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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Diabetes-Related Cognitive Impairment Diseases

edited by

Masashi Tanaka

submission deadline 20 Jun 2025 | 1 articles | Viewed by 8167 | Submission Open

Keywords: Alzheimer’ s disease; amyloid-hyperglycemia; insulin resistance; mitochondrial dysfunction; cerebrovascular diseases; metabolic diseases; neuroinflammation; tau hyperphosphorylation; type 2 diabetes; vascular cognitive impairment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Comprehensive Insights into Molecular Mechanisms and Pathophysiology of Spinal Cord Injury

edited by

Jivko V. Stoyanov

submission deadline 20 Jun 2025 | 5 articles | Viewed by 8052 | Submission Open

Keywords: spinal cord injury; pathophysiology; molecular mechanisms; omics approaches; genomics; proteomics; metabolomics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Proteomics in Cancer

edited by

Leo Kei Iwai

submission deadline 20 Jun 2025 | 4 articles | Viewed by 8042 | Submission Open

Keywords: cancer; proteomics; mass spectrometry; molecular targets; biomarker

(This special issue belongs to the Section Molecular Oncology)

Recent Progress in Regenerative Therapy Using Blood-Derived Biomaterials

edited by

Tomoyuki Kawase

Takashi Ushiki

and Tomoharu Mochizuki

submission deadline 20 Jun 2025 | 4 articles | Viewed by 7923 | Submission Open

Keywords: blood-derived biomaterial; platelet-rich plasma; autologous protein solution; mechanism; platelet; coagulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research on HIV Virus and Infection

edited by

Patricia Price

submission deadline 20 Jun 2025 | 4 articles | Viewed by 7840 | Submission Open

Keywords: HIV; viral proteins; immunogenetics; pathogenesis

(This special issue belongs to the Section Molecular Immunology)

Advances in the Application of Nanomaterials in Environmental Remediation

edited by

Po-Hsiang Chang

submission deadline 20 Jun 2025 | 3 articles | Viewed by 7832 | Submission Open

Keywords: porous materials; nanomaterials; adsorption mechanism; metal– organic framework materials; heavy metals; organic contaminants; pharmaceuticals; molecular simulation; morphology

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Research on the Pancreatic Cancer

edited by

Tetsufumi Takahashi

and

Akira Sato

submission deadline 20 Jun 2025 | 3 articles | Viewed by 7823 | Submission Open

Keywords: PDAC; biomarker; metastasis; chemoresistance

(This special issue belongs to the Section Molecular Oncology)

Bioactive Lipids and Their Derivatives in Biomedical Applications

edited by

Marcelo Einicker-Lamas

submission deadline 20 Jun 2025 | 3 articles | Viewed by 7670 | Submission Open

Keywords: bioactive lipids; phospholipids; sphingolipids; signaling; prostanoids; fatty acids; endocannabinoids; cholesterol; cell membrane; receptors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Obstetrical and Gynaecological Disorders

edited by

Panagiotis Christopoulos

submission deadline 20 Jun 2025 | 6 articles | Viewed by 7542 | Submission Open

Keywords: female reproduction; infertility; embryo development; genealogical disorders; cancer; biomarkers; molecular therapy; epigenetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring the Molecular Mechanisms of the Microbiome in Reproductive Health and Reproductive Immunity

edited by

Panagiotis Christopoulos

submission deadline 20 Jun 2025 | 2 articles | Viewed by 7456 | Submission Open

Keywords: microbiome; infertility; reproduction; male; female; pregnancy; immunology; immune tolerance

(This special issue belongs to the Section Molecular Immunology)

Macrophages in Human Diseases and Their Treatment

edited by

Mirjana Jerkic

submission deadline 20 Jun 2025 | 3 articles | Viewed by 7267 | Submission Open

Keywords: macrophages; organ dysfunction; human diseases; involvement of macrophages in treatment options

(This special issue belongs to the Section Molecular Immunology)

