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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Role of Ion Channels in Health and Disease
edited by
submission deadline 20 Dec 2025 | Viewed by 195 | Submission Open
Keywords: ion channel; molecular mechanisms; channelopathies; drug discovery; electrophysiology
(This special issue belongs to the Section Molecular Biology)
Molecular Basis of Inorganic Phosphate Transport Regulation in Protozoan Parasites submission deadline 20 Dec 2025 | Viewed by 188 | Submission Open
Keywords: inorganic phosphate transport; protozoan parasites; cell proliferation
(This special issue belongs to the Section Molecular Biology)
The Molecular Life of Sperm: New Horizons in Male Infertility submission deadline 20 Dec 2025 | Viewed by 186 | Submission Open
Keywords: human sperm; fertilization; infertility; biomarkers; genetics
(This special issue belongs to the Section Molecular Biology)
Male Reproduction: Unveiling the Molecular Revolution
edited by
submission deadline 20 Dec 2025 | Viewed by 134 | Submission Open
Keywords: testosterone; spermatogenesis; capacitation; acrosome reaction; endocrine disruptors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Molecular Mechanisms of Human Papillomavirus Family (HPV) Induced Oncogenesis, 2nd Edition
edited by
submission deadline 20 Dec 2025 | Viewed by 134 | Submission Open
Keywords: human papillomavirus (HPV); oncogenesis; mechanism; diagnosis; classification; etiology; pathophysiology; biochemistry; genetics; molecular biology; epidemiology; cervical cancer; oropharyngeal cancer; oncology
(This special issue belongs to the Section Molecular Oncology)
Molecular Research of Neonicotinoid Toxicity
edited by
submission deadline 20 Dec 2025 | Viewed by 132 | Submission Open
Keywords: neonicotinoids; sex-specific effects; brain– gut– microbiome; endocrine organs; genotoxic effects; epigenetic effects
(This special issue belongs to the Section Molecular Toxicology)
Advancing Mental Disorder Therapies: Drug Repositioning and Translational Insights from Animal Models
edited by Claudia Bregonzio and Mariela Fernanda Pérez
submission deadline 20 Dec 2025 | Viewed by 130 | Submission Open
Keywords: anxiety; depression; Parkinson's disease; Alzheimer; schizophrenia; neurotransmitter imbalance; novel treatments; new pharmacological targets; preclinical studies
(This special issue belongs to the Section Molecular Neurobiology)
Stress Adaptation and Immune Surveillance: Extracellular Vesicles, Autophagy, and Inflammasomes in Cancer and Neurodegeneration
edited by Seema Singh
submission deadline 20 Dec 2025 | Viewed by 119 | Submission Open
Keywords: autophagy; ferroptosis; inflammasome activation; extracellular vesicle (EV); cancer; neurodegeneration; chronic infections
(This special issue belongs to the Section Molecular Immunology)
Molecular Mechanisms of Stem Cell-Mediated Tendon Regeneration: From Signaling Pathways to Therapeutic Applications
edited by
submission deadline 20 Dec 2025 | Viewed by 106 | Submission Open
Keywords: regenerative medicine; tissue engineering; stem cells; scaffolds; 3D in vitro models; tenogenic differentiation; tendon regeneration; molecular mechanisms; intercellular crosstalk; paracrine signaling; extracellular matrix remodeling
(This special issue belongs to the Section Molecular Biology)
Molecular Aspects of Tumor Radiotherapy
edited by
submission deadline 20 Dec 2025 | Viewed by 93 | Submission Open
Keywords: radiotherapy resistance; tumor microenvironment; DNA damage response; metabolic reprogramming; combination therapies
(This special issue belongs to the Section Molecular Oncology)
Redox Physiology
edited by Mateusz Mołoń
submission deadline 21 Dec 2025 | Viewed by 401 | Submission Open
Keywords: redox physiology; reactive oxygen species (ROS); reactive nitrogen species (RNS); oxidative stress; oxidation; redox signaling
(This special issue belongs to the Section Molecular Biology)
Spectroscopic Techniques in Molecular Sciences
edited by
submission deadline 25 Dec 2025 | 5 articles | Viewed by 3160 | Submission Open
Keywords: spectroscopy; the structure; dynamics; interactions; and functions of molecules; chemical; biological; pharmaceutical; and materials systems
(This special issue belongs to the Section Molecular Biology)
25th Anniversary of IJMS: Updates and Advances in “Molecular Immunology”
edited by
submission deadline 25 Dec 2025 | 3 articles | Viewed by 2292 | Submission Open
Keywords: inflammation; innate immunity; adaptive immunity; genetics; epigenetics; immunometabolism; receptors; cytokines; cell therapy; immune checkpoint inhibitors
(This special issue belongs to the Section Molecular Immunology)
Epigenetic Regulation and Molecular Mechanisms in Cardiovascular Diseases submission deadline 25 Dec 2025 | 1 articles | Viewed by 2117 | Submission Open
