenvironment; immunotherapies; novel combination therapies
(This special issue belongs to the Section Molecular Oncology)
Advanced Research in Retina: 3rd Edition submission deadline 30 Sep 2025 | 3 articles | Viewed by 2541 | Submission Open
Keywords: glaucoma; age-related macular degeneration; diabetic retinopathy; neurodegenerative diseases; diagnostic techniques; therapeutic strategies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Evolution and Genomics: Relevance to Current Issues
edited by and Sally Lloyd
submission deadline 30 Sep 2025 | 2 articles | Viewed by 2454 | Submission Open
Keywords: paralogy; synteny; evolution; genomics; duplication; haplotype
(This special issue belongs to the Section Molecular Genetics and Genomics)
Bioactive Compounds from Natural Products for the Prevention and Treatment of Chronic Diseases, 3rd Edition
edited by
submission deadline 30 Sep 2025 | 2 articles | Viewed by 2304 | Submission Open
Keywords: natural products; natural products isolation; bioactive natural compounds; inflammation; neurodegenerative diseases; skin diseases; cancer; metabolic syndrome; chronic diseases
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Glioblastoma: From Molecular Mechanisms to Therapies
edited by Lata Adnani
submission deadline 30 Sep 2025 | 2 articles | Viewed by 2214 | Submission Open
Keywords: glioblastoma; heterogeneity; tumor microenvironment; therapy resistance; immunotherapy; extracellular vesicles; biomarkers; vascular endothelial cells; pericytes; blood– brain barrier
(This special issue belongs to the Section Molecular Oncology)
Molecular Targeted Therapy for Gliomas
edited by Ka-Kit Leung
submission deadline 30 Sep 2025 | 1 articles | Viewed by 2168 | Submission Open
Keywords: targeted therapy; glioma and glioblastoma; treatment strategies; identification of biomarkers; diagnosis; prognosis; molecular pathology; signalling pathways; molecular imaging; tumour microenvironment
(This special issue belongs to the Section Molecular Oncology)
The Food Processing Industry’s 200th Anniversary: Bioactive Compounds, Antioxidants, and Potential Health Benefits (2nd Edition) submission deadline 30 Sep 2025 | 2 articles | Viewed by 1822 | Submission Open
Keywords: antioxidants; bioactive compounds; food processing; functional foods; green processes; health potentials; molecular mechanisms; polyphenols; shelf life; vitamins
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Drug Repurposing in Rare Diseases: From Molecular Insights to Patient Benefits
edited by Claudia Fuchs
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1799 | Submission Open
Keywords: rare diseases/rare genetic diseases; drug repurposing/repositioning; molecular insights; shared molecular pathways; preclinical trials; case studies
(This special issue belongs to the Section Molecular Pharmacology)
New Advances in Erythrocyte Biology and Functions
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1700 | Submission Open
Keywords: erythrocyte; red blood cells; red blood functions; vascular function; blood bank storage
(This special issue belongs to the Section Molecular Biology)
Molecular Insight into Bone Diseases
edited by Gaia Palmini
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1158 | Submission Open
Keywords: mineralization; bone diseases; rare bone diseases; non-coding RNAs; fibrous bone dysplasia; tumoral calcinosis; osteosarcoma; Ewing sarcoma; osteoporosis; Gorham-Stout disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Innovative Approaches for Investigations on Protein Interactions submission deadline 30 Sep 2025 | 1 articles | Viewed by 1141 | Submission Open
Keywords: protein– protein and protein– ligand interactions; proteomics; innovative approaches; LC-MS/MS; immunometric techniques; interactome; drug discovery and development
(This special issue belongs to the Section Biochemistry)
Association Between Oxidative Stress and Metabolic Diseases
edited by
submission deadline 30 Sep 2025 | 2 articles | Viewed by 1038 | Submission Open
Keywords: metabolic disease; oxidative stress; low-grade inflammation; antioxidant; endocrine disease; radical species
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Hypoxia: Molecular Mechanism and Health Effects submission deadline 30 Sep 2025 | Viewed by 803 | Submission Open
