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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular and Cellular Mechanisms of Tissue Regeneration: Experimental Models and Emerging Approaches

edited by

Daiva Bironaite

submission deadline 30 Apr 2027 | Viewed by 292 | Submission Open

Keywords: regenerative medicine; stem cells; inflammation; degenerative disease models; extracellular matrix remodeling and intracellular signaling; tissue engineering; biomaterials and bioactive scaffolds; organoids; translational and cell-based therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Plant Transporters and Tolerance Proteins

edited by Kun Qiao

submission deadline 30 Apr 2027 | Viewed by 287 | Submission Open

Keywords: heavy metal; transporter; antioxidant; ornamental plants and horticulture; ion transport; phytoremediation; biofortification

(This special issue belongs to the Section Molecular Plant Sciences)

Mapping Lipid Metabolism in Cancer: Cellular, Metabolic, and Molecular Approaches

edited by

Iorio Egidio

submission deadline 30 Apr 2027 | Viewed by 287 | Submission Open

Keywords: lipid metabolism; cancer; metabolomics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Insights into Plant–Soil–Microbe Interactions Under Abiotic Stress

edited by

Youcai Xiong

and

Muhammad Abrar

submission deadline 30 Apr 2027 | Viewed by 274 | Submission Open

Keywords: abiotic stress; microbial metabolites; molecular signaling; plant–microbe interactions; plant stress tolerance; rhizosphere microbiome; stress-responsive genes

(This special issue belongs to the Section Molecular Plant Sciences)

Epigenetic and Molecular Control of Plant Hormones in Development and Abiotic Adaptation

edited by

Leonardo Bruno

and

Emanuela Talarico

submission deadline 30 Apr 2027 | Viewed by 270 | Submission Open

Keywords: plant hormones; phytohormone signaling; epigenetic regulation; chromatin remodeling; abiotic stress; plant development; hormone crosstalk; stress adaptation; epigenetic memory

(This special issue belongs to the Section Molecular Plant Sciences)

Ion and Molecular Transport in Nanopores/Channels

edited by Haiqi Gao

submission deadline 30 Apr 2027 | Viewed by 266 | Submission Open

Keywords: gas separation; desalination; ion separation; COF; nanoporous graphene; first-principle calculation; molecular dynamics simulation; machine learning

(This special issue belongs to the Section Materials Science)

Neuroimmune Interactions: From Physiology to Pathology

edited by

Chih-Li Chen

submission deadline 30 Apr 2027 | Viewed by 266 | Submission Open

Keywords: neuroimmune interactions; metabolic and mitochondria reprogramming; sensory neurons; neurodegeneration; neuropathic and nociplastic pain; neuroinflammation cancer neuroimmunology glial cells

(This special issue belongs to the Section Molecular Neurobiology)

RNA Structure and Regulation in Biological Processes

edited by Changrui Lu

submission deadline 30 Apr 2027 | Viewed by 262 | Submission Open

Keywords: RNA structure; RNA three-dimensional conformation; RNA dynamics; RNA chemical modifications; structural biology; RNA–protein interactions; RNA structures in plant disease resistance; viral RNA structure and function; computational structure prediction; host–pathogen interactions

(This special issue belongs to the Section Biochemistry)

Challenges and Innovation in Neurodegenerative Diseases, 3rd Edition

edited by

King-Ho Cheung

submission deadline 30 Apr 2027 | Viewed by 245 | Submission Open

Keywords: neurodegenerative diseases; pathogenesis; biomarkers; disease model; natural product; new drug discovery; therapy; machine learning; stem cell therapy

(This special issue belongs to the Section Molecular Neurobiology)

Forward in Vasculitis: Genetics and Beyond, 2nd Edition

edited by

Marija Jelusic

submission deadline 30 Apr 2027 | Viewed by 244 | Submission Open

Keywords: systemic vasculitides; ethiopathogenesis; risk factors; genetics; genomics; proteomics; transcriptomics; epigenetics; molecular pathways; novel therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Design, Synthesis and Evaluation of Anticancer Agents

edited by

Gourav Kumar

submission deadline 30 Apr 2027 | Viewed by 240 | Submission Open

Keywords: anticancer drug design; structure–activity relationship (SAR); molecular targets in cancer; synthetic antitumor agents; in vitro and ex vivo cancer models; molecular pharmacology