Keywords: epigenetic regulation; cardiovascular disease; DNA methylation; histone modifications; non-coding RNAs; vascular inflammation; myocardial remodeling; molecular mechanisms; thera-peutic targets
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Endocrine Regulation in Health and Diseases
edited by Fady Hannah-Shmouni
submission deadline 25 Dec 2025 | 1 articles | Viewed by 2049 | Submission Open
Keywords: exposome and endocrine disruptors; endocrine-disrupting chemicals (EDCs); environmental toxicology and hormonal health; epigenetics and endocrine function; endocrine regulation and chronic disease; public health and exposure mitigation; endocrine disruptors in the home and community
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular and Genetic Advances in Plant Breeding
edited by Francesca Taranto
submission deadline 25 Dec 2025 | 2 articles | Viewed by 1949 | Submission Open
Keywords: genetic diversity; next-generation sequencing; marker-assisted selection; GWAS/QTL mapping; KASP genotyping; molecular biology   TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in English   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com
(This special issue belongs to the Section Molecular Plant Sciences)
Therapeutic Horizons of Oligosaccharides: Molecular Mechanisms and Therapeutic Potential submission deadline 25 Dec 2025 | 2 articles | Viewed by 1925 | Submission Open
Keywords: oligosaccharides; bacterial infection; multidrug-resistant
(This special issue belongs to the Section Molecular Microbiology)
Skin Cancer: From Molecular Pathophysiology to Novel Treatment
edited by Soon-Hyo Kwon
submission deadline 25 Dec 2025 | 2 articles | Viewed by 1852 | Submission Open
Keywords: basal cell carcinoma; malignant melanoma; molecular genetics; epigenetics; signaling pathways; tumor microenvironment; tumor resistance; biomarkers; molecular target; multiomics; genomics; transcriptomics; proteomics; metabolomics; skin cancer; squamous cell carcinoma
(This special issue belongs to the Section Molecular Oncology)
New Insights into Tryptophan Metabolism
edited by
submission deadline 25 Dec 2025 | Viewed by 261 | Submission Open
Keywords: tryptophan; serotonin; kynurenine; indole; metabolism; IPA; Tph; IDO1; health; disease
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Roots, Transporters, and Signals: Molecular Insights into Plant Mineral Nutrition and Heavy Metals Stress
edited by
submission deadline 25 Dec 2025 | Viewed by 184 | Submission Open
Keywords: plant mineral nutrition; heavy metals; toxic element; transporter; signaling pathway
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Insights in Diabetes submission deadline 25 Dec 2025 | Viewed by 179 | Submission Open
Keywords: insulin signalling pathway; pancreatic beta-cell dysfunction; oxidative stress; epigenetic modifications; metabolic memory; small regulatory RNAs (miRNAs); inflammation and insulin resistance; glucagon-like peptide-1 (GLP-1); glucose-dependent insulinotropic polypeptide (GIP); molecular therapeutic targets; glucose homeostasis regulation
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Microbial Bioconversion of Agri-Food Waste for the Production of Pharmacologically Active Compound
edited by Alicia Paz
submission deadline 25 Dec 2025 | Viewed by 113 | Submission Open
Keywords: microbial bioconversion; agri-food waste valorization; bioactive compounds; bioprocess optimization; pharmaceuticals; functional foods; cosmetic bioactives
(This special issue belongs to the Section Molecular Microbiology)
Emerging Strategy in Bacterial Antibiotic Resistance
edited by Lili Li
submission deadline 28 Dec 2025 | Viewed by 92 | Submission Open
Keywords: fast detection; antimicrobial resistance; virulence; antibacterial action of natural compounds
(This special issue belongs to the Section Molecular Microbiology)
Molecular Investigations in Neurodevelopmental Disorders
edited by Giorgio Medici
submission deadline 30 Dec 2025 | 9 articles | Viewed by 32590 | Submission Open
Keywords: neurodevelopmental disorders; brain; neurons; synapses; molecular research; regulatory networks; molecular pathways; biomarkers; therapies
(This special issue belongs to the Section Molecular Neurobiology)
Recent Research on Hypertension and Related Complications
edited by
submission deadline 30 Dec 2025 | 5 articles | Viewed by 21923 | Submission Open
Keywords: arterial hypertension; cardiovascular disease; pathophysiology; molecular mechanisms; complications
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Musculoskeletal Disorders: From Molecular Pathology to Novel Therapeutic Approach submission deadline 30 Dec 2025 | 9 articles | Viewed by 20249 | Submission Open
Keywords: joints; skeletal muscles; tendons; ligaments; fascia; articular cartilage; intervertebral discs; physiotherapy; novel therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Traumatic Brain Injury/Chronic Traumatic Encephalopathy as Cause of Alzheimer’s Disease: Physics and Molecular Biology in the Genesis of Neurodegeneration?
