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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cardiovascular Calcification: New Insights into Degenerative Mechanisms and Therapeutic Perspectives

edited by Antonella Bonetti

submission deadline 10 Feb 2026 | Viewed by 136 | Submission Open

Keywords: ectopic calcification; tissue calcinosis; cardiovascular calcification; anti-calcific effect; calcification reduction; anti-calcific model

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms Driving Liver Disease: From Cellular Stress to Therapeutic Targets

edited by

Konstantinos Arvanitakis

submission deadline 18 Feb 2026 | Viewed by 1853 | Submission Open

Keywords: liver disease; molecular mechanisms; hepatocellular stress; fibrosis; non-coding RNAs; metabolism; MASLD; liver fibrosis; hepatocellular carcinoma; therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genetic and Molecular Markers in Prostate Cancer

edited by Thaidy Moreno-Rodriguez

submission deadline 19 Feb 2026 | Viewed by 111 | Submission Open

Keywords: prostate cancer; genetic markers; androgen receptor signaling; molecular biomarkers; therapy resistance mechanisms; liquid biopsy; precision oncology

(This special issue belongs to the Section Molecular Oncology)

Molecular and Cellular Mechanisms of Spinal Cord Injury and Repair

edited by Victoria Moreno-Manzano

submission deadline 20 Feb 2026 | 10 articles | Viewed by 31130 | Submission Open

Keywords: spinal cord injury; molecular changes; neuronal degeneration; circuit regeneration; transcriptomics; cell imaging; single-cell analysis; cell communication; behavior; functional outputs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Dysbiosis in Chronic Diseases

edited by

Ana Isabel Beltrán-Velasco

submission deadline 20 Feb 2026 | 5 articles | Viewed by 30622 | Submission Open

Keywords: microbiota; dysbiosis; microbiota– gut– brain axis; microorganism; metabolites; clinical practices; prebiotics; probiotics

(This special issue belongs to the Section Molecular Microbiology)

Probiotics in Health and Disease

edited by

Jasna Novak

submission deadline 20 Feb 2026 | 3 articles | Viewed by 27123 | Submission Open

Keywords: probiotic; microbiota; quality; dysbiosis

(This special issue belongs to the Section Molecular Microbiology)

Chimeric Antigen Receptors Against Cancers and Autoimmune Diseases

edited by

Niels Schaft

submission deadline 20 Feb 2026 | 9 articles | Viewed by 26114 | Submission Open

Keywords: chimeric antigen receptor (CAR); cancer; autoimmune disease; solid tumor; effector cell; CAR format; CAR transfer; tumor microenvironment; targeted antigen

(This special issue belongs to the Section Molecular Immunology)

Tumor Microenvironments: Molecular Mechanisms and Signaling Pathways Involved in Metastatic Progression

edited by Sonam Mittal

submission deadline 20 Feb 2026 | 8 articles | Viewed by 25877 | Submission Open

Keywords: tumor microenvironment; metastasis; metabolism; cytokines; cancer-derived extracellular vesicles; metabolic reprogramming

(This special issue belongs to the Section Molecular Oncology)

Plant Metabolomics: Uncovering the Hidden World of Plant Secondary Metabolites

edited by

Jen-Tsung Chen

submission deadline 20 Feb 2026 | 12 articles | Viewed by 25290 | Submission Open

Keywords: metabolomics; secondary metabolites; plant biochemistry; mass spectrometry; NMR spectroscopy; plant signaling pathways; natural products; chemical ecology; metabolic profiling; phytochemicals; medicinal plants; herbal medicines

(This special issue belongs to the Section Molecular Plant Sciences)

Advanced Research in Prediction of Protein Structure and Function, 2nd Edition

edited by

Shuai Cheng Li

submission deadline 20 Feb 2026 | 5 articles | Viewed by 24957 | Submission Open

Keywords: prediction; protein structure; protein function; protein complex; machine learning; deep learning; multiple sequence alignment

(This special issue belongs to the Section Molecular Informatics)

Advancements in Cancer Biomarkers

edited by

Christos Mikropoulos

submission deadline 20 Feb 2026 | 11 articles | Viewed by 22422 | Submission Open

