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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Drug Discovery: Design, Synthesis and Activity Evaluation

edited by

Joana L. C. Sousa

and

Artur M. S. Silva

submission deadline 20 Sep 2025 | 4 articles | Viewed by 5814 | Submission Open

Keywords: drug design; organic synthesis; biological activity evaluation; biologically active compounds; diagnostic/therapeutic agents; labeled ligands; structure– activity relationships (SARs); structural biological studies; computational studies; pharmacokinetics/pharmacodynamics; drug delivery

(This special issue belongs to the Section Molecular Pharmacology)

Arrhythmias: Molecular Mechanisms and Therapeutic Strategies

edited by

Yung-Lung Chen

submission deadline 20 Sep 2025 | 3 articles | Viewed by 5742 | Submission Open

Keywords: cardiac arrhythmias; atrial fibrillation; ventricular arrhythmia; electrophysiologic alternation; ion channel; connexin; autonomic nerve system dysfunction; sleep-disordered breathing; obstructive sleep apnea

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Physiological Mechanisms of Exercise

edited by Zoran Nikolovski

submission deadline 20 Sep 2025 | 3 articles | Viewed by 5716 | Submission Open

Keywords: molecular biology; biochemistry and exercise; athletic performance; multi-omic

(This special issue belongs to the Section Molecular Biology)

Apoptosis and Autophagy as Strategies in Cancer Treatment

edited by Dorota Ciołczyk-Wierzbicka

submission deadline 20 Sep 2025 | 3 articles | Viewed by 5565 | Submission Open

Keywords: apoptosis; autophagy; cancer therapy/treatment; drug resistance; signaling pathways

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Research for Legume Genomics, Genetics, and Breeding, 2nd Edition

edited by

Naoufal Lakhssassi

submission deadline 20 Sep 2025 | 3 articles | Viewed by 5562 | Submission Open

Keywords: legumes; genomics; plant breeding; seed composition; gene function; biotic and abiotic stress; legume pathogen resistance/mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Exploring the Pathogenetic Mechanisms in Respiratory Virus Infections: Recent Advances and Future Directions

edited by

Marta De Angelis

submission deadline 20 Sep 2025 | 3 articles | Viewed by 5261 | Submission Open

Keywords: respiratory viruses; virus-host interactions; inflammation; metabolic pathways

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights in Prion Diseases

edited by

Eva Bagyinszky

submission deadline 20 Sep 2025 | 1 articles | Viewed by 5049 | Submission Open

Keywords: prion diseases; prion mutation; genetic modifier; neurodegenerative diseases; therapy; neuroprotection

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms of Microbe–Skin Interactions

edited by

Friedrich Götz

submission deadline 20 Sep 2025 | 3 articles | Viewed by 5030 | Submission Open

Keywords: colonization; cosmetics; diseases (e.g.; acne; diabetic foot syndrome (DFS); psoriasis; etc.); health; immunity; lipidomics; metabolomics; metagenomics; neurotransmitter; physiology; skin habitat; skin microbiota; prebiotics; probiotics; wound healing

(This special issue belongs to the Section Molecular Microbiology)

Noncovalent Interactions and Applications in Materials and Catalysis

edited by Snežana D. Zarić

submission deadline 20 Sep 2025 | 4 articles | Viewed by 4926 | Submission Open

Keywords: noncovalent interactions; materials; catalysis; crystal structures; quantum chemistry calculations; hydrogen bonds; stacking interactions; spectroscopy

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Basis of Pancreatic Secretion and Metabolism

edited by

Dongki Yang

submission deadline 20 Sep 2025 | 4 articles | Viewed by 4893 | Submission Open

Keywords: exocrine of the pancreas; endocrine of the pancreas; acute pancreatitis; chronic pancreatitis; cystic fibrosis; pancreatic metabolic hormones; pancreatic metabolic disease; mechanism of pancreatic bicarbonate secretion; the sodium bicarbonate cotransporter (NBC); cystic fibrosis transmembrane conductance regulator (CFTR); regulators of the ion channels and ion transporters involved in secretion