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms of Obesity and Metabolic Diseases: 2nd Edition

edited by

Liliya Mihaylova

submission deadline 30 Apr 2027 | Viewed by 237 | Submission Open

Keywords: molecular pharmacology; molecular mechanisms; obesity; metabolic diseases; metabolic syndrome; type 2 diabetes; atherosclerosis; cardio-metabolic disorders; metabolic dysfunction-associated steatotic liver disease

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Recent Progress on Optical Molecular Sensors

edited by

Nicola Y. Edwards

submission deadline 30 Apr 2027 | Viewed by 203 | Submission Open

Keywords: molecular sensors; chemosensors; luminescence; fluorescence; absorbance; chemometrics; computational studies; sensor arrays; receptors; assays

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Immunotherapy in Food Allergy: Toward Precision, Safety and Long-Term Tolerance

edited by

Natalia Ukleja-Sokołowska

submission deadline 30 Apr 2027 | Viewed by 188 | Submission Open

Keywords: food allergy; immunotherapy; immune tolerance; biomarkers

(This special issue belongs to the Section Molecular Immunology)

Molecular Insights into Electrocatalytic Water Splitting and Sustainable Hydrogen Production

edited by

Md Ahasan Habib

submission deadline 30 Apr 2027 | Viewed by 161 | Submission Open

Keywords: electrocatalytic water splitting; sustainable hydrogen production; molecular insights; reaction mechanisms; hydrogen evolution reaction (HER); oxygen evolution reaction (OER); active site engineering; structure–activity relationships; advanced functional materials; density functional theory (DFT); proton exchange membrane (PEM) electrolyzer; anion exchange membrane (AEM) water electrolysis; degradation mechanisms; green hydrogen production; electrocatalyst durability

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Biochemical Mechanisms of the Gut–Brain Axis: Microbial Metabolites, Barrier Integrity, and Neuroimmune Signaling

edited by

Sidharth Prasad Mishra

submission deadline 30 Apr 2027 | Viewed by 146 | Submission Open

Keywords: gut–brain axis; gut microbiota; microbial metabolites; intestinal barrier integrity; neuroimmune signaling; host-microbiome interactions; microbiome-brain communication; neuroinflammation; multi-omics; microbiome-based therapeutics

(This special issue belongs to the Section Molecular Biology)

Targeting Membrane Proteins: Structure, Function, and Dynamic Relationships

edited by Ki-Young Lee

submission deadline 30 Apr 2027 | Viewed by 128 | Submission Open

Keywords: membrane proteins; conformational dynamics; allosteric regulation; signal transduction; drug discovery; cryo-electron microscopy; nuclear magnetic resonance spectroscopy; artificial intelligence; membrane mimetics

(This special issue belongs to the Section Molecular Biology)

Bioactive Compounds and Fermented Foods: Molecular Mechanisms and Health Benefits

edited by Vishal Kumar and

Ki Sung Kang

submission deadline 30 Apr 2027 | Viewed by 100 | Submission Open

Keywords: fermented foods; bioactive compounds; natural extracts

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advanced Research on Functional Genomics and Genome Editing in Plants

edited by

Rushil Ramesh Mandlik

submission deadline 30 Apr 2027 | Viewed by 57 | Submission Open

Keywords: CRISPR/Cas; genome editing; functional genomics; plant biotechnology; gene regulation; base editing; prime editing; gene overexpression; multi-omics; crop improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Gut Microbiota and Microbe-Host Interactions in Cancer

edited by

Jessie Qiaoyi Liang

submission deadline 30 Apr 2027 | Viewed by 54 | Submission Open

Keywords: microbe–host interaction; metabolite; virulence factor; cancer signaling; gene regulation

