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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Nanobiotechnology: Breaking Barriers in Phytomedicine submission deadline 31 Jan 2027 | Viewed by 348 | Submission Open
Keywords: nanotechnology; nanobiotechnology; phytocompounds; phytochemistry; natural products
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Insights into Porous Polymers
edited by Bolin Ji
submission deadline 31 Jan 2027 | Viewed by 347 | Submission Open
Keywords: porous organic polymer; covalent organic framework; adsorption and separation of gases; energy storage materials; water treatment; antimicrobial; fluorescence imaging; tumor treatment
(This special issue belongs to the Section Materials Science)
Immunity and Autoimmunity in Cardiovascular and Respiratory Diseases
edited by
submission deadline 31 Jan 2027 | Viewed by 347 | Submission Open
Keywords: cardiovascular diseases; respiratory diseases; autoimmune diseases; T cell; B cell; lipid mediators; autoantibodies; genetic variants; mucin
(This special issue belongs to the Section Molecular Immunology)
Organoid Models: Advancing the Study of Disease Mechanisms and Nutritional Regulations
edited by and Pinghuang Liu
submission deadline 31 Jan 2027 | Viewed by 346 | Submission Open
Keywords: organoids; disease mechanisms; nutritional regulation; disease modeling; stem cells
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Exploring the Chemistry of 2D Transition Metal Carbides and Nitrides (MXenes): Synthesis Methods and Surface Chemistry
edited by
submission deadline 31 Jan 2027 | Viewed by 343 | Submission Open
Keywords: synthesis optimization of non-Al MAX phase; wet chemical etching of non-Al MAX phase; molten salt etching of non-Al MAX phase; surface modification of MXenes; colloidal stability of MXenes; solution process of MXenes
(This special issue belongs to the Section Materials Science)
Angiogenesis: Mechanisms and Targets in a Wide Spectrum of Diseases
edited by Lei Phillip Wang
submission deadline 31 Jan 2027 | Viewed by 337 | Submission Open
Keywords: angiogenesis; immune–vascular interactions; cancer; autoimmune disease; neurodegenera-tion; blood–brain barrier; biomarkers; therapeutic targeting
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Neuroinflammation in Neuropsychiatric Disorders
edited by Dmitrii A. Pavlov and
submission deadline 31 Jan 2027 | Viewed by 337 | Submission Open
Keywords: neuroinflammation; GSK-3β; neuropsychiatric disorders; depression; anxiety; brain circuits; microglia; astrocytes; gut–brain axis; synaptic plasticity
(This special issue belongs to the Section Molecular Neurobiology)
Role of Ion Channels in Heart Health and Diseases
edited by Ernesto Alejandro Aiello
submission deadline 31 Jan 2027 | Viewed by 336 | Submission Open
Keywords: ion channels; heart; channelopathies; hypertrophy; heart failure; ischemia; hypertension; inflammation
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Cancer Nanomedicine
edited by Hari Krishnareddy Rachamala and Sandeep Atla
submission deadline 31 Jan 2027 | Viewed by 333 | Submission Open
Keywords: cancer nanomedicine; lipid nanoparticles; polymeric nanoparticles; nano-immunotherapy; targeted drug delivery; personalized cancer vaccines; mRNA delivery; tumor microenvironment; theranostics; precision oncology
(This special issue belongs to the Section Molecular Oncology)
Proteoglycans and Glycosaminoglycans in Cancer Biology and Therapy
edited by Masao Nakamura
submission deadline 31 Jan 2027 | Viewed by 327 | Submission Open
Keywords: proteoglycans; glycosaminoglycans; tumor microenvironment; chondroitin sulfate; heparan sulfate; sulfation patterns; extracellular matrix remodeling; metastasis and invasion; angiogenesis; immune evasion; antibody therapeutics and ADCs; drug resistance mechanisms
(This special issue belongs to the Section Molecular Oncology)
Recent Advances in Electrochemical Properties
edited by
submission deadline 31 Jan 2027 | Viewed by 321 | Submission Open
