International Journal of Molecular Sciences

Cellular Pathways and Cytokine Networks in Tuberous Sclerosis: Mechanisms and Therapeutic Targets

edited by Uchenna John Unachukwu

submission deadline 30 Sep 2026 | Viewed by 499 | Submission Open

Keywords: mTOR signaling dysregulation; neurocristopathy; cytokine crosstalk; TSC1/TSC2 complex; epigenetic modifiers; metabolic reprogramming; molecular biomarkers; spatial transcriptomics

(This special issue belongs to the Section Molecular Biology)

Omega-6 and Omega-3 Fatty Acid Imbalance: Roles in Human Health and Pathogenesis of Diseases

edited by

Jing X. Kang

submission deadline 30 Sep 2026 | Viewed by 490 | Submission Open

Keywords: omega-6/omega-3 ratio; omega-6 fatty acids; omega-3 fatty acids; omega-6/omega-3 imbalance; lipid metabolism; inflammation; chronic diseases; cardiovascular disease; cancer; metabolic syndrome; neurodegenerative diseases; autoimmune diseases; nutritional interventions; polyunsaturated fatty acids (PUFAs); molecular mechanisms; disease pathogenesis; disease management; health promotion

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Computational Intelligence and Algorithmic Advances in Genome Editing

edited by

Anderson Rodrigues dos Santos

submission deadline 30 Sep 2026 | 1 articles | Viewed by 483 | Submission Open

Keywords: CRISPR/cas systems; genome engineering; bioinformatics; gRNA design; off-target prediction; machine learning; structural modeling; molecular informatics; DNA repair pathways

(This special issue belongs to the Section Molecular Informatics)

Patient-Derived iPSC Models in Chronic Disease Research

edited by

Valentina Parra

submission deadline 30 Sep 2026 | Viewed by 456 | Submission Open

Keywords: induced pluripotent stem cells; patient-derived iPSCs; chronic diseases; disease modeling; molecular mechanisms; stem cell differentiation; gene editing; organoids; personalized medicine; multi-omics

(This special issue belongs to the Section Molecular Biology)

Research on Immune Mechanisms in Kidney Disease

edited by Niels Olsen Saraiva Câmara

submission deadline 30 Sep 2026 | Viewed by 455 | Submission Open

Keywords: kidney disease; molecular sensors; kidney metabolism; immunity; AKI to CKD transition

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

DNA Damage, DNA Repair, and Cancer, 3rd Edition

edited by

Kazuhiko Kuwahara

submission deadline 30 Sep 2026 | 1 articles | Viewed by 442 | Submission Open

Keywords: DNA-damage response; DNA repair molecules; genome instability; cellular senescence; animal models; DNA damage; DNA repair and cancer

(This special issue belongs to the Section Molecular Oncology)

Novel Molecular Pathways and Therapeutic Strategies in Atherosclerotic Cardiovascular Disease

edited by

Elisabeta Badila

and Catalin Adrian Buzea

submission deadline 30 Sep 2026 | Viewed by 438 | Submission Open

Keywords: atherogenesis; vascular inflammation; immune modulation; lipid metabolism; clonal hematopoiesis (CHIP); endothelial dysfunction; plaque instability; epigenetic regulation; molecular signaling pathways; precision cardiovascular medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Molecular Plant Physiology and Genomic Breeding of Cereals

edited by

Abdullah Shalmani

submission deadline 30 Sep 2026 | Viewed by 437 | Submission Open

Keywords: cereals; molecular physiology; genomic breeding; stress tolerance; functional genomics; genome editing; QTL mapping; multiomics; genotype–environment interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Fungi: From Molecular Biology to Biotechnology Applications

edited by

Ljiljana Janjušević

and

Ljiljana Šašić Zorić

submission deadline 30 Sep 2026 | 1 articles | Viewed by 428 | Submission Open

Keywords: fungi; fungal secondary metabolome; fungal bioactive compounds; edible and medicinal fungi; nutraceuticals; functional foods; fungal biotechnology; metabolomics; fungal natural products; fungal metabolism

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms of Gut Microbiota-Mediated Drug Efficacy and Toxicity

edited by

Jin-Yi Wan

submission deadline 30 Sep 2026 | Viewed by 427 | Submission Open

Keywords: gut microbiota; pharmacomicrobiomics; drug metabolism; drug toxicity; drug efficacy; xenobiotic biotransformation; precision medicine; cancer immunotherapy; fecal microbiota transplantation; host–microbiome interactions

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Metabolomics in Cancer: From Biomarkers to Therapeutic Insights

edited by Filipa Amaro,

Paula Guedes de Pinho

and

Joana Pinto

submission deadline 30 Sep 2026 | Viewed by 414 | Submission Open

Keywords: cancer metabolomics; metabolic reprogramming; biomarker discovery; precision oncology; machine learning; clinical data integration; translational cancer research

(This special issue belongs to the Section Molecular Oncology)

Genome-Wide Association Studies of Complex Diseases and Related Endophenotypes and Biomarkers

edited by M. Ilyas Kamboh

submission deadline 30 Sep 2026 | Viewed by 411 | Submission Open

Keywords: genome-wide association studies; complex diseases; endophenotypes; biomarkers; rare variants; copy number variants; diverse populations

(This special issue belongs to the Section Molecular Genetics and Genomics)

Inflammatory Bowel Disease and Cardiometabolic Comorbidities: Molecular Mechanisms and Therapeutic Perspectives

edited by

Dimitrios Patoulias

and

Christos Mademlis

submission deadline 30 Sep 2026 | Viewed by 406 | Submission Open

Keywords: cardiovascular–kidney–metabolic syndrome; diabetes; obesity; cardiovascular disease; inflammatory bowel disease; Crohn’s disease; ulcerative colitis; inflammation; endothelial dysfunction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Determinants of Cardiovascular Diseases

edited by

Susan Darroudi

submission deadline 30 Sep 2026 | 1 articles | Viewed by 405 | Submission Open

Keywords: atherosclerosis; hypertension; diabetes; dyslipidemia; endothelial dysfunction; vascular remodeling; inflammation and oxidative stress; mitochondrial dysfunction; molecular diagnostics; heart function

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Integrating Multi-Omics Approaches in Fish Immunology to Improve Aquaculture Sustainability

edited by

Parasuraman Aiya Subramani

submission deadline 30 Sep 2026 | Viewed by 404 | Submission Open

Keywords: machine learning; network analysis; vaccine development; genomic selection; single-cell RNA-seq; meta-analysis; innate immunity; biomarker discovery

(This special issue belongs to the Section Molecular Immunology)

Novel Insights into Endothelial Cell Biology

edited by

Takato Hara

and

Toshiyuki Kaji

submission deadline 30 Sep 2026 | Viewed by 395 | Submission Open

Keywords: endothelial cell heterogeneity; mechanotransduction; endothelial–immune interactions; endothelial senescence; vascular barrier regulation; extracellular vesicles; angiogenesis and vascular remodeling; endothelial metabolism; endothelial regulation of the fibrinolytic system

(This special issue belongs to the Section Molecular Biology)

Advances in Therapeutic Antibody Engineering

edited by

Chatchai Tayapiwatana

submission deadline 30 Sep 2026 | Viewed by 385 | Submission Open

Keywords: therapeutic antibodies; bispecific antibodies; antibody-drug conjugates (ADCs); nanobodies; AI-driven drug design; Fc engineering; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

Genetic Diversity, Founder Effects, and Migration in Neurodegeneration: Molecular and Population Perspectives

edited by

Dasiel Oscar Borroto-Escuela

submission deadline 30 Sep 2026 | Viewed by 384 | Submission Open

Keywords: neurodegeneration; population genetics; founder effects; genetic diversity; migration and disease risk; spinocerebellar ataxia; Alzheimer’s disease; Parkinson’s disease; genetic epidemiology; underrepresented populations

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Interplay: Natural Antioxidants as Modulators of Redox Homeostasis

edited by

Giovanni Pratelli

and

Daniela Carlisi

submission deadline 30 Sep 2026 | Viewed by 384 | Submission Open

Keywords: natural antioxidants; oxidative stress; chronic diseases; molecular mechanisms; cancer; neurodegenerative diseases; metabolic disorders; redox biology; omics; precision medicine

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Pituitary Neuroendocrine Tumors: From Growth Control to Plasticity and Evolutionary Pathogenesis

edited by Ana Lucía De Paul and Liliana del Valle Sosa

submission deadline 30 Sep 2026 | Viewed by 368 | Submission Open

Keywords: tumor heterogeneity; tumor biomarkers; transcriptomics; molecular neuroscience; clinical treatment; pathogenesis; pituitary neuroendocrine tumors; neuroendocrine tumors; nonfunctional; PIT1; pituitary adenoma

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Role of Bifunctional Antibodies in Human Cancer

edited by

Alessandro Canella

submission deadline 30 Sep 2026 | Viewed by 365 | Submission Open

Keywords: bispecific antibodies; tumor immune microenvironment (TIME); cancer immunotherapy; tumor associated antigens; biomarker discovery; T cell engagers (BiTEs, TriTEs, TriKEs); dual affinity retargeting antibodies (DARTs); Fc engineering and FcγR modulation; tumor associated antigen (TAA) avidity optimization; immune reprogramming; bispecific antibody pharmacokinetics and biodistribution; antibody–drug conjugate (ADC) hybrid formats; bifunctional antibodies

(This special issue belongs to the Section Molecular Oncology)

Molecular Studies of Cartilage Deformation

edited by

Kazuo Yudoh

submission deadline 30 Sep 2026 | Viewed by 361 | Submission Open

Keywords: osteoarthritis; chondrocyte; mitochondria function; mechanical stress; oxidative stress; cartilage metabolism

(This special issue belongs to the Section Molecular Biology)

Current Trends in Nanophotonics and Molecular-Scale Light Control

edited by Mitradeep Sarkar

submission deadline 30 Sep 2026 | Viewed by 350 | Submission Open

Keywords: nanophotonics; light–matter interaction; metamaterials and 2D materials; photonic crystals; molecular sensing and imaging; quantum and nonlinear optics

(This special issue belongs to the Section Molecular Nanoscience)

Procoagulant Platelets in Vascular Disease and Beyond

edited by

Paresh P. Kulkarni

submission deadline 30 Sep 2026 | Viewed by 346 | Submission Open

Keywords: procoagulant platelets; thrombosis; hemostasis; coagulation; bleeding; vascular disease; cancer; cardiometabolic syndrome; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Inherited Endocrine Tumors: Genetics, Genomics, and Molecular Pathogenesis

edited by Vito Guarnieri,

Alberto Falchetti

and Antonio Stefano Salcuni

submission deadline 30 Sep 2026 | Viewed by 340 | Submission Open

Keywords: parathyroid; adrenal; pancreas; thyroid; pituitary

(This special issue belongs to the Section Molecular Genetics and Genomics)

Future Perspective and Challenge of Nanomaterials

edited by

Antreas Afantitis

submission deadline 30 Sep 2026 | Viewed by 337 | Submission Open

Keywords: nanomaterial; nanoinformatics; materials informatics; functional material; molecular dynamics

(This special issue belongs to the Section Molecular Nanoscience)

Regulatory T Cells and Immune Tolerance: From Nobel Discoveries to Clinical Breakthroughs

edited by Raquel López-Mejías

submission deadline 30 Sep 2026 | Viewed by 333 | Submission Open

Keywords: regulatory T cells (Tregs); immune tolerance; FOXP3 gene; therapies; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

TRIM Family Proteins and Beyond: Molecular Mechanisms in Tissue Homeostasis and Disease

edited by

Chuanxi Cai

submission deadline 30 Sep 2026 | Viewed by 332 | Submission Open

Keywords: TRIM family proteins; E3 ubiquitin ligases; protein homeostasis; autophagy and selective autophagy; innate immunity and antiviral defense; signal transduction; post-translational modifications; phase separation; tissue homeostasis; cancer biology; heart failure; neurodegeneration; inflammation and immunity; molecular mechanisms of disease; biomarkers and therapeutic targets

(This special issue belongs to the Section Molecular Biology)

Biological Effects and Toxicity of Nanomaterials

edited by Lucyna Kapka-Skrzypczak

submission deadline 30 Sep 2026 | Viewed by 326 | Submission Open

Keywords: nanotoxicology; nanomaterials; biological effects; cytotoxicity; oxidative stress; inflammation; genotoxicity; immunotoxicity; risk assessment; nanosafety; nanomedicine; environmental health; in vitro models; in vivo studies

(This special issue belongs to the Section Molecular Nanoscience)

Targeted Therapies and Chemoresistance in Gastrointestinal Cancers

edited by Zheng Chen

submission deadline 30 Sep 2026 | Viewed by 320 | Submission Open

Keywords: gastrointestinal cancer; targeted therapy; chemoresistance; drug resistance; precision medicine; molecular biomarkers; signal transduction; tumor microenvironment; immunotherapy; novel therapeutics

(This special issue belongs to the Section Molecular Oncology)

Advances in Cell Signaling Pathways and Signal Transduction, 2nd Edition

edited by

Susumu Ohya

and Katsuhiko Muraki

submission deadline 30 Sep 2026 | Viewed by 317 | Submission Open

Keywords: signaling pathway; signal transduction; cell biology; signal transduction; cell communication; cell signaling

(This special issue belongs to the Section Biochemistry)

Deep Learning for Bioinformatics and Biomedicine

edited by

Burak Tasci

submission deadline 30 Sep 2026 | Viewed by 314 | Submission Open

Keywords: bioinformatics; deep learning; genomics (DNA); histopathology; multi-omics; molecular biomarkers; drug discovery; computational pathology; systems biology; precision medicine

(This special issue belongs to the Section Molecular Informatics)

Molecular Immunity to Parasitic Infections

edited by Jamie A. Whitelaw and Stuart Woods

submission deadline 30 Sep 2026 | Viewed by 309 | Submission Open

Keywords: parasitology; immunology; vaccines; cell therapy; gene editing; parasitic diseases; immune responses; inflammation; molecular mechanisms; immune evasion; host cell invasion and manipulation

(This special issue belongs to the Section Molecular Immunology)

State-of-the-Art Molecular Plant Sciences in Thailand

edited by

Mayura Veerana

submission deadline 30 Sep 2026 | Viewed by 304 | Submission Open

Keywords: molecular plant sciences; plant biotechnology; functional genomics; molecular breeding; plant stress responses; omics technologies; plant–microbe interactions; sustainable agriculture; crop improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Genetics in Metabolic Syndrome and Diabetes

edited by

Marijn Speeckaert

submission deadline 30 Sep 2026 | Viewed by 300 | Submission Open

Keywords: metabolic syndrome; diabetes mellitus; genetic variants; epigenetics; insulin resistance; obesity; dyslipidemia; inflammation; oxidative stress; mitochondrial dysfunction; non-coding RNAs; transcriptomics; proteomics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Insights into Animal Nutrition: Oxidative Stress, Polyphenols and Functional Feed Materials

edited by

Sotiria Makri

and

Dimitrios Kouretas

submission deadline 30 Sep 2026 | Viewed by 292 | Submission Open

Keywords: animal nutrition; oxidative stress; reactive oxygen species; polyphenols; feed materials; molecular nutrition; antioxidant defense; animal physiology; nutritional toxicology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Targeting in Neuroinflammation: Uncovering Mechanisms, Pharmacological Targets and Neuropharmaceutical Developments

edited by

Nataša Mitrović

submission deadline 30 Sep 2026 | Viewed by 290 | Submission Open

Keywords: neuroinflammation; neurodegenerative disorders; neuro-immune crosstalk; glial cells; neuroprotective/anti-inflammatory agents; therapeutic strategies; pharmacological treatments

(This special issue belongs to the Section Molecular Neurobiology)

Multiscale Toxicology: From Cell Models to Whole Organisms

edited by

Elvira Brunelli

and

Rachele Macirella

submission deadline 30 Sep 2026 | Viewed by 288 | Submission Open

Keywords: toxicology; ecotoxicology; environmental risk assessment; multiscale toxicology; emerging contaminants; sentinel species; omics; mixture toxicity

(This special issue belongs to the Section Molecular Toxicology)

Molecular Mechanisms Underlying Genetic Variants of Parkinson’s Disease

edited by Michael Schlossmacher and

Ari Zimran

submission deadline 30 Sep 2026 | Viewed by 283 | Submission Open

Keywords: DNA; PD prevention; genetic variants of Parkinson's disease

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Basis of Rare Diseases and Functional Variant Interpretation

edited by

Adrijan Sarajlija

submission deadline 30 Sep 2026 | Viewed by 283 | Submission Open

Keywords: rare diseases; functional variant interpretation; variants of uncertain significance; molecular pathogenesis; functional assays; genotype–phenotype correlation; multiomics; clinical genetics

(This special issue belongs to the Section Molecular Genetics and Genomics)

From Soil to Gut: Molecular Mechanisms of Microbial Remediation for Planetary and Human Health

edited by

Yi Yang

, Hao Zhou and

Xin Jin

submission deadline 30 Sep 2026 | Viewed by 281 | Submission Open

Keywords: microbiome restoration; biotherapeutic agents; in vivo/vitro detoxification; dysbiosis rescue; synthetic consortia; host-microbe interactions; bioremediation; ecohealth

(This special issue belongs to the Section Molecular Microbiology)

Molecular Studies of Antibacterial Materials

edited by

Anna Baranowska-Korczyc

and

Adriana Nowak

submission deadline 30 Sep 2026 | Viewed by 281 | Submission Open

Keywords: antibacterial materials; molecular mechanisms; antimicrobial resistance; antimicrobial nanomaterials; antimicrobial polymers; microbial adhesion; microbial biofilms; biofilm inhibition; reactive oxygen species (ROS); antimicrobial coatings; bacterial membrane disruption; controlled ion release; biocompatibility and cytotoxicity assessment

(This special issue belongs to the Section Materials Science)

Genomics Research on Plant Stress Resistance

edited by

Muhammad Waseem

submission deadline 30 Sep 2026 | Viewed by 279 | Submission Open

Keywords: stress-responsive genes; muti-omics; stress memory / priming; tolerance mechanisms

(This special issue belongs to the Section Molecular Genetics and Genomics)

Trends in Allergy and Autoimmunity: Pathogenesis, Biomarkers, and Treatment (Second Edition)

edited by

Ilaria Mormile

submission deadline 30 Sep 2026 | Viewed by 279 | Submission Open

Keywords: allergy; autoimmunity; autoimmune diseases; asthma; allergic rhinitis; urticaria; inflammation in allergic and autoimmune diseases; molecular pathway involved in allergic and autoimmune diseases; biomarkers of allergic and autoimmune diseases; target therapy

(This special issue belongs to the Section Molecular Immunology)

Enhancing Plant Traits Through In Vitro Culture

edited by Jacek Gawroński

submission deadline 30 Sep 2026 | Viewed by 278 | Submission Open

Keywords: plant tissue culture; somatic embryogenesis; organogenesis; micropropagation; callus culture; in vitro regeneration; in vitro mutagenesis; haploid and doubled haploid production; molecular markers; genetic analysis; genomics; transcriptomics; epigenetic regulation; proteomic profiling; molecular mechanisms; gene expression analysis

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms and Treatments in Respiratory Diseases

edited by

Yoshihiko Chiba

submission deadline 30 Sep 2026 | Viewed by 278 | Submission Open

Keywords: respiratory diseases; molecular mechanisms; airway inflammation; airway hyperresponsiveness; epithelial barrier function; cytokines and signaling pathways; tissue remodeling and fibrosis; ion channels and transporters; targeted therapy; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research on Drug Delivery in Health and Disease

edited by

Alejandro Ruiz-Picazo

submission deadline 30 Sep 2026 | Viewed by 277 | Submission Open

Keywords: precision medicine; nanomedicine; targeted delivery; biomarkers; personalized therapy; adaptive systems; AI-driven drug delivery

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Research into the Applications of Metabolites from Marine Organisms

edited by Carlos García

submission deadline 30 Sep 2026 | Viewed by 276 | Submission Open

Keywords: quantitative analysis; secondary metabolites; bioactive; disease; molecular insight; natural compounds

(This special issue belongs to the Section Biochemistry)

Interactions Between Rhizosphere Microbiota and Plants

edited by

Anna Gałązka

submission deadline 30 Sep 2026 | Viewed by 275 | Submission Open

Keywords: microbiome and mycobiome of soil and plant rhizosphere; endorhizosphere; next-generation sequencing; soil and plant biodiversity

(This special issue belongs to the Section Molecular Plant Sciences)

Immunological Mechanisms Against Human Fungal Pathogens

edited by

Kritsada Pruksaphon

submission deadline 30 Sep 2026 | Viewed by 273 | Submission Open

Keywords: fungal drug resistance; thermally dimorphic fungus; host–pathogen interaction; structural biology of host–pathogen interfaces; immune evasion or immune escape; monoclonal antibodies or therapeutic antibodies; structural antibodies; X-ray crystallography and cryo-electron microscopy (Cryo-EM); molecular docking or molecular dynamics simulations; extracellular vesicles; damage response framework

(This special issue belongs to the Section Molecular Immunology)

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