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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular and Biomaterial Advances in Tissue Engineering

edited by

Haishan Shi

and

Jinfeng He

submission deadline 31 Dec 2026 | Viewed by 153 | Submission Open

Keywords: tissue engineering; regenerative medicine; biomaterials; stem cells; 3D bioprinting; molecular mechanisms; extracellular matrix

(This special issue belongs to the Section Materials Science)

Molecular Mechanisms and Applications of Phage Infection and Host Resistance

edited by Rajnikant Sharma

submission deadline 31 Dec 2026 | Viewed by 153 | Submission Open

Keywords: bacteriophages; phage therapy; phage–host interactions; bacterial host resistance; antimicrobial resistance; biotechnology applications

(This special issue belongs to the Section Molecular Microbiology)

Cellular and Molecular Mechanisms of Exercise-Induced Tissue Adaptation in Health, Disease and Performance

edited by

Gilberto E. Shiguemoto

and

Wladimir Rafael Beck

submission deadline 31 Dec 2026 | Viewed by 152 | Submission Open

Keywords: skeletal muscle plasticity; exerkines and tissue crosstalk; molecular signaling pathways; exercise training adaptation; mitochondrial function; mitokines and metabolic crosstalk; epigenetic regulation; myokines

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Biomarkers in Allergic and Immune-Mediated Diseases

edited by

Luisa Ricciardi

submission deadline 31 Dec 2026 | Viewed by 150 | Submission Open

Keywords: allergy; clinical immunology; autoimmune diseases; IgE; auto-antibodies; biomarkers; inflammation

(This special issue belongs to the Section Molecular Immunology)

Neuroinflammation: Molecular Targets and Therapeutic Advances

edited by

Tamás Körtési

submission deadline 31 Dec 2026 | Viewed by 148 | Submission Open

Keywords: neuroinflammation; neuroimmune signaling; migraine; neuropeptides; glutamatergic system; kynurenine pathway; microglia; astrocytes; neurodegeneration; therapeutic targets

(This special issue belongs to the Section Molecular Neurobiology)

Molecular and Cellular Basis of Chronic Pain

edited by

Kuthati Yaswanth

submission deadline 31 Dec 2026 | Viewed by 147 | Submission Open

Keywords: neuro–immune crosstalk; chondroprotection; subchondral bone remodeling; central sensitization; nociceptive signaling pathways; health supplements

(This special issue belongs to the Section Molecular Neurobiology)

Cholangiocarcinoma: Molecular Diagnosis and Future Therapeutic Perspectives

edited by

Diamantis I. Tsilimigras

and

Ioannis Ntanasis-Stathopoulos

submission deadline 31 Dec 2026 | Viewed by 144 | Submission Open

Keywords: cholangiocarcinoma; molecular diagnostics; precision oncology; biomarkers; targeted therapy; immunotherapy; tumor microenvironment; genomics; liquid biopsy; translational medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Spinal Muscular Atrophy: From Genetics to Therapeutics

edited by Eduardo F. Tizzano and

Lucia Tabares

submission deadline 31 Dec 2026 | Viewed by 141 | Submission Open

Keywords: spinal muscular atrophy; motor neuron; survival motor neuron genes; genetic modifiers; disease-modifying therapies; multisystemic disease; synapsis; later-onset phenotypes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Evolution of Plant Genomes and Stress Adaptation

edited by

Zhonghu Li

submission deadline 31 Dec 2026 | Viewed by 140 | Submission Open

Keywords: plant genomics; molecular evolution; population genetics; stress adaptation; lineage divergence

(This special issue belongs to the Section Molecular Plant Sciences)

Neuroimmune Crosstalk Across Neurodegenerative Disorders

edited by Muhammad Sohail Khan

submission deadline 31 Dec 2026 | Viewed by 137 | Submission Open

Keywords: neuroimmune crosstalk; neuroinflammation; neurodegeneration; microglia astrocytes; Alzheimer’s disease; Parkinson’s disease; extracellular vesicles; biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

