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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms Regulating Stress Tolerance in Ornamental Plants
edited by
submission deadline 20 May 2027 | Viewed by 205 | Submission Open
Keywords: ornamental plants; biotic stresses; abiotic stresses; signal transduction pathways; transcription factors; functional proteins; transcription; translation; post-translational modification
(This special issue belongs to the Section Molecular Plant Sciences)
Editorial Board Members’ Collection Series in Antibiotic Resistance
edited by and
submission deadline 20 May 2027 | Viewed by 1 | Submission Open
Keywords: antimicrobial resistance; antibiotics; environmental pollutants; co-selection; One Health
(This special issue belongs to the Section Molecular Microbiology)
Melanoma: Molecular Mechanism and Therapy, 2nd Edition
edited by
submission deadline 30 May 2027 | 3 articles | Viewed by 4195 | Submission Open
Keywords: melanoma progression; melanoma metastasis; molecular background; targeted therapies; immunotherapy; acquired drug resistance; prognostic and predictive markers; therapeutic targets
(This special issue belongs to the Section Molecular Oncology)
Molecular Evolution of the Vertebrate Immune System
edited by
submission deadline 30 May 2027 | 1 articles | Viewed by 1565 | Submission Open
Keywords: immune system; molecular evolution; V (D) J recombination; RAG transposon; comparative genomics
(This special issue belongs to the Section Molecular Biology)
Agronomic Regulation of Crop Environmental Adaptation and Grain Safety: Physiological and Molecular Mechanisms
edited by and
submission deadline 30 May 2027 | Viewed by 44 | Submission Open
Keywords: agronomic management; environmental adaptation; molecular regulation; physiological and biochemical mechanisms; crop quality formation; plant-soil-microbe interactions; heavy metal detoxification; nitrogen-use efficiency; photosynthetic efficiency
(This special issue belongs to the Section Molecular Plant Sciences)
State-of-the-Art Molecular Plant Sciences in China
edited by Xiaoling Sun
submission deadline 30 May 2027 | Viewed by 32 | Submission Open
Keywords: molecular plant science; plant molecular biology; plant physiology and development; plant omics and bioinformatics; plant biotechnology
(This special issue belongs to the Section Molecular Plant Sciences)
Exploring UV-Induced Disease: Insights into Mechanisms and Innovative Strategies for Prevention and Therapy
edited by Hui Xu and
submission deadline 31 May 2027 | 2 articles | Viewed by 3047 | Submission Open
Keywords: ultraviolet radiation; skin; DNA damage; DNA repair; immunosuppression; inflammatory disease; autoimmune disease; melanoma; non-melanoma skin cancers; genetic susceptibility; chemopre-vention; tumor immunotherapy; skin organoids for UV study; new animal models
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Aspects of Diabetes and Its Complications
edited by
submission deadline 31 May 2027 | 3 articles | Viewed by 2913 | Submission Open
Keywords: obesity; insulin resistance; type 2 diabetes; atherosclerosis; endothelial dysfunction; cardiovascular disease; peripheral artery disease; diabetic feet; diabetic micoangiopathy; diabetic neuropathy; regenerative medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Flow Cytometry as a Tool for Diagnostics and Biomarker Research submission deadline 31 May 2027 | 1 articles | Viewed by 2276 | Submission Open
Keywords: biomarkers; flow cytometry; spectral cytometry; mass cytometry; translational research; human health
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Biology on Environmental Microorganisms
edited by
submission deadline 31 May 2027 | 3 articles | Viewed by 2050 | Submission Open
Keywords: environmental microbiology; metagenomics; microbial interactions; phage–host dynamics; horizontal gene transfer; biogeochemical cycles; antimicrobial resistance; single-cell methods; microbiome engineering; environmental biotechnology
(This special issue belongs to the Section Molecular Microbiology)
Neurobiology Linking Alcohol Addiction to Psychiatry Symptoms submission deadline 31 May 2027 | 1 articles | Viewed by 2042 | Submission Open
Keywords: alcohol use disorder (AUD); psychiatry; neurobiology; biomarkers; translational
(This special issue belongs to the Section Molecular Neurobiology)
New Insights into Environmental Stresses and Plants: Second Edition
edited by
submission deadline 31 May 2027 | 1 articles | Viewed by 1590 | Submission Open
Keywords: abiotic stress; biotic stress; adaptation; gene function; omics; metabolic regulation; stress signal; molecular mechanism
(This special issue belongs to the Section Molecular Plant Sciences)
Protein Dynamics in Cancer Drug Resistance: Mechanisms and Therapeutic Opportunities
edited by Slovénie Pyndiah
submission deadline 31 May 2027 | 1 articles | Viewed by 1562 | Submission Open
