Antioxidants as Regulators of Metabolic Pathways: Potential and Therapeutic Strategies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 20 August 2025 | Viewed by 4517
Special Issue Editors
Interests: oxidative stress; antioxidant defence; biochemical changes; mitochondrial respiration; hemolysis; melatonin; L-arginine; krebs cycle intermediates
Special Issues, Collections and Topics in MDPI journals
Interests: pollution-induced oxidative damage; toxicity and oxidative injury; heavy metals; ecotoxicology; ecophysiology; nitric oxide; environmental stressors; environmental stressors in human and animal health; antioxidant defense in pathology; redox imbalance in human and animal diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Metabolic pathways are the intricate networks of biochemical reactions that sustain life by converting nutrients into energy and essential biomolecules. The proper functioning of these pathways is essential for maintaining cellular homeostasis and overall health. However, metabolic processes are also a source of reactive oxygen species (ROS) which, when present in excess, can lead to oxidative stress. Oxidative stress has been implicated in the pathogenesis of many chronic diseases, including cancer, neurodegenerative disorders, cardiovascular disease, and diabetes. As a result, the regulation of oxidative stress by antioxidants has become an important area of research.
The study of antioxidants as modulators of metabolic pathways is not only fundamental to understanding disease mechanisms but also has significant therapeutic potential. Targeting oxidative stress with antioxidant therapies offers a promising approach to managing and potentially preventing metabolic disorders and their complications. In addition, advances in our understanding of how specific antioxidants interact with metabolic pathways may lead to the development of more effective and targeted treatments.
This Special Issue, entitled “Antioxidants as Regulators of Metabolic Pathways: Potential and Therapeutic Strategies” aims to highlight the latest scientific developments in this rapidly evolving field. It will cover a wide range of research topics, from the molecular mechanisms underlying antioxidant action in metabolic regulation to preclinical and clinical studies exploring their therapeutic applications. By bringing together cutting-edge research, this Special Issue aims to provide a comprehensive overview of the current state and future directions in the use of antioxidants to modulate metabolic pathways, ultimately contributing to the development of novel therapeutic strategies for a wide range of diseases.
In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:
- Mechanisms of antioxidant action in metabolic pathways.
- Role of antioxidants in regulating glucose metabolism.
- Impact of antioxidants on lipid metabolism and cardiovascular health.
- Antioxidants in energy metabolism.
- Antioxidants and insulin sensitivity.
- Therapeutic potential of antioxidants in metabolic disorders.
- Dietary antioxidants and their impact on metabolic pathways.
- Redox regulation of metabolic enzymes.
- Antioxidants and mitochondrial function.
- Synergistic effects of antioxidants and metabolic pathway modulators.
- Molecular mechanisms of antioxidant-induced metabolic reprogramming.
- Comparative studies of antioxidants and metabolic pathways across species.
Dr. Halina Tkaczenko
Prof. Dr. Natalia Kurhaluk
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- antioxidants
- metabolic pathways
- oxidative stress
- cellular homeostasis
- redox signaling
- energy metabolism
- lipid metabolism
- therapeutic strategies
- chronic diseases
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