Molecular Research of Multi-omics in Cancer

edited by

Siddharth Pratap

submission deadline 20 Jun 2025 | 4 articles | Viewed by 7182 | Submission Open

Keywords: bioinformatics; biomedical informatics; high-throughput sequencing (HTS)/next-generation sequencing (NGS); DNA-Seq/genomics; RNA-Req/transcriptomics; mass spectrometry/proteomics

(This special issue belongs to the Section Molecular Oncology)

COVID-19: Advances in Pathophysiology and Therapeutics

edited by

Karolina Akinosoglou

submission deadline 20 Jun 2025 | 4 articles | Viewed by 6990 | Submission Open

Keywords: COVID-19; SARS-CoV-2; pathophysiology; immunology; pharmacotherapy; biomarkers; comorbidities; clinical management; disease severity; treatment efficacy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring Cytochromes P450: Drug Metabolism, Endogenous Metabolism, and Human Health

edited by Ewa Bromek,

Władysława Anna Daniel

and Wojciech Kuban

submission deadline 20 Jun 2025 | 4 articles | Viewed by 6982 | Submission Open

Keywords: cytochrome P450; drug metabolism; endogenous substrate metabolism; liver metabolism; brain metabolism

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advancements in Personalized Medicine: Integrating Genomic Insights and Therapeutic Strategies

edited by

Mariarosaria Boccellino

submission deadline 20 Jun 2025 | 3 articles | Viewed by 6890 | Submission Open

Keywords: personalized medicine; genomic insights; therapeutic strategies; molecular profiling; precision medicine; molecular targets; precision oncology; genomic biomarkers

(This special issue belongs to the Section Molecular Genetics and Genomics)

New Insights into Radiation Oncology

edited by

Birgit Lohberger

submission deadline 20 Jun 2025 | 3 articles | Viewed by 6672 | Submission Open

Keywords: particle irradiation; proton and carbon ion irradiation; molecular and cellular radiobiology; influence of particle irradiation on physiology and signal transduction cascades of tumor cells; radiation physics; radiation therapy of malignant bone tumors

(This special issue belongs to the Section Molecular Oncology)

Thyroid Dysfunctions: Molecular Mechanisms Underlying Clinical Consequences

edited by

Jacopo Manso

submission deadline 20 Jun 2025 | 3 articles | Viewed by 6587 | Submission Open

Keywords: thyroid; thyroid dysfunctions; thyroid hormones; thyroid disorders; molecular mechanisms

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Impact of Diet on the Endocrine System: Insights into Cellular and Molecular Mechanisms

edited by

Gaia Favero

and

Luca Vanella

submission deadline 20 Jun 2025 | 2 articles | Viewed by 6514 | Submission Open

Keywords: antioxidants; diet; endocrine system; ROS; lifestyle; nutraceuticals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Advances in Research on Alzheimer’s Disease: 2nd Edition

edited by

Stella Gagliardi

and

Carlo Morasso

submission deadline 20 Jun 2025 | 3 articles | Viewed by 6474 | Submission Open

Keywords: therapy; prevention; new molecules; Alzheimer’ s disease; genetics; nanoformulation; targets; dementia; biomarker discovery

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Advances in Dry Eye Syndrome

edited by Maria Jesus Giráldez-Fernández and

Anxo Fernández Ferreiro

submission deadline 20 Jun 2025 | 4 articles | Viewed by 6455 | Submission Open

Keywords: dry eye disease; tear film osmolarity; tear film; artificial tear substitutes; biological tear substitutes; tear fluid biomarkers; tear film lipid layer; meibomian gland dysfunction; evaporative dry eye; aqueous deficiency dry eye; ocular surface inflammation; cytokines; histological analysis; pharmacological treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research on Immune Cells and Cytokines (2nd Edition)

edited by

Athanasia Mouzaki

submission deadline 20 Jun 2025 | 5 articles | Viewed by 6435 | Submission Open

Keywords: immune cells; cytokines; immunomodulatory treatments; immune diseases; immune system

(This special issue belongs to the Section Molecular Immunology)

