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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Investigating Gut Axes: Pathophysiological Functions and Therapeutic Strategies

edited by

Alessio Ardizzone

and

Sarah Adriana Scuderi

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1773 | Submission Open

Keywords: gut–brain axis; gut–heart axis; gut–liver axis; neurological diseases; cancer; novel and alternative therapies; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Medicinal Fungi and Plants: From Bioactive Compounds to Therapeutic Mechanisms

edited by

Jasmina Glamočlija

and

Ana Ćirić

submission deadline 20 Oct 2026 | 2 articles | Viewed by 1732 | Submission Open

Keywords: medicinal fungi; medicinal plants; molecular mechanisms; bioactive compounds; metabolomics; phytochemistry; natural products; network pharmacology; molecular docking; functional foods; therapeutic development

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Molecular Research in Colitis

edited by

Pablo García-Miranda

and

María Vázquez-Carretero

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1730 | Submission Open

Keywords: colitis; inflammatory bowel disease (IBD); gut-brain axis; intestinal barrier; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Regulation and Mechanisms of Nitric Oxide in Endothelial Cells and Beyond

edited by

Roberto Berra-Romani

and

Francesco Moccia

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1712 | Submission Open

Keywords: nitric oxide (NO); endothelial cells; endothelial nitric oxide synthase (eNOS); vascular homeostasis; vasodilation; endothelial dysfunction; molecular signaling; vascular diseases; reactive oxygen species (ROS); nitric oxide regulation

(This special issue belongs to the Section Biochemistry)

Molecular Insights into Cerebrovascular Diseases

edited by

Mariagiovanna Cantone

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1665 | Submission Open

Keywords: cerebrovascular diseases; stroke; vascular dementia; molecular mechanisms; biomarkers; omics; therapeutic targets; translational medicine

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Surfactant Systems: Thermodynamics, Molecular Interactions, and Applications

edited by

Mihalj Poša

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1596 | Submission Open

Keywords: micelles; mixed micelles; thermodynamic functions of micellization; micellar solubilization; enthalpy–entropy compensation; boundary surface; Langmuir isotherm; theoretical models

(This special issue belongs to the Section Biochemistry)

Plant Responses to Environmental Stresses: Physiological and Molecular Mechanisms

edited by

Viviana Maresca

and

Alessia Postiglione

submission deadline 20 Oct 2026 | 2 articles | Viewed by 1566 | Submission Open

Keywords: plant stress; abiotic stress; biotic stress; oxidative stress; antioxidant enzymes; reactive oxygen species (ROS); phytoremediation; biomonitoring; secondary metabolites; molecular mechanisms; omics approaches; bryophytes; heavy metals; plant–microbe interactions

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of Dietary Fibre, Nutrition in Gastrointestinal Diseases

edited by

Sara Jarmakiewicz-Czaja

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1484 | Submission Open

Keywords: dietary fibre; gut microbiome; gastrointestinal disease; inflammatory bowel disease; nutrients; nutrition

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Relationships Between Diabetic Retinal Neuropathies and Vascular Pathologies in Diabetic Retinopathy

edited by

Steven Abcouwer

and David A. Antonetti

submission deadline 20 Oct 2026 | 2 articles | Viewed by 1451 | Submission Open

Keywords: retinal neurons; retinal vasculature; diabetic retinopathy; diabetic macular edema (DME); neurovascular coupling; neurovascular unit (NVU); diabetic vascular pathology; diabetic retinal neuropathy; diabetic retinal neurodegeneration; retinal thinning in diabetes; photoreceptor pathology in diabetes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Functional (Pharmaco) Genomics and Genetics in Atrial Fibrillation Associated with Sudden Cardiac Death Syndromes

edited by

Hector Barajas-Martinez

and

Anthony Ashton

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1436 | Submission Open

Keywords: atrial fibrillation; sudden cardiac death syndromes; channelopathies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Mechanisms and Pathophysiology of Nerve Regeneration

edited by Fabian Szepanowski and Mark Stettner

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1435 | Submission Open

Keywords: nerve injury; nerve inflammation; autoimmune neuropathies; immune-mediated neuropathies; polyneuropathies; peripheral neuroinflammation; nerve regeneration; Schwann cell; Schwann cell differentiation; repair Schwann cell

