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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advancements and Trends in Plant Genomics
edited by Rongbin Hu
submission deadline 31 Jul 2025 | Viewed by 124 | Submission Open
Keywords: plant; genomics; next-generation sequencing; third-generation sequencing; CRISPR-Cas
(This special issue belongs to the Section Molecular Plant Sciences)
Mechanism Research on Listeria monocytogenes and Its Control submission deadline 31 Jul 2025 | Viewed by 120 | Submission Open
Keywords: Listeria monocytogenes; virulence; biofilm; pathogenicity; control; prevention; food safety
(This special issue belongs to the Section Molecular Microbiology)
The Immune Regulation of Osteoclasts
edited by
submission deadline 31 Jul 2025 | Viewed by 118 | Submission Open
Keywords: hematopoietic stem cells; osteoclasts; osteoblasts; osteocytes; stromal cells; T cells; B cells; macrophages; dendritic cells; interleukins; cytokines
(This special issue belongs to the Section Molecular Immunology)
Tuberculosis: Host Immunity, Diagnosis and Treatment submission deadline 31 Jul 2025 | Viewed by 117 | Submission Open
Keywords: tuberculosis; immune response; diagnosis; treatment; antibiotics; resistance
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Current Developments in Glioblastoma Research and Therapy: 2nd Edition submission deadline 31 Jul 2025 | Viewed by 115 | Submission Open
Keywords: diagnostic; prognostic and predictive biomarkers of glioblastoma; ways to target glioma stem cells; targeting glioblastoma-related signaling pathways; epigenetics of glioblastoma; treatment resistance mechanisms; novel treatment options for glioblastoma; combinatorial therapies; immunotherapy; nanotherapy; the application of CRISPR/Cas9 in glioma research; molecular testing of long-term glioblastoma survivors
(This special issue belongs to the Section Molecular Neurobiology)
Exploring the New Cancer Biomarkers: Progress and Prospects submission deadline 31 Jul 2025 | Viewed by 114 | Submission Open
Keywords: prevention; diagnostic; prognostic; response; liquid biopsy; image biomarkers; clinicopathological biomarkers
(This special issue belongs to the Section Molecular Oncology)
The Neurotoxicity of Amyloid β-Protein
edited by
submission deadline 31 Jul 2025 | Viewed by 112 | Submission Open
Keywords: alzheimer’ s disease; amyloid-β ; oligomer; phosphorylated tau; neurotoxicity; oxidative stress; biomarker; early diagnosis; Aβ -targeted therapy
(This special issue belongs to the Section Molecular Neurobiology)
Endometriosis Pathophysiology, Diagnosis and Emerging Therapeutic Strategies submission deadline 31 Jul 2025 | Viewed by 109 | Submission Open
Keywords: endometriosis; pathophysiology; infertility; biomarkers; pharmacological treatments
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Understanding Plant-Microbe Interactions submission deadline 31 Jul 2025 | Viewed by 104 | Submission Open
Keywords: phytomicrobiome; symbiosis; pathogen resistance; microbial signalling
(This special issue belongs to the Section Molecular Plant Sciences)
Biosynthesis of Phytochemicals and Their Applications in Novel Drug Lead Development
edited by
submission deadline 31 Jul 2025 | Viewed by 104 | Submission Open
Keywords: biosynthesis of phytochemicals in plants; phytochemical isolation; phytochemical structure; animal and human protein targets of phytochemicals; chemical derivatives of phytochemicals
(This special issue belongs to the Section Molecular Biology)
The Plant Phenotyping and Phenomics for Breeding
edited by
submission deadline 31 Jul 2025 | Viewed by 102 | Submission Open
Keywords: plant phenomics; high-throughput phenotyping (HTP); genotype– phenotype association; non-invasive imag-ing; functional genomics; environmental interactions
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Bioinformatics of Peptides and Proteins
edited by
submission deadline 31 Jul 2025 | Viewed by 100 | Submission Open
Keywords: bioinformatics; peptides; proteins; computational modeling; peptide– protein interactions; multi-omics; peptide and protein design; comparative proteomics; molecular dynamics
(This special issue belongs to the Section Molecular Informatics)
Synthesis and Transformations of Bioactive Cyclic Imides
edited by
submission deadline 31 Jul 2025 | Viewed by 97 | Submission Open
Keywords: PROTAC; phthalimides; maleimides; cyclic imides; targeted protein degradation; protein labeling; antibody–drug conjugates; drug design and synthesis; drug conjugation