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Advances in Cell Proliferation, Senescence and Apoptosis

edited by

Chuanxi Cai

submission deadline 20 Sep 2025 | 3 articles | Viewed by 4822 | Submission Open

Keywords: biological molecules; cell proliferation; senescence; apoptosis; human diseases

(This special issue belongs to the Section Molecular Biology)

CNS Injuries: 2nd Edition

edited by

Sudhanshu Raikwar

submission deadline 20 Sep 2025 | 1 articles | Viewed by 4749 | Submission Open

Keywords: stroke; TBI; brain edema; SCI; spinal cord edema; neuroinflammation; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Cellular and Molecular Biology in the Compromised Neonate

edited by

Tim G. A. M. Wolfs

submission deadline 20 Sep 2025 | 1 articles | Viewed by 4745 | Submission Open

Keywords: compromised neonate; infections; placental dysfunction; disrupted oxygen supply; molecular and cellular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Application of Natural Products in Biomedicine and Pharmacotherapy: 2nd Edition

edited by

George Miloshev

submission deadline 20 Sep 2025 | 4 articles | Viewed by 4735 | Submission Open

Keywords: natural products; biomedicine; genotoxicity; epigenetics; aging

(This special issue belongs to the Section Molecular Pharmacology)

New Advances in Stem Cells in Human Health and Diseases

edited by

Elisaveta N. Voynova

submission deadline 20 Sep 2025 | 3 articles | Viewed by 4626 | Submission Open

Keywords: stem cells biology; iPSCs; hESC

(This special issue belongs to the Section Molecular Biology)

Bacterial Adaptation Strategies to the Host: From Acute, Aggressive to Chronic, Dormant Infections, 2nd Edition

edited by

Bettina Löffler

submission deadline 20 Sep 2025 | 2 articles | Viewed by 4603 | Submission Open

Keywords: dormancy; phenotype switching; bacterial stress; survival strategies; persisters; resuscitation; starvation; cell cycle arrest; ATP homeostasis

(This special issue belongs to the Section Molecular Microbiology)

Advances in Melanoma and Skin Cancers: 2nd Edition

edited by

Domenico Mallardo

Debora Basile

and Maria Grazia Vitale

submission deadline 20 Sep 2025 | 5 articles | Viewed by 4593 | Submission Open

Keywords: melanoma; immunotherapy; biomarkers; translational research; drug repurposing; clinical outcome; prognostic markers; predictive markers; combination immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Therapies for Metabolic-Associated Fatty Liver Diseases

edited by Yi-Ming Arthur Chen

submission deadline 20 Sep 2025 | 2 articles | Viewed by 4557 | Submission Open

Keywords: metabolic-associated fatty liver disease; MAFLD; metabolic dysfunction-associated steatohepatitis; MASH; molecular mechanism; genetic polymorphism; individualized medicine; prevention; new drug development; health supplements; diagnosis; epidemiology; lifestyle

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Compounds for Counteracting GI and Liver Diseases

edited by

Daniela Gabbia

and

Raquel Abalo

submission deadline 20 Sep 2025 | 4 articles | Viewed by 4515 | Submission Open

Keywords: natural compounds; gastrointestinal diseases; liver diseases; pharmacological potential

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Bioactive Compounds and Their Anticancer Effects

edited by

Ji Hoon Jung

submission deadline 20 Sep 2025 | 2 articles | Viewed by 4477 | Submission Open

Keywords: ferroptosis; natural compounds; bioactive compounds; p53; anti-cancer drugs