Emerging Strategies for Spinal Cord Injury: Cellular and Molecular Targets for SCI Repair and Recovery

edited by Karen L. Lankford

submission deadline 31 Dec 2026 | Viewed by 132 | Submission Open

Keywords: spinal cord injury; chronic; acute; miRs; mRNA; inflamasome; extracellular matrix; integrins; neurogenesis; myelin; sulphate proteoglycans (CSPG); myelin-derived inhibitors (MAIs)

(This special issue belongs to the Section Molecular Neurobiology)

Biomedical and Biological Applications of Organic Chemical Molecules and Materials

edited by Katarzyna Kotwica-Mojzych

submission deadline 31 Dec 2026 | Viewed by 130 | Submission Open

Keywords: organic molecules; medicinal chemistry; heterocyclic compounds; biomaterials; nanomaterials; drug discovery; anticancer agents; molecular mechanisms; tissue engineering; regenerative medicine

(This special issue belongs to the Section Materials Science)

Molecular and Physicochemical Research Progress of Orthodontic Materials: From Metal Alloys to Dental Resins

edited by

Marcin Mikulewicz

submission deadline 31 Dec 2026 | Viewed by 129 | Submission Open

Keywords: orthodontic archwires; ion release; acrylic resin; colour stability; surface roughness; corrosion; dental materials; biomechanics; microbial colonisation; prosthodontics; orthodontics; oral environment

(This special issue belongs to the Section Materials Science)

Recent Research and Developments in Antimicrobial Natural Products

edited by

Ki-Young Kim

submission deadline 31 Dec 2026 | Viewed by 129 | Submission Open

Keywords: antimicrobial natural products; antimicrobial resistance; plant-derived antimicrobials; microbial secondary metabolites; marine; natural products; antimicrobial peptides; lead compound discovery; mechanism of action; AI-assisted drug discovery; translational development

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Natural Compounds in Cancer Therapy and Prevention, 3rd Edition

edited by

Federica Finetti

and

Lorenza Trabalzini

submission deadline 31 Dec 2026 | Viewed by 128 | Submission Open

Keywords: cancer therapy; cancer prevention; natural compounds; metastasis; immunomodulation; adjuvant therapy; preventive therapy; drug discovery; natural drugs

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Biology and the Genetic Breeding of Aquatic Animals: Breakthroughs and Challenges (3rd Edition)

edited by

Hongyan Xu

and

Ke Feng

submission deadline 31 Dec 2026 | Viewed by 124 | Submission Open

Keywords: transgenic; genetic breeding; omics; gene expression and regulation; aquatic animals

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Hypertension, Diabetes and Obesity

edited by

Shin-Da Lee

submission deadline 31 Dec 2026 | Viewed by 119 | Submission Open

Keywords: hypertension; diabetes; obesity; metabolic syndrome; cardiometabolic; neurocardiometabolic; endothelial dysfunction; oxidative stress; inflammation; apoptosis; cardiovascular disease with comorbidity; chronic kidney disease with comorbidity; neurology disease with comorbidity; exercise training; pharmacological intervention; nutritional intervention; precision medicine; biomarkers; molecular mechanisms; translational medicine

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances and Perspectives in Cyanobacterial Research

edited by

Mathias Chia

submission deadline 31 Dec 2026 | Viewed by 117 | Submission Open

Keywords: cyanobacteria; molecular biology; genomics; transcriptomics; proteomics; metabolomics; cyanotoxins; secondary metabolites; nitrogen fixation; synthetic biology

(This special issue belongs to the Section Molecular Plant Sciences)

Beyond Antimicrobial Resistance: Molecular Mechanisms of Bacterial Survival Strategies and Next-Generation Therapeutic Approaches

edited by

Ksenia Szymanek-Majchrzak

submission deadline 31 Dec 2026 | Viewed by 116 | Submission Open

Keywords: antimicrobial resistance; heteroresistance; persistence; biofilm; bacterial adaptation; antimicrobial tolerance; anti-biofilm therapy; next-generation therapeutics

(This special issue belongs to the Section Molecular Microbiology)