edited by
submission deadline 30 Dec 2025 | 6 articles | Viewed by 19823 | Submission Open
Keywords: traumatic brain injury (TBI); chronic traumatic encephalopathy (CTE); head impacts; Alzheimer's disease (AD); neurodegeneration
(This special issue belongs to the Section Molecular Neurobiology)
Biomedical Applications of Mesenchymal Stem Cells submission deadline 30 Dec 2025 | 7 articles | Viewed by 19122 | Submission Open
Keywords: mesenchymal stem cells; cell differentiation; cell therapy; regenerative medicine; tissue homeostasis; cartilage
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Mechanisms and Treatments in Neurodegenerative Diseases submission deadline 30 Dec 2025 | 7 articles | Viewed by 18678 | Submission Open
Keywords: neurodegenerative diseases; regenerative therapy; neuroprotection; neurodegeneration; pathogenetic mechanisms; cell therapy
(This special issue belongs to the Section Molecular Neurobiology)
Neurobiological Mechanisms of Addictive Disorders
edited by Liliana Marina Cancela
submission deadline 30 Dec 2025 | 7 articles | Viewed by 18459 | Submission Open
(This special issue belongs to the Section Molecular Neurobiology)
The Characterization and Application of Enzymes in Bioprocesses submission deadline 30 Dec 2025 | 9 articles | Viewed by 16381 | Submission Open
Keywords: biocatalysts; enzymatic characterization; enzymatic action; protein engineering; biocatalysts application; bioprocessing
(This special issue belongs to the Section Biochemistry)
Potential Prevention and Treatment of Neurodegenerative Disorders submission deadline 30 Dec 2025 | 5 articles | Viewed by 16248 | Submission Open
Keywords: neurodegenerative disorders; molecular biomarkers; oxidative stress; therapeutic strategies; disease prevention
(This special issue belongs to the Section Molecular Neurobiology)
Challenges and Innovation in Neurodegenerative Diseases, 2nd Edition
edited by
submission deadline 30 Dec 2025 | 7 articles | Viewed by 15560 | Submission Open
Keywords: neurodegenerative diseases; pathogenesis; biomarkers; disease model; natural product; new drug discovery; therapy; machine learning; stem cell therapy
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Mechanisms and Signalling Pathways in Cardiovascular Pathophysiology
edited by Ernesto Alejandro Aiello
submission deadline 30 Dec 2025 | 5 articles | Viewed by 15481 | Submission Open
Keywords: heart; vascular; signaling; cardiovascular disease; mechanism
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Animal Research Model for Neurological Diseases, 2nd Edition submission deadline 30 Dec 2025 | 5 articles | Viewed by 13709 | Submission Open
Keywords: experimental models; mouse; rat; zebrafish; neurological disease; Alzheimer’ s disease; Parkinson’ s disease; neurodegeneration; neuroregeneration
(This special issue belongs to the Section Molecular Neurobiology)
Host-Pathogen Interaction, 6th Edition
edited by
submission deadline 30 Dec 2025 | 5 articles | Viewed by 12342 | Submission Open
Keywords: microorganisms; pathogen; bacteria; yeasts; protozoa; host organisms
(This special issue belongs to the Section Molecular Microbiology)
The Role of Toll-Like Receptors (TLRs) in Infection and Inflammation: Third Edition
edited by and
submission deadline 30 Dec 2025 | 7 articles | Viewed by 11836 | Submission Open
Keywords: toll-like receptors (TLR); pathogen associated molecular patterns (PAMPs); sepsis; bacterial infections; viral infections; Myd88; TRIF; NF-kappaB; COVID-19; coagulopathies
(This special issue belongs to the Section Molecular Immunology)
Molecular Mechanisms and Therapeutic Innovations in Neurodegenerative Diseases: 2nd Edition
edited by Melania Maria Serafini and
submission deadline 30 Dec 2025 | 4 articles | Viewed by 10162 | Submission Open
Keywords: Alzheimer’ s disease; strokes; multiple sclerosis; amyotrophic lateral sclerosis; polyneuropathies; pain; diabetic retinopathy; neuroinflammation; dietary supplements; microbiome
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Advances in Cancer and Cell Metabolism—2nd Edition submission deadline 30 Dec 2025 | 7 articles | Viewed by 9896 | Submission Open
Keywords: cell metabolism; cancer metabolism; cancer cell; oxidative stress; gene expression; signaling pathways; metabolic regulation; tumor growth; energy metabolism; metabolic phenotype; metabolic substrates