Keywords: biomarkers; ctDNA; mircroRNA; proteomics; gene methylation; TIL; transcriptomics; micro RNA; tumor microenvironment; gene methylation; proteomics

(This special issue belongs to the Section Molecular Oncology)

Autoimmune Diseases: From Pathogenesis to Treatment and Prognostic Markers

edited by Alessandra Bettiol

submission deadline 20 Feb 2026 | 10 articles | Viewed by 22086 | Submission Open

Keywords: autoimmune diseases; inflammation; immunity; pathogenesis; immunosuppressants; biologics; biomarkers

(This special issue belongs to the Section Molecular Immunology)

Molecular Insights in Steroid Biosynthesis and Metabolism

edited by Amanda C. Swart

submission deadline 20 Feb 2026 | 6 articles | Viewed by 21344 | Submission Open

Keywords: steroid biosynthesis; steroid metabolism; aldo-keto reductase (AKR); cytochrome P450; steroid reductase (SRD5A); 17β -hydroxysteroid dehydrogenases (17β HSD); 11β -hydroxysteroid dehydrogenase (11β HSD); reproduction and sexual differentiation; endogenous cardiac steroids; anabolic steroids; prostate cancer; gut microbiome; immune system; inflammation; cardiovascular disease (CVD); kidney function; hormone replacement therapy (HRT)

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Mechanisms of Alzheimer’s Disease

edited by Sudip Dhakal

submission deadline 20 Feb 2026 | 10 articles | Viewed by 20507 | Submission Open

Keywords: Alzheimer’ s disease; amyloid beta; tauopathy; autophagy; stress response; mitochondrial dysfunction; cognitive decline; biomarkers; disease models

(This special issue belongs to the Section Molecular Neurobiology)

Recent Molecular Trends and Prospects in Kidney Diseases

edited by

Federico Greco

and

Carlo A. Mallio

submission deadline 20 Feb 2026 | 6 articles | Viewed by 17759 | Submission Open

Keywords: nephrology; molecular biology; renal disease; genomic research; kidney molecular pathways; biomarkers in renal disease; transcriptomics of renal dysfunction; omics approaches in kidney research; molecular diagnostics for renal diseases; pharmacogenomics in kidney treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Anti-Cancer, Anti-Inflammatory, and Antioxidation Active Substances: 3rd Edition

edited by

Ming-Ju Hsieh

submission deadline 20 Feb 2026 | 13 articles | Viewed by 17620 | Submission Open

Keywords: anti-inflammatory; anti-cancer; antioxidants; antiproliferative; antiviral; antibacterial; antibodies; molecular mechanism; chemoresistance; molecular biology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Therapeutic Strategies in Allergic Diseases

edited by

Sylwia Smolińska

submission deadline 20 Feb 2026 | 6 articles | Viewed by 17347 | Submission Open

Keywords: molecular allergy diagnostics; allergen identification; allergen neutralization/elimination strategies; allergen immunotherapy; impact of pollution on allergies; new allergens; cross-reactivity; unexpected allergen sources

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Products from Plants: Association with Human Health and Therapeutic Benefits

edited by

Andrey Marchev

and

Nikolina Mihaylova

submission deadline 20 Feb 2026 | 7 articles | Viewed by 16708 | Submission Open

Keywords: botanical products; phytochemicals; bio/pharmacological compounds; cellular and molecular targets; molecular and physiological mechanism; human health; disease prevention and treatment; inflammatory diseases; age-related disorders; chronic and (auto)immune diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Postharvest Biology and Molecular Research of Fruits

edited by

Xiangbin Xu

submission deadline 20 Feb 2026 | 6 articles | Viewed by 16097 | Submission Open

Keywords: postharvest biology; fruit; storage technologies; molecular mechanisms; senescence; chilling injury; browning; nutrition; disease; toxin

(This special issue belongs to the Section Molecular Plant Sciences)

