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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Plant-Sourced Functional and Bioactive Compounds—Nature’s Blueprint for Improving Human Well-Being submission deadline 20 Mar 2026 | 8 articles | Viewed by 26788 | Submission Open
Keywords: plants; antioxidants; phytochemicals; phyto-nutrition; natural products; health enhancing
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advances in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), 2nd Edition submission deadline 20 Mar 2026 | 4 articles | Viewed by 25206 | Submission Open
Keywords: ME/CFS; PASC; long COVID-19; inflammation; innate immunity; adaptive immunity; mast cell activation; post-infection syndrome; metabolism; autoantibodies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Serum Amyloid A (SAA) Family: (Patho)Physiological Functions in (Non)Mammalian Systems submission deadline 20 Mar 2026 | 7 articles | Viewed by 25140 | Submission Open
Keywords: Serum Amyloid A in (Non)Mammalian systems; phylogenetic overview of different SAA isoforms; expression of SAA1-4 on mRNA and protein level; comparison of SAA with other acute-phase reactants; role of SAA during normal development and inflammation; role of SAA in cancer and other malignancies; potential role of SAA as a suitable biomarker during disease progression
(This special issue belongs to the Section Biochemistry)
Molecular Therapeutics for Diabetes and Related Complications, 2nd Edition
edited by
submission deadline 20 Mar 2026 | 8 articles | Viewed by 24717 | Submission Open
Keywords: diabetes; diabetes complications; molecular therapeutics; drug development; hyperglycemia; insulin resistance; cell signaling and oxidative stress
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Novel Therapeutic Strategies for Neurodegenerative Disease submission deadline 20 Mar 2026 | 4 articles | Viewed by 23894 | Submission Open
Keywords: neurodegenerative diseases; Alzheimer’ s disease; Parkinson’ s disease; therapy
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Cell Metabolism in Endocrine Diseases
edited by
submission deadline 20 Mar 2026 | 7 articles | Viewed by 23567 | Submission Open
Keywords: cellular metabolism; homeostasis; endocrine disorders; hormonal signals; dynamic system
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Recent Advances in Human Papillomavirus (HPV) Research
edited by
submission deadline 20 Mar 2026 | 3 articles | Viewed by 23053 | Submission Open
Keywords: human papillomavirus (HPV)/genetics; HPV-associated cancers; HPV cell-free DNA (cfDNA); HPV circulating tumor DNA (ctDNA); HPV circulating tumor cells (CTCs); carcinogenesis/genetics; CRISPR-cas systems/genetics; digital PCR; molecular diagnostics/methods; point-of-care diagnostics/methods; next-generation sequencing/methods; single-cell sequencing/methods; genomics; epigenomics; proteomics; metagenomics; phylogenomics; virus evolution; virus– host interactions; virus integration/genetics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Lung Cancers: An Update on Molecular Diagnostics and Therapy
edited by
submission deadline 20 Mar 2026 | 6 articles | Viewed by 22620 | Submission Open
Keywords: lung cancer; cancer cachexia; prognosis; anti-lung cancer agents
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Beyond Digestion: The Role of Gut Microbiota in Metabolism, Immunity and Brain Function
edited by
submission deadline 20 Mar 2026 | 5 articles | Viewed by 20891 | Submission Open
Keywords: gut dysbiosis; gut microbiota; metabolism
(This special issue belongs to the Section Molecular Immunology)
Viral Infections and Immune Responses submission deadline 20 Mar 2026 | 8 articles | Viewed by 20849 | Submission Open
Keywords: virus; infections; immune response; T-cells; B-cells; antibodies; neutralizing activity
(This special issue belongs to the Section Molecular Immunology)
Extracellular Vesicles: From Molecular Mechanisms to Therapeutic Applications
edited by Jung-Hyun Lee
submission deadline 20 Mar 2026 | 7 articles | Viewed by 20510 | Submission Open
Keywords: extracellular vesicles; intercellular communications; biomarkers; drug delivery systems
(This special issue belongs to the Section Biochemistry)
Molecular and Cellular Perspectives on Wound Healing submission deadline 20 Mar 2026 | 7 articles | Viewed by 20418 | Submission Open
Keywords: chronic wound healing; scarring; biomarkers; inflammation; angiogenesis; infection; extracellular matrix; biomaterials; tissue regeneration; therapeutic targets; innovative therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research in Obesity and Obesity Related Disorders: 3rd Edition
edited by
submission deadline 20 Mar 2026 | 7 articles | Viewed by 19913 | Submission Open