Keywords: electrochemical properties; electrode materials; electrodeposition; electrocatalysis; corrosion protection; electrochemical sensors; energy storage and conversion; electrochemical impedance spectroscopy; thin films and coatings; nanostructured materials; computational electrochemistry; artificial intelligence; explainable AI; machine learning; structure–property relationships
(This special issue belongs to the Section Materials Science)
Advanced Molecular Mechanisms, Bioprocessing and Functional Evaluation of Edible Plants: From Bioactive-Ingredient Enhancement to Health-Promoting Applications
edited by Hongxun Tao, and
submission deadline 31 Jan 2027 | Viewed by 317 | Submission Open
Keywords: edible plants; plant foods; molecular mechanisms; advanced bioprocessing; bioactive ingredients; functional evaluation; health-promoting applications; structure–function relationship; signal transduction pathways; bioavailability and metabolism; gut microbiota modulation; omics technologies
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Nutrition and Gut Health in Production Animals
edited by Shimeng Huang
submission deadline 31 Jan 2027 | 1 articles | Viewed by 315 | Submission Open
Keywords: production animals; molecular nutrition; gut health; gut microbiota; intestinal barrier; mucosal immunity; host–microbe interactions; microbial metabolites; feed additives; amino acid nutrition; probiotics; prebiotics; mycotoxins; multi-omics; animal performance
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Mechanisms and Treatments of Adenosine Signaling-Regulated Diseases
edited by
submission deadline 31 Jan 2027 | Viewed by 313 | Submission Open
Keywords: adenosine signaling; adenosine signaling–regulated diseases; adenosine receptors; A1, A2A, A2B and A3 receptors; purinergic signaling; extracellular adenosine; adenosine-mediated inflammation; adenosine in cancer and fibrosis; therapeutic targeting of adenosine pathways
(This special issue belongs to the Section Molecular Biology)
Molecular Engineering in Insoluble Antibacterial Particle for Medical Devices
edited by Ole T. Jensen
submission deadline 31 Jan 2027 | Viewed by 311 | Submission Open
Keywords: antibacterial; quaternary ammonium silica particles; bactericidal mechanism; antibacterial particle; medical devices
(This special issue belongs to the Section Materials Science)
Genetics- and Genomics-Based Wheat Improvement and Breeding
edited by Jian Ma
submission deadline 31 Jan 2027 | Viewed by 307 | Submission Open
Keywords: wheat crop; germplasm; genetics; genomics; breeding
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in MaternalFetal/Neonatal Interactions: Implications for Infant Immunity and Long-Term Health submission deadline 31 Jan 2027 | Viewed by 302 | Submission Open
Keywords: immune development; microbiome; epigenetic mechanisms; autoimmune diseases; breastfeednig
(This special issue belongs to the Section Molecular Immunology)
Mitochondria: Molecular Targeting in Cancer, Neurodegenerative Diseases, and Aging submission deadline 31 Jan 2027 | Viewed by 297 | Submission Open
Keywords: mitochondrial bioenergetics; metabolic reprogramming; enzymatic regulation; oxidative phosphorylation (OXPHOS); mitochondrial permeability transition pore (mPTP); small-molecule inhibitors; mitochondria-targeted therapeutics; oncometabolites; mithophagy; proteostasis
(This special issue belongs to the Section Molecular Biology)
Gut Microbiota and Host Interactions: From Metabolites to Metabolic Diseases
edited by
submission deadline 31 Jan 2027 | Viewed by 297 | Submission Open
Keywords: gut microbiota; omics science; microbial metabolites; dysbiosis; gut–organ axis; cardiometabolic disease
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Small-Molecule Fluorescent Probes: From Design to Biological Applications
edited by Qinglong Qiao
submission deadline 31 Jan 2027 | Viewed by 294 | Submission Open