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Emerging Advances in Cancer Biomarkers: Machine Learning, Radiomics, Genomics, and More

edited by

Hung-Yu Lin

and

Pei-Yi Chu

submission deadline 20 Sep 2025 | 2 articles | Viewed by 4380 | Submission Open

Keywords: cancers; biomarkers; precision medicine; artificial intelligence; machine learning; radiomics; genomics; radiogenomics; multi-omics; pharmacogenetics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advanced Synthetic Methodologies in Drug Development

edited by

Davide Moi

submission deadline 20 Sep 2025 | 3 articles | Viewed by 4346 | Submission Open

Keywords: organic chemistry; medicinal chemistry; catalysis; photo-catalysis; green chemistry; drug design; drug analysis; flow chemistry

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Neurodegenerative Diseases and Inflammation: Pathogenesis, Biomarkers and Treatments

edited by

Luisa Agnello

and Anna Maria Ciaccio

submission deadline 20 Sep 2025 | 1 articles | Viewed by 4277 | Submission Open

Keywords: neurodegeneration; inflammation; biomarkers; Alzheimer’ s disease; molecular mechanism; pathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biofunctional Coatings for Medical Applications

edited by

Liviu Duta

Valentina Grumezescu

and

Gabriela Dorcioman

submission deadline 20 Sep 2025 | 4 articles | Viewed by 4263 | Submission Open

Keywords: biofunctional coatings; thin film deposition techniques; surface engineering; tissue engineering; materials’ doping and co-doping; medical applications

(This special issue belongs to the Section Materials Science)

TRP Channels for Pain, Itch and Inflammation Relief: 2nd Edition

edited by

Arpad Szallasi

and

Ari-Pekka Koivisto

submission deadline 20 Sep 2025 | 2 articles | Viewed by 4143 | Submission Open

Keywords: TRP channels; “ thermoTRP” channels; neuropathic pain; inflammatory pain; cancer pain; pruritic skin iseases; itch; neurogenic inflammation; migraine

(This special issue belongs to the Section Molecular Immunology)

Molecular Genetics of Breast Cancer—Recent Progress

edited by

Virginia Valentini

submission deadline 20 Sep 2025 | 2 articles | Viewed by 4043 | Submission Open

Keywords: hereditary cancer; female breast cancer; male breast cancer; molecular oncology; cancer genetics; NGS of gene panels; transcriptomics; genetic predisposition to breast cancer; breast cancer risk; tumor profiling; predictive biomarkers; personalized treatment

(This special issue belongs to the Section Molecular Oncology)

Flow Cytometry: Applications and Challenges

edited by

Alessandra Falda

submission deadline 20 Sep 2025 | 3 articles | Viewed by 4021 | Submission Open

Keywords: flow cytometry; non-conventional flow cytometry; hematology; morphology; molecular tests; cell biology; immunology; target therapy; microbiology; antigens; functional mechanisms; new technologies

(This special issue belongs to the Section Molecular Biology)

New Trends in Research on Cerebral Ischemia

edited by Hideaki Imai

submission deadline 20 Sep 2025 | 2 articles | Viewed by 3798 | Submission Open

Keywords: white matter damage; ischemia; axon regeneration; intervention; cell transplantation; exosome therapy; stem cells; myelin integrity; neurological disorders; neural repair; cognitive impairments

(This special issue belongs to the Section Molecular Neurobiology)

The Role of Oxidative Stress and Antioxidants in Human Disease

edited by

Federica Mannino

submission deadline 20 Sep 2025 | 3 articles | Viewed by 3769 | Submission Open

Keywords: oxidative stress; free radicals; antioxidants; reactive oxygen species (ROS); polyphenols

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Redox Enzymes: Molecular Mechanisms, Structural Features, Physiological Roles

edited by

Vitaliy Borisov

and

Elena Forte

submission deadline 20 Sep 2025 | 2 articles | Viewed by 3761 | Submission Open

Keywords: metalloenzyme; terminal oxidase; cytochrome; heme; respiratory chain; photosynthesis; enzyme activation and inhibition; ROS scavenging enzyme; reactive oxygen species; ROS defense mechanism; molecular bioenergetics; drug target

(This special issue belongs to the Section Molecular Biophysics)