Keywords: biochemistry and molecular medicine; molecular and cellular mechanisms of disease pathogenesis; pathogenesis of metabolic disorders; the role of interaction between genetic and environmental factors in the pathogenesis of non-communicable diseases; atherosclerosis; obesity; obesity-related metabolic diseases and cancers
(This special issue belongs to the Section Molecular Biology)
Natural Product-Based Strategy for Skin Inflammatory Disorders and Regeneration
edited by
submission deadline 20 Mar 2026 | 6 articles | Viewed by 19357 | Submission Open
Keywords: inflammatory skin disorders; skin wound healing and regeneration; skin aging; bioactive natural compound; derivative and conjugate; plant extract; beneficial effect and application; molecular mechanism
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Recent Advances in RNA Drug Development
edited by Hidenori Tani
submission deadline 20 Mar 2026 | 3 articles | Viewed by 18853 | Submission Open
Keywords: RNA therapeutics; drug development; antisense oligonucleotides; siRNA; miRNA; aptamers; CRISPR-Cas9; delivery systems; clinical applications; emerging technologies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Insights in Translational Bioinformatics: Second Edition
edited by
submission deadline 20 Mar 2026 | 5 articles | Viewed by 18744 | Submission Open
Keywords: translational research; sequencing; single cell; spatial biology; treatment; diagnostics; machine learning; artificial intelligence; model; computational biology
(This special issue belongs to the Section Molecular Informatics)
Molecular Insights into Zoonotic Diseases submission deadline 20 Mar 2026 | 6 articles | Viewed by 17121 | Submission Open
Keywords: mycobacterial diseases; bubonic and pneumonic plague; Q fever; cat scratch disease; Mediterranean fever; HIV; malaria; ADIS; SARS-CoV-2; adjunctive therapy; immune-enhancing agents; antimycobacterial compounds; host-directed therapies; pathogenesis; modulation of host immune responses
(This special issue belongs to the Section Molecular Microbiology)
Innovative Molecular Strategies in Biomedicine
edited by
submission deadline 20 Mar 2026 | 4 articles | Viewed by 16920 | Submission Open
Keywords: bioprinting; organ-on-chip; venom-derived therapeutics; 3D in vitro models; skeletal muscle models; toxic peptides; peptide expression; nanoparticles in medicine; protein and peptide drug delivery; peptide-based biomaterials; self-assembled hydrogels; molecular therapeutics; nanotechnology in drug delivery; regenerative medicine; tissue engineering
(This special issue belongs to the Section Materials Science)
Hormone Replacement Therapy submission deadline 20 Mar 2026 | 2 articles | Viewed by 15826 | Submission Open
Keywords: hormone replacement therapy; molecular insights; endocrine signaling; precision medicine; gene expression; epigenetics; non-coding RNAs; personalized regimens
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Latest Advances in Reproduction Biology
edited by Clara Malo
submission deadline 20 Mar 2026 | 9 articles | Viewed by 15751 | Submission Open
Keywords: gamete formation; fertilization; embryo formation; embryo implantation; fertility; infertility; molecular markers; reproductive biology
(This special issue belongs to the Section Molecular Biology)
Molecular Research on Diabetes and Obesity
edited by
submission deadline 20 Mar 2026 | 5 articles | Viewed by 15731 | Submission Open
Keywords: obesity; diabetes; hypothalamus; insulin resistance; glucose homeostasis; lipid metabolism; adipose tissue; cardiovascular tissue
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Mitochondria: Transport of Metabolites Across Biological Membranes submission deadline 20 Mar 2026 | 3 articles | Viewed by 15475 | Submission Open
Keywords: mitochondria; mitochondrial transporters; mitochondrial metabolism; transport proteins; translocases carriers; mitochondrial carriers; mitochondrial diseases; mitochondrial permeability; apoptosis
(This special issue belongs to the Section Molecular Biology)
Lipid Metabolism in Human Health and Diseases
edited by
submission deadline 20 Mar 2026 | 4 articles | Viewed by 15234 | Submission Open
Keywords: lipids; fatty acids; lipid metabolism; metabolic disorders; cardiovascular diseases; neurodegenerative diseases; cancers
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Advances in Pathogenesis, Molecular Mechanisms, and Therapeutic Strategies for Neurodegenerative Diseases
edited by
submission deadline 20 Mar 2026 | 6 articles | Viewed by 15067 | Submission Open
Keywords: neurodegeneration; molecular pathways; protein aggregation; gene therapy; neuroprotection
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Diabetes and Metabolic Dysfunction submission deadline 20 Mar 2026 | 6 articles | Viewed by 14963 | Submission Open
Keywords: diabetes; metabolic dysfunction; glucose metabolism; metabolic disturbances; complications
