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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Research on Diabetes and Obesity

edited by

Shin-Da Lee

submission deadline 20 Mar 2026 | 5 articles | Viewed by 12814 | Submission Open

Keywords: obesity; diabetes; hypothalamus; insulin resistance; glucose homeostasis; lipid metabolism; adipose tissue; cardiovascular tissue

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Basis of Pancreatic Secretion and Metabolism

edited by

Dongki Yang

submission deadline 20 Mar 2026 | 5 articles | Viewed by 12423 | Submission Open

Keywords: exocrine of the pancreas; endocrine of the pancreas; acute pancreatitis; chronic pancreatitis; cystic fibrosis; pancreatic metabolic hormones; pancreatic metabolic disease; mechanism of pancreatic bicarbonate secretion; the sodium bicarbonate cotransporter (NBC); cystic fibrosis transmembrane conductance regulator (CFTR); regulators of the ion channels and ion transporters involved in secretion

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Diabetes and Metabolic Dysfunction

edited by

Vasilis Tsimihodimos

submission deadline 20 Mar 2026 | 6 articles | Viewed by 12287 | Submission Open

Keywords: diabetes; metabolic dysfunction; glucose metabolism; metabolic disturbances; complications

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

CNS Injuries: 2nd Edition

edited by

Sudhanshu Raikwar

submission deadline 20 Mar 2026 | 1 articles | Viewed by 12163 | Submission Open

Keywords: stroke; TBI; brain edema; SCI; spinal cord edema; neuroinflammation; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Heart Failure: From Molecular Basis to Therapeutic Strategies

edited by

Michele Ciccarelli

submission deadline 20 Mar 2026 | 5 articles | Viewed by 12158 | Submission Open

Keywords: heart failure; cardiac metabolism; mitochondria; inflammatory pathway; neurohormonal system; therapeutical strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Unraveling the Molecular Mechanisms of Neurodegeneration

edited by

Michela Ferrucci

submission deadline 20 Mar 2026 | 4 articles | Viewed by 12059 | Submission Open

Keywords: protein accumulation; mitochondria; genetic and epigenetic alterations; oxidative stress; apoptosis; autophagy

(This special issue belongs to the Section Molecular Neurobiology)

Lipid Metabolism in Human Health and Diseases

edited by

Arianna Vignini

submission deadline 20 Mar 2026 | 4 articles | Viewed by 11984 | Submission Open

Keywords: lipids; fatty acids; lipid metabolism; metabolic disorders; cardiovascular diseases; neurodegenerative diseases; cancers

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Mechanisms and Therapies for Metabolic-Associated Fatty Liver Diseases

edited by Yi-Ming Arthur Chen

submission deadline 20 Mar 2026 | 3 articles | Viewed by 11883 | Submission Open

Keywords: metabolic-associated fatty liver disease; MAFLD; metabolic dysfunction-associated steatohepatitis; MASH; molecular mechanism; genetic polymorphism; individualized medicine; prevention; new drug development; health supplements; diagnosis; epidemiology; lifestyle

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanism and Treatment of Diabetes Mellitus and Its Complications

edited by

Bernd Stratmann

submission deadline 20 Mar 2026 | 6 articles | Viewed by 11869 | Submission Open

Keywords: MODY; LADA; diabetes late complications; molecular mechanisms; omics; polyneuropathy; microvascular disease; macrovascular disease; liver disease

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

New Advances in Medical Microbiology

edited by

Alberto Rizzo

submission deadline 20 Mar 2026 | 4 articles | Viewed by 11807 | Submission Open

Keywords: clinical microbiology; clinical virology; SARS-CoV-2; HPV; sexually transmitted infections; respiratory viruses; emerging pathogens; opportunistic infections

(This special issue belongs to the Section Molecular Microbiology)

