Neuroimmune Interactions: From Physiology to Pathology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 145
Special Issue Editor
Interests: hepatitis B; hepatocellular carcinoma; cytokines; lymphocytes; inflammation; cell culture; cell signaling; liver diseases and immunology; immunity; adaptive immunity
Special Issue Information
Dear Colleagues,
Neuroimmune communication is a crucial mechanism for regulating tissue homeostasis, host defense, and disease progression. Increasing evidence shows that the bidirectional interaction between the nervous and immune systems plays essential roles in maintaining physiological balance while also contributing to various pathological processes, including chronic inflammation, neuropathic pain, neurodegeneration, autoimmune disorders, metabolic diseases, and cancer. Understanding how neuroimmune interactions shift from physiological regulation to pathological dysregulation is therefore of utmost importance.
This Special Issue aims to provide a comprehensive overview of recent advances in the molecular, cellular, and systemic mechanisms underlying neuroimmune crosstalk. We welcome original research articles and review papers that explore both central and peripheral neuroimmune interfaces, with particular emphasis on mechanistic insights and translational relevance. Topics of interest include, but are not limited to, neuroimmune regulation in tissue homeostasis, interactions between glial and immune cells, neuron-immune interactions, metabolic and mitochondrial reprogramming in neuroimmune signaling, and the role of neuroimmune networks in chronic inflammatory and degenerative diseases.
We are particularly interested in studies that employ cutting-edge technologies such as single-cell omics, spatial transcriptomics, advanced imaging, and bioengineered disease models to elucidate neuroimmune pathways. Research that explores therapeutic strategies, including neuromodulation, metabolic targeting, and immune reprogramming, is also strongly encouraged.
By integrating findings from physiology to pathology, this Special Issue aims to highlight emerging paradigms and identify novel therapeutic opportunities in neuroimmune physiology and pathology.
Dr. Chih-Li Chen
Guest Editor
Manuscript Submission Information
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Keywords
- neuroimmune interactions
- metabolic and mitochondria reprogramming
- sensory neurons
- neurodegeneration
- neuropathic and nociplastic pain
- neuroinflammation cancer neuroimmunology glial cells
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