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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Nanomaterials in Tissue Engineering and Regenerative Medicine: Recent Advances and Future Prospects

edited by

Kapil D. Patel

submission deadline 28 Feb 2026 | Viewed by 149 | Submission Open

Keywords: nanoparticles; nanofibers; nanotubes; nanocomposites; hydrogels; ceramics; bioactive glass nanoparticles; tissue engineering; regenerative medicine

(This special issue belongs to the Section Molecular Nanoscience)

Dermatological Perspectives on Connective Tissue Diseases

edited by Yoshihide Asano

submission deadline 28 Feb 2026 | Viewed by 148 | Submission Open

Keywords: connective tissue diseases; systemic sclerosis; systemic lupus erythematosus; dermatomyo-sitis; rheumatoid arthritis; Sjö gren’ s syndrome; skin immunology; fibrosis; cytokines; targeted therapy

(This special issue belongs to the Section Molecular Biology)

Exploring Melatonin and Related Indolic Agents

edited by

Burkhard Poeggeler

submission deadline 28 Feb 2026 | Viewed by 147 | Submission Open

Keywords: aging; antioxidant; bioenergetic agent; biological clock; immunomodulation; indole-3-propionic acid; indole-3-propionamide; melatonin; senescence; tryptophan

(This special issue belongs to the Section Molecular Pharmacology)

Applications of Photodynamic Therapy in Cancer

edited by

Natalia Belén Rumie Vittar

submission deadline 28 Feb 2026 | Viewed by 144 | Submission Open

Keywords: tumor microenvironment; CAF; hypoxia; immune evasion; combined therapies; new cellular or molecular targets

(This special issue belongs to the Section Molecular Oncology)

Insights into Multiple Myeloma: Immune Microenvironment, Disease Mechanisms, and Therapeutic Innovations

edited by

Ichiro Hanamura

submission deadline 28 Feb 2026 | Viewed by 142 | Submission Open

Keywords: multiple myeloma; bone marrow microenvironment; disease biology; disease progression; treatment resistance; CAR-T cells; bispecific antibodies (BsAbs); antibody-drug conjugates (ADCs); tumor– host interaction

(This special issue belongs to the Section Molecular Oncology)

Hepatocardiac Interactions and the Utility of Hepatic Biomarkers in Cardiovascular Disease

edited by

Wioletta Szczurek-Wasilewicz

submission deadline 28 Feb 2026 | Viewed by 141 | Submission Open

Keywords: hepatocardiac interactions; hepatic biomarkers; cardiovascular disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Strategies for the Discovery, Optimization, and Efficient Use of Green Pesticides

edited by

Hongjian Song

submission deadline 28 Feb 2026 | Viewed by 141 | Submission Open

Keywords: natural-product-based pesticides; total synthesis; structural optimization; bioactivity evaluation; structure– activity relationship

(This special issue belongs to the Section Molecular Pharmacology)

Neutrophil Extracellular Traps (NETs) in Human Disease: From Molecular Mechanisms to Therapeutic Translation

edited by

Michael Boettcher

and Julia Elrod

submission deadline 28 Feb 2026 | Viewed by 140 | Submission Open

Keywords: neutrophil extracellular traps (NETs); molecular mechanisms; human disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Liver Pathophysiology and Its Role in Systemic Diseases

edited by Vassilios Sevastianos

submission deadline 28 Feb 2026 | Viewed by 139 | Submission Open

Keywords: liver disease; endocrine functions; liver-targeted drugs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular, Cellular Mechanisms and Pathophysiology of Glioblastoma

edited by Agnieszka Rusak

submission deadline 28 Feb 2026 | Viewed by 139 | Submission Open

Keywords: glioblastoma; targeted terapy; molecular patchway; drug carriers; biomaterials

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research of Cognitive Impairment and Neuropsychiatric Symptoms in Late Life: From Pathogenesis to Treatment

edited by

Ioannis Liampas

submission deadline 28 Feb 2026 | Viewed by 138 | Submission Open

Keywords: dementia; Alzheimer’ s disease; mild cognitive impairment; mild behavioral impairment; movement disorders; Parkinson’ s disease; biomarkers; neurogenetics; molecular research

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms of Vascular Sclerosis

edited by Michishige Terasaki

submission deadline 28 Feb 2026 | Viewed by 138 | Submission Open

Keywords: atherosclerosis; genes; dyslipidemia; diabetes; macrophages; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Endometriosis: Focusing on Molecular and Cellular Research, 2nd Edition

edited by

Alfonso Baldi

submission deadline 28 Feb 2026 | Viewed by 132 | Submission Open

Keywords: endometriosis; reproductive system; endometrial cell; novel treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Osteogenesis: 2nd Edition

edited by

Andrea Del Fattore

submission deadline 28 Feb 2026 | Viewed by 132 | Submission Open

Keywords: osteogenesis; osteoblast; bone formation; disease; bone

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Cancer Nanomedicine: Imaging, Targeting and Therapeutic Applications

edited by

Marvin Xavierselvan

and

Steven Fiering

submission deadline 28 Feb 2026 | Viewed by 130 | Submission Open

Keywords: cancer nanomedicine; multimodal imaging; nanoparticle drug delivery; tumor targeting; theranostic nanoparticles; combination therapies