Bio/Synthesis, Design and Characterization of Materials from Natural Resources

edited by

Catalina Natalia Cheaburu-Yilmaz

submission deadline 31 Dec 2026 | Viewed by 115 | Submission Open

Keywords: biosynthesis; biopolymers; green chemistry; functional materials; renewable resources; electroactive materials

(This special issue belongs to the Section Materials Science)

Transition Metal Catalysis: Constructing Complex Structures and Introducing Chirality

edited by Guodu Liu

submission deadline 31 Dec 2026 | Viewed by 110 | Submission Open

Keywords: transition metal catalysis; asymmetric synthesis; chiral ligands; cross-coupling reactions; catalytic hydrogenation; organometallic chemistry; synthetic methodology; homogeneous catalysis; total synthesis; medicinal chemistry; chemical biology

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Mechanisms and Therapeutic Implications in Cardiovascular Diseases

edited by Luyao Wang

submission deadline 31 Dec 2026 | Viewed by 104 | Submission Open

Keywords: cardiovascular diseases (CVDs); molecular mechanisms; target discovery; therapeutic implications; drug development

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Therapeutic Innovations in Hypercholesterolemia and Dyslipidemia

edited by

Baskaran Gunasekaran

submission deadline 31 Dec 2026 | Viewed by 104 | Submission Open

Keywords: hypercholesterolemia; dyslipidemia; cholesterol Metabolism; lipid homeostasis; transcriptomics; nutraceuticals; phytosterols; precision medicine; cardiovascular disease; molecular therapeutic

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Complexity of Metabolic Dysfunction-Associated Steatotic Liver Disease: From Bench to Clinical Practice

edited by

Łukasz Bułdak

submission deadline 31 Dec 2026 | Viewed by 103 | Submission Open

Keywords: MASLD; liver steatosis; steatohepatitis; liver cirrhosis; hepatocellular carcinoma; obesity; type 2 diabetes; hyperlipidemia; quality of life; in vivo; in vitro; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Ecophysiological Plant Responses to Environmental Stress

edited by

Md Jahirul Islam

submission deadline 31 Dec 2026 | Viewed by 102 | Submission Open

Keywords: environmental stress; abiotic stress tolerance; plant stress physiology; molecular stress responses; oxidative stress and antioxidants; gene expression and signaling pathways; climate change adaptation in plants; crop resilience and sustainable agriculture

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Insights into Hormonal Disturbances in Respiratory Disorders

edited by

Dominika Zając

submission deadline 31 Dec 2026 | Viewed by 99 | Submission Open

Keywords: hormonal disturbances; obesity; diabetes mellitus; hypo-/hyperthyroidism; PCOS; menopause; respiratory diseases; asthma; obstructive sleep apnea (OSA); airway obstruction; airway inflammation; pulmonary arterial hypertension (PAH); recurrent respiratory infections; respiratory failure; allergy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Applications of Natural Products in Nanotechnology

edited by Mehmet Gokhan Halici

submission deadline 31 Dec 2026 | Viewed by 87 | Submission Open

Keywords: natural products; nanotechnology; green synthesis; biologically mediated nanomaterials

(This special issue belongs to the Section Molecular Nanoscience)

Novel Strategies for Enzyme-Based Biosensors

edited by

Roxana Apetrei

submission deadline 31 Dec 2026 | Viewed by 84 | Submission Open

Keywords: molecular recognition; biocatalysis; biological receptors; nanozymes; molecularly imprinted polymers; transduction interfaces

(This special issue belongs to the Section Macromolecules)

Molecular Insights into Sustainable Food and Packaging Systems

edited by

Kingwascharapong Passakorn

submission deadline 1 Jan 2027 | Viewed by 129 | Submission Open

Keywords: molecular food science and molecular interactions; structure–function relationships of food biomolecules; bioactive compounds and functional ingredients; food quality, stability, and functionality; alternative proteins; sustainable processing and circular economy; by-product valorization; biodegradable and active packaging; biomaterials for food and packaging applications; advanced analytical and characterization techniques

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Uncovering the Advantages of Natural Medicines in Treating and Preventing Diseases

edited by

Xingkang Wu

submission deadline 20 Jan 2027 | Viewed by 173 | Submission Open

Keywords: natural medicine; natural product; natural product derivatives; traditional medicine; extract; therapeutic efficacy; toxicological effects; multi-target, multi-pathway