Advances in Pathogenesis, Molecular Mechanisms, and Therapeutic Strategies for Neurodegenerative Diseases

edited by

Abdullah Sheikh

submission deadline 20 Mar 2026 | 5 articles | Viewed by 11781 | Submission Open

Keywords: neurodegeneration; molecular pathways; protein aggregation; gene therapy; neuroprotection

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cellular Plasticity and EMT in Cancer and Fibrotic Diseases

edited by

Sabrina Lisi

and

Margherita Sisto

submission deadline 20 Mar 2026 | 5 articles | Viewed by 11471 | Submission Open

Keywords: fibrosis; epithelial– mesenchymal transition; epithelial– mesenchymal plasticity; cancer; fibrotic diseases; inflammation; metastases

(This special issue belongs to the Section Molecular Biology)

Molecular Genetics in Ovarian Cancer

edited by

Bruna Scaggiante

submission deadline 20 Mar 2026 | 6 articles | Viewed by 10923 | Submission Open

Keywords: chemotherapy resistance; differential gene expression; genomic structural variation; ovarian cancer mutations; ovarian cancer metastasis; ovarian cancer treatment; novel molecular targets

(This special issue belongs to the Section Molecular Genetics and Genomics)

Inflammatory Bowel Disease and Microbiome

edited by Abigail Raffner Basson

submission deadline 20 Mar 2026 | 4 articles | Viewed by 10906 | Submission Open

Keywords: inflammatory bowel disease; Crohn’ s disease; ulcerative colitis; gut microbiota; diet; treatment; pathogenesis; biomarker

(This special issue belongs to the Section Molecular Microbiology)

The Role of SARS-CoV-2 in Immunomodulation—Post-Pandemic Reflection on the Role of Viruses in Human Immunology

edited by

Katarzyna A. Lisowska

submission deadline 20 Mar 2026 | 6 articles | Viewed by 10695 | Submission Open

Keywords: SARS-CoV-2; COVID-19; immunomodulation; T cells; B cells; dendritic cells; monocytes; cytokines

(This special issue belongs to the Section Molecular Immunology)

Advanced Molecular Research on the Diagnosis and Treatment of Chronic Liver Diseases

edited by

Hirayuki Enomoto

submission deadline 20 Mar 2026 | 3 articles | Viewed by 10541 | Submission Open

Keywords: biomarker; genomic research; epigenomic research; molecular mechanisms; viral hepatitis; alcoholic-related liver disease; non-alcoholic fatty liver disease; autoimmune liver diseases; liver cirrhosis; hepatocellular carcinoma

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Vegetable Genetics and Genomics, 3rd Edition

edited by

Yunsong Lai

and

Xixiang Li

submission deadline 20 Mar 2026 | 7 articles | Viewed by 10275 | Submission Open

Keywords: major vegetable crops; genome; variome; genotyping; GWAS; QTL mapping; functional genome; metabolome; breeding target characters; genetic mechanism; functional genes

(This special issue belongs to the Section Molecular Plant Sciences)

Signaling Pathways and Novel Therapies in Heart Disease

edited by

Anindita Das

submission deadline 20 Mar 2026 | 4 articles | Viewed by 10269 | Submission Open

Keywords: heart failure; arrhythmias; ischemic heart disease; myocardial regeneration; inflammation; gene- or cell-based therapy; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Density Functional Theory and Related Methods for Molecular Computational Chemistry

edited by Paolo Umari

submission deadline 20 Mar 2026 | 4 articles | Viewed by 10131 | Submission Open

Keywords: density functional theory; quantum chemistry; algorithms; quantum computing; high-performance computing; machine learning; many-body perturbations theory; quantum Monte Carlo

(This special issue belongs to the Section Molecular Informatics)