Keywords: hypoxia; inflammation; oxidative stress; metabolic conditions; hypoxia-inducible factors (HIFs); oxidative stress; mitochondrial dysfunction; angiogenesis; metabolic reprogramming; apoptosis
(This special issue belongs to the Section Molecular Biology)
MicroRNAs as Biomarkers and Therapeutic Targets in Human Diseases
edited by Elena V. Bichenkova
submission deadline 30 Sep 2025 | 2 articles | Viewed by 802 | Submission Open
Keywords: microRNA biomarkers; diagnostic profiling; expression patterns; miRNA therapeutics; antimiRs; miRNA mimics; hybridisation; sequence-specificity; miRNA knockdown
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Research Advances in Retinal Neurodegeneration and Neuroprotection Strategies
edited by and
submission deadline 30 Sep 2025 | Viewed by 729 | Submission Open
Keywords: retinal neurodegeneration; retinal neuroprotection; retinal pigment epithelium dysfunction; electrophysiology; molecular targets; drug delivery
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Osteoblast Differentiation in Human Health and Disease
edited by Younho Han
submission deadline 30 Sep 2025 | 1 articles | Viewed by 486 | Submission Open
Keywords: osteoblast differentiation; bone remodeling; mesenchymal stem cells; skeletal diseases; osteogenesis; bone mineralization; osteoporosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Natural Products in Treating Human Diseases
edited by Luís R. Silva
submission deadline 30 Sep 2025 | Viewed by 480 | Submission Open
Keywords: natural products; phytochemicals; biological potential; pharmacological activity; health promoters; chronic diseases
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Optical Materials: Molecular Advances of Their Synthesis, Properties and Medical Applications submission deadline 30 Sep 2025 | Viewed by 471 | Submission Open
Keywords: optical materials; luminescence; luminescence thermometry; laser materials; phosphors; biocompatible optical materials; optical imaging; fluorescent nanoparticles; rare-earth ion-doped nanomaterials; hard and soft tissue engineering; laser imaging systems
(This special issue belongs to the Section Materials Science)
Bioactive Compound Delivery Systems and Microbiome Interactions submission deadline 30 Sep 2025 | Viewed by 388 | Submission Open
Keywords: bioactive compounds; delivery systems; gut microbiome; personalized nutrition; bioavailability; encapsulation technologies; microbiome– bioactive interactions; targeted delivery; precision nutrition; synergistic interactions
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanism of VCP/p97 in Health and Diseases
edited by
submission deadline 30 Sep 2025 | Viewed by 374 | Submission Open
Keywords: AAA ATPase; VCP/p97/cdc48/TER ATPase; AAA ATPase; protein unfolding; protein degradation; protein quality control; ERAD; mitochondria-associated degradation; lysosome degradation; ribosome-associated degradation; membrane fusion and trafficking; ubiquitin; TDP43; inclusion body myopathy (IBM); paget disease (PD); frontotemporal dementia (FD); MSP1; amyotrophic lateral sclerosis (ALS); charcot-marie-tooth disease 2Y; Parkinson’ s disease; intellectual development disabilities (IDDs); lysosomal diseases; tauopathies
(This special issue belongs to the Section Molecular Biology)
Current Trends in Redox Physiology Research
edited by Fotios Tekos
submission deadline 30 Sep 2025 | Viewed by 350 | Submission Open
Keywords: redox biology; oxidative stress; antioxidant mechanisms; redox signaling; cellular homeostasis; inflammation and redox; nutritional redox modulation; environmental toxicology and redox; mitochondrial dysfunction; oxidative stress biomarkers
(This special issue belongs to the Section Biochemistry)
X-Linked Disorders: Epigenetic and Environmental Modulation of Phenotypes
edited by Yoram Chaiter and
submission deadline 30 Sep 2025 | Viewed by 325 | Submission Open
Keywords: X-linked disorders; epigenetics; environmental factors; gene expression; clinical manifestations
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Insights into the Precision Medicine on Neoplastic Diseases: Challenges, Perspectives and Opportunities
edited by
submission deadline 30 Sep 2025 | Viewed by 323 | Submission Open
Keywords: cancer; molecular biology; precision medicine; targeted therapy
(This special issue belongs to the Section Molecular Oncology)
New Advances in Platelet Biology and Functions: 3rd Edition