Inflammatory Bowel Diseases: Molecular Mechanism and Therapeutics

edited by

Woon Kyu Lee

submission deadline 20 Feb 2026 | 4 articles | Viewed by 16050 | Submission Open

Keywords: inflammatory bowel disease; IBD; ulcerative colitis; Crohn’ s disease; animal models

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Bioactive Nutrients Promoting Health Through Gut Microbiota: 3rd Edition

edited by

Baojun Xu

and

Matteo Bordiga

submission deadline 20 Feb 2026 | 3 articles | Viewed by 15764 | Submission Open

Keywords: phytochemicals; complex carbohydrates; gut microbiota; prebiotics; probiotics; inflammation; molecular mechanisms; human health

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Organoids and Organs-on-Chip for Medical Research

edited by

Miguel Hueso

submission deadline 20 Feb 2026 | 4 articles | Viewed by 15640 | Submission Open

Keywords: organoids; organs-on-chip; tissue engineering; disease modeling; biomarkers; molecular pathways; nanotechnology; preclinical models; artificial organs; artificial intelligence; personalized medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Omics: Sensing, Signaling, Regulation and Homeostasis

edited by

Margherita-Gabriella De Biasi

submission deadline 20 Feb 2026 | 6 articles | Viewed by 15158 | Submission Open

Keywords: plant homeostasis; omics; transcriptomics; metabolomics; proteomics; genomics; ionomics; environmental stress; regulatory mechanisms; metabolic processes; systems biology

(This special issue belongs to the Section Molecular Plant Sciences)

Mitochondrial Function in Health and Diseases

edited by Sally P. Wheatley

submission deadline 20 Feb 2026 | 5 articles | Viewed by 14622 | Submission Open

Keywords: mitochondria; metabolism; lipid; ATP; respiration; calcium; iron; inheritance; apoptosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genomics and Proteomics of Cancer

edited by

Raffaella Lazzarini

submission deadline 20 Feb 2026 | 6 articles | Viewed by 13949 | Submission Open

Keywords: cancer; carcinogenesis; genetic; epigenetic modification; protein expression; protein phosphorylation; proteomic

(This special issue belongs to the Section Molecular Oncology)

Antioxidants as Regulators of Metabolic Pathways: Potential and Therapeutic Strategies

edited by Halina Tkaczenko and

Natalia Kurhaluk

submission deadline 20 Feb 2026 | 2 articles | Viewed by 13655 | Submission Open

Keywords: antioxidants; metabolic pathways; oxidative stress; cellular homeostasis; redox signaling; energy metabolism; lipid metabolism; therapeutic strategies; chronic diseases

(This special issue belongs to the Section Molecular Biology)

Neurodegenerative Diseases: From Molecular Mechanisms to Pathophysiology (Second Edition)

edited by

Anne Vejux

submission deadline 20 Feb 2026 | 2 articles | Viewed by 13013 | Submission Open

Keywords: neurodegenerative diseases; molecular mechanisms; physiology; cell death; autophagy; oxidative stress; inflammation; genetic factors; diet; cognitive functions; exosomes; blood– brain barrier; immunity

(This special issue belongs to the Section Molecular Neurobiology)

Cheminformatics in Drug Discovery and Green Synthesis

edited by

Ana Amić

submission deadline 20 Feb 2026 | 7 articles | Viewed by 12851 | Submission Open

Keywords: cheminformatics; drug discovery; databases; in silico methods; green chemistry

(This special issue belongs to the Section Molecular Informatics)

New Insights into Aquaporins: 2nd Edition

edited by

Graça Soveral

and

Inês Vieira Da Silva

submission deadline 20 Feb 2026 | 5 articles | Viewed by 12720 | Submission Open

Keywords: aquaporin; membrane channel; regulation; pathophysiology; drug target

(This special issue belongs to the Section Molecular Biology)

Drug-Induced Modulation and Immunotherapy of Leukemia

edited by Helga Maria Schmetzer

submission deadline 20 Feb 2026 | 4 articles | Viewed by 12403 | Submission Open

Keywords: leukemia; dendritic cells; immunotherapy; immune modulation

(This special issue belongs to the Section Molecular Immunology)