Fish Immunology, 5th Edition

edited by

Alberto Cuesta

and

Elena Chaves-Pozo

submission deadline 20 Sep 2025 | 3 articles | Viewed by 3751 | Submission Open

Keywords: fish immunology; innate immunity; acquired immunity; leucocytes; disease; immunostimulants; immunodepression; inflammation

(This special issue belongs to the Section Molecular Immunology)

Molecular Genetics and Breeding Mechanisms in Domestic Animals: 3rd Edition

edited by

Guiping Zhao

submission deadline 20 Sep 2025 | 4 articles | Viewed by 3719 | Submission Open

Keywords: animal genetics; animal breeding; functional genomics; multiomics analysis; molecular immunity; interactions between microbe and host

(This special issue belongs to the Section Molecular Genetics and Genomics)

Role of Natural Products in Health and Diseases

edited by

Katarína Bauerová

submission deadline 20 Sep 2025 | 2 articles | Viewed by 3657 | Submission Open

Keywords: natural products; health; chronic diseases; biomolecular research; functional food; oncology; rheumatology; infections; inflammation; autoimmunity

(This special issue belongs to the Section Molecular Pharmacology)

Interactions of Microbiome in Skin, Gastrointestinal, and Mucocutaneous Diseases

edited by Capercomorin S. Pitchumoni and

Bijan Safai

submission deadline 20 Sep 2025 | 2 articles | Viewed by 3433 | Submission Open

Keywords: human microbiome; immune system; skin disease; gut– skin axis; gut flora; microbe-host interactions; microbial metabolites; dysbiosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Perspectives in Nanomedicine

edited by

Stefano Leporatti

submission deadline 20 Sep 2025 | 1 articles | Viewed by 3399 | Submission Open

Keywords: nanomedicine; drug delivery; nano therapy and diagnostics; micro and nanofluidic tools; hybrid nanoparticles; CAR-T nanotechnologies

(This special issue belongs to the Section Molecular Nanoscience)

TRP Channel, 2nd Edition

edited by

Louis Premkumar

submission deadline 20 Sep 2025 | 2 articles | Viewed by 3371 | Submission Open

Keywords: TRP; TRPAnkyrin; TRPCanonical; TRPMelastatin; TRPPolycystin; TRPVanilloid

(This special issue belongs to the Section Molecular Pharmacology)

Bioactive Compounds in Human Brain Structures and Diseases: 2nd Edition

edited by

Terezia Kiskova

submission deadline 20 Sep 2025 | 2 articles | Viewed by 3270 | Submission Open

Keywords: brain; brain cancer; depression; neurodegenerative disorders; natural compounds

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Polymers and Polysaccharides in Delivery Systems

edited by

Stefania Racovita

submission deadline 20 Sep 2025 | 2 articles | Viewed by 3248 | Submission Open

Keywords: polysaccharides; synthetic polymers; drug delivery systems; enzyme drugs; gene delivery; targeted release; controlled drug delivery systems

(This special issue belongs to the Section Molecular Pharmacology)

Recent Progress in Advanced Computing Techniques for Molecules and Nanomaterials

edited by

Joonho Bae

submission deadline 20 Sep 2025 | 1 articles | Viewed by 3160 | Submission Open

Keywords: nanomaterials; machine learning; artificial intelligence; computing techniques; modeling; energy storage; catalysis

(This special issue belongs to the Section Molecular Nanoscience)

Targeted Radioligand Therapy and Immunotherapy for Cancer Treatment

edited by

Jinda Fan

and

Carolina de Aguiar Ferreira

submission deadline 20 Sep 2025 | 1 articles | Viewed by 3139 | Submission Open

Keywords: targeted radioligand therapy; immunotherapy; receptor targeting; tumor-specific antigens; immune checkpoint inhibitors; radiosensitization; tumor microenvironment; combination therapy

(This special issue belongs to the Section Molecular Oncology)