Skin Diseases: From Molecular Pathology to Novel Therapeutic Approaches

edited by

Alicja Forma

submission deadline 20 Jun 2025 | 4 articles | Viewed by 6427 | Submission Open

Keywords: skin physiology and pathology; skin cancer; autoimmune skin diseases; microbial infections of skin; sexually transmitted diseases; molecular pathology; therapeutic advancements

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Therapeutic Approaches to Osteoarthritis

edited by

Masato Sato

submission deadline 20 Jun 2025 | 4 articles | Viewed by 6311 | Submission Open

Keywords: mode of action; molecular mechanisms; pathogenesis; drug delivery; disease-modifying drug; translational research; cell therapy; regenerative medicine

(This special issue belongs to the Section Molecular Pharmacology)

Hepatocellular Carcinoma: Latest Research in Pathogenesis, Detection and Treatment, 2nd Edition

edited by

Cristian Turato

and

Stefania Cannito

submission deadline 20 Jun 2025 | 2 articles | Viewed by 6219 | Submission Open

Keywords: human hepatocellular carcinoma (HCC); tumour microenvironment; biomarkers; immunotherapy; epigenetic modulators; precise medicine; combination strategies

(This special issue belongs to the Section Molecular Oncology)

Developing Methods and Molecular Basis in Plant Biotechnology

edited by

Wojciech Makowski

and

Mateusz Labudda

submission deadline 20 Jun 2025 | 5 articles | Viewed by 6107 | Submission Open

Keywords: plant biotechnology; plant genetics; plant proteomics; plant metabolomics; stress

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Advances in Pediatric Diseases

edited by Elvira Pota and Alessandra Di Paola

submission deadline 20 Jun 2025 | 4 articles | Viewed by 6005 | Submission Open

Keywords: pediatric patients; pediatric diseases; molecular mechanisms; molecular therapies; molecular target; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Helicobacter pylori Infections and Treatments

edited by

Dmitry Bordin

submission deadline 20 Jun 2025 | 3 articles | Viewed by 5867 | Submission Open

Keywords: H. pylori; gastritis; carcinogenesis; mechanisms of pathogenicity; molecular pathology; molecular genetics; microbiome modulation; antibiotic resistance; eradication

(This special issue belongs to the Section Molecular Microbiology)

Molecular Structure, Electronic and Vibrational Spectra: Experiment and Theoretical Calculations in Fundamental Science and Materials Science

edited by

Georgiy V. Girichev

submission deadline 20 Jun 2025 | 4 articles | Viewed by 5860 | Submission Open

Keywords: molecular structure; nature of chemical bonding; IR spectra; EA spectra; NMR; XRD; DFT; ab initio

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Recombinant Proteins, Protein Folding and Drug Discovery

edited by

Mohamed Raafat El-Gewely

submission deadline 20 Jun 2025 | 3 articles | Viewed by 5859 | Submission Open

Keywords: heterologous hosts for gene expression; recombinant therapeutic proteins; antigens; and antibodies; large scale production of recombinant proteins; recombinant protein bioreactor; downstream processing of recombinant proteins; codon optimization for protein expression; refolding of misfolded recombinant proteins; solubilization of aggregated and inclusion bodies of recombinant proteins; protein target validation for drug discovery and development; protein target expression for drug discovery and development; metabolic engineering of recombinant protein production; regulatory noncoding RNAs to boost the expression of protein; the use of foldases & conformases in recombinant protein expression; delivery of therapeutic proteins; therapeutic protein Vs mRNA therapeutics

(This special issue belongs to the Section Biochemistry)

Gynecological Cancer: Targeted Therapeutics and Future Perspectives

edited by

Angela Santoro

submission deadline 20 Jun 2025 | 2 articles | Viewed by 5848 | Submission Open

Keywords: molecular background; precision medicine; histomolecular diagnosis; targeted therapies; clinical trials; overall survival; disease-free survival; gynecological cancer; whole genomic assay; molecular biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Molecular and Cellular Mechanisms of Neurodegenerative Diseases, 2nd Edition

