Circadian Clocks and Immunity: Unraveling the Rhythm of Immune Function
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 25 August 2026 | Viewed by 178
Special Issue Editors
Interests: chronic inflammatory diseases; immune-mediated hearing disorders; macrophage and T cell biology; inflammasome activation; biomarkers; therapeutic targets
Special Issues, Collections and Topics in MDPI journals
2. BRIDGES-Biotechnology Research, Innovation and Design for Health Products, Polytechnic University of Guarda, 6300-559 Guarda, Portugal
Interests: circadian rhythm; blood-cerebrospinal fluid barrier; drug delivery; chronotherapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The interplay between circadian clocks and the immune system has garnered increasing attention in recent years, revealing a complex and dynamic relationship that influences health and disease. Circadian clocks, the endogenous time-keeping mechanisms present in nearly all cells, orchestrate daily physiological and behavioral rhythms, including immune function. Emerging evidence highlights the profound impact of circadian rhythms on the regulation of immune responses, inflammation, and host–pathogen interactions. Dysregulation of these clocks, whether through environmental, genetic, or lifestyle factors, has been implicated in a range of immune-mediated disorders, including autoimmunity, infections, and cancer. This Special Issue invites contributions that explore the molecular and cellular mechanisms underlying circadian regulation of immunity, the role of circadian disruption in disease pathogenesis, and potential therapeutic strategies leveraging circadian biology. We welcome the submission of original research, reviews, and perspectives addressing topics such as clock-controlled gene expression in immune cells, circadian modulation of inflammatory pathways, and the implications of chronotherapy in immunological diseases. By advancing our understanding of circadian–immune crosstalk, this Special Issue aims to shed light on novel opportunities for improving human health.
Dr. Vincent Yuan
Dr. Telma Quintela
Guest Editors
Manuscript Submission Information
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Keywords
- circadian rhythm
- biological clocks
- immune regulation
- innate immunity
- adaptive immunity
- inflammation
- chronotherapy
- immune-metabolic regulation
- tissue-resident immune cells
- autoimmune disease
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