(This special issue belongs to the Section Molecular Nanoscience)

Current Research on Neuroprotective Phytochemicals and Their Multi-Target Mechanisms

edited by

Gerardo Álvarez-Rivera

and

Alejandro Cifuentes

submission deadline 28 Feb 2026 | Viewed by 129 | Submission Open

Keywords: Alzheimer’ s disease; neuroprotective phytochemicals; green extraction; technologies; blood– brain barrier permeability; bioavailability; multi-target mechanisms; omics approaches; nanodelivery systems; brain health; neuroprotection

(This special issue belongs to the Section Molecular Neurobiology)

Structural Studies of Phosphorus Compounds Today

edited by

Irina Rusakova

submission deadline 28 Feb 2026 | Viewed by 129 | Submission Open

Keywords: 31P NMR; NMR; organophosphorus compounds; transition-metal complexes with organophosphorus ligands; relativistic effects; solvent effects; quantum chemistry methods for NMR; chemical structure studies; chemistry of organophosphorus compounds

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Immune Responses, Viral Infection and Neurodegenerative Diseases

edited by

Xin Dang

and Barbara Hanson

submission deadline 28 Feb 2026 | Viewed by 127 | Submission Open

Keywords: immune response; innate immunity; viral neuropathogenesis; viral biomarker; AD; PD; neurodegenerative diseases

(This special issue belongs to the Section Molecular Immunology)

Application of Spectroscopic Methods in Molecular Biology Research

edited by

Łukasz Laskowski

submission deadline 28 Feb 2026 | Viewed by 127 | Submission Open

Keywords: spectroscopy; molecular characterization; biomaterials; computational chemistry; structure– property relationships; biomolecular interactions; biomedical applications

(This special issue belongs to the Section Molecular Biology)

Sigma-1 Receptor: Signaling, Functions and Therapeutic Potential

edited by Gabriela Cristina Brailoiu and Eugen Brailoiu

submission deadline 28 Feb 2026 | Viewed by 126 | Submission Open

Keywords: Sigma-1R; intracellular receptor; molecular mechanisms; calcium signaling; neurological diseases; neurodegenerative diseases; pain; cancer; addiction

(This special issue belongs to the Section Molecular Biology)

Inorganic Chemistry: From Molecules to Materials

edited by

Zoi Lada

submission deadline 28 Feb 2026 | Viewed by 125 | Submission Open

Keywords: inorganic chemistry; molecular design and reactivity; metal– organic frameworks (MOFs); spin crossover compounds; functional materials; structure– property relationships

(This special issue belongs to the Section Materials Science)

Natural Products—the Underestimated Source of New Solutions for the Innovative Antimicrobial Therapies

edited by

Piotr Okińczyc

, Jarosław Widelski and

Jakub Szperlik

submission deadline 28 Feb 2026 | Viewed by 124 | Submission Open

Keywords: plant; medicines; natural product; antimicrobial activity; drug resistance; chemical analysis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Perspectives on Female Infertility and Fertility

edited by

Seung-Yup Ku

submission deadline 28 Feb 2026 | Viewed by 124 | Submission Open

Keywords: female infertility; molecular mechanisms of reproduction; oocyte maturation and development; reproductive aging; polycystic ovary syndrome; endometriosis; epigenetic regulation in reproduction; oxidative stress and mitochondrial dysfunction; reproductive biomarkers; precision medicine and regenerative therapies

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Therapeutic Strategies for Surgical Tissue Damage, Repair and Regeneration

edited by Alex K. Wong

submission deadline 28 Feb 2026 | Viewed by 123 | Submission Open

Keywords: surgical injury; tissue regeneration; vasculogenesis; wound healing in compromised settings; molecular therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Angiogenesis: Mechanisms and Targets in a Wide Spectrum of Diseases

edited by Lei Phillip Wang

submission deadline 28 Feb 2026 | Viewed by 123 | Submission Open

Keywords: angiogenesis; immune– vascular interactions; cancer; autoimmune disease; neurodegenera-tion; blood– brain barrier; biomarkers; therapeutic targeting

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Cellular Research on Taste Receptors

edited by

Ana R. Costa

submission deadline 28 Feb 2026 | Viewed by 123 | Submission Open

Keywords: taste receptors; taste signaling; gustatory system; molecular signaling; cellular mechanisms; health and disease; functional roles; neurobiology of taste; cancer biology and metastasis; translational research