New Insights in Antibody Therapy

edited by

Loredana Frasca

submission deadline 20 Feb 2026 | 4 articles | Viewed by 12386 | Submission Open

Keywords: biological therapy; antibody therapy; non-communicable diseases; infectious diseases; chronic disease

(This special issue belongs to the Section Molecular Immunology)

New Molecular Mechanisms in the Development of Brain Tumors and Metastases

edited by

Raffaele Addeo

Michele Caraglia

and

Marianna Abate

submission deadline 20 Feb 2026 | 5 articles | Viewed by 12001 | Submission Open

Keywords: brain tumor; brain metastasis; blood– brain barrier; target therapy; cancer molecular biology; brain tumor microenvironment; molecular biomarkers

(This special issue belongs to the Section Molecular Oncology)

Chronic Rhinosinusitis: Aetiology, Immunology and Treatment, 3rd Edition

edited by

Seung-Heon Shin

submission deadline 20 Feb 2026 | 3 articles | Viewed by 11564 | Submission Open

Keywords: innate immunity; adaptive immunity; protease; cytokine; inflammation; epithelial cells; fibroblasts; eosinophils; lymphocytes; biologics

(This special issue belongs to the Section Molecular Immunology)

Machine Learning and Bioinformatics in Human Health and Disease: 2nd Edition

edited by

Andreas Leiherer

submission deadline 20 Feb 2026 | 6 articles | Viewed by 11120 | Submission Open

Keywords: machine learning; bioinformatics; deep learning; multi-omics approaches; genetic risk factors; drug interactions; precision medicine; neurodegenerative diseases; disease diagnosis; epidemic prediction

(This special issue belongs to the Section Molecular Informatics)

Role of MicroRNAs in Human Diseases: 2nd Edition

edited by

Lorenzo F. Sempere

submission deadline 20 Feb 2026 | 8 articles | Viewed by 10866 | Submission Open

Keywords: microRNAs; miRNAs; miRs; preclinical models; target interaction; regulatory networks; oncology; cancer biology; cardiovascular disease; neurodegenerative conditions; diagnostic applications; therapeutic development and clinical trials

(This special issue belongs to the Section Molecular Genetics and Genomics)

Heterocyclic Compounds: Synthesis, Design, and Biological Activity

edited by

Josef Jampilek

submission deadline 20 Feb 2026 | 9 articles | Viewed by 10848 | Submission Open

Keywords: heterocycles; bioactive molecules and materials; pharmacophore; design; targeting; computer studies; synthesis and analysis; natural compounds; carbohydrates; physicochemical properties; biological screening

(This special issue belongs to the Section Biochemistry)

The Biochemistry, Molecular and Cell Biology Beyond Flowers

edited by

Isabel Marques

submission deadline 20 Feb 2026 | 3 articles | Viewed by 10834 | Submission Open

Keywords: flowers; homeotic genes; MADSBox; molecular expression; pollination; stress; transcription factors

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Insulin Resistance Research: 2nd Edition

edited by

Byungyong Ahn

submission deadline 20 Feb 2026 | 2 articles | Viewed by 10831 | Submission Open

Keywords: insulin resistance; obesity; metabolic diseases; diabetes; metabolism; inflammation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Immunotherapy Versus Immune Modulation of Leukemia

edited by Helga Maria Schmetzer

submission deadline 20 Feb 2026 | 6 articles | Viewed by 10790 | Submission Open

Keywords: leukemia; immunotherapy; immune modulation; antileukemic; drug resistance

(This special issue belongs to the Section Molecular Oncology)

Genes and Human Diseases: 3rd Edition

edited by

Mikhail I. Churnosov

submission deadline 20 Feb 2026 | 8 articles | Viewed by 10325 | Submission Open

Keywords: genes; human diseases; genetic-epidemiological studies; genetic factors; susceptibility

(This special issue belongs to the Section Molecular Genetics and Genomics)

Health-Promoting Effects of Medicinal and Edible Plants and Their Molecular Mechanism

edited by

Baojun Xu

and

Matteo Bordiga

submission deadline 20 Feb 2026 | 5 articles | Viewed by 9890 | Submission Open

Keywords: medicinal plants; edible plants; health-promoting effect; molecular mechanism; phytochemicals; diseases; curing targets; signaling pathway