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 272 | Submission Open
Keywords: platelet microparticles; thrombosis; inflammation; oxidative stress; antiplatelet drug; signal transduction; immunity; tumor growth
(This special issue belongs to the Section Molecular Biology)
Lipid Emulsion and Other Treatment in Drug Toxicity
edited by
submission deadline 30 Sep 2025 | Viewed by 271 | Submission Open
Keywords: lipid emulsions; toxicity; toxic drug; anesthetic drug
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Mechanisms of Various Diseases and Drugs Involved in Vascular Tone Regulation in Cardiovascular Disease
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 271 | Submission Open
Keywords: vasoconstriction; vasodilation; calcium; protein kinase C; Rho-kinase; hypertension; nitric oxide
(This special issue belongs to the Section Molecular Biology)
Advances in Tumor Necrosis Factor and Inflammatory Diseases
edited by Salah Amasheh
submission deadline 30 Sep 2025 | Viewed by 256 | Submission Open
Keywords: tumor necrosis factor; inflammatory chronic disease; experimental biomedicine; epithelium; pathophysiology; immunology; therapeutic stategies
(This special issue belongs to the Section Molecular Oncology)
Computational Studies of Ionic Liquids and Their Analogues
edited by and Elisabete Ferreira
submission deadline 30 Sep 2025 | Viewed by 212 | Submission Open
Keywords: ionic liquids; deep eutectic solvents; molecular dynamics; density functional theory; COSMO-RC; machine learning; ab initio
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Molecular Insights into Hepatocellular Carcinoma: From Carcinogenesis to Liver Transplantation
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 152 | Submission Open
Keywords: hepatocarcinogenesis; molecular pathogenesis; tumor microenvironment; metabolic dysfunction-associated fatty liver disease (MAFLD); metastasis; genetic and epigenetic alterations; biomarkers; precision oncology; targeted therapy; immunotherapy; therapy resistance; immune escape; tumor recurrence; transplant oncology
(This special issue belongs to the Section Molecular Oncology)
Molecular Pathophysiology of Dermatitis: Mechanisms and Therapeutic Perspectives submission deadline 30 Sep 2025 | Viewed by 149 | Submission Open
Keywords: immune-mediated skin diseases; molecular mechanism of dermatitis; new therapeutic substances and treatment techniques; dermatitis; skin diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advancements in Molecular Science, Material Analysis, and Surface Treatments: Paving the Way for Future Technological Innovations
edited by
submission deadline 30 Sep 2025 | Viewed by 136 | Submission Open
Keywords: materials; surface treatments; corrosion; nanomaterials; coatings; molecular interactions; deposition
(This special issue belongs to the Section Materials Science)
Natural Active Substances in Human Diseases
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 136 | Submission Open
Keywords: natural active substances; bioactive compounds; molecular mechanisms; traditional medicine; metabolic disorders; inflammatory diseases; neurodegenerative diseases
(This special issue belongs to the Section Bioactives and Nutraceuticals)
The Regulation of Microorganisms on Human Endocrine and Metabolic Systems
edited by Thi Phuong Nam Bui and Valentina Tremaroli
submission deadline 30 Sep 2025 | Viewed by 134 | Submission Open
Keywords: human gut microbiome; endocrine signaling; metabolism; obesity; type 2 diabetes; cardiometabolic diseases
(This special issue belongs to the Section Molecular Microbiology)
Molecular Mechanisms and Functions of Extracellular Vesicles
edited by and Jameel M. Inal
submission deadline 30 Sep 2025 | Viewed by 128 | Submission Open
Keywords: extracellular vesicles; molecular mechanisms; biomarkers; liquid biopsy; cell-communication; cellular function; pathobiology; clinical
(This special issue belongs to the Section Molecular Biology)
Heat Shock Proteins (HSPs): Biological Functions and Mechanisms of Actions submission deadline 30 Sep 2025 | Viewed by 115 | Submission Open
Keywords: heat shock proteins; apoptosis; immune cell activation; stress responses; misfolded proteins; cellular chaperones; cell signaling
(This special issue belongs to the Section Biochemistry)
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