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Heart Failure: From Molecular Basis to Therapeutic Strategies
edited by
submission deadline 20 Mar 2026 | 6 articles | Viewed by 14193 | Submission Open
Keywords: heart failure; cardiac metabolism; mitochondria; inflammatory pathway; neurohormonal system; therapeutical strategies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cellular Plasticity and EMT in Cancer and Fibrotic Diseases submission deadline 20 Mar 2026 | 5 articles | Viewed by 14108 | Submission Open
Keywords: fibrosis; epithelial– mesenchymal transition; epithelial– mesenchymal plasticity; cancer; fibrotic diseases; inflammation; metastases
(This special issue belongs to the Section Molecular Biology)
Unraveling the Molecular Mechanisms of Neurodegeneration
edited by
submission deadline 20 Mar 2026 | 5 articles | Viewed by 14012 | Submission Open
Keywords: protein accumulation; mitochondria; genetic and epigenetic alterations; oxidative stress; apoptosis; autophagy
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Basis of Pancreatic Secretion and Metabolism
edited by
submission deadline 20 Mar 2026 | 5 articles | Viewed by 13981 | Submission Open
Keywords: exocrine of the pancreas; endocrine of the pancreas; acute pancreatitis; chronic pancreatitis; cystic fibrosis; pancreatic metabolic hormones; pancreatic metabolic disease; mechanism of pancreatic bicarbonate secretion; the sodium bicarbonate cotransporter (NBC); cystic fibrosis transmembrane conductance regulator (CFTR); regulators of the ion channels and ion transporters involved in secretion
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Mechanism and Treatment of Diabetes Mellitus and Its Complications
edited by
submission deadline 20 Mar 2026 | 6 articles | Viewed by 13873 | Submission Open
Keywords: MODY; LADA; diabetes late complications; molecular mechanisms; omics; polyneuropathy; microvascular disease; macrovascular disease; liver disease
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Zebrafish as a Model in Human Disease: 3rd Edition submission deadline 20 Mar 2026 | 5 articles | Viewed by 13796 | Submission Open
Keywords: zebrafish; CRISPR/Cas9; transgenic lines; biosensors; endothelial cells; extracellular matrix; genetic mutant for human disease modeling; xenografts
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
CNS Injuries: 2nd Edition
edited by
submission deadline 20 Mar 2026 | 1 articles | Viewed by 13771 | Submission Open
Keywords: stroke; TBI; brain edema; SCI; spinal cord edema; neuroinflammation; neurodegeneration
(This special issue belongs to the Section Molecular Neurobiology)
Advanced Molecular Research on the Diagnosis and Treatment of Chronic Liver Diseases
edited by
submission deadline 20 Mar 2026 | 3 articles | Viewed by 13697 | Submission Open
Keywords: biomarker; genomic research; epigenomic research; molecular mechanisms; viral hepatitis; alcoholic-related liver disease; non-alcoholic fatty liver disease; autoimmune liver diseases; liver cirrhosis; hepatocellular carcinoma
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Therapies for Metabolic-Associated Fatty Liver Diseases
edited by Yi-Ming Arthur Chen
submission deadline 20 Mar 2026 | 3 articles | Viewed by 13514 | Submission Open
Keywords: metabolic-associated fatty liver disease; MAFLD; metabolic dysfunction-associated steatohepatitis; MASH; molecular mechanism; genetic polymorphism; individualized medicine; prevention; new drug development; health supplements; diagnosis; epidemiology; lifestyle
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Toll-Like Receptors (TLRs) in Infection and Inflammation: Third Edition
edited by and
submission deadline 20 Mar 2026 | 8 articles | Viewed by 13456 | Submission Open
Keywords: toll-like receptors (TLR); pathogen associated molecular patterns (PAMPs); sepsis; bacterial infections; viral infections; Myd88; TRIF; NF-kappaB; COVID-19; coagulopathies
(This special issue belongs to the Section Molecular Immunology)
The Role of SARS-CoV-2 in Immunomodulation—Post-Pandemic Reflection on the Role of Viruses in Human Immunology submission deadline 20 Mar 2026 | 8 articles | Viewed by 13154 | Submission Open
Keywords: SARS-CoV-2; COVID-19; immunomodulation; T cells; B cells; dendritic cells; monocytes; cytokines
(This special issue belongs to the Section Molecular Immunology)
New Advances in Medical Microbiology
edited by
submission deadline 20 Mar 2026 | 4 articles | Viewed by 12967 | Submission Open
Keywords: clinical microbiology; clinical virology; SARS-CoV-2; HPV; sexually transmitted infections; respiratory viruses; emerging pathogens; opportunistic infections
(This special issue belongs to the Section Molecular Microbiology)
Molecular Genetics in Ovarian Cancer
edited by
submission deadline 20 Mar 2026 | 7 articles | Viewed by 12873 | Submission Open