(This special issue belongs to the Section Molecular Biology)

Mechanisms and Applications of Heterosis in Plants

edited by

Wenxin Liu

submission deadline 28 Feb 2026 | Viewed by 122 | Submission Open

Keywords: heterosis; mechanism; prediction; application; breeding; plant

(This special issue belongs to the Section Molecular Plant Sciences)

Bioactive Phytochemicals in Plant Extracts: A Comprehensive Analysis of Their Diverse Chemical Structures and Therapeutic and Functional Effects

edited by

Truc Cong Ho

submission deadline 28 Feb 2026 | Viewed by 122 | Submission Open

Keywords: extraction; phytochemicals; bioactive compounds; second metabolites; nutraceuticals; polyphenols; flavonoids; biological effects; therapeutic effects

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Targeting and Pharmacology of Neuroinflammation

edited by

Lisa Lione

submission deadline 28 Feb 2026 | Viewed by 121 | Submission Open

Keywords: glia-targeted therapeutics; neuroinflammation; CNS drug development; astrocyte; microglia; neurodegeneration; translational neuroscience; biomarkers; human genetics; cytokine signaling

(This special issue belongs to the Section Molecular Neurobiology)

Microbiota and Gut–Brain–Eye Neuromodulators in Neurodegenerative Disorders: Biomolecular Targets and Therapeutic Challenges

edited by

Alessandra Micera

and

Filippo Biamonte

submission deadline 28 Feb 2026 | Viewed by 121 | Submission Open

Keywords: gut microbiota; brain; eye diseases; neuroinflammation; neurodegeneration; chronic inflammation; chronic pain; probiotics; gastrointestinal disorders; metabolic diseases; machine learning; artificial intelligence

(This special issue belongs to the Section Molecular Neurobiology)

Molecular and Cellular Mechanisms of Taste and Smell: From Physiology to Pathology

edited by

Mariano Mastinu

submission deadline 28 Feb 2026 | Viewed by 117 | Submission Open

Keywords: taste; olfaction; taste/smell processing; chemosensory dysfunction; genetic variations; neurodegeneration; perireceptor space; sensory nutrition; hypogeusia and hyposmia

(This special issue belongs to the Section Molecular Biology)

Transcriptional Regulation in Plant Development: 3rd Edition

edited by

Konstantinos E. Vlachonasios

submission deadline 28 Feb 2026 | Viewed by 117 | Submission Open

Keywords: environmental stresses; plant development; vegetative development; plant physiology and biochemistry; transcriptional regulation; plant– environment interactions

(This special issue belongs to the Section Molecular Plant Sciences)

New Perspectives of Colloids for Biological Applications, 2nd Edition

edited by

Agnieszka Ewa Wia̧cek

submission deadline 28 Feb 2026 | Viewed by 115 | Submission Open

Keywords: colloids; emulsions; dispersions; stability; size distribution; zeta potential; optical/rheological properties; medicine; pharmaceuticals; cosmetics

(This special issue belongs to the Section Materials Science)

Roles and Mechanisms of Non-Coding RNAs in Human Health and Disease: 2nd Edition

edited by

Marco Ragusa

and

Cristina Barbagallo

submission deadline 28 Feb 2026 | Viewed by 115 | Submission Open

Keywords: non-coding RNAs; microRNAs; long non-coding RNAs; circular RNAs; biomarkers; polymorphisms; cancer; degenerative diseases; therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Roles and Mechanisms of Non-Coding RNAs in Cancer

edited by Stefano Sechi and Daniela Scarabino

submission deadline 28 Feb 2026 | Viewed by 114 | Submission Open

Keywords: cancer; non-coding RNA (ncRNA); translational medicine; oncological therapy; biomarker; piRNA; lncRNA; circRNA

(This special issue belongs to the Section Molecular Genetics and Genomics)

Sex Differences in Preclinical and Clinical Studies

edited by

Flavia Franconi

Valeria Raparelli

and

Ilaria Campesi

submission deadline 28 Feb 2026 | Viewed by 113 | Submission Open

Keywords: cellular and in vitro studies; genetic and epigenetic studies; intersectional studies; observational studies; pharmacological studies; pragmatic studies; randomized control trials; disease management

(This special issue belongs to the Section Molecular Biology)

Molecular Immunity to Parasitic Infections

edited by Jamie A. Whitelaw and Stuart Woods

submission deadline 28 Feb 2026 | Viewed by 113 | Submission Open

Keywords: parasitology; immunology; vaccines; cell therapy; gene editing; parasitic diseases; immune responses; inflammation; molecular mechanisms; immune evasion; host cell invasion and manipulation