Gynecologic Diseases: From Molecular Basis to Therapy

edited by Domenico Baldini

submission deadline 20 Mar 2026 | 2 articles | Viewed by 10114 | Submission Open

Keywords: infertility; sterility; gynecologic desease; genetic; IVF; gynecologic therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Hormone Replacement Therapy

edited by

Marco Antonio Botelho

and

Raouf A. Khalil

submission deadline 20 Mar 2026 | 2 articles | Viewed by 9585 | Submission Open

Keywords: hormone replacement therapy; molecular insights; endocrine signaling; precision medicine; gene expression; epigenetics; non-coding RNAs; personalized regimens

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Research Progress of Skin and Skin Diseases: 2nd Edition

edited by

Ji Hyun Lee

submission deadline 20 Mar 2026 | 5 articles | Viewed by 9562 | Submission Open

Keywords: atopic dermatitis; psoriasis; alopecia; vitiligo; acne; skin cancer; JAK-STAT; inflammatory skin disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring Biological Mechanisms and Therapeutic Strategies for Substance Use Disorders

edited by Thomas Paparrigopoulos

submission deadline 20 Mar 2026 | 3 articles | Viewed by 9508 | Submission Open

Keywords: addiction; alcohol use disorder; opioid use disorder; substance use disorders; physical exercise; physical activity; molecular mechanisms; neuroendocrine system

(This special issue belongs to the Section Molecular Neurobiology)

New Therapies and Strategies in the Treatment of Neurodegenerative Diseases

edited by

Polina Petkova-Kirova

submission deadline 20 Mar 2026 | 3 articles | Viewed by 9467 | Submission Open

Keywords: neurodegenerative diseases; Alzheimer’ s disease; Parkinson’ s disease; Huntington’ s disease; aging; memory; dementia; motor dysfunction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Toxicity of Metals, Metal-Based Drugs, and Microplastics

edited by

Agnieszka Scibior

Manuel Aureliano

and

Juan Llopis

submission deadline 20 Mar 2026 | 4 articles | Viewed by 8994 | Submission Open

Keywords: metal toxicity and pollution; microplastic toxicity and pollution; metal and microplastic bioaccumulation; metal-based drugs; protein metalation; human health problems; diseases; in vitro/in vivo studies; human studies

(This special issue belongs to the Section Molecular Toxicology)

Ocular Ischemic Diseases: From Molecular Mechanisms to Therapeutics

edited by

Deokho Lee

submission deadline 20 Mar 2026 | 4 articles | Viewed by 8947 | Submission Open

Keywords: diabetic retinopathy; retinopathy of prematurity; retinal vein occlusion; retinal artery occlusion; pathologic myopia; age-related macular degeneration; glaucoma; ocular ischemic syndrome

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Chromatin Structure and Dynamics

edited by Stephanie Portillo-Ledesma

submission deadline 20 Mar 2026 | 5 articles | Viewed by 8783 | Submission Open

Keywords: chromatin structure and dynamics; genome architecture; epigenetic regulation

(This special issue belongs to the Section Biochemistry)

Molecular Mechanism in Cardiovascular Pathology

edited by Andrea Marzullo

submission deadline 20 Mar 2026 | 6 articles | Viewed by 8692 | Submission Open

Keywords: cardiovascular diseases; molecular biology; sudden death; cardiomyopathies; heart failure; coronary artery diseases; pericarditis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Autoimmune Diseases

edited by

Tsvetelina Velikova

submission deadline 20 Mar 2026 | 4 articles | Viewed by 8521 | Submission Open

Keywords: autoimmunity; autoimmune mechanisms; molecular pathogenesis; immune signalling pathways; cytokine regulation; epigenetics in autoimmunity; molecular biomarkers; gene expression profiling; regulatory T cells; immunogenetics; molecular therapeutics; signal transduction; immunometabolism; microRNA in autoimmunity

(This special issue belongs to the Section Molecular Immunology)

Protein Methyltransferases in Human Health and Diseases

edited by

Byron Baron

submission deadline 20 Mar 2026 | 3 articles | Viewed by 8454 | Submission Open

Keywords: lysine and arginine methylation; mass spectrometry; PTM cross talk; functional proteomics; cancer; neurological disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pathophysiology and New Therapies of Alopecia

edited by Jong-Hyuk Sung

submission deadline 20 Mar 2026 | 2 articles | Viewed by 8387 | Submission Open

Keywords: alopecia; pathophysiology; novel pharmacological treatments; regenerative medicines; gene therapy; cell therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Applications of Bacteriophages

edited by

Grzegorz Wegrzyn

submission deadline 20 Mar 2026 | 1 articles | Viewed by 8360 | Submission Open

Keywords: bacteriophages; gene cloning; phage display technology; phage

(This special issue belongs to the Section Molecular Biology)

Recent Progress in Advanced Computing Techniques for Molecules and Nanomaterials

edited by

Joonho Bae

submission deadline 20 Mar 2026 | 1 articles | Viewed by 8272 | Submission Open

Keywords: nanomaterials; machine learning; artificial intelligence; computing techniques; modeling; energy storage; catalysis

(This special issue belongs to the Section Molecular Nanoscience)

MAPK Signaling Cascades in Human Health and Diseases, 2nd Edition

edited by Galia Maik-Rachline

submission deadline 20 Mar 2026 | 2 articles | Viewed by 7993 | Submission Open

Keywords: ERK1/2; p38; JNK; ERK5; MEK; MEKK; raf; stimulated nuclear translocation; targeted therapy; resistance mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Strategies to Improve the Detection of Human Papillomavirus (HPV) Persisting Infections

edited by

Marianna Martinelli

submission deadline 20 Mar 2026 | 4 articles | Viewed by 7922 | Submission Open

Keywords: human papillomavirus; HPV; viral load; genotyping; oncogenic transcripts; biomarkers

(This special issue belongs to the Section Molecular Microbiology)

Mitochondria: Central Players in Cancer

edited by

Annamaria Piscazzi

and

Domenica Mangieri

submission deadline 20 Mar 2026 | 4 articles | Viewed by 7858 | Submission Open

Keywords: mitochondria; cancer; tumorigenesis; oxidative phosphorylation; glycolysis; Warburg effect; reactive oxygen species (ROS); apoptosis; mitochondrial dysfunction; metabolic reprogram-ming; cancer therapy

(This special issue belongs to the Section Molecular Biology)

Protein Aggregation and Proteinopathies

edited by Hongyu Hu

submission deadline 20 Mar 2026 | 2 articles | Viewed by 7755 | Submission Open

Keywords: protein aggregation; inclusion; sequestration; interaction; phase transition; proteostasis; proteinopathy

(This special issue belongs to the Section Molecular Biology)

Understanding Allergy and Asthma at the Molecular Level

edited by

Cenk Suphioglu

submission deadline 20 Mar 2026 | 1 articles | Viewed by 7751 | Submission Open

Keywords: allergy; asthma; allergens; allergic asthma; thunderstorm asthma; cell culture; biomarkers; proteomics; metabolomics; lipidomics; genomics; recombinant allergens; recombinant hypoallergens; signalling; inhibitors; cytokines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cutting-Edge Research on Nanosensors and Microsensors

edited by

Beata Paczosa-Bator

submission deadline 20 Mar 2026 | 2 articles | Viewed by 7344 | Submission Open

Keywords: nanosensors and microsensors; innovations; nanomaterials; nanotechnology; biomedical devices; point-of-care and point-of-use testing; environmental control

(This special issue belongs to the Section Materials Science)

Modulation of the Immune System and Oxidative Stress in Liver Illnesses

edited by

Vlad Pădureanu

and Dan Ionuț Gheonea

submission deadline 20 Mar 2026 | 2 articles | Viewed by 7248 | Submission Open

Keywords: oxidative stress; liver illnesses; immune system; inflammatory

(This special issue belongs to the Section Molecular Immunology)

Virus Engineering and Applications: 3rd Edition

edited by

Laura Menotti

submission deadline 20 Mar 2026 | 3 articles | Viewed by 7186 | Submission Open

Keywords: virus engineering; oncolytic virotherapy; immunovirotherapy; viral biotechnology

(This special issue belongs to the Section Molecular Microbiology)

Mitochondrial Metabolism Alterations in Health and Disease: 2nd Edition

edited by

Vincenza Dolce

Rosita Curcio

and

Graziantonio Lauria

submission deadline 20 Mar 2026 | 2 articles | Viewed by 7142 | Submission Open

Keywords: mitochondrial Metabolism; mitochondrial disorders; cellular processes; dysregulation organisms’ physiology

(This special issue belongs to the Section Biochemistry)

Advanced Research in Retina: 3rd Edition

edited by

Juan J. Salazar

and

José A. Fernández-Albarral

submission deadline 20 Mar 2026 | 4 articles | Viewed by 6927 | Submission Open

Keywords: glaucoma; age-related macular degeneration; diabetic retinopathy; neurodegenerative diseases; diagnostic techniques; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Breeding for Abiotic Stress Tolerance in Crops (Second Edition)

edited by

Mario A. Pagnotta

submission deadline 20 Mar 2026 | 6 articles | Viewed by 6473 | Submission Open

Keywords: plant breeding; advance molecular approach; molecular characterization; environmental stresses plant tolerance; resistant genes; QTLs; drought; salinity; climatic changes

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research and Insight into Endocannabinoid System

edited by

Jorge Manzanares

and

Francisco Navarrete

submission deadline 20 Mar 2026 | 3 articles | Viewed by 6418 | Submission Open

Keywords: endocannabinoid system; molecular research; biomarker; translational

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Induced Pluripotent Stem and Extracellular Vesicles in Biomedicine

edited by

Ylenia Della Rocca

Francesca Diomede

and

Jacopo Pizzicannella

submission deadline 20 Mar 2026 | 2 articles | Viewed by 6323 | Submission Open

Keywords: induced pluripotent stem; embryonic stem cells; extracellular vesicles; tissue development; translational medicine

(This special issue belongs to the Section Molecular Biology)

New Advances in Molecular Research in Leukemia

edited by

Akiyoshi Takami

Jorge Luis Espinoza

and

Carla Di Stefano

submission deadline 20 Mar 2026 | 2 articles | Viewed by 6022 | Submission Open

Keywords: acute lymphoblastic leukemia (ALL); chronic lymphocytic leukemia (CLL); acute myelogenous leukemia (AML); chronic myelogenous leukemia (CML); hairy cell leukemia (HCL); T-cell prolymphocytic leukemia (T-PLL); large granular lymphocytic leukemia; measurable residual disease (MRD)

(This special issue belongs to the Section Molecular Oncology)

Mechanism and Treatment Progress of Liver Disease

edited by Yohei Shirakami

submission deadline 20 Mar 2026 | 3 articles | Viewed by 5988 | Submission Open

Keywords: liver diseases; MASLD; alcoholic liver disease; liver cancer; viral hepatitis; sarcopenia

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Discovery, Extraction, Synthesis, and Application of Natural Products

edited by

Hah Young Yoo

, Kang Hyun Lee and

Taek Lee

submission deadline 20 Mar 2026 | 2 articles | Viewed by 5981 | Submission Open

Keywords: antibiotics; antioxidants; biomass; bioactive molecule; biological activity; biosynthesis; biosensor; biomedicine; biotechnology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Big Data in Multi-Omics

edited by

Dimitrios Vlachakis

and

George P. Chrousos

submission deadline 20 Mar 2026 | 2 articles | Viewed by 5818 | Submission Open

Keywords: data science; big data; omics; data management; data analytics TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back // This page is in Shona Translate to Simplified Chinese Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh Always translate Shona to Simplified Chinese Never translate Shona Never translate admin.mdpi.com

(This special issue belongs to the Section Molecular Informatics)

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