(This special issue belongs to the Section Biochemistry)
Effects of Co-Exposure of Pollutants on Animal Models
edited by
submission deadline 31 Jul 2025 | Viewed by 97 | Submission Open
Keywords: environmental health; biological systems; toxic exposure; co-exposure; physiological mechanisms; behavioral responses; gene expression; epigenetic effects; molecular research
(This special issue belongs to the Section Molecular Toxicology)
Advancing Mycorrhizal Research for Promoting Plant Growth Under Abiotic Stress submission deadline 31 Jul 2025 | Viewed by 95 | Submission Open
Keywords: plant-mycorrhizal symbiosis; climate changes; environmental stress; plant stress-tolerance
(This special issue belongs to the Section Molecular Plant Sciences)
Investigating Gut Axes: Pathophysiological Functions and Therapeutic Strategies submission deadline 31 Jul 2025 | Viewed by 95 | Submission Open
Keywords: gut– brain axis; gut– heart axis; gut– liver axis; neurological diseases; cancer; novel and alternative therapies; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Polymer Materials Related to Food Packaging
edited by
submission deadline 31 Jul 2025 | Viewed by 93 | Submission Open
Keywords: polymeric materials; food packaging; biodegradable polymers; active packaging; intelligent packaging; nanocomposites; sustainability; circular economy; barrier properties; life cycle assessment
(This special issue belongs to the Section Macromolecules)
Latest Research in Photocatalysis submission deadline 31 Jul 2025 | Viewed by 91 | Submission Open
Keywords: design; simulation; synthesis; properties; functionalities; reactions; photocatalysis
(This special issue belongs to the Section Biochemistry)
Transcription Factors in Plant Gene Expression Regulation, 2nd Edition
edited by
submission deadline 31 Jul 2025 | Viewed by 91 | Submission Open
Keywords: plant trans-factor; cis-active sequence; post-translational modification; dimerization and oligomerization; DNA modules
(This special issue belongs to the Section Molecular Plant Sciences)
Genomics and Epigenomics in Molecular Neurobiology
edited by
submission deadline 31 Jul 2025 | Viewed by 91 | Submission Open
Keywords: genomics of brain disorders; neuroepigenetics; neurodegenerative disorders; Alzheimer’ s disease; Parkinson’ s disease
(This special issue belongs to the Section Molecular Neurobiology)
Unravelling the Intricate Link Between Microvascular Dysfunction and Cardiovascular Disease
edited by Róbert Pórszász
submission deadline 31 Jul 2025 | Viewed by 89 | Submission Open
Keywords: microvascular dysfunction; cardiovascular pathogenesis; endothelial dysfunction; oxidative stress; nitric oxide bioavailability; VEGF dysregulation; endothelin-1 overactivity; heart failure with preserved ejection fraction (HFpEF); pharmacological interventions; microcirculation-targeted therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Interaction Between Cell and Virus, 3rd Edition
edited by
submission deadline 31 Jul 2025 | Viewed by 89 | Submission Open
Keywords: viral replication; gene expression; lytic infection; viral structure; viral assembly; cell signaling pathway; post-translational modification; immune evasion; viral tumorigenesis; antiviral medication
(This special issue belongs to the Section Molecular Microbiology)
Leukemias: Molecular Pathogenesis and Influence of the Microenvironment submission deadline 31 Jul 2025 | Viewed by 89 | Submission Open
Keywords: acute myeloid leukemia; bone marrow microenvironment; cell– cell communication; drug resistance; leukemic stem cell; myelodysplastic syndrome; therapeutic strategy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Impact of Biomolecules on the Pathogenesis of Oral and Periodontal Diseases
edited by
submission deadline 31 Jul 2025 | Viewed by 84 | Submission Open
Keywords: biomolecules; inflammatory mediators; enzymes; cytokines; dysbiosis; microbiome; genetic and epigenetic factors; oral and periodontal diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Bioinspired and Emerging Functionalized Nanostructures for Precision Drug Delivery submission deadline 31 Jul 2025 | Viewed by 82 | Submission Open
Keywords: nanostructured materials; nanobiomaterials; nanocomposites; drug delivery systems; targeted therapies; controlled release; responsive functionalities; theranostics; biomedical applications; therapeutic innovations; bioinspired nanostructures; personalized medicine
