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Roots, Transporters, and Signals: Molecular Insights into Plant Mineral Nutrition and Heavy Metals Stress

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Plant Sciences".

Deadline for manuscript submissions: 20 August 2026 | Viewed by 937

Editor


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Guest Editor
Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, SP6 Lecce-Monteroni, 73100 Lecce, Italy
Interests: mechanisms of mineral nutrient uptake in plants; impact of heavy metals on plant nutrient homeostasis; role of the rhizosphere microbiome in plant nutrient and heavy metal dynamics; sustainable agricultural practices for managing mineral nutrition and mitigating heavy metal stress
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Special Issue Information

Dear Colleagues,

Plant mineral nutrition is a finely tuned process involving the uptake, transport, and homeostasis of essential elements such as nitrogen, phosphorus, potassium, calcium, iron, and zinc. These processes are tightly regulated at the molecular level through a complex network of transporters, transcription factors, signaling molecules, and hormonal crosstalk.

In parallel, plants are increasingly exposed to non-essential and potentially toxic elements such as cadmium, lead, and arsenic, which can disrupt nutrient acquisition, interfere with cellular functions, and compromise plant health. Understanding the molecular and physiological mechanisms by which plants distinguish between essential and toxic elements is crucial for both sustainable agriculture and environmental management.

This Special Issue aims to gather recent advances in the molecular mechanisms that govern mineral nutrition and heavy metal dynamics in plants. We welcome original research articles and comprehensive reviews covering a range of topics, including (but not limited to):

  • Identification, regulation, and function of ion transporters;
  • Nutrient sensing and signaling pathways;
  • Crosstalk between nutrient uptake and heavy metal detoxification;
  • Plant responses to toxic elements at molecular and cellular levels;
  • Genetic and biotechnological approaches to enhance nutrient use efficiency;
  • Strategies for phytoremediation and resilience to metal-contaminated environments;
  • Comparative studies across model species, crops, and wild plants under both controlled and field conditions.

By integrating insights from molecular biology, plant physiology, and environmental sciences, this Special Issue aims to advance our understanding of how plants navigate the dual challenges of mineral nutrition and heavy metal exposure in an increasingly complex environment.

Dr. Alessio Aprile
Guest Editor

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plant mineral nutrition
  • heavy metals
  • toxic element
  • transporter
  • signaling pathway

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Published Papers (1 paper)

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Review

26 pages, 5573 KB  
Review
Advances in Molecular Mechanisms Underlying Cadmium Accumulation and Detoxification in Durum Wheat (Triticum turgidum L. subsp. durum (Desf.) Husn.)
by Sami ur Rehman, Michele Benedetti, Ignazio Allegretta and Alessio Aprile
Int. J. Mol. Sci. 2026, 27(13), 5802; https://doi.org/10.3390/ijms27135802 - 26 Jun 2026
Viewed by 292
Abstract
Cadmium (Cd) pollution adversely affects crop productivity and grain quality. Durum wheat (Triticum turgidum L. subsp. durum (Desf.) Husn.), a widely consumed cereal crop, can accumulate substantial levels of Cd in edible tissues, threatening human health. Therefore, advances in understanding Cd toxicity [...] Read more.
Cadmium (Cd) pollution adversely affects crop productivity and grain quality. Durum wheat (Triticum turgidum L. subsp. durum (Desf.) Husn.), a widely consumed cereal crop, can accumulate substantial levels of Cd in edible tissues, threatening human health. Therefore, advances in understanding Cd toxicity in plants and the molecular mechanisms underlying Cd accumulation and detoxification are needed to develop resistant cultivars and ensure safe food production. Although Cd homeostasis has been previously studied in bread wheat, its accumulation varies among species and cultivars owing to differences in their physiological and genetic makeup. However, the molecular mechanisms underlying Cd homeostasis in durum wheat have not been comprehensively reviewed. Here, we synthesize current knowledge on the molecular basis of Cd uptake, transport, and detoxification in durum wheat. Specialized transporter families, including MRPs/ABCCs, HMAs, and members of the YSL, ZIFL, and IREG families, play critical roles in mediating Cd compartmentalization and limiting its cytosolic toxicity. Genes such as HMT1, TdHMA3-B1a, and members of the NAS gene family significantly reduced Cd accumulation in grains. Future studies should focus on the integration of physiological, molecular genetics, and multi-omics approaches to uncover the regulatory networks controlling Cd homeostasis in durum wheat. Full article
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