(This special issue belongs to the Section Bioactives and Nutraceuticals)

In Silico Methods of Assessing the Therapeutic Potential of Natural Substances

edited by

Radosław Zajdel

and

Anna Merecz-Sadowska

submission deadline 20 Feb 2026 | 5 articles | Viewed by 9711 | Submission Open

Keywords: in silico screening; natural products; molecular docking; computational drug discovery; QSAR modeling; molecular dynamics simulations; natural compounds; drug-target interactions; virtual screening; structure-activity relationships; computational chemistry; cheminformatics; ADMET prediction; bioinformatics; phytochemicals; machine learning in drug discovery; computer-aided drug design; pharmacophore modeling; natural therapeutics; computational pharmacology

(This special issue belongs to the Section Molecular Informatics)

Molecular Studies in Aging, 2nd Edition

edited by

Rosa Mancinelli

submission deadline 20 Feb 2026 | 4 articles | Viewed by 9647 | Submission Open

Keywords: senescence; active aging; sarcopenia; osteoporosis; oxidative stress; brain aging; cardiovascular aging

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in the Genetics, Epidemiology and Management of Myopathies

edited by

Efthimios Dardiotis

and

Vasileios Siokas

submission deadline 20 Feb 2026 | 2 articles | Viewed by 8912 | Submission Open

Keywords: myopathies; muscle disorders; muscle weakness; muscle pain; myalgia

(This special issue belongs to the Section Molecular Biology)

Endothelial Dysfunction and Its Related Cardiometabolic Disorders: From Mechanisms to Targeted Therapies

edited by

Nacci Carmela

submission deadline 20 Feb 2026 | 3 articles | Viewed by 8825 | Submission Open

Keywords: endothelial dysfunction; endothelial activation; endothelial nitric oxide synthase; cardiometabolic disease; vascular inflammation; chemokines; adipocytokines; atherosclerosis; diabetes; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Cytokines and Autoantibodies Against Cytokines in Health and Disease

edited by

Juan Bautista De Sanctis

submission deadline 20 Feb 2026 | 1 articles | Viewed by 8714 | Submission Open

Keywords: cytokine; autoantibodies; cytokine therapy; cytokine inhibition

(This special issue belongs to the Section Molecular Immunology)

MicroRNAs as Biomarkers and Therapeutic Targets in Human Diseases

edited by Elena V. Bichenkova

submission deadline 20 Feb 2026 | 6 articles | Viewed by 8630 | Submission Open

Keywords: microRNA biomarkers; diagnostic profiling; expression patterns; miRNA therapeutics; antimiRs; miRNA mimics; hybridisation; sequence-specificity; miRNA knockdown

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Bioactive Compounds in Health and Disease

edited by

Luís Silva

submission deadline 20 Feb 2026 | 3 articles | Viewed by 8515 | Submission Open

Keywords: phenolic compounds; bioactive compounds; health-promoting properties; human diseases; chronic diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Biocatalysis of Compounds for Pharmaceutical and Biomedical Applications

edited by

Tomasz Siodmiak

submission deadline 20 Feb 2026 | 3 articles | Viewed by 8370 | Submission Open

Keywords: biocatalysis; biomedical application; biotechnology; compounds for pharmacy; compounds for biomedicine; enantiomers; enzyme activity; enzyme engineering; enzyme immobilization; kinetic resolution; pharmaceutical application; supports materials

(This special issue belongs to the Section Molecular Pharmacology)

Progression of Multiple Sclerosis: Environmental Factors, Genetics, Therapeutics and Immunopathogenesis

edited by Alberto Gajofatto

submission deadline 20 Feb 2026 | 4 articles | Viewed by 8211 | Submission Open

Keywords: multiple sclerosis; disability progression; neurodegeneration; pathogenesis; immunology; risk factor; environment; genetics; treatment

(This special issue belongs to the Section Molecular Neurobiology)

Displaying special issue 751-800 on page 16 of 67.

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