Keywords: fluorescent probes; fluorescence imaging; biosensors; molecular design; biological applications
(This special issue belongs to the Section Molecular Biophysics)
Latest Research in Bioactive Compounds
edited by
submission deadline 31 Jan 2027 | Viewed by 293 | Submission Open
Keywords: peptides; nervous system; feeding regulation; glucose; lipid metabolism
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Recent Progress in Fabrication, Properties, and Applications of Biomaterials for Tissue Engineering submission deadline 31 Jan 2027 | Viewed by 290 | Submission Open
Keywords: biomedical applications; tissue engineering; biomaterials; nanomaterials; scaffolds; hydrogels; cell–material interaction; 3D printing; bioreactors
(This special issue belongs to the Section Materials Science)
Molecular Research on Development and Inhibition of Oral Biofilms
edited by Arunima Mishra
submission deadline 31 Jan 2027 | Viewed by 289 | Submission Open
Keywords: oral biofilms; dental plaque; biofilm structure/architecture; oral biofilm management; quorum-sensing inhibitors; anti-microbial peptides; glucosyltransferases; coaggregation
(This special issue belongs to the Section Molecular Microbiology)
New Perspectives and Challenges in the Mechanisms, Diagnosis and Management of Skin Diseases
edited by , Daniela Kovacs and
submission deadline 31 Jan 2027 | Viewed by 286 | Submission Open
Keywords: skin diseases; precision medicine; molecular pathogenesis; regenerative medicine; lipidomics; targeted biologics; inflammatory skin diseases; skin cancers; skin aging; gut–skin axis; skin regeneration
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms Regulating Oxidative and Stress Responses in Pseudomonas aeruginosa: Implications for Adaptation and Virulence
edited by Magdalena Pezzoni
submission deadline 31 Jan 2027 | Viewed by 285 | Submission Open
Keywords: Pseudomonas aeruginosa; oxidative stress; stress response regulation; redox homeostasis; transcriptional regulation; small RNAs; virulence and persistence; antibiotic resistance
(This special issue belongs to the Section Molecular Microbiology)
Research on Plant-Microbe Interaction
edited by Yelda Özden Çiftçi
submission deadline 31 Jan 2027 | Viewed by 284 | Submission Open
Keywords: biofertilizers; plant-microbe interactome; synthetic symbiosis; rhizosphere engineering
(This special issue belongs to the Section Molecular Plant Sciences)
Beyond Solid-State Drugs: Liquid-State Pharmaceutical Re-Engineering—from Molecular Design to Delivery Performance submission deadline 31 Jan 2027 | Viewed by 283 | Submission Open
Keywords: liquid-state pharmaceuticals; pharmaceutical re-engineering; active pharmaceutical ingredient ionic liquids (API-ILs); deep eutectic and ionic systems; solid-to-liquid drug transformation; physicochemical property modulation; structure–property–performance relationships; non-oral drug delivery; molecular design of pharmaceutical materials; drug solubility enhancement; permeability and drug delivery; solid-to-liquid transformation; transdermal delivery; pharmaceutical material design; ionic and hydrogen-bonded pharmaceutical systems
(This special issue belongs to the Section Molecular Pharmacology)
Natural Active Compounds Targeting Obesity
edited by Mariana Sarto Figueiredo
submission deadline 31 Jan 2027 | Viewed by 278 | Submission Open
Keywords: obesity; bioactive compounds; functional foods; food as medicine; natural products; comorbidities
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Advances in Polymer–Surfactant Systems: Interactions, Self-Assembly, and Functional Applications
edited by Francisco Ríos
submission deadline 31 Jan 2027 | Viewed by 277 | Submission Open
Keywords: polymer–surfactant interactions; molecular self-assembly; colloidal and interfacial systems; soft matter chemistry; micellization; nanostructured materials; stimuli-responsive polymers; molecular modeling and simulations
(This special issue belongs to the Section Materials Science)