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Applications of Stem Cells and Extracellular Vesicles in Regenerative Medicine submission deadline 30 Dec 2025 | 3 articles | Viewed by 9328 | Submission Open
Keywords: regenerative medicine; pluripotent stem cells; cell differentiation; tissue engineering; gene editing; therapeutic potential; clinical applications; neurodegenerative disorders; disease modeling
(This special issue belongs to the Section Molecular Biology)
Genetic and Molecular Mechanisms of Obesity submission deadline 30 Dec 2025 | 3 articles | Viewed by 8545 | Submission Open
Keywords: obesity; insulin signal transduction; insulin sensitivity; co-morbidities; genetics; epigenetics; miRNAs; DNA methylation; molecular mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Central and Local Modulators of Reproduction and Fertility: An Update (4th Edition) submission deadline 30 Dec 2025 | 4 articles | Viewed by 8538 | Submission Open
Keywords: reproduction; fertility; HPG axis; testis; ovary; spermatogenesis; ovogenesis; gametes; GnRH; gonadotropins; sex steroids; kisspeptins; GnIH; metabolic sensors; leptin; endocannabinoids; autocrine/paracrine regulators; protein/peptide hormones; lipid mediators; epigenetics
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Pathogenicity and Antibiotic Resistance of Helicobacter pylori
edited by
submission deadline 30 Dec 2025 | 2 articles | Viewed by 8441 | Submission Open
Keywords: Helicobacter pylori; antibiotic resistance; antibiotic tolerance; point mutations; efflux pumps; biofilm formation; coccoid forms; membrane vesicles; virulence factors
(This special issue belongs to the Section Molecular Microbiology)
Mitochondrial Biology and Human Diseases submission deadline 30 Dec 2025 | 4 articles | Viewed by 8254 | Submission Open
Keywords: mitochondria; mitochondrial gene expression; bioenergetics; mitochondriopathies; human diseases
(This special issue belongs to the Section Molecular Biology)
Advances in Molecular Research on Autoimmune Diseases, 2nd Edition
edited by
submission deadline 30 Dec 2025 | 4 articles | Viewed by 7972 | Submission Open
Keywords: autoimmune markers; immunology; pathogenesis; immunogenetics; animal models; immunotherapy
(This special issue belongs to the Section Molecular Immunology)
Chromatin Remodelers as Players and Drivers in Pathological States
edited by Matteo De March
submission deadline 30 Dec 2025 | 3 articles | Viewed by 7435 | Submission Open
Keywords: protein structure/function; chromatin remodelers; DNA repair; oncogene/oncosuppressor; cancer
(This special issue belongs to the Section Molecular Biology)
IJMS 25th Anniversary: Updates and Progress on Bioactives and Nutraceuticals
edited by
submission deadline 30 Dec 2025 | 6 articles | Viewed by 7071 | Submission Open
Keywords: natural products; bioactive; nutraceutical; nutrient; health; dietary; functional food; vitamins; phytochemicals
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Non-small Cell Lung Cancer: From Molecular Mechanisms to Therapeutic Strategies
edited by
submission deadline 30 Dec 2025 | 3 articles | Viewed by 6703 | Submission Open
Keywords: NSCLC; predictive and prognostic biomarkers; immunotherapy; targeted therapy; special populations
(This special issue belongs to the Section Molecular Oncology)
Omics Technologies in Molecular Biology
edited by
submission deadline 30 Dec 2025 | 3 articles | Viewed by 6698 | Submission Open
Keywords: omics technologies; genomics; transcriptomics; proteomics; metabolomics; lipidomics; phenomics; enviromics; big data; machine learning; molecular biology
(This special issue belongs to the Section Molecular Biology)
25th Anniversary of IJMS: Updates and Advances in Molecular Microbiology
edited by
submission deadline 30 Dec 2025 | 5 articles | Viewed by 6632 | Submission Open
Keywords: bacteria fungi; bacteriophages; microalgae; microbiome; gut microbiota; environmental microbiome; microbiome– brain– gut axis; virus– host interactions; emerging viruses re-emerging viruses; virus mutation; biofilm antimicrobial; SARS-CoV-2 (COVID-19)
(This special issue belongs to the Section Molecular Microbiology)
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