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Drug Discovery: Emerging Radiotracers and Small Molecule Inhibitors for Cancer and Neurological Disorders

edited by

Ramya Tokala

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1374 | Submission Open

Keywords: radiotracers; cytotoxic agents; drug discovery; molecular imaging; cancer therapy; neurological disorders; radiochemistry; medicinal chemistry; theranostics; drug development; molecular diagnostics

(This special issue belongs to the Section Molecular Pharmacology)

Recent Advances in Rheumatic Diseases and Rheumatoid Arthritis

edited by

Ilaria Mormile

submission deadline 20 Oct 2026 | 2 articles | Viewed by 1365 | Submission Open

Keywords: rheumatoid arthritis; systemic lupus erythematous; systemic sclerosis; Sjögren’s syndrome; psoriatic arthritis; rare autoimmune rheumatic diseases; vasculitis; biological therapies

(This special issue belongs to the Section Molecular Immunology)

Advanced Composite Materials: Innovative Molecular Design, Cross-Scale Materials Characterization and Integrated Engineering Applications

edited by

Zhengzhi Mu

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1349 | Submission Open

Keywords: composite materials; molecular design; cross-scale characterization; advanced synthesis; integrated applications

(This special issue belongs to the Section Materials Science)

Design, Synthesis, Application and Mechanism of Functional Polymers

edited by Jingyuan Liu

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1348 | Submission Open

Keywords: functional polymers; polymer synthesis; structure–property relationship; molecular mode of actions; interfacial interaction; molecular design; smart materials; functional coatings; biomedical applications; energy storage

(This special issue belongs to the Section Materials Science)

The Role of Toll-Like Receptors (TLRs) in Infection and Inflammation: 4th Edition

edited by

Ralf Kircheis

and

Oliver Planz

submission deadline 20 Oct 2026 | 2 articles | Viewed by 1304 | Submission Open

Keywords: toll-like receptors (TLR); pathogen associated molecular patterns (PAMPs); sepsis; bacterial infections; viral infections; Myd88; TRIF; NF-kappaB; COVID-19; coagulopathies

(This special issue belongs to the Section Molecular Immunology)

Polymer Biocomposites: Synthesis, Applications and End-Life

edited by

Maria Chiara Mistretta

and

Manuela Ceraulo

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1212 | Submission Open

Keywords: polymer biocomposites; biodegradable polymers; molecular design and synthesis; functional modifications; biodegradation

(This special issue belongs to the Section Materials Science)

Lung Cancer: Molecular Basis and Treatment Strategies

edited by

Hamada A.A. Noreldeen

submission deadline 20 Oct 2026 | Viewed by 1145 | Submission Open

Keywords: adenocarcinoma; oncogenic drivers; precision oncology; signal transduction; tumor microenvironment; targeted therapy; resistance mechanisms; epigenetics; biomarker discovery; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Neural Stem Cells as Tools for Therapies: Challenges and Future Perspectives

edited by

Daniele Bottai

submission deadline 20 Oct 2026 | 1 articles | Viewed by 1057 | Submission Open

Keywords: spinal cord injury; spinal muscular atrophy; amyotrophic lateral sclerosis; neurological diseases; neural stem cell differentiation; cellular models; transplantation; trophic factor release

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Cell Adhesion

edited by

Surajit Bhattacharjya

submission deadline 20 Oct 2026 | Viewed by 1015 | Submission Open

Keywords: cell adhesion; cell–cell communication; structures; drug discovery; integrins; cadherins; selectins

(This special issue belongs to the Section Molecular Biophysics)

Amyloid-β: An Antimicrobial Defense Peptide

edited by

Anna Lia Asti

submission deadline 20 Oct 2026 | 1 articles | Viewed by 937 | Submission Open

Keywords: amyloid (Aß); aggregation prone regions (ARPs); lipopolysaccharide (LPS); amphipathic molecules; LL-37 peptide; neurodegeneration; aggregation inhibition; Alzheimer's disease (AD)

(This special issue belongs to the Section Molecular Biology)

Advanced Research in Crops: From Physiology to Breeding

edited by

Guang Chen

and Edyta Zdunek-Zastocka

submission deadline 20 Oct 2026 | 1 articles | Viewed by 884 | Submission Open

Keywords: crops; stress; cultivation measures; molecular mechanisms; breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms and Therapeutic Strategies for Oral Mucosal Diseases: From Radiotherapy-Induced Damage to Other Pathologies

edited by

Fernanda Gonçalves Salum

submission deadline 20 Oct 2026 | 1 articles | Viewed by 808 | Submission Open

Keywords: oral mucosal diseases; drug-induced oral lesions; radiotherapy- and chemotherapy-induced oral disorders; targeted therapy- and immunotherapy-induced stomatitis; oxidative stress and inflammation; oral microbiome and immunity; nanomedicine and biomaterials; photobiomodulation and photodynamic therapy; oral potentially malignant disorders; oral oncology; immune modulation; tissue regeneration and repair; translational research; investigational therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Electrochemical Detection: A Molecular-Level Perspective

edited by Katarzyna Fendrych and

Joanna Smajdor-Baran

submission deadline 20 Oct 2026 | 1 articles | Viewed by 777 | Submission Open

Keywords: electrochemical detection; molecular sensing; biosensors; nanostructured electrodes; biomolecular interactions; electroanalytical chemistry; molecular electrochemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

The Plant Phenotyping and Phenomics for Breeding

edited by

Jaeil Lyu

submission deadline 20 Oct 2026 | Viewed by 767 | Submission Open

Keywords: plant phenomics; high-throughput phenotyping (HTP); genotype–phenotype association; non-invasive imag-ing; functional genomics; environmental interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Immunotherapy for Cancer: From Molecular Basis to Novel Biomarkers and Therapeutic Targets—2nd Edition

edited by

Laura Conti

and

Valentina Audrito

submission deadline 20 Oct 2026 | 1 articles | Viewed by 767 | Submission Open

Keywords: tumor microenvironment; immune suppression; metabolic and molecular mechanisms of resistance to therapy; tumor immune escape; immunotherapy; immune checkpoint inhibitors; cancer vaccination; tumor-infiltrating cells; biomarkers; tumor antigens; cancer metabolism

(This special issue belongs to the Section Molecular Oncology)

Mitochondrial Disorders: From Molecular Mechanisms to New Therapies

edited by

Yury Ladilov

and

Muhammad Aslam

submission deadline 20 Oct 2026 | Viewed by 708 | Submission Open

Keywords: mitochondrial disorders; mitochondrial dysfunction; molecular mechanisms; targeted therapeutic approaches; mitochondrial biology regulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Activation of the Blood–Brain Barrier and Neurological Dysfunction: 2nd Edition

edited by

Monique F. Stins

submission deadline 20 Oct 2026 | 1 articles | Viewed by 678 | Submission Open

Keywords: blood–brain barrier; neuro-infectious diseases; microbes; traumatic brain injury; Alzheimer’s disease; Parkinson’s disease; schizophrenia; cerebral vasculature; vascular heterogeneity; white matter; gray matter; therapeutic delivery; opening the BBB; neuro vascular unit

(This special issue belongs to the Section Molecular Neurobiology)

Advances in the Nanoparticles-Based Drug Delivery in Cancer Therapy

edited by

André F. Moreira

submission deadline 20 Oct 2026 | Viewed by 632 | Submission Open

Keywords: nanoparticle-based drug delivery; stimuli responsive; cancer targeting; theragnostic nanoparticles; protein corona; combinatorial drug therapies; tumor penetration; cancer cells uptake

(This special issue belongs to the Section Molecular Nanoscience)

The Impact of Circulating Biomarkers and Metabolites on Cardiometabolic Disease and Cancer: New Insights and Therapeutic Opportunities

edited by Melania Gaggini and

Cristina Vassalle

submission deadline 20 Oct 2026 | Viewed by 500 | Submission Open

Keywords: lipidomic; metabolomic; lipotoxicity; oxidative stress; amino acids; metabolic disease; cardiovascular risk; tumorigenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring Molecular Progression in Inorganic Synthesis

edited by

Suraj Kumar Pathak

submission deadline 20 Oct 2026 | Viewed by 488 | Submission Open

Keywords: inorganic synthesis; materials science; catalysis; energy materials; bioinorganic systems; organometallic compounds; supramolecular chemistry; molecular design

(This special issue belongs to the Section Materials Science)

Molecular Mechanisms of SARS-CoV-2 Infection and Pathogenesis

edited by

Virginia Lotti

and

Erica Diani

submission deadline 20 Oct 2026 | Viewed by 420 | Submission Open

Keywords: SARS-CoV-2; molecular virology; host–pathogen interactions

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Allergic Asthma

edited by

Luisa Ricciardi

submission deadline 20 Oct 2026 | Viewed by 416 | Submission Open

Keywords: allergic asthma; molecular mechanisms; allergen exposure; T2 inflammation; inhaler treatment; biological treatment

(This special issue belongs to the Section Molecular Immunology)

Cancer Nanomedicine: Imaging, Targeting and Therapeutic Applications

edited by

Marvin Xavierselvan

and

Steven Fiering

submission deadline 20 Oct 2026 | Viewed by 392 | Submission Open

Keywords: cancer nanomedicine; multimodal imaging; nanoparticle drug delivery; tumor targeting; theranostic nanoparticles; combination therapies

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Research in Obesity and Obesity Related Disorders: 4th Edition

edited by

Grażyna Nowicka

submission deadline 20 Oct 2026 | 1 articles | Viewed by 374 | Submission Open

Keywords: adipocyte biology; adipocyte tissue; adipocyte tissue dysfunction; cellular patterns; molecular patterns; epigenetics; gene expression; DNA damage; inflammation; oxidative stress; metabolic disorders; cancer

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Sustainable Nanomaterials for Environmental Remediation

edited by

Odín Reyes−Vallejo

and

Francisco J. Cano

submission deadline 20 Oct 2026 | Viewed by 363 | Submission Open

Keywords: nanomaterials; environmental remediation; adsorption; photocatalysis; membrane separation; biomass-derived materials; sustainable and conventional synthesis; CO2 capture and conversion; water, air, and soil treatment; structure–property relationships

(This special issue belongs to the Section Molecular Nanoscience)

Advances in Diagnostic, Prognostic and Predictive Biomarkers in Prostate Cancer

edited by Radka S. Stoyanova

submission deadline 20 Oct 2026 | Viewed by 336 | Submission Open

Keywords: prostate cancer; molecular biomarkers; imaging; non-invasive biomarkers; liquid biopsy

(This special issue belongs to the Section Molecular Oncology)

Epigenetic Elicitation of Dormant Microorganisms for Anti-Cancer Therapy

edited by

Komal Anjum

submission deadline 20 Oct 2026 | Viewed by 325 | Submission Open

Keywords: dormant microbes; epigenetic; bioactive molecules; anti-cancer therapy; biosynthetic pathways; bioactive secondary metabolites

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advanced Molecular Research in Bio-Based Polymeric Materials

edited by

Wanwitoo Wanmolee

submission deadline 20 Oct 2026 | Viewed by 325 | Submission Open

Keywords: bio-based polymers; lignin; cellulose; biopolymers; sustainable materials; green chemistry; biomass valorization; biocomposites; functional materials; sustainable packaging

(This special issue belongs to the Section Materials Science)

Omics-Based Regulatory Networks in Plant Abiotic Stress Tolerance

edited by

Xujun Zhu

submission deadline 20 Oct 2026 | Viewed by 236 | Submission Open

Keywords: omics; plant abiotic stress tolerance; drought/salt/heat stress; genomics; transcriptomics; proteomics; metabolomics; epigenomics; stress regulatory networks; crop resilience

(This special issue belongs to the Section Molecular Plant Sciences)

The Involvement of Stem Cells in Cancer

edited by

Kuo-Shyang Jeng

submission deadline 20 Oct 2026 | Viewed by 234 | Submission Open

Keywords: cancer; stem cells; signaling pathways; self-renewal; treatment

(This special issue belongs to the Section Molecular Oncology)

Neural Damage and Fibrosis: From Mechanisms to Therapy

edited by

Savaș Kaya

and Ayça Taş

submission deadline 20 Oct 2026 | Viewed by 227 | Submission Open

Keywords: fibrosis; inflammation; oxidative stress; glial activation; neurodegeneration; gene expression; molecular signaling pathways; biomarkers; translational research

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Plant Genomics and Genetics: 4th Edition

edited by

Hengling Wei

submission deadline 20 Oct 2026 | Viewed by 202 | Submission Open

Keywords: plant genomics; plant genetics; abiotic stresses; salt resistance; genome; next-generation sequencing

(This special issue belongs to the Section Molecular Genetics and Genomics)

The Role of Fatty Acids in Metabolic Disease

edited by

Danijela Ristić-Medić

and

Snježana Petrović

submission deadline 20 Oct 2026 | Viewed by 195 | Submission Open

Keywords: fatty acids; FADS; inflammation; insulin resistance; lipid mediators; lipid metabo-lism; lipotoxicity; metabolic diseases; nutrition; oxidative stress

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

New Molecular Insights for Enhancing Plant Resilience to Abiotic Stress

edited by

Aliki Kapazoglou

submission deadline 20 Oct 2026 | Viewed by 191 | Submission Open

Keywords: abiotic stress; tolerance; plant resilience; crop sustainability; environmental conditions; climate change; gene regulation; epigenetic mechanisms; microbiome

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Microbiology in the Omics Era: Genomics, Metagenomics and Computational Insights

edited by

Fei Liu

submission deadline 23 Oct 2026 | 3 articles | Viewed by 14137 | Submission Open

Keywords: microbial genomics; metagenomics; computational biology; antimicrobial resistance; host–microbe interactions; multi-omics integration; bioinformatics tools; machine learning in microbiology

(This special issue belongs to the Section Molecular Microbiology)

Molecular and Neuromuscular Mechanisms in Skeletal Muscle Aging, 2nd Edition

edited by

Rosa Mancinelli

submission deadline 23 Oct 2026 | 5 articles | Viewed by 13659 | Submission Open

Keywords: aging; sarcopenia; neuromuscular junction; molecular muscle modifications; myokines

(This special issue belongs to the Section Molecular Biology)

Latest Advances in Oxidative Stress and Brain Injury

edited by

Vittorio Fineschi

submission deadline 23 Oct 2026 | 2 articles | Viewed by 13478 | Submission Open

Keywords: measurement of ROS; pathology of brain injuries; traumatic brain injuries; hypoxic–ischemic brain damage; experimental models of brain injury; targeted therapy of brain injuries; drug abuse and ROS; histological diagnosis of brain injuries; epigenetics of brain injuries; miRNA and prognosis of neural damage; novel approaches and proofs of principle in therapy; quality of life after brain injury

(This special issue belongs to the Section Molecular Neurobiology)

Antioxidants: The Molecular Guardians Against Oxidative Stress

edited by

Karolina A. Wojtunik-Kulesza

submission deadline 23 Oct 2026 | 5 articles | Viewed by 12285 | Submission Open

Keywords: antioxidant; free radical; oxidative stress; essential oils; secondary plant metabolites

(This special issue belongs to the Section Biochemistry)

Eye Diseases: From Pathophysiology to Novel Therapeutic Approaches

edited by

Tomasz Chorągiewicz

and

Joanna Dolar-Szczasny

submission deadline 23 Oct 2026 | 5 articles | Viewed by 11230 | Submission Open

Keywords: eye diseases; genetic; biochemical; proteomic; cellular and physiological level; innovative therapeutic approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 651-700 on page 14 of 63.

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