edited by

Hongjun (Harry) Fu

submission deadline 20 Jun 2025 | 2 articles | Viewed by 5807 | Submission Open

Keywords: neurodegenerative diseases; Alzheimer’ s disease (AD); Parkinson’ s disease (PD); frontotemporal lobar degeneration (FTLD); amyotrophic lateral sclerosis (ALS); Huntington’ s disease (HD); prion diseases; cellular and molecular mechanisms; omics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Research on Bioactives from Natural Products

edited by

Carmen Lizette Del-Toro-Sánchez

submission deadline 20 Jun 2025 | 4 articles | Viewed by 5797 | Submission Open

Keywords: antioxidants; molecular models; natural products; bioactive compounds; food; materials; antimicrobials; mechanisms of action; extraction techniques; health benefits

(This special issue belongs to the Section Molecular Biology)

Advances in Molecular Research on Autoimmune Diseases, 2nd Edition

edited by

Davide Cossu

submission deadline 20 Jun 2025 | 4 articles | Viewed by 5791 | Submission Open

Keywords: autoimmune markers; immunology; pathogenesis; immunogenetics; animal models; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

New Advances in Protein Structure, Function and Design

edited by

Angelo Facchiano

submission deadline 20 Jun 2025 | 3 articles | Viewed by 5761 | Submission Open

Keywords: AI applications in molecular structure; molecular simulations; new bioinformatics tools; protein structure; protein function; protein– protein interaction; online resources

(This special issue belongs to the Section Molecular Informatics)

Advances in Antimicrobial Nanomaterials 2.0

edited by

Irena Maliszewska

submission deadline 20 Jun 2025 | 3 articles | Viewed by 5684 | Submission Open

Keywords: metallic nanoparticles; bimetallic nanoparticles; antimicrobial activity; polymeric nanomaterials; nanoplatforms; nanoparticle functionalization; delivery of antimicrobial agents

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Research in Infective Mycobacteria

edited by

Giovanni Stelitano

submission deadline 20 Jun 2025 | 4 articles | Viewed by 5619 | Submission Open

Keywords: infections; mycobacteria; molecular biology; antimicrobials; bacteria biochemistry

(This special issue belongs to the Section Molecular Microbiology)

Advances in Diagnostics: Applications of Nucleic Acids and Their Analogs

edited by

Annalisa Masi

Barbara Pascucci

and

Maria Moccia

submission deadline 20 Jun 2025 | 3 articles | Viewed by 5591 | Submission Open

Keywords: nucleic acids; PNAs; ASOs; aptamers; CRISPR; biomarkers

(This special issue belongs to the Section Molecular Genetics and Genomics)

Viral Infections: Physiology, Pathophysiology, Pathogenesis, Diagnosis and Treatment

edited by Dominika Marta Stygar and

Barbara Bażanów

submission deadline 20 Jun 2025 | 5 articles | Viewed by 5574 | Submission Open

Keywords: viral infections; virus mutations; molecular diagnostic methods; antiviral drugs/preparations; viral diseases physiological mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Hematopoietic System under Physiological Conditions and Following Hematopoietic Reconstitution or Stress: 2nd Edition

edited by

Alexander V. Belyavsky

submission deadline 20 Jun 2025 | 4 articles | Viewed by 5532 | Submission Open

Keywords: hematopoietic stem/progenitor cells; hematopoietic differentiation; hematopoietic niches; niche-HSC/progenitor cell interactions; steady-state hematopoiesis; reconstituted hematopoiesis; hematopoietic stress response; cell fate tracing

(This special issue belongs to the Section Molecular Biology)

Central and Local Modulators of Reproduction and Fertility: An Update (4th Edition)

edited by

Rosaria Meccariello

submission deadline 20 Jun 2025 | 4 articles | Viewed by 5500 | Submission Open

Keywords: reproduction; fertility; HPG axis; testis; ovary; spermatogenesis; ovogenesis; gametes; GnRH; gonadotropins; sex steroids; kisspeptins; GnIH; metabolic sensors; leptin; endocannabinoids; autocrine/paracrine regulators; protein/peptide hormones; lipid mediators; epigenetics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Gene Transfer in Brain Disorders

edited by

Tam Thanh Quach

, Lluís Samaranch and Anne-Marie Duchemin

submission deadline 20 Jun 2025 | 1 articles | Viewed by 5488 | Submission Open

Keywords: intellectual disability; neurodegenerative disorders; psychiatric diseases; gene transfer; AAV