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Novel Insights into Active Substances and Extracts

edited by Diamanto Lazari and

Charikleia Paloukopoulou

submission deadline 20 Jan 2027 | Viewed by 128 | Submission Open

Keywords: bioactive compounds; natural products; synthetic molecules; functional materials; molecular mechanisms; cell signaling; oxidative stress; structure–activity relationships; nutraceuticals; molecular pharmacology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Advances in Anticancer Agents: Discovery, Development, and Clinical Applications

edited by

Nicoletta Cordani

submission deadline 20 Jan 2027 | Viewed by 110 | Submission Open

Keywords: anticancer agents; targeted therapy; immunotherapy; drug discovery; precision oncology; biomarkers; drug resistance; combination therapy; translational research; clinical applications

(This special issue belongs to the Section Molecular Pharmacology)

Melanoma: Advances in Biology and Treatment

edited by

Joanne Tobacman

submission deadline 20 Jan 2027 | Viewed by 102 | Submission Open

Keywords: chondroitin sulfate; proteoglycans; chondroitin sulfatases; sulfotransferases; microenvironment; checkpoint inhibitor combinations

(This special issue belongs to the Section Molecular Biology)

Nanodelivery Systems in Health and Disease: Molecular Design and Biomedical Applications

edited by

Chi Lin

submission deadline 25 Jan 2027 | Viewed by 128 | Submission Open

Keywords: nanodelivery systems; molecular design; targeted drug delivery; stimuli-responsive nanocarriers; supramolecular assembly; bioactive molecules; nucleic acid delivery; biomedical applications; nutraceutical delivery

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Basis of Vector–Host–Pathogen Interactions

edited by

Van Lun Low

submission deadline 28 Jan 2027 | Viewed by 119 | Submission Open

Keywords: vector–host–pathogen interactions; vector-borne diseases; vector competence; host immune responses; pathogen transmission; molecular mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Cancer-Driving Molecules: From Molecular Mechanisms to Novel Therapeutics

edited by

Georgios Pantouris

submission deadline 29 Jan 2027 | 8 articles | Viewed by 13033 | Submission Open

Keywords: cancer; mechanism of action; tumor microenvironment; immune system; DNA/RNA/protein; small-molecule probes; activation/inhibition; biological activity

(This special issue belongs to the Section Molecular Oncology)

Emerging Trends of Biotechnology in Bioremediation and Biodegradation

edited by

Marta Alejandra Polti

submission deadline 29 Jan 2027 | 1 articles | Viewed by 3123 | Submission Open

Keywords: emerging technologies; biological treatment; environmental sustainability; innovative methodologies; ecosystem restoration

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Hypertension

edited by Pedro A. José

submission deadline 29 Jan 2027 | 2 articles | Viewed by 2593 | Submission Open

Keywords: salt sensitivity; inverse salt sensitivity; epigenetics; genetics; organ-to-organ communication

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Plant Nutrient Uptake and Signaling Networks

edited by

Tarek Alshaal

submission deadline 29 Jan 2027 | 1 articles | Viewed by 980 | Submission Open

Keywords: rhizosphere interactions; ion homeostasis; transporter regulation; signal transduction; transcriptional control; nutrient use efficiency; root architecture; plant–microbe symbiosis; abiotic stress adaptation; omics integration

(This special issue belongs to the Section Molecular Plant Sciences)

Plant Genome Editing: Recent Advances and Future Perspectives

edited by

Hakim Manghwar

submission deadline 29 Jan 2027 | 1 articles | Viewed by 742 | Submission Open

Keywords: gene knockout; gene knock-in; gene knockdown; base editing; transcription activation; prime editing; off-target analysis; new CRISPR variants; high-throughput genome editing system

(This special issue belongs to the Section Molecular Plant Sciences)