Bridging Molecular Endotypes and Clinical Phenotypes in Sleep Apnea-From Mechanistic Insights to Precision Therapeutics
edited by
submission deadline 31 Jan 2027 | Viewed by 277 | Submission Open
Keywords: obstructive sleep apnea; phenotype; REM-OSA; POSA; COMISA; daytime sleepiness; home gardening; insulin resistance; obesity; retrognathia
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Liposome-Related Nanotechnology and Lipid-Based Nanocarriers
edited by
submission deadline 31 Jan 2027 | Viewed by 276 | Submission Open
Keywords: liposomes; lipid nanoparticles; solid lipid nanoparticles; nanostructured lipid carriers; nanocarriers; drug delivery; controlled release
(This special issue belongs to the Section Molecular Nanoscience)
Adaptive Strategies of Plants to Water Stress
edited by Weitao Jia
submission deadline 31 Jan 2027 | Viewed by 270 | Submission Open
Keywords: adaptive strategies; submergence; post-submergence; waterlogging; drought; plant physiology; phenotypic plasticity; omics; epigenetic regulation; molecular mechanism
(This special issue belongs to the Section Molecular Plant Sciences)
Advanced Studies on Bioactive Natural Products for Human Health
edited by
submission deadline 31 Jan 2027 | Viewed by 268 | Submission Open
Keywords: medicinal and aromatic plants; bioactive natural products; phytochemistry; phenolic compounds; metabolomics; antioxidant activity; anticancer activity; molecular mechanisms; phytochemical profiling; nutraceuticals
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Panomics Approaches for Deciphering Salinity Stress Tolerance in Plants submission deadline 31 Jan 2027 | Viewed by 266 | Submission Open
Keywords: salinity stress; panomics integration; multi-omics; salt tolerance; spatial transcriptomics; AI-driven breeding; systems biology; climate-smart crops; molecular breeding
(This special issue belongs to the Section Molecular Plant Sciences)
Advancements of Nanomaterials in Applied Molecular Science
edited by , and Pollyana Souza Castro
submission deadline 31 Jan 2027 | Viewed by 264 | Submission Open
Keywords: nanotechnology; nanomaterials; molecular science; microfluidics; biosensors
(This special issue belongs to the Section Molecular Nanoscience)
DNA Repair Mechanisms in Neurological Disorders
edited by Camila Araújo Bernardino Garcia
submission deadline 31 Jan 2027 | Viewed by 257 | Submission Open
Keywords: DNA repair; somatic mosaicism; focal cortical dysplasia; epilepsy genetics; cortical malformations; neurodevelopmental disorders; genomic instability; precision medicine
(This special issue belongs to the Section Molecular Neurobiology)
Polymer Biomaterials in Urology: Innovations and Applications
edited by
submission deadline 31 Jan 2027 | Viewed by 253 | Submission Open
Keywords: polymer biomaterials; polymer implants; protheses; injectables; drug delivery systems; reconstruction
(This special issue belongs to the Section Macromolecules)
Plant Gaseous Signaling Molecules
edited by
submission deadline 31 Jan 2027 | Viewed by 247 | Submission Open
Keywords: gasotransmitters; plants; signaling pathway; biotic and abiotic stresses; growth and development
(This special issue belongs to the Section Molecular Plant Sciences)
Platelet-Mediated Immune Regulation in Cancer
edited by
submission deadline 31 Jan 2027 | Viewed by 246 | Submission Open
Keywords: platelets; tumor immunity; megakaryocyte; immunotherapy; lymphocytes; microvesicles; immune suppression; metastasis
(This special issue belongs to the Section Molecular Immunology)
Design and Engineering of Polymeric Systems for Biomedical Applications submission deadline 31 Jan 2027 | Viewed by 242 | Submission Open
Keywords: polymers; polymer systems; drug delivery; tissue engineering; medical devices; regenerative medicine
(This special issue belongs to the Section Macromolecules)
Neurodegenerative Diseases: Linking Autophagy, Oxidative Stress, ER Stress and Neuroinflammation
edited by