Keywords: chemotherapy resistance; differential gene expression; genomic structural variation; ovarian cancer mutations; ovarian cancer metastasis; ovarian cancer treatment; novel molecular targets
(This special issue belongs to the Section Molecular Genetics and Genomics)
Inflammatory Bowel Disease and Microbiome
edited by Abigail Raffner Basson
submission deadline 20 Mar 2026 | 4 articles | Viewed by 12677 | Submission Open
Keywords: inflammatory bowel disease; Crohn’ s disease; ulcerative colitis; gut microbiota; diet; treatment; pathogenesis; biomarker
(This special issue belongs to the Section Molecular Microbiology)
Exploring Biological Mechanisms and Therapeutic Strategies for Substance Use Disorders
edited by Thomas Paparrigopoulos
submission deadline 20 Mar 2026 | 3 articles | Viewed by 12621 | Submission Open
Keywords: addiction; alcohol use disorder; opioid use disorder; substance use disorders; physical exercise; physical activity; molecular mechanisms; neuroendocrine system
(This special issue belongs to the Section Molecular Neurobiology)
Toxicity of Metals, Metal-Based Drugs, and Microplastics submission deadline 20 Mar 2026 | 5 articles | Viewed by 12423 | Submission Open
Keywords: metal toxicity and pollution; microplastic toxicity and pollution; metal and microplastic bioaccumulation; metal-based drugs; protein metalation; human health problems; diseases; in vitro/in vivo studies; human studies
(This special issue belongs to the Section Molecular Toxicology)
Signaling Pathways and Novel Therapies in Heart Disease
edited by
submission deadline 20 Mar 2026 | 4 articles | Viewed by 11835 | Submission Open
Keywords: heart failure; arrhythmias; ischemic heart disease; myocardial regeneration; inflammation; gene- or cell-based therapy; precision medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Vegetable Genetics and Genomics, 3rd Edition
edited by and
submission deadline 20 Mar 2026 | 7 articles | Viewed by 11697 | Submission Open
Keywords: major vegetable crops; genome; variome; genotyping; GWAS; QTL mapping; functional genome; metabolome; breeding target characters; genetic mechanism; functional genes
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Research Progress of Skin and Skin Diseases: 2nd Edition
edited by
submission deadline 20 Mar 2026 | 5 articles | Viewed by 11379 | Submission Open
Keywords: atopic dermatitis; psoriasis; alopecia; vitiligo; acne; skin cancer; JAK-STAT; inflammatory skin disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Density Functional Theory and Related Methods for Molecular Computational Chemistry
edited by Paolo Umari
submission deadline 20 Mar 2026 | 4 articles | Viewed by 11309 | Submission Open
Keywords: density functional theory; quantum chemistry; algorithms; quantum computing; high-performance computing; machine learning; many-body perturbations theory; quantum Monte Carlo
(This special issue belongs to the Section Molecular Informatics)
Plant Resilience: Insights into Abiotic and Biotic Stress Adaptations
edited by
submission deadline 20 Mar 2026 | 6 articles | Viewed by 11195 | Submission Open
Keywords: plants; basis of life; environmental stress; complex responses; molecular mechanisms; abiotic and biotic stress adaptations
(This special issue belongs to the Section Molecular Plant Sciences)
Gynecologic Diseases: From Molecular Basis to Therapy
edited by Domenico Baldini
submission deadline 20 Mar 2026 | 2 articles | Viewed by 11190 | Submission Open
Keywords: infertility; sterility; gynecologic desease; genetic; IVF; gynecologic therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Pathophysiology and New Therapies of Alopecia
edited by Jong-Hyuk Sung
submission deadline 20 Mar 2026 | 2 articles | Viewed by 11108 | Submission Open
Keywords: alopecia; pathophysiology; novel pharmacological treatments; regenerative medicines; gene therapy; cell therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Therapies and Strategies in the Treatment of Neurodegenerative Diseases submission deadline 20 Mar 2026 | 3 articles | Viewed by 11104 | Submission Open
Keywords: neurodegenerative diseases; Alzheimer’ s disease; Parkinson’ s disease; Huntington’ s disease; aging; memory; dementia; motor dysfunction
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Advances in Autoimmune Diseases submission deadline 20 Mar 2026 | 5 articles | Viewed by 10975 | Submission Open
Keywords: autoimmunity; autoimmune mechanisms; molecular pathogenesis; immune signalling pathways; cytokine regulation; epigenetics in autoimmunity; molecular biomarkers; gene expression profiling; regulatory T cells; immunogenetics; molecular therapeutics; signal transduction; immunometabolism; microRNA in autoimmunity
(This special issue belongs to the Section Molecular Immunology)
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