Mitochondrial Signaling Pathways in Inflammation and Diseases

edited by

Francesca Oppedisano

and

Cristina Algieri

submission deadline 29 Jan 2027 | Viewed by 527 | Submission Open

Keywords: mitochondria; cell metabolism; inflammatory mitochondrial signalling; metabolic pathways; mitochondrial dysfunction; mtDNA; cGAS-STING pathway; NLRP3 inflammasome; human pathology

(This special issue belongs to the Section Biochemistry)

Emerging Metabolomics Techniques and Applications

edited by Jun Han

submission deadline 29 Jan 2027 | Viewed by 287 | Submission Open

Keywords: metabolomics; lipidomics; bioinformatics; micro-extraction; chemical derivatization; liquid chromatography-mass spectrometry (LC-MS); matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS); gas chromatography-mass spectrometry (GC-MS); metabolic profiling; biomarker assay

(This special issue belongs to the Section Molecular Informatics)

Molecular Mechanisms Underlying Glomerular and Tubular Kidney Diseases

edited by

Gabriel Estrela

submission deadline 29 Jan 2027 | Viewed by 124 | Submission Open

Keywords: acute kidney injury (AKI); chronic kidney disease (CKD); glomerular injury; tubular epithelial cells; podocyte dysfunction; renal fibrosis; inflammation and immune response; epithelial–mesenchymal transition (EMT); mitochondrial dysfunction; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Perspectives on the Gut-Brain Axis: Multiomics, Machine Learning, and Therapeutic Interventions

edited by Gabriela Ibáñez-Cervantes and

Cindy Bandala

submission deadline 29 Jan 2027 | Viewed by 66 | Submission Open

Keywords: gut–brain axis; multi-omics integration; metagenomics and metabolomics; single-cell transcriptomics; machine learning algorithms; predictive computational models; psychobiotics and postbiotics; neuroinflammation; synaptic plasticity; metabolic diseases

(This special issue belongs to the Section Molecular Microbiology)

Calcium Homeostasis of Cells in Health and Disease: Third Edition

edited by

Péter Szentesi

and

László Csernoch

submission deadline 30 Jan 2027 | 6 articles | Viewed by 10906 | Submission Open

Keywords: Ca2+; calcium homeostasis; calcium-binding proteins; aging; disease

(This special issue belongs to the Section Biochemistry)

Exosomes and Extracellular Vesicles in Health and Diseases: 4th Edition

edited by

Manuela Zavatti

and

Francesca Beretti

submission deadline 30 Jan 2027 | 6 articles | Viewed by 4864 | Submission Open

Keywords: exosome; extracellular vesicles; network signals; biomarkers; pathological conditions

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Substances from Plants: Discovery and Functional Characterization

edited by

Mohamed Ouknin

and

Lhou Majidi

submission deadline 30 Jan 2027 | 2 articles | Viewed by 2090 | Submission Open

Keywords: plant bioactive compounds; phytochemicals; natural products; functional characterization; phytochemical profiling; metabolomics; structure–activity relationships; biological activities

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Biology of Cancer—Implications for Diagnosis and Treatment: 4th Edition

edited by

Stergios Boussios

and

Tania Vanessa Pierfelice

submission deadline 30 Jan 2027 | 3 articles | Viewed by 1900 | Submission Open

Keywords: cancer molecular biology; tumor microenvironment; cancer biomarkers; precision oncology; cancer metabolism; translational cancer research

(This special issue belongs to the Section Molecular Oncology)

Recent Advances in Fungal–Host Interactions

edited by Julliana Ribeiro Alves Santos

submission deadline 30 Jan 2027 | Viewed by 299 | Submission Open

Keywords: fungal–host interactions; fungal pathogens in humans; fungal pathogens in plants; fungal–host molecular interaction; fungal pathogenicity; molecular basis of antifungal resistance

(This special issue belongs to the Section Molecular Immunology)

Plant-Derived Bioactives: Antioxidant Mechanisms and Preventive Health Strategies, 2nd Edition

edited by

Charles Manful

submission deadline 30 Jan 2027 | Viewed by 253 | Submission Open

Keywords: antioxidant; plant-derived bioactive compounds; flavonoids; oxidative stress; mechanisms of action

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Displaying special issue 1851-1900 on page 38 of 62.

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