(This special issue belongs to the Section Molecular Neurobiology)

Growth Hormone Deficiency: Molecular Pathologies and Therapeutic Strategies

edited by

Renata Stawerska

submission deadline 20 Jun 2025 | 4 articles | Viewed by 5382 | Submission Open

Keywords: growth hormone (GH); growth hormone deficiency (GHD); growth hormone therapy; long-acting growth hormone (LAGH); insulin-like growth factor-1 (IGF-1); growth hormone secretagogues; signaling pathways of the GH-IGF-1 axis; transition phase

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances of Novel Pharmaceutical Designs for Anti-Cancer Therapies, 3rd Edition

edited by

Bernhard Biersack

submission deadline 20 Jun 2025 | 2 articles | Viewed by 5344 | Submission Open

Keywords: cancer; anticancer drugs; drug design; targeted therapy; immunotherapy; molecular target; molecular mechanism; drug resistance

(This special issue belongs to the Section Molecular Pharmacology)

Molecular and Cellular Mechanisms of Pancreatic Cancer

edited by

Sanith Cheriyamundath

submission deadline 20 Jun 2025 | 2 articles | Viewed by 5339 | Submission Open

Keywords: PDAC; metastasis; tumor microenvironment; cancer-associated fibroblasts; KRAS; immune cells; inhibitors; resistance; signaling pathways; EMT

(This special issue belongs to the Section Molecular Oncology)

Advances in Structure, Function and Molecular Targeting of DNA Topoisomerases: 2nd Edition

edited by Joseph E. Deweese and Neil Osheroff

submission deadline 20 Jun 2025 | 3 articles | Viewed by 5273 | Submission Open

Keywords: topoisomerase; DNA supercoiling; DNA topology; anticancer; antimicrobial; DNA damage

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Lung Cancer: Translational Perspectives

edited by

Mariaenrica Tinè

submission deadline 20 Jun 2025 | 2 articles | Viewed by 5246 | Submission Open

Keywords: lung cancer; oncogene; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Editorial Board Members’ Collection Series: "Enzyme Inhibition"

edited by

Claudiu T. Supuran

and

Piotr Paneth

submission deadline 20 Jun 2025 | 2 articles | Viewed by 5171 | Submission Open

Keywords: enzyme inhibition; enzyme activators; magnesium/calcium-containing enzymes; zinc/iron enzymes; PROTACs; cancer; drug resistance; antiinfectives

(This special issue belongs to the Section Biochemistry)

Advances in Molecular Modeling, Docking and Simulations of Protein Structure, 2nd Edition

edited by

Lorant Janosi

submission deadline 20 Jun 2025 | 3 articles | Viewed by 5159 | Submission Open

Keywords: molecular modeling; protein structure; molecular mechanisms; protein interactomics; ligand design; peptides; molecular dynamics; molecular docking

(This special issue belongs to the Section Macromolecules)

Bioactive Compounds in the Prevention of Chronic Diseases

edited by

Diego A. Moreno

Antonio J. Ruiz-Alcaraz

and

Paola Maycotte

submission deadline 20 Jun 2025 | 3 articles | Viewed by 5121 | Submission Open

Keywords: bioactives; chronic disease; inflammation; oxidative stress; obesity; diabetes; cancer

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Mitochondrial Dysfunction and Oxidative Stress in Parkinson’s Disease

edited by

Iain P. Hargreaves

submission deadline 20 Jun 2025 | 2 articles | Viewed by 5066 | Submission Open

Keywords: Parkinson’ s disease (PD); reactive oxygen species (ROS); oxidative stress (OS); mitochondrial respiratory chain (MRC); mitochondrial dysfunction; glutathione; pentose phosphate pathway

(This special issue belongs to the Section Molecular Neurobiology)

Displaying special issue 601-650 on page 13 of 67.

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