(This special issue belongs to the Section Molecular Nanoscience)
The Application of Large Language Model and Agents in Molecular Medicine and Molecular Biology
edited by and Hao Lv
submission deadline 31 Jul 2025 | Viewed by 82 | Submission Open
Keywords: large language models; artificial intelligence; agents; biological data; medical data
(This special issue belongs to the Section Molecular Informatics)
Peptide and Protein Drugs Against Infectious Diseases and Allergic Diseases
edited by
submission deadline 31 Jul 2025 | Viewed by 79 | Submission Open
Keywords: peptide and protein drugs; infectious diseases; allergic diseases; hormones; antimicrobial peptides; neuropeptides; cell-penetrating peptides; enzyme inhibitors; vaccines; antibodies
(This special issue belongs to the Section Molecular Pharmacology)
Inflammatory Bowel Disease: Pathogenesis and Novel Therapeutic Approaches
edited by Francisco Giner
submission deadline 31 Jul 2025 | Viewed by 77 | Submission Open
Keywords: coeliac disease; microscopic colitis; Crohn’ s disease; ulcerative colitis; microbiota; biological therapies; refractory disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Synthesis, Biosynthesis and Implications of Chalcones
edited by
submission deadline 31 Jul 2025 | Viewed by 76 | Submission Open
Keywords: chalcones; biosynthesis; biochemistry
(This special issue belongs to the Section Biochemistry)
Molecular, Cellular and Systems Research on Neuroanatomy, Brain Function and Its Impact on Human Behavior
edited by
submission deadline 31 Jul 2025 | Viewed by 76 | Submission Open
Keywords: central nervous system; neuroanatomy; human behavior; nuclei; neuronal circuits; connectivity channels
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Mechanisms of Plant Adaptation to Stress
edited by Yuanchun Ma
submission deadline 31 Jul 2025 | Viewed by 75 | Submission Open
Keywords: plant; environmental stresses; signaling pathways; stress-responsive genes; transcription factors; phytohormones; crop resilience; breeding; genetic engineering
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Vitiligo: From Mechanisms to Treatment Innovations
edited by Hyun Jeong Ju
submission deadline 31 Jul 2025 | Viewed by 75 | Submission Open
Keywords: autoimmune disease; cytokine signaling; depigmentation; immunotherapy; melanocyte regeneration; microbiome; oxidative stress; vitiligo
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Research in Alzheimer’s Disease: Advances and Perspectives
edited by
submission deadline 31 Jul 2025 | Viewed by 74 | Submission Open
Keywords: neuroinflammation; synaptic dysfunction; oxidative stress; neurofibrillary tangles; mitochondrial dysfunction; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Emerging Therapeutic Potential of Organic Compound in Diseases submission deadline 31 Jul 2025 | Viewed by 73 | Submission Open
Keywords: organic compounds; chemical analysis; medicinal chemistry; organic chemistry; organic synthesis; characterization techniques; cancers; chronic diseases; civilization diseases; degenerative and neurodegenerative diseases
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Natural Compounds in Neurological Diseases
edited by
submission deadline 31 Jul 2025 | Viewed by 72 | Submission Open
Keywords: natural compounds; neuroprotection; neuroinflammation; oxidative stress; mitochondrial dysfunction; autophagy; bioactive molecules (polyphenols; flavonoids; melatonin; etc.); nutraceuticals (bioactive peptides; hydrolysates; etc.); neurodegenerative diseases
(This special issue belongs to the Section Molecular Neurobiology)
Microgravity, Cell Shape and Gene Expression: State of the Art, Challenges and Prospects
edited by Masahiro Terada
submission deadline 31 Jul 2025 | Viewed by 72 | Submission Open
Keywords: microgravity; space radiation; closed environment; space flight; parabolic flight; clinostat; human; rodent; microorganism; countermeasure; artificial gravity
(This special issue belongs to the Section Molecular Biology)
Metabolic Dynamics and Immune Surveillance in the Tumor Microenvironment
edited by
submission deadline 31 Jul 2025 | Viewed by 71 | Submission Open
Keywords: cancer; TME; metabolism; immune cells; signaling pathway; therapy
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Neurodegenerative Diseases: From Molecular Mechanisms to Pathophysiology (Second Edition)
edited by
submission deadline 31 Jul 2025 | Viewed by 70 | Submission Open