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research on Dental Restorative Materials

edited by Yuanyuan Han

submission deadline 30 Apr 2027 | Viewed by 39 | Submission Open

Keywords: dental restorative materials; dental biomaterials; bioactive materials; molecular mechanisms; biocompatibility; remineralization; tissue regeneration; regenerative dentistry

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Multi-Omics-Driven Precision Oncology: Bridging Bioinformatics, Translational Research and Clinical Implementation

edited by Yang Shi and

Yin Wan

submission deadline 30 Apr 2027 | Viewed by 39 | Submission Open

Keywords: multi-omics; cancer bioinformatics; computational oncology; precision oncology; translational oncology; cancer genomics; transcriptomics; proteomics; metabolomics; single-cell omics; spatial omics; tumor microenvironment; molecular biomarkers; artificial intelligence; clinical implementation

(This special issue belongs to the Section Molecular Oncology)

Regulation of Intestinal Barrier Function

edited by

Vanessa D’Antongiovanni

submission deadline 30 Apr 2027 | Viewed by 39 | Submission Open

Keywords: intestinal epithelial barrier; gut inflammation; immune cells; enteric glia; enteric nervous system; gut–brain axis; microbiota; neuroinflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms Governing Microbial Bioremediation Performance in Environmental Matrices

edited by

Armstrong Omoregie

submission deadline 30 Apr 2027 | Viewed by 38 | Submission Open

Keywords: microbial bioremediation performance; catabolic gene expression; functional metagenomics and metatranscriptomics; degradative enzyme kinetics; transformation products and degradation pathways; stable isotope probing; contaminant speciation and immobilisation stability; microbially induced biomineralisation; bioaugmentation and inoculum persistence; environmental matrices

(This special issue belongs to the Section Molecular Microbiology)

Latest Reviews in Molecular Plant Science 2027

edited by

Maoteng Li

and

Jinsong Bao

submission deadline 30 Apr 2027 | Viewed by 31 | Submission Open

Keywords: gene cloning and gene functional analysis; gene editing; multi-omics integration analysis; plant development; metabolic pathway; biotic and abiotic stresses

(This special issue belongs to the Section Molecular Plant Sciences)

Current Advances in Neuroinflammation Research

edited by

Tauheed Ishrat

submission deadline 30 Apr 2027 | Viewed by 31 | Submission Open

Keywords: neuroinflammation; microglia; astrocytes; NLRP3 inflammasome; neurovascular unit; blood–brain barrier; traumatic brain injury; ischemic stroke; Alzheimer’s disease; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Cancer Gene Expression and Cell Pathways

edited by Cristina Moraes Junta

submission deadline 30 Apr 2027 | Viewed by 29 | Submission Open

Keywords: gene regulation; RNA regulation; epigenetics; RNA splicing/isoforms; signaling pathways; transcriptomics; functional genomics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Towards an Operational DNA-Based Quantum Computational Platform with DNA Data Storage

edited by Koen L.M. Bertels

submission deadline 30 Apr 2027 | Viewed by 25 | Submission Open

Keywords: DNA-based quantum computing; molecular qubits; DNA data storage; quantum entanglement; DNA nanotechnology; quantum information processing; scalable quantum platforms; molecular electronics

(This special issue belongs to the Section Molecular Informatics)

Molecular Research Landscape of Nucleic Acid Aptamers, Diagnosis and Therapies

edited by Silvia Catuogno

submission deadline 30 Apr 2027 | Viewed by 18 | Submission Open

Keywords: aptamers; SELEX; targeted therapy; targeted drug delivery; precision medicine; early diagnosis; non-invasive diagnostics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cardiomyopathies: Molecular Mechanisms and Therapies

edited by

Raffaella Lombardi

Suet Nee Chen

and Marcello Rubino

submission deadline 30 Apr 2027 | Viewed by 15 | Submission Open

Keywords: cardiomyopathies; molecular mechanisms; genomics; multi-omics; molecular therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Perspectives into Ovarian Function and Aging

edited by

Josè Roberto Viana Silva

submission deadline 30 Apr 2027 | Viewed by 10 | Submission Open

Keywords: oocyte; oxidative stress; epigenetics; intraovarian microenvironment; regenerative medicine