Keywords: drug resistance; cancer proteome; protein turnover; post-translational modifications; targeted therapy; stress adaptation
(This special issue belongs to the Section Molecular Oncology)
Molecular Insight into Nematodes Management
edited by
submission deadline 31 May 2027 | 1 articles | Viewed by 1194 | Submission Open
Keywords: biological control; micro-organisms; molecular identification; biodiversity; climatic changes; soil nema-todes; cultural practices; host plant resistance; anaerobic soil disinfection; biofumigation
(This special issue belongs to the Section Molecular Biology)
Bioactive Compounds and Molecular Mechanisms in Health and Disease submission deadline 31 May 2027 | Viewed by 893 | Submission Open
Keywords: bioactive compounds; molecular mechanisms; metabolic regulation; inflammation; oxidative stress; signaling pathways; chronic diseases; translational research; systems biology; disease prevention and therapy
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Lipid Metabolism in Aging and Diseases: From Mechanisms to Therapy
edited by
submission deadline 31 May 2027 | 1 articles | Viewed by 744 | Submission Open
Keywords: lipid metabolism; degenerative diseases; cardiovascular pathologies; neurodegeneration; inflammation; autoimmunity; cancer; lipid droplets; bioactive molecules; drug repositioning; oxidative stress; mitochondrial dysfunction; inflammatory processes
(This special issue belongs to the Section Biochemistry)
Molecular Determinants of Cardiovascular Diseases
edited by
submission deadline 31 May 2027 | 1 articles | Viewed by 740 | Submission Open
Keywords: atherosclerosis; hypertension; diabetes; dyslipidemia; endothelial dysfunction; vascular remodeling; inflammation and oxidative stress; mitochondrial dysfunction; molecular diagnostics; heart function
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
MiRNA Regulation in the Early PME/TME: The Role of Non-Cancer Cells and the ECM in Solid Tumours
edited by
submission deadline 31 May 2027 | 1 articles | Viewed by 566 | Submission Open
Keywords: microRNAs; early tumor microenvironment (TME); stromal/ECM interaction; vascularization; ECM remodelling; signalling pathways
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms of GPCR Signaling
edited by
submission deadline 31 May 2027 | Viewed by 440 | Submission Open
Keywords: biased signaling; allosteric modulation; receptor conformations; spatiotemporal signaling; allosteric modulation; receptor trafficking; signaling networks; structure-based drug design
(This special issue belongs to the Section Biochemistry)
Advanced Drug Delivery Systems: From Nanocarrier Design to Translation submission deadline 31 May 2027 | Viewed by 140 | Submission Open
Keywords: nanocarriers; stimuli-responsive; targeted delivery; biocompatibility; scale-up; nanomedicine
(This special issue belongs to the Section Materials Science)
Molecular Mechanisms Linking Environmental Pollutant Exposure to Human Health and Development submission deadline 31 May 2027 | Viewed by 99 | Submission Open
Keywords: environmental pollutants; molecular toxicology; developmental toxicology; particulate matter; metals and metalloids; pesticides; persistent organic pollutants; PFAS; environmental pharmaceuticals; microplastics; nanoplastics; mixture toxicity; adverse outcome pathways; human biomonitoring; toxicokinetics; oxidative stress; genotoxicity; epigenetics; endocrine disruption; neurodevelopment; human health risk assessment
(This special issue belongs to the Section Molecular Toxicology)
Drought‑Stress‑Induced Physiological and Molecular Changes in Plants
edited by
submission deadline 31 May 2027 | Viewed by 27 | Submission Open
Keywords: drought stress; abiotic stress; physiological response; reactive oxygen species; osmotic adjustment; molecular regulation; transcription factors; signal transduction; plant adaptation; omics; crop resilience
(This special issue belongs to the Section Molecular Plant Sciences)
Functional Polymeric Biomaterials: From Molecular Engineering to Biomedical Applications submission deadline 1 Jun 2027 | Viewed by 79 | Submission Open
Keywords: polymeric biomaterials; biodegradable polymers; molecular design; AI-driven materials design; structure–property relationships; biomolecule–material interactions; biocompatibility; drug delivery systems; tissue engineering; regenerative medicine
(This special issue belongs to the Section Materials Science)
Skin Cancer: From Molecular Pathophysiology to Novel Treatment
edited by Soon-Hyo Kwon
submission deadline 20 Jun 2027 | 6 articles | Viewed by 8121 | Submission Open
Keywords: basal cell carcinoma; malignant melanoma; molecular genetics; epigenetics; signaling pathways; tumor microenvironment; tumor resistance; biomarkers; molecular target; multiomics; genomics; transcriptomics; proteomics; metabolomics; skin cancer; squamous cell carcinoma
(This special issue belongs to the Section Molecular Oncology)