Keywords: neurodegenerative diseases; molecular mechanisms; physiology; cell death; autophagy; oxidative stress; inflammation; genetic factors; diet; cognitive functions; exosomes; blood– brain barrier; immunity
(This special issue belongs to the Section Molecular Neurobiology)
Cardiovascular Disease: Molecular Advances on Pathophysiology and Therapies—2nd Edition
edited by
submission deadline 31 Jul 2025 | Viewed by 70 | Submission Open
Keywords: cardiovascular disease; heart failure; biomarkers; pathophysiology; ischemic heart disease; atherosclerosis; coronary microvascular dysfunction; pharmacology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant Genome Evolution and Environmental Adaptation
edited by
submission deadline 31 Jul 2025 | Viewed by 69 | Submission Open
Keywords: plant phylogeny; genome evolution; molecular evolution of cytoplasmic genomes; species divergence
(This special issue belongs to the Section Molecular Plant Sciences)
Insights in Metabolomics: Chromatography and Mass Spectrometry Applications in Cancer Research
edited by
submission deadline 31 Jul 2025 | Viewed by 69 | Submission Open
Keywords: metabolomics; chromatography; mass spectrometry; molecular oncology; cancer pathways; precision medicine
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Metal-Organic Frameworks: Pioneering New Solutions for Biomedical Challenges submission deadline 31 Jul 2025 | Viewed by 69 | Submission Open
Keywords: MOFs; biomedical advances; drug delivery; personalized medicine; biomedical imaging; bio-sensor; smart MOFs; nanomedicine; cancer therapy
(This special issue belongs to the Section Materials Science)
The Interaction Between Tumor Microenvironment and Cancer Stem Cell
edited by
submission deadline 31 Jul 2025 | Viewed by 68 | Submission Open
Keywords: tumor microenvironment; cancer stem cells; innate and adaptive immunity; mesenchymal stromal cells
(This special issue belongs to the Section Molecular Oncology)
Biomechanics and Molecular Research on Glioblastoma: 2nd Edition
edited by
submission deadline 31 Jul 2025 | Viewed by 68 | Submission Open
Keywords: GBM; molecular pathways; biomechanics; oncogene; cancer; microenvironment; drug targeting; diagnostic; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms and Neural Circuits in Behavioral Neuroscience
edited by Matteo Di Segni and Rossella Ventura
submission deadline 31 Jul 2025 | Viewed by 68 | Submission Open
Keywords: behavioral neuroscience; neural circuits; psychopathology; neuroscience; drug addiction; depression; mental illness
(This special issue belongs to the Section Molecular Neurobiology)
NURR1 Biology in Neurological Disorders and Other Diseases submission deadline 31 Jul 2025 | Viewed by 67 | Submission Open
Keywords: NURR1; regulation; chronic diseases; inflammation; neurodegenerative diseases; neurological diseases; cancer; inflammatory diseases
(This special issue belongs to the Section Molecular Biology)
DNA Methylation and Histone Modifications in Cellular Homeostasis
edited by
submission deadline 31 Jul 2025 | Viewed by 67 | Submission Open
Keywords: chromatin modification; DNA methylation; histone post-translational modifications; transcriptional regulation; epigenetic landscapes; cellular homeostasis; epigenome analysis; eukaryotic evolution
(This special issue belongs to the Section Molecular Genetics and Genomics)
Progression of Multiple Sclerosis: Environmental Factors, Genetics, Therapeutics and Immunopathogenesis
edited by Alberto Gajofatto
submission deadline 31 Jul 2025 | Viewed by 67 | Submission Open
Keywords: multiple sclerosis; disability progression; neurodegeneration; pathogenesis; immunology; risk factor; environment; genetics; treatment
(This special issue belongs to the Section Molecular Neurobiology)
Age-Dependence of Neuroimmune Reactions
edited by
submission deadline 31 Jul 2025 | Viewed by 66 | Submission Open
Keywords: age; neuroimmune dynamics; neuroimmune interaction; immune system; the central nervous system; age-related neuroinflammation; neurodegenerative diseases
(This special issue belongs to the Section Molecular Immunology)
Nanotechnology for Food Science—Innovations and Sustainable Solutions
edited by
submission deadline 31 Jul 2025 | Viewed by 66 | Submission Open
Keywords: nanotechnology; nanomaterial synthesis; food safety; food science; nano-engineered food additives; nano-sensors
(This special issue belongs to the Section Molecular Nanoscience)
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