Procoagulant Platelets in Vascular Disease and Beyond
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 10
Special Issue Editor
Special Issue Information
Dear Colleagues,
There are at least two distinct populations of activated platelets. Proaggregatory platelets, which are characterized by integrin activation and low phosphatidylserine (PS) exposure, form aggregates through fibrinogen bridges. However, procoagulant platelets are recognized by integrin inactivation and high PS exposure, providing a surface for the assembly of tenase and prothrombinase complexes, which are 105-106-fold and 300000-fold more active than soluble coagulation factors. Procoagulant platelets thus dramatically accelerate coagulation and fibrin clot formation.
While most healthy individuals do not have circulating procoagulant platelets, ~30% of normal donor platelets adopt a procoagulant phenotype ex vivo following exposure to a combination of thrombin and collagen. Elevated procoagulant platelet response to agonists has been reported in several vascular disorders, such as stroke, heparin-induced thrombocytopenia, and vaccine-induced thrombotic thrombocytopenia. Procoagulant platelets have also been associated with non-vascular disorders such as cardiometabolic syndrome, cancer, and inflammation, where their formation may reflect dysregulated thrombosis and hemostasis. In contrast, Scott syndrome, a bleeding disorder, results from mutation in TMEM16F, leading to deficient platelet PS exposure. Other bleeding disorders may also involve decreased generation of procoagulant platelets. This Issue will highlight the role of procoagulant platelets in vascular diseases and beyond, the underlying mechanisms, and potential clinical implications.
Dr. Paresh P. Kulkarni
Guest Editor
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Keywords
- procoagulant platelets
- thrombosis
- hemostasis
- coagulation
- bleeding
- vascular disease
- cancer
- cardiometabolic syndrome
- inflammation
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