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular and Therapeutic Advances in Retinal Diseases

edited by

Jaeyon Won

submission deadline 30 Apr 2027 | Submission Open

Keywords: retinal diseases; retinal degeneration; age-related macular degeneration; diabetic retinopathy; inherited retinal diseases; gene therapy; regenerative medicine; retinal imaging; molecular mechanisms; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Invasive Candidiasis

edited by

Jordi Ibañez Nolla

and

Miquel Nolla-Salas

submission deadline 30 Apr 2027 | Submission Open

Keywords: candidiasis; non-neutropenic; immunoparalysis

(This special issue belongs to the Section Molecular Microbiology)

Genetic Research on Epilepsy

edited by

Ivan O. Litvinenko

and Krasteva Marina Petrova

submission deadline 30 Apr 2027 | Submission Open

Keywords: developmental and epileptic encephalopathies (DEEs); genetic basis of focal and generalized epilepsies; genetics of febrile seizures and febrile seizure syndromes; genotype–phenotype correlations in genetic epilepsies; novel epilepsy-associated genes and pathogenic variants; pharmacogenomics and treatment response in epilepsy; gene-targeted and molecular therapies for epilepsy; genetic predictors of seizure recurrence and prognosis; genetic determinants of epilepsy comorbidities (autism, intellectual disability, psychiatric disorders); cost-effectiveness and clinical utility of genetic testing; implementation of genomic medicine in routine epilepsy care; clinical decision support using genomic data; genetic screening in neonatal intensive care and pediatric neurology; prenatal diagnosis and reproductive counseling in inherited epilepsies; real-world evidence on the impact of genetic diagnosis; future perspectives in precision epilepsy medicine

(This special issue belongs to the Section Molecular Neurobiology)

Molecular and Cellular Mechanisms of Type 1 Diabetes: From Pathogenesis to Therapeutic Innovation

edited by Preeti Chhabra

submission deadline 30 Apr 2027 | Submission Open

Keywords: type 1 diabetes; pancreatic β cells; autoimmunity; β-cell stress; antigen presentation; immune tolerance; immunotherapy; immunometabolism; gut microbiome; microRNAs; proteomics; single-cell and spatial omics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Non-Coding RNAs in Cancer Pharmacology: Mechanisms, Drug Response and Therapeutic Targets

edited by

Dimitra Ioanna Lampropoulou

and

Maria Gazouli

submission deadline 1 May 2027 | Viewed by 56 | Submission Open

Keywords: non-coding RNAs; microRNAs; long non-coding RNAs; circular RNAs; cancer; anticancer therapy; drug response; therapeutic resistance; therapeutic targets; precision oncology

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms Regulating Stress Tolerance in Ornamental Plants

edited by

Haizhen Zhang

submission deadline 20 May 2027 | Viewed by 210 | Submission Open

Keywords: ornamental plants; biotic stresses; abiotic stresses; signal transduction pathways; transcription factors; functional proteins; transcription; translation; post-translational modification

(This special issue belongs to the Section Molecular Plant Sciences)

Editorial Board Members’ Collection Series in Antibiotic Resistance

edited by

Guyue Cheng

and

Xiangyue Xu

submission deadline 20 May 2027 | Viewed by 32 | Submission Open

Keywords: antimicrobial resistance; antibiotics; environmental pollutants; co-selection; One Health

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms of Plant Development and Environmental Adaptation

edited by

Haizhen Zhang

and

Haoqin Zhao

submission deadline 20 May 2027 | Viewed by 18 | Submission Open

Keywords: plant development; environmental adaptation; metabolic reprogramming; stress responses; epigenetic regulation; phytohormone signaling; transcriptional regulation

(This special issue belongs to the Section Molecular Plant Sciences)