submission deadline 31 Jan 2027 | Viewed by 240 | Submission Open
Keywords: neurodegenerative diseases; autophagy; oxidative stress; endoplasmic reticulum stress; neuroinflammation; microglia; astrocytes; protein aggregation; proteostasis; mitochondrial dysfunction; reactive oxygen species (ROS); unfolded protein response (UPR); neuroprotection; alzheimer's disease
(This special issue belongs to the Section Molecular Neurobiology)
New Advances in Spinal Cord Injury
edited by
submission deadline 31 Jan 2027 | Viewed by 239 | Submission Open
Keywords: spinal cord injury; neural regeneration; regenerative medicine; stem cell therapy; induced pluripotent stem cells; mesenchymal stem cells; neural progenitor cells; biomaterials; neuroinflammation; neuromodulation
(This special issue belongs to the Section Molecular Neurobiology)
Immunogenetics in the Era of Genomic Medicine: From Diversity to Clinical Translation
edited by Khalid Sadki
submission deadline 31 Jan 2027 | Viewed by 239 | Submission Open
Keywords: immunogenomics; genetic diversity; disease association; cancer immunology; bioinformatics; artificial intelligence; big data analysis; multi-omics; single-cell sequencing; translational immunology; precision medicine; underrepresented populations
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular and Biomarker Advances in Gynecologic Oncology
edited by
submission deadline 31 Jan 2027 | Viewed by 238 | Submission Open
Keywords: gynecologic oncology; epithelial ovarian cancer; prognostic biomarkers; tumor microenvironment; systemic inflammation; precision medicine; targeted therapy; clinical risk stratification
(This special issue belongs to the Section Molecular Oncology)
Anticancer Drugs: Molecular Research and Progress submission deadline 31 Jan 2027 | Viewed by 234 | Submission Open
Keywords: anticancer agents; molecular mechanisms; drug design; computational chemistry; experimental oncology
(This special issue belongs to the Section Molecular Oncology)
New Insights in Urological Cancers
edited by Xuan-Mei Piao
submission deadline 31 Jan 2027 | Viewed by 228 | Submission Open
Keywords: urological cancers; bladder cancer; prostate cancer; kidney cancer; upper urinary tract cancer; testicular cancer; penile cancer; urothelial carcinoma; squamous cell carcinoma; adenocarcinoma; molecular oncology; cancer biomarkers; tumor microenvironment; immunotherapy; multi-omics
(This special issue belongs to the Section Molecular Oncology)
Multi-Omics-Driven Advances in Plant Sciences
edited by Sheikh Mansoor
submission deadline 31 Jan 2027 | Viewed by 224 | Submission Open
Keywords: multi-omics; plant genomics; transcriptomics; metabolomics; crop improvement; abiotic and biotic stress tolerance; plant–microbe interactions; functional genomics
(This special issue belongs to the Section Molecular Plant Sciences)
Oxidative Stress in Human Diseases: Molecular Mechanisms, Biomarkers, and Therapeutic Perspectives
edited by , and Sara Spinelli
submission deadline 31 Jan 2027 | Viewed by 220 | Submission Open
Keywords: oxidative stress; ROS; antioxidants; redox biology; inflammation; biomarkers; chronic diseases; neurodegeneration; cancer; metabolism; mitochondria; aging; translational medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Therapeutic Strategies for Intrahepatic Cholangiocarcinoma submission deadline 31 Jan 2027 | Viewed by 220 | Submission Open
Keywords: intrahepatic cholangiocarcinoma; molecular therapy; targeted therapy; immunotherapy; biomarkers; tumor microenvironment; genomic alterations; liquid biopsy; resistance mechanisms; precision oncology
(This special issue belongs to the Section Molecular Oncology)
Functional Epigenomics in Plants
edited by
submission deadline 31 Jan 2027 | Viewed by 219 | Submission Open
Keywords: epigenomics; crop improvement; epigenetic variation; functional genomics; DNA methylation
(This special issue belongs to the Section Molecular Plant Sciences)
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