Small Molecule Drug Design and Research: 3rd Edition

edited by

Adel Nefzi

submission deadline 20 Sep 2025 | 2 articles | Viewed by 3119 | Submission Open

Keywords: drug design; diversity-oriented synthesis; combinatorial chemistry; computationally guided synthesis; drug-like compounds; computer modeling techniques

(This special issue belongs to the Section Molecular Pharmacology)

Pituitary Tumors: An Update in the Pathogenetic Mechanisms, the Diagnostic Methods and the Therapeutic Approaches

edited by

Dimitrios Kanakis

submission deadline 20 Sep 2025 | 3 articles | Viewed by 3118 | Submission Open

Keywords: pituitary neuroendocrine tumors (PitNETs); pituitary transcription factors; PIT1; TPIT; SF1; GATA3; ERα ; pituicytoma; hypothalamic neurocytoma; hypothalamic gangliocytoma

(This special issue belongs to the Section Molecular Oncology)

Technical Developments and Recent Applications of Cellular Molecular Imaging

edited by Hanae Sato

submission deadline 20 Sep 2025 | 2 articles | Viewed by 3094 | Submission Open

Keywords: fluorescence imaging; optogenetics; single-molecule imaging; cellular dynamics; real-time imaging; structural and functional imaging; multimodal imaging

(This special issue belongs to the Section Molecular Biology)

Advances in Electrochemotherapy

edited by Jurij Novickij,

Julita Kulbacka

and

Maja Čemažar

submission deadline 20 Sep 2025 | 2 articles | Viewed by 3026 | Submission Open

Keywords: electrochemotherapy; drug delivery; pulsed electric fields; cancer; drug resistance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Analysis and Applications of Comparative and Functional Genomic on Horticultural Plants: 2nd Edition

edited by

Xiaoming Song

submission deadline 20 Sep 2025 | 3 articles | Viewed by 3026 | Submission Open

Keywords: horticultural plants; gene family; comparative genomics; genome evolution; gene function; gene expression; database construction; tool development

(This special issue belongs to the Section Molecular Genetics and Genomics)

Editorial Board Members’ Collection Series: Autoimmune Diseases—2nd Edition

edited by

Yves Renaudineau

and

Dirk Roggenbuck

submission deadline 20 Sep 2025 | 2 articles | Viewed by 2880 | Submission Open

Keywords: autoimmunity; autoimmune diseases; immunotherapy; biomarkers; pathogenic mechanisms

(This special issue belongs to the Section Molecular Immunology)

DNA and mRNA-Based Vaccines Against Infectious Diseases

edited by

Wentao Li

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2870 | Submission Open

Keywords: mRNA vaccines; DNA vaccines; vaccine delivery; infectious disease; animal model

(This special issue belongs to the Section Molecular Immunology)

Musculoskeletal Disorders: From Molecular Pathology to Novel Therapeutic Approach

edited by

María Orosia Lucha López

submission deadline 20 Sep 2025 | 2 articles | Viewed by 2846 | Submission Open

Keywords: joints; skeletal muscles; tendons; ligaments; fascia; articular cartilage; intervertebral discs; physiotherapy; novel therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Anti-Inflammatory Activity of Natural Products of Plant Origin

edited by Radoslaw Zajdel

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2800 | Submission Open

Keywords: anti-inflammatory; phytochemicals; natural products; medicinal plants; inflammation; cytokines; NF-κ B pathway; cyclooxygenase inhibitors; flavonoids; terpenoids; polyphenols; molecular mechanisms; drug discovery; ethnopharmacology; metabolomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Wheat Genetics and Genomics: 3rd Edition

edited by

Xiaojun Nie

submission deadline 20 Sep 2025 | 4 articles | Viewed by 2728 | Submission Open

Keywords: wheat; genetics; molecular breeding; genome variation; multiomics

(This special issue belongs to the Section Molecular Plant Sciences)

Displaying special issue 2151-2200 on page 44 of 69.

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