The Chitosan Biomaterials: Advances and Challenges, 3rd Edition
edited by , and Cristina Elena Dinu-Pirvu
submission deadline 20 Jun 2027 | 1 articles | Viewed by 1625 | Submission Open
Keywords: chitosan; chitosan biomaterials; chitosan derivatives; drug delivery; wound healing; tissue regeneration; dentistry; smart biomaterials
(This special issue belongs to the Section Materials Science)
Molecular Progression of Genome-Related Diseases: 2nd Edition
edited by
submission deadline 25 Jun 2027 | 6 articles | Viewed by 23178 | Submission Open
Keywords: next-generation sequencing; genetic diseases; multifactorial diseases; diagnostic tolls; human health
(This special issue belongs to the Section Molecular Genetics and Genomics)
Mitochondrial Function in Human Health and Disease: 3rd Edition
edited by
submission deadline 25 Jun 2027 | 4 articles | Viewed by 4520 | Submission Open
Keywords: mitochondial genesis and disease; mitochondrial function and aging; mitochondrial dysfunction and cancer; mitochondrial function and apoptosis; mitophage; autophage; mitochondrial AKT
(This special issue belongs to the Section Biochemistry)
Colorectal Cancer: A Molecular Genetics Perspective (2nd Edition)
edited by
submission deadline 25 Jun 2027 | 1 articles | Viewed by 709 | Submission Open
Keywords: colorectal cancer; chromosomal and microsatellite instability; CpG island methylator phenotype; molecular characteristics; early diagnosis; targeted therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Innovative Strategies in Cancer Therapy submission deadline 30 Jun 2027 | 3 articles | Viewed by 8312 | Submission Open
Keywords: tumor microenvironment; small molecules; IDO1 inhibition; checkpoint inhibitor therapy; adoptive T cell therapy; metabolic reprogram; resistance mechanisms; immune modulation; immune reconstitution; combination therapy; immunosuppression
(This special issue belongs to the Section Molecular Oncology)
Targeting Oxidative Stress: New Insights into Disease Pathogenesis, Emerging Preventive Strategies and Novel Therapeutic Approaches
edited by Fabio Vivarelli and
submission deadline 30 Jun 2027 | 3 articles | Viewed by 3573 | Submission Open
Keywords: metabolism; inflammation; oxidative stress; diabetes; natural oxidative stress modulators; novel preventive/therapeutic strategies; ageing; cardiovascular diseases; regenerative medicine; neurodegeneration; environmental exposure; cancer
(This special issue belongs to the Section Molecular Biology)
Effects of Bioactive Compounds in Cardiovascular and Neurological Diseases submission deadline 30 Jun 2027 | 1 articles | Viewed by 2848 | Submission Open
Keywords: inflammation; oxidative stress; bioactive compounds; cardiovascular diseases; neurological diseases
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Cancer Drug Resistance and Therapeutic Targets submission deadline 30 Jun 2027 | 1 articles | Viewed by 1476 | Submission Open
Keywords: drug resistance; therapeutic targets; efflux transporters’ oncogenic signaling pathways; tumor microenvironment; dna damage/repair; personalized therapies
(This special issue belongs to the Section Molecular Oncology)
Sex and Gender Medicine: New Horizons in Human Health and Disease
edited by , Eliana Ferroni and
submission deadline 30 Jun 2027 | 1 articles | Viewed by 601 | Submission Open
Keywords: sex differences; gender medicine; personalized medicine; health inequities; intersectionality; precision health
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cell Penetrating Peptides: Novel Therapeutic Tools for Drug Delivery
edited by
submission deadline 30 Jun 2027 | Viewed by 469 | Submission Open
Keywords: cell-penetrating peptides; peptide design; drug delivery; controlled and release; clinical applica-tions; penetration mechanisms
(This special issue belongs to the Section Molecular Pharmacology)
From Molecular Understanding to Ecological Significance: Understanding Marine Reproductive Biology
edited by
submission deadline 30 Jun 2027 | Viewed by 458 | Submission Open
Keywords: reproductive biology; gametogenesis; bivalves reproduction; biodiversity; endocrine regulation; gametogenesis; molecular signaling; genomics; fertilization; population dynamics; ecological resilience
(This special issue belongs to the Section Molecular Biology)
Molecular Pharmacology and Analytical Characterisation of Bioactive Natural Products submission deadline 30 Jun 2027 | Viewed by 64 | Submission Open
Keywords: natural products; molecular pharmacology; bioactive compounds; herbal medicine; HPTLC; LC–MS/MS; metabolomics; chemometrics; natural product standardization; antioxidant activity; pharmacogenomics; transcriptomics; nutrigenomics; multi-omics; gene expression; genomic biomarkers
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Biosynthesis and Activity Mechanism of Plant Essential Oils submission deadline 30 Jun 2027 | Viewed by 23 | Submission Open
Keywords: essential oils; biosynthesis; terpenoids; MVA and MEP pathways; secondary metabolites; biological activity; mechanism of action; antimicrobial activity; natural products; metabolomics
(This special issue belongs to the Section Biochemistry)
HIV Infection, Pathogenesis and Treatment
edited by
submission deadline 20 Jul 2027 | 4 articles | Viewed by 12895 | Submission Open
Keywords: HIV Infection; HIV; host immune responses; pathogenesis
(This special issue belongs to the Section Molecular Microbiology)
Nanoparticle Toxicity: Beyond Chemical Composition—the Critical Role of Physicochemical Properties
edited by
submission deadline 31 Jul 2027 | 2 articles | Viewed by 1461 | Submission Open
Keywords: nanotoxicology; engineered nanomaterials; physicochemical properties; risk assessment; reactive oxygen species (ROS); protein corona; cellular uptake; regulatory science; safe-by-design
(This special issue belongs to the Section Molecular Toxicology)
Selected Papers from the HSG-2025 Conference
edited by
submission deadline 31 Jul 2027 | 1 articles | Viewed by 962 | Submission Open
Keywords: metagenomics; genomics; metabarcoding; next-generation sequencing; transcriptomics; translatomics; NGS data analysis
(This special issue belongs to the Section Molecular Genetics and Genomics)
Machine Learning in RNA and Chromatin Dynamics
edited by Haopeng Yu
submission deadline 31 Jul 2027 | Viewed by 570 | Submission Open
Keywords: machine learning; chromatin architecture; RNA dynamics; genomic foundation models; computational biology
(This special issue belongs to the Section Molecular Biology)
Advances in Viral Cancers and Virotherapies submission deadline 31 Jul 2027 | Viewed by 91 | Submission Open
Keywords: oncogenic virus; oncolytic virus; lymphomagenesis; oncogenesis; immunotherapy; immune modulation; drug resistance; transformation; inflammation; DNA repair
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research on Aging: Genetics, Epigenetics and Biomolecular Interventions
edited by
submission deadline 31 Jul 2027 | Viewed by 67 | Submission Open
Keywords: aging; biomarkers; bioactive nutrients; centenarians; life-extending interventions; exercise; red wine; stress resistance and metabolism; age-related diseases
(This special issue belongs to the Section Molecular Biology)
Exploring Molecular Mechanisms of Neuroendocrine Tumors
edited by and Michele Ghidini
submission deadline 31 Jul 2027 | Viewed by 47 | Submission Open
Keywords: rare tumours; neuroendocrine neoplasms; translational research; gut microbiome; liquid biopsy; novel targets; VHL1; predictive biomarkers; tumour microenvironment
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Microbiome, Host Immunity and Biotechnology
edited by
submission deadline 31 Jul 2027 | Viewed by 16 | Submission Open
Keywords: microbial biotechnology; microbiome and host immunity; bioactive metabolites and natural products; cellular and tissue engineering; gut barrier and metabolic regulation; oncological microenvironment; plant–microbe interactions and agricultural biotechnology; multi‑omics and sequencing
(This special issue belongs to the Section Molecular Microbiology)
Bioinformatics Analysis of Single Cell and Spatial Multi-Omics
edited by Fahong Yu
submission deadline 20 Aug 2027 | 1 articles | Viewed by 1430 | Submission Open
Keywords: bioinformatics; single-cell omics; spatial multi-omics; matabolomics; genomics; transcriptomics; proteomics; next-generation sequencing techniques
(This special issue belongs to the Section Molecular Informatics)
Multiple Myeloma: Cancer Therapy and the Tumour Microenvironment
edited by Ruba Al Abdulla
submission deadline 20 Aug 2027 | Viewed by 370 | Submission Open
Keywords: multiple myeloma; cancer resistance; therapeutic strategies; stroma cells; cancer microenvironment; cancer immunity
(This special issue belongs to the Section Molecular Oncology)
Emerging Therapies in Breast Cancer
edited by
submission deadline 28 Aug 2027 | Viewed by 82 | Submission Open
Keywords: breast cancer; tumor microenvironment; targeted therapy; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms, Biomarkers, and Translational Research in Stroke and Neurotrauma
edited by Kang-Ho Choi
submission deadline 30 Aug 2027 | Viewed by 46 | Submission Open
Keywords: stroke; cerebrovascular disease; endovascular thrombectomy; prognostic biomarkers; molecular pathophysiology; neurovascular imaging; lipidomic metabolites; experimental neurology; clinical trial methodologies; novel therapeutic approaches
(This special issue belongs to the Section Molecular Neurobiology)
Research on Genomics of Crop Stress Tolerance
edited by
submission deadline 31 Aug 2027 | 3 articles | Viewed by 1343 | Submission Open
Keywords: crop stress tolerance; genomic research; molecular mechanisms; multi-omics approaches; epigenetic modifications
(This special issue belongs to the Section Molecular Genetics and Genomics)
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