(This special issue belongs to the Section Molecular Immunology)

Research into the Synthesis and Activities of Anticancer Compounds

edited by

Daniel Plano Amatriain

submission deadline 28 Feb 2026 | Viewed by 112 | Submission Open

Keywords: cancer; synthesis; cell biology; molecular biology; chemistry; preclinical development

(This special issue belongs to the Section Molecular Biology)

New Advances in Metastasis and Therapy: Targeting the Tumor Microenvironment

edited by

Ravi Thakur

submission deadline 28 Feb 2026 | Viewed by 110 | Submission Open

Keywords: cellular crosstalk; growth factors and cytokines; metastatic cascade; metabolic reprogramming; targeting tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Mechanisms and Pathways of Actions for Nutritional Effects on Brain Health

edited by

Fahimeh Martami

submission deadline 28 Feb 2026 | Viewed by 110 | Submission Open

Keywords: brain health; neuroplasticity; neurotransmission; neuroinflammation; oxidative stress; brain metabolism

(This special issue belongs to the Section Molecular Neurobiology)

Next-Generation Therapeutic Polymers: From Molecular Design to Dual Antibacterial/Antithrombotic Action

edited by

Piotr Dobrzynski

submission deadline 28 Feb 2026 | Viewed by 109 | Submission Open

Keywords: antibacterial polymers; antifouling polymers; anticoagulant polymers; heparin-mimicking polymers; heparin-conjugated polymers; phosphorylcholine-based polymers; polymeric nitric oxide donors; polymers; loaded with silver ions; or antibiotics; antibacterial nano- and micro particles; anticoagulant layers

(This special issue belongs to the Section Materials Science)

Metabolic Signaling and Inflammation in Cardiac Pathophysiology

edited by

Maria Luisa Barcena

submission deadline 28 Feb 2026 | Viewed by 108 | Submission Open

Keywords: cardiac metabolism; inflammation; metabolic signaling; heart disease; therapeutic targets

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

RNA Biology and Regulation, 2nd Edition

edited by

Naoyuki Kataoka

submission deadline 28 Feb 2026 | Viewed by 107 | Submission Open

Keywords: RNA processing; RNA transport; RNA localization; RNA editing; RNA synthesis; RNA stability; RNA modification; translation; transcription; RNA metabolism; human diseases

(This special issue belongs to the Section Molecular Genetics and Genomics)

Heterogeneous Catalysis Towards a Sustainable Future: Energy Conversion and Green Synthesis

edited by Chen Wu and

Shaodong Zhou

submission deadline 28 Feb 2026 | Viewed by 107 | Submission Open

Keywords: heterogeneous catalysis; CO2 hydrogenation; CO2 electroreduction; water splitting; Fischer-Tropsch synthesis; oxidative coupling of methane; methane dry reforming; green synthesis; fine chemicals; sustainable energy; catalyst design; active site engineering; single-atom catalysts; metal– organic frameworks; zeolites; nanostructured catalysts; in situ and operando characterizations; photocatalysis; electrocatalysis; biomass valorization; reaction engineering; renewable feedstocks

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Cellular Senescence at the Crossroads: From Cancer Protection to Chronic Disease

edited by

Alexander Lang

submission deadline 28 Feb 2026 | Viewed by 105 | Submission Open

Keywords: cellular senescence; SASP (Senescence-associated secretory phenotype); senolytics; therapeutic targeting; biomarkers of senescence

(This special issue belongs to the Section Molecular Biology)

Training Immunity and Reprogramming Monocytes and Macrophages in Health and Disease

edited by Eugenio A. Carrera Silva

submission deadline 28 Feb 2026 | Viewed by 101 | Submission Open

Keywords: monocytes; macrophage plasticity; regulatory reprogramming; chronic inflammation

(This special issue belongs to the Section Molecular Immunology)

Advances in Anticancer Drug Discovery: Design, Synthesis and Molecular Insights

edited by

Michele De Franco

submission deadline 28 Feb 2026 | Viewed by 101 | Submission Open

Keywords: anticancer agents; drug design; drug synthesis; structure-activity relationship (SAR); target interactions; medicinal chemistry; lead optimization; targeted therapy; bioactive compounds

(This special issue belongs to the Section Molecular Pharmacology)

Recent Research on Noble Metal Nanoparticles

edited by

Shinmori Hideyuki

submission deadline 28 Feb 2026 | Viewed by 101 | Submission Open

Keywords: nanostructure; gold nanoparticles; silver nanoparticles; heterometallic nanoparticles; core– shell structure; surface chemistry; colloid chemistry; localized surface plasmon resonance

(This special issue belongs to the Section Molecular Nanoscience)

Latest Advances in Autoimmune and Inflammatory Rheumatic Diseases

edited by