Novel Natural Compound for Wound and Tissue Repair and Regeneration: 4th Edition

edited by

Elia Ranzato

submission deadline 25 May 2027 | 1 articles | Viewed by 1897 | Submission Open

Keywords: wound repair; tissue regeneration; natural compounds; phytochemicals; molecular mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Melanoma: Molecular Mechanism and Therapy, 2nd Edition

edited by

Balázs Margit

submission deadline 30 May 2027 | 3 articles | Viewed by 4228 | Submission Open

Keywords: melanoma progression; melanoma metastasis; molecular background; targeted therapies; immunotherapy; acquired drug resistance; prognostic and predictive markers; therapeutic targets

(This special issue belongs to the Section Molecular Oncology)

Molecular Evolution of the Vertebrate Immune System

edited by

Pierre Pontarotti

submission deadline 30 May 2027 | 1 articles | Viewed by 1697 | Submission Open

Keywords: immune system; molecular evolution; V (D) J recombination; RAG transposon; comparative genomics

(This special issue belongs to the Section Molecular Biology)

State-of-the-Art Molecular Plant Sciences in China

edited by Xiaoling Sun

submission deadline 30 May 2027 | Viewed by 106 | Submission Open

Keywords: molecular plant science; plant molecular biology; plant physiology and development; plant omics and bioinformatics; plant biotechnology

(This special issue belongs to the Section Molecular Plant Sciences)

Agronomic Regulation of Crop Environmental Adaptation and Grain Safety: Physiological and Molecular Mechanisms

edited by

Ligeng Jiang

and

Sun Yujun

submission deadline 30 May 2027 | Viewed by 54 | Submission Open

Keywords: agronomic management; environmental adaptation; molecular regulation; physiological and biochemical mechanisms; crop quality formation; plant-soil-microbe interactions; heavy metal detoxification; nitrogen-use efficiency; photosynthetic efficiency

(This special issue belongs to the Section Molecular Plant Sciences)

Environmental Pollutants Exposure and Toxicity

edited by

Tzveta Georgieva

submission deadline 31 May 2027 | 5 articles | Viewed by 4459 | Submission Open

Keywords: environmental pollutants exposure assessment; molecular methods; biomarkers; human safety; environmental safety

(This special issue belongs to the Section Molecular Toxicology)

Exploring UV-Induced Disease: Insights into Mechanisms and Innovative Strategies for Prevention and Therapy

edited by Hui Xu and

Ying Huang

submission deadline 31 May 2027 | 2 articles | Viewed by 3080 | Submission Open

Keywords: ultraviolet radiation; skin; DNA damage; DNA repair; immunosuppression; inflammatory disease; autoimmune disease; melanoma; non-melanoma skin cancers; genetic susceptibility; chemopre-vention; tumor immunotherapy; skin organoids for UV study; new animal models

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Aspects of Diabetes and Its Complications

edited by

Giuseppe Murdolo

submission deadline 31 May 2027 | 3 articles | Viewed by 3047 | Submission Open

Keywords: obesity; insulin resistance; type 2 diabetes; atherosclerosis; endothelial dysfunction; cardiovascular disease; peripheral artery disease; diabetic feet; diabetic micoangiopathy; diabetic neuropathy; regenerative medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Flow Cytometry as a Tool for Diagnostics and Biomarker Research

edited by

Leslie Chavez-Galan

submission deadline 31 May 2027 | 1 articles | Viewed by 2306 | Submission Open

Keywords: biomarkers; flow cytometry; spectral cytometry; mass cytometry; translational research; human health

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Biology on Environmental Microorganisms

edited by

Mariusz Cycoń

submission deadline 31 May 2027 | 3 articles | Viewed by 2105 | Submission Open

Keywords: environmental microbiology; metagenomics; microbial interactions; phage–host dynamics; horizontal gene transfer; biogeochemical cycles; antimicrobial resistance; single-cell methods; microbiome engineering; environmental biotechnology

(This special issue belongs to the Section Molecular Microbiology)

Neurobiology Linking Alcohol Addiction to Psychiatry Symptoms

edited by