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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Phage Therapy: Breakthroughs and Challenges

edited by

Spyridon Megremis

and

Anisha Mahendra Thanki

submission deadline 31 Oct 2026 | Viewed by 454 | Submission Open

Keywords: phage therapy; phage production; phage engineering; phage genomics; phage evolution; phage structural biology

(This special issue belongs to the Section Molecular Microbiology)

From Molecular Mechanisms to Precision Medicine in Gastrointestinal Cancers: (Epi)genetics, Pharmacogenomics, and Emerging Biomarkers

edited by

Kostas A. Triantaphyllopoulos

submission deadline 31 Oct 2026 | Viewed by 442 | Submission Open

Keywords: gastrointestinal and colorectal cancer; genetic and epigenetic regulation; multi-omics and computational biology; molecular pathology and biomarker discovery; translational and precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Compounds from Microorganisms and Their Biotechnological Applications

edited by

Christian Anumudu

submission deadline 31 Oct 2026 | Viewed by 440 | Submission Open

Keywords: microbial bioactive compounds; secondary metabolites; natural products; antimicrobial agents; drug discovery; metabolomics; genomics; synthetic biology; fermentation biotechnology; bioprocessing; enzyme biotechnology; microbial peptides; polysaccharides; industrial biotechnology; biopharmaceuticals; anticancer compounds; anti-inflammatory agents; microbiome-derived compounds; sustainable production

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms of Melanoma Resistance to Targeted Therapy

edited by

Ignacija Vlasic

and

Anđela Horvat

submission deadline 31 Oct 2026 | Viewed by 427 | Submission Open

Keywords: melanoma; targeted therapy; mechanisms of therapy resistance; predictive biomarkers

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Disease-Modifying Strategies in Type 1 Diabetes

edited by

Tarun Pant

submission deadline 31 Oct 2026 | Viewed by 425 | Submission Open

Keywords: type 1 diabetes; molecular mechanisms; disease-modifying strategies; immunometabolism; cytokine signaling; precision immunotherapy

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Effects of Dietary Factors and Nutrition on Chronic Disease

edited by

Zaidatul Akmal Othman

and

Zaida Zakaria

submission deadline 31 Oct 2026 | 1 articles | Viewed by 423 | Submission Open

Keywords: dietary patterns; chronic disease prevention; functional foods and bioactive compounds; nutritional epidemiology; gut microbiota; metabolic health

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Bioactive Lipid Metabolites in Age-Related Comorbidities: From Mechanisms to Therapeutics

edited by

Sadanand Fulzele

submission deadline 31 Oct 2026 | Viewed by 423 | Submission Open

Keywords: lipid metabolites; aging; sarcopenia; osteoporosis; osteoarthritis

(This special issue belongs to the Section Biochemistry)

Ophthalmology: New Molecular Insights and Therapeutic Strategies

edited by

Meritxell López-Gallardo

and

José A. Fernández-Albarral

submission deadline 31 Oct 2026 | Viewed by 417 | Submission Open

Keywords: ophthalmology; molecular mechanisms; neuroinflammation; oxidative stress; retinal degeneration; neuroprotection; gene therapy; regenerative medicine; ocular biomarkers; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Estrogen Therapy for CNS Diseases

edited by

Istvan Merchenthaler

submission deadline 31 Oct 2026 | Viewed by 417 | Submission Open

Keywords: estrogen; central nervous system (CNS) diseases; neurodegenerative disorders

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Polysaccharides: Properties, Structure and Biological Activity

edited by

Thanapon Charoenwongpaiboon

submission deadline 31 Oct 2026 | Viewed by 412 | Submission Open

Keywords: polysaccharides; oligosaccharides; carbohydrate engineering; glycosidic linkage; polysaccharide modification; bioactive carbohydrates; prebiotic activity; immunomodulatory effects; antioxidant activity; functional biomaterials

(This special issue belongs to the Section Macromolecules)

Research Progress on Food Packaging Materials

edited by Ayca Aydogdu Emir

submission deadline 31 Oct 2026 | Viewed by 406 | Submission Open

Keywords: bio-based polymers; biodegradable packaging; active packaging; intelligent systems; antimicrobial films; nanotechnology; agri-food by-products; shelf-life extension; molecular interactions; sustainable materials

(This special issue belongs to the Section Materials Science)

Advances in Computational Research in Molecular Oncology: Tumor Initiation, Progression, and Treatment

edited by

Lip Yee Por

submission deadline 31 Oct 2026 | Viewed by 399 | Submission Open

Keywords: artificial intelligence; molecular oncology; multi-omics; digital twin; systems biology

(This special issue belongs to the Section Molecular Oncology)

Mesenchymal Stromal/Stem Cells (MSCs) in Regenerative Medicine

edited by

Miomir Knezevic

submission deadline 31 Oct 2026 | Viewed by 396 | Submission Open

Keywords: mesenchymal stromal cells; mesenchymal stem cells; regenerative medicine; cell therapy; immunomodulation; molecular mechanisms; extracellular vesicles; translational research; clinical applications; tissue regeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular-Scale Design, Synthesis, and Applications of (Photo)Electrochemical Materials for Sustainable Energy and Environmental Solutions

edited by

Shiwei Lin

and

Zhaohui Xiao

submission deadline 31 Oct 2026 | Viewed by 395 | Submission Open

Keywords: molecular-scale material engineering; photoelectrocatalysis/electrocatalysis; sustainable energy conversion; atomic-precision synthesis; environmental remediation technologies

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Mechanistic Insights into the Ubiquitin System’s Role in Cellular Signal Transduction and Homeostasis

edited by Michael Massiah

submission deadline 31 Oct 2026 | Viewed by 395 | Submission Open

Keywords: ubiquitination; protein homeostasis; deubiquitinases; E3-associated diseases; autophagy; ubiquitin dysregulation; proteasome-targeting; protac

(This special issue belongs to the Section Molecular Biology)

Gene Variants and Phenotypic Diversity: Insights into CFTR, SLC Transporters and Disease

edited by Veronique Ladeveze

submission deadline 31 Oct 2026 | 1 articles | Viewed by 395 | Submission Open

Keywords: mutations; polymorphisms; alternative splicing; exon skipping; intron retention; CFTR (ABCC7); cystic fibrosis; SLC16a3; Alzheimer’s disease; pulmonary and brain cancer

(This special issue belongs to the Section Molecular Genetics and Genomics)

Neuroendocrine Tumors (NETs): New Molecular Insights

edited by Juan Pablo Petiti

submission deadline 31 Oct 2026 | Viewed by 394 | Submission Open

Keywords: neuroendocrine neoplasms; cell signaling; biomarkers; molecular targets; tumor progression; invasion

(This special issue belongs to the Section Molecular Oncology)

Molecular Plant Abiotic Stress: Recent Advances and Challenges

edited by

Quaid Hussain

submission deadline 31 Oct 2026 | Viewed by 388 | Submission Open

Keywords: abiotic stress; plant stress tolerance; molecular mechanisms; gene expression; transcription factors; stress signaling pathways; functional genomics; plant hormones; omics technologies; gene family

(This special issue belongs to the Section Molecular Plant Sciences)

Natural Antioxidants from Plant Sources: Functional Roles and Health Implications

edited by

Socorro Vanesca Frota Gaban

submission deadline 31 Oct 2026 | Viewed by 382 | Submission Open

Keywords: plant-derived antioxidants; polyphenols; oxidative stress; functional foods; preventive nutrition

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advanced Drug Delivery Systems: From Nanocarrier Design to Translation Application

edited by Santu Sarkar

submission deadline 31 Oct 2026 | 1 articles | Viewed by 381 | Submission Open

Keywords: nanocarriers; clinical translation; targeted delivery; immunogenicity; formulation strategies

(This special issue belongs to the Section Molecular Nanoscience)

Eco-Conscious Therapeutics: Molecular Foundations and Future Directions in Green Medicine

edited by

Adi Lahat

and

Kassem Sharif

submission deadline 31 Oct 2026 | Viewed by 368 | Submission Open

Keywords: green medicine; molecular therapeutics; sustainable healthcare; biomarker profiling; predictive toxicology; eco-friendly drug design; environmental impact; biodegradable materials

(This special issue belongs to the Section Molecular Toxicology)

Molecular Progress of Cardiovascular and Metabolic Disease

edited by

Ilenia Calcaterra

submission deadline 31 Oct 2026 | Viewed by 366 | Submission Open

Keywords: cardiometabolic continuum; endothelial dysfunction; heart failure; metabolic complications

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Expanding Genetic Landscape of Parkinson's Disease

edited by

Christos Koros

and

Vasilios C. Constantinides

submission deadline 31 Oct 2026 | Viewed by 364 | Submission Open

Keywords: Parkinson’s disease; monogenic; polygenic risk score; alpha-synuclein

(This special issue belongs to the Section Molecular Neurobiology)

Collagen and Lipid-Based Nanoagents/Nanoparticles: Chemical Investigation and Delivery

edited by

Riyanto Teguh Widodo

submission deadline 31 Oct 2026 | 1 articles | Viewed by 362 | Submission Open

Keywords: collagen nanoparticles; lipid nanoparticles; drug delivery system; nanocarriers; liposomes; niosomes; nanostructured lipid carriers; biocompatibility; surface functionalisation; nanoagents; molecular characterisation; controlled release

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms and Therapeutics in Chronic Kidney Diseases

edited by

Haiyong Chen

submission deadline 31 Oct 2026 | Viewed by 360 | Submission Open

Keywords: chronic kidney disease; molecular pathway; cellular interaction; post-translational modification; genetics; renal injury susceptibility; molecular-based intervention; therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Integrating Molecular Genetic and Geospatial Approaches for Advanced Monitoring of Plant Biodiversity

edited by

Luigi De Masi

and

Marina Maura Calandrelli

submission deadline 31 Oct 2026 | Viewed by 357 | Submission Open

Keywords: plant biodiversity; biodiversity monitoring; genetic diversity; gene flow; population structure; landscape genetics; adaptive variation; spatiotemporal modelling; genetic erosion; conservation biology; geospatial analysis; remote sensing

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms of Environment-Induced Human Diseases

edited by

Halim İşsever

submission deadline 31 Oct 2026 | 1 articles | Viewed by 357 | Submission Open

Keywords: environmental exposures; heavy metal toxicity; environment-induced human diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Multicomponent Reactions (MCR) in Organic Synthesis

edited by

Diana Camelia Nuta

, Camelia Elena Stecoza and Carmen Limban

submission deadline 31 Oct 2026 | Viewed by 346 | Submission Open

Keywords: multicomponent reactions; one-pot synthesis; green chemistry; drug discovery; bignelli reaction; mannich reaction; hantzsch reaction; sustainable synthesis; nanoparticle catalysts; supramolecular chemistry; mechanochemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Research on Beneficial Mechanisms of Plant Growth Promoting Bacteria

edited by

Laith K.T. Al-Ani

submission deadline 31 Oct 2026 | Viewed by 329 | Submission Open

Keywords: biological control; plant resistance; induce systemic resistance (ISR); antifungal compounds; secondary compounds; siderophores; next-generation sequencing; soil biodiversity; microbiome; PGPF; trichoderma; mushroom; DSE; mycorrhiza

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Reprogramming of Mitochondrial Signalling and Metabolism in Cancers

edited by

Yunfeng Zhao

submission deadline 31 Oct 2026 | Viewed by 312 | Submission Open

Keywords: mitochondria; metabolic reprogramming; cancer metabolism; redox signaling

(This special issue belongs to the Section Molecular Oncology)

Quorum Quenching in Medicine–Molecular Interactions

edited by

Emil Paluch

submission deadline 31 Oct 2026 | Viewed by 310 | Submission Open

Keywords: quorum sensing; quorum quenching; biofilm; virulence; host; pathogenicity

(This special issue belongs to the Section Molecular Microbiology)

Cold Atmospheric Plasma Effect on Cancer Cells

edited by

Pradeep Lamichhane

and

Tirtha Raj Acharya

submission deadline 31 Oct 2026 | Viewed by 306 | Submission Open

Keywords: cold atmospheric plasma; plasma medicine; cancer cells; reactive oxygen species; molecular mechanisms; apoptosis; redox biology; immunogenic cell death; plasma oncology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Organ Axis: Insights from Molecular Metabolism

edited by

Peiwen Wang

submission deadline 31 Oct 2026 | Viewed by 298 | Submission Open

Keywords: organ axis; molecular metabolism; interorgan crosstalk; metabolic regulation; metabolic diseases; biomarkers; molecular pathways; metabolites

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Exploring Plant Growth and Development: From Molecular Mechanisms to Environmental Adaptations

edited by Lénia Rodrigues,

Hélia Cardoso

and

Catarina Campos

submission deadline 31 Oct 2026 | Viewed by 294 | Submission Open

Keywords: plant growth and development; molecular pathways; phytohormones; genome editing; high-throughput; omics; crop resilience; plant stress responses and adaptations

(This special issue belongs to the Section Molecular Plant Sciences)

Plant Bioactives: Sustainable Extraction, Characterization, and Antimicrobial Potential

edited by

Muhammad Saleem Kalhoro

submission deadline 31 Oct 2026 | Viewed by 289 | Submission Open

Keywords: plant extracts; bioactive compounds; phytochemistry; natural compounds; green based extraction; therapeutic potential

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Heart Failure: From Pathophysiology to Therapeutic Targets

edited by

Michele Correale

submission deadline 31 Oct 2026 | Viewed by 285 | Submission Open

Keywords: heart failure; pathophysiology; pharmacological targets; congestion; edema; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Dysfunctional Neural Circuits in Brain Disorders

edited by

Yun Li

submission deadline 31 Oct 2026 | Viewed by 282 | Submission Open

Keywords: dynamic wiring; brain network; brain connectivity; neuropathology; neuromodulation; neuroplasticity; circuit mapping

(This special issue belongs to the Section Molecular Neurobiology)

Metal Complexes: From Synthesis to Pharmacological Studies and Application

edited by Joksimović Nenad and

Snežana Stojanović

submission deadline 31 Oct 2026 | Viewed by 279 | Submission Open

Keywords: metal complexes; medicinal inorganic chemistry; bioactive ligands; pharmacological activity; molecular docking; biomolecular interactions; anticancer agents; antimicrobial activity; coordination chemistry; structure–activity relationship

(This special issue belongs to the Section Molecular Pharmacology)

Microplastics and Nanoplastics: Cellular Toxicity and Health Implications

edited by Gaetana Gambino

submission deadline 31 Oct 2026 | Viewed by 275 | Submission Open

Keywords: microplastics (MPs); nanoplastics (NPs); cellular toxicity; human health; oxidative stress; inflammation; genotoxicity; mitochondrial; dysfunction; bioaccumulation; mechanistic toxicology

(This special issue belongs to the Section Molecular Toxicology)

Latest Research Progress in Sport Genomics

edited by

Korkut Ulucan

submission deadline 31 Oct 2026 | Viewed by 275 | Submission Open

Keywords: sport genetics; genomics; athlete; performance; microbiota; epigenetics; injury; psychogenomics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Mechanisms of Resistance to Targeted Cancer Therapies

edited by

Patrick Ming-Kuen Tang

and

Dongmei Zhang

submission deadline 31 Oct 2026 | Viewed by 267 | Submission Open

Keywords: cancer therapy; drug resistance; molecular mechanism; artificial intelligence; singel-cell bioinformatics; spatial analysis

(This special issue belongs to the Section Molecular Oncology)

Toward an Integrated Understanding of Circadian and Neuroendocrine Interactions in Health and Disease

edited by

Estela Maris Muñoz

and

Agata Rita Carpentieri

submission deadline 31 Oct 2026 | Viewed by 265 | Submission Open

Keywords: chronobiology; circadian system; neuroendocrine system; multidirectional crosstalk; neurons; endocrine cells; endocrine regulation; zeitgebers; hormones; neurotransmitters; homeostasis; diseases

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Heart Diseases: Molecular Research and Novel Therapies

edited by Monika M. Gladka

submission deadline 31 Oct 2026 | Viewed by 262 | Submission Open

Keywords: cardiovascular diseases; molecular mechanisms; cardiac remodeling; heart failure; gene regulation; epigenetics; non-coding RNA; inflammation; regenerative medicine; novel therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Immune Crosstalk Between Host and Pathogens

edited by

Ulrike Kemmerling

and

Christian Castillo

submission deadline 31 Oct 2026 | Viewed by 258 | Submission Open

Keywords: host-pathogen interactions; virus; bacteria; parasites; innate immunity; adaptive immunity, signal transduction; immune evasion; cytokines; inflammation

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms and Therapeutic Approaches in Glaucoma and Retinal Neurodegeneration

edited by Yukihiro Shiga

submission deadline 31 Oct 2026 | Viewed by 257 | Submission Open

Keywords: glaucoma; retinal neurodegeneration; retinal ganglion cells; mitochondrial dysfunction; neuroinflammation; neuro-glial interactions; multi-omics; biomarkers; disease-modifying therapies; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Docking Studies and Enzyme Inhibitory Assessment of Synthesized Heterocyclic Compounds

edited by

Mohamed Maatallah

submission deadline 31 Oct 2026 | Viewed by 255 | Submission Open

Keywords: heterocyclic compounds; molecular docking; enzyme inhibition; structure activity relationships (SAR); synthetic medicinal chemistry; computational chemistry; in silico drug design; ADMET prediction; molecular dynamics simulation

(This special issue belongs to the Section Biochemistry)

T-Cell Function and Molecular Regulation

edited by

Davide Raineri

and

Hugo Abreu

submission deadline 31 Oct 2026 | Viewed by 254 | Submission Open

Keywords: T-cell activation and differentiation; immune checkpoints; signaling pathways; epigenetic modifications; immune tolerance; T-cell exhaustion; adoptive immunotherapy; cytokine signaling

(This special issue belongs to the Section Molecular Immunology)

Molecular Insights into Cancer Biomarkers and Targeted Therapies in Solid Tumors

edited by Michele Ghidini

submission deadline 31 Oct 2026 | Viewed by 253 | Submission Open

Keywords: cancer biomarkers; target therapies; solid tumors; mutations; molecular biology; immunotherapy; TKI inhibitors; monoclonal antibodies; NGS; molecular panel

(This special issue belongs to the Section Molecular Oncology)

Effects and Applications of Nanoparticles in Plant-Pathogen Interactions and Plant Physiology

edited by

Solabomi Olaitan Ayoade

submission deadline 31 Oct 2026 | Viewed by 249 | Submission Open

Keywords: plant–pathogen interaction; nanotechnology; plant physiology; transcriptomics; DNA methylation; antimicrobial mechanism; metabolomics; microbial structure analysis

(This special issue belongs to the Section Molecular Plant Sciences)

The Basic Mechanisms of Brain Inflammation

edited by

Diogo Dominguini

submission deadline 31 Oct 2026 | Viewed by 248 | Submission Open

Keywords: health sciences; neuroscience; pathophysiology; cognitive impairment; inflammation; mental health; oxidative stress

(This special issue belongs to the Section Molecular Immunology)

Displaying special issue 1001-1050 on page 21 of 63.

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