Multiscale Toxicology: From Cell Models to Whole Organisms
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 49
Special Issue Editors
Interests: ecotoxicology and environmental toxicology; effects of organic and inorganic pollutants on aquatic and terrestrial vertebrates; reproduction and development; innovative approaches in ecotoxicology; in vivo experimental models; molecular and morpho-functional methods in toxicological research; structure and function of respiratory organs
Special Issues, Collections and Topics in MDPI journals
Interests: aquatic ecosystems; microscopy; transmission electron microscopy; scanning electron microscopy; ecotoxicology; heavy metals; pesticides; xenobiotics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Modern toxicology and ecotoxicology are rapidly evolving toward integrative frameworks that link molecular perturbations to adverse outcomes at higher levels of biological organisation, and advances in cellular models, high-throughput screening, omics technologies, and computational approaches have greatly improved our ability to identify mechanisms of toxicity for a wide range of chemicals.
Despite these advances, a major scientific challenge remains: translating mechanistic information obtained in vitro and at sub-organismal levels into biologically relevant responses observed in whole organisms and populations. Bridging these biological scales is essential for improving environmental and human health risk assessment, understanding cross-species sensitivity, and developing predictive frameworks that connect laboratory findings with real-world environmental outcomes.
To address these challenges and promote interdisciplinary discussion across biological scales, we are pleased to invite you to contribute to the Special Issue entitled “Multiscale Toxicology: From Cell Models to Whole Organisms.”
This Special Issue aims to collect high-quality original research articles and reviews that examine toxicological processes across multiple levels of biological organisation, integrating mechanistic, organismal, and ecological perspectives. The topic fully aligns with the journal’s scope and brings together ecotoxicology, mechanistic toxicology, new approach methodologies (NAMs), and systems biology to address complex toxicological questions relevant to both environmental and human health.
We welcome submissions addressing, but not limited to, the following topics:
- Molecular and cellular mechanisms of toxicity;
- Omics technologies and biomarkers;
- High-throughput screening (HTS) and computational toxicology;
- New Approach Methodologies (NAMs), organoids, and microphysiological systems;
- In vitro to in vivo extrapolation (IVIVE);
- Developmental, reproductive, and chronic toxicity;
- Comparative and cross-species sensitivity;
- Ecotoxicology across biological scales;
- Environmental and human health risk assessment;
- Effects of chemical mixtures and multiple stressors;
- Emerging contaminants (e.g., pharmaceuticals, microplastics, nanomaterials, PFAS).
We look forward to receiving your contributions.
Prof. Dr. Elvira Brunelli
Dr. Rachele Macirella
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- toxicology
- ecotoxicology
- environmental risk assessment
- multiscale toxicology
- emerging contaminants
- sentinel